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Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

Pennanen, Corina, Kivipelto, Miia, Tuomainen, Susanna, Hartikainen, Päivi, Hänninen, Tuomo, Laakso, Mikko P, Hallikainen, Merja, Vanhanen, Matti, Nissinen, Aulikki, Helkala, Eeva-Liisa, Vainio, Pauli, Vanninen, Ritva, Partanen, Kaarina, Soininen, Hilkka·2004·Neurobiology of Aging

DOI 10.1016/s0197-4580(03)00084-8

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“Mini-mental state”
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Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
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“Furthermore, no significant neuronal loss in ERC was detectable in a study on cognitively normal aged people (between the age of 60 and 90), while a very severe neuronal loss is seen in ERC even in the very mild AD cases [17].”
Background
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
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“Therefore, our data is well in line with the assumption that the pathology of AD starts in ERC, providing in vivo evidence for the Braak stages [6,7].”
Result

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3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer’s disease
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Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
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Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
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“The hippocampus appears particularly vulnerable to aging, exhibiting the first signs of degeneration in Alzheimer’s disease (Bobinski et al., 2000; Johnson et al., 2012; Pennanen et al., 2004).”
Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment
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Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease
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Functional implications of hippocampal volume and diffusivity in mild cognitive impairment
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Self-citation
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Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment
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Authors: Pennanen, C., Kivipelto, M., Tuomainen, S., Hartikainen, P., Hänninen, T., Laakso, M. P., Hallikainen, M., Vanhanen, M., Nissinen, A., Helkala, E.-L., Vainio, P., Vanninen, R., Partanen, K., & Soininen, H.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2004-03
Volume: 25
Issue: 3
Pages: 303-310
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(03)00084-8
OpenAlex: W2021720039
Cited by: 643
References: 14
FWCI: 10.51
Type: journal article
Language: en
Open access: closed

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Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

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