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Cited by 313

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

Open access
Hu, Xiuli, Yu, Jicheng, Qian, Chenggen, Lu, Yue, Kahkoska, Anna R., Xie, Zhigang, Jing, Xiabin, Buse, John B., Gu, Zhen·2017·ACS Nano
DOI 10.1021/acsnano.6b06892
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Abstract

-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (PBE)-conjugated polyserine (designated mPEG-b-P(Ser-PBE)) and loaded with glucose oxidase (GOx) and insulin. The polymeric vesicles function as both moieties of the glucose sensing element (GOx) and the insulin release actuator to provide basal insulin release as well as promote insulin release in response to hyperglycemic states. In the current study, insulin release responds quickly to elevated glucose and its kinetics can be modulated by adjusting the concentration of GOx loaded into the microneedles. In vivo testing indicates that a single patch can regulate glucose levels effectively with reduced risk of hypoglycemia.

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Crossref · 10.1021/acsnano.6b06892

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Metadata

Authors
Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., Jing, X., Buse, J. B., & Gu, Z.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2017-01-04
Volume
11
Issue
1
Pages
613-620
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/acsnano.6b06892
OpenAlex
W2569734753
Cited by
313
References
53
FWCI
18.75
Type
journal article
Language
en
Open access
green

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