Effects of α-2A adrenergic receptor agonist on time and risk preference in primates
Open accessAbstract
Rationale Subjective values of actions are influenced by the uncertainty and immediacy of expected rewards. Multiple brain areas, including the prefrontal cortex and basal ganglia, are implicated in selecting actions according to their subjective values. Alterations in these neural circuits, therefore, might contribute to symptoms of impulsive choice behaviors in disorders such as substance abuse and attention-deficit hyperactivity disorder (ADHD). In particular, the α-2A noradrenergic system is known to have a key influence on prefrontal cortical circuits, and medications that stimulate this receptor are currently in use for the treatment of ADHD. Objective We tested whether the preference of rhesus monkeys for delayed and uncertain reward is influenced by the α-2A adrenergic receptor agonist, guanfacine. Methods In each trial, the animal chose between a small, certain and immediate reward and another larger, more delayed reward. In half of the trials, the larger reward was certain, whereas in the remaining trials, the larger reward was uncertain. Results Guanfacine increased the tendency for the animal to choose the larger and more delayed reward only when it was certain. By applying an econometric model to the animal's choice behavior, we found that guanfacine selectively reduced the animal's time preference, increasing their choice of delayed, larger rewards, without significantly affecting their risk preference. Conclusions In combination with previous findings that guanfacine improves the efficiency of working memory and other prefrontal functions, these results suggest that impulsive choice behaviors may also be ameliorated by strengthening prefrontal functions.
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Guanfacine improves ability of a young monkey to wait for a larger reward, a measure of impulse control.
“Guanfacine also improves the ability of a young monkey to wait for a larger reward”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Kim, Bobeica, Gamo, Arnsten, & Lee, 2012
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Article Dopamine Reward Prediction Error Responses Reflect Marginal Utility
Stauffer, W. R., Lak, A., & Schultz, W. (2014)
- Authors
- Kim, S., Bobeica, I., Gamo, N. J., Arnsten, A. F. T., & Lee, D.
- Affiliations
- Yale University (US)
- Corresponding author
- Lee, Daeyeol
- Venue
- Psychopharmacology
- Published
- 2011-10-07
- Volume
- 219
- Issue
- 2
- Pages
- 363-375
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3269972
- OpenAlex
- W1998060466
- Cited by
- 47
- References
- 94
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 13 · 2013: 3 · 2012: 4
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- Shire
- National Institutes of Health
- National Institute on Drug Abuse (RL1DA024855)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- guanfacine, time preference, risk preferences, delay discounting, uncertainty, impulsive choice, rhesus monkeys, prefrontal cortex, basal ganglia, subjective value, ADHD treatment, working memory
- MeSH terms
- Animals, Conditioning, Operant, Decision Making, Macaca mulatta, Male, Reward, Risk-Taking, Time Factors, Guanfacine, Adrenergic alpha-2 Receptor Agonists
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