Antiestrogens and Selective Estrogen Receptor Modulators as Multifunctional Medicines. 1. Receptor Interactions

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

Hulley, S. (1998) · JAMA · doi:10.1001/jama.280.7.605 · Cited by 6,216

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G., Enmark, E., Pelto-Huikko, M., Nilsson, S., & Gustafsson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,788

Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene<SUBTITLE>Results From a 3-Year Randomized Clinical Trial</SUBTITLE>

Ettinger, B. (1999) · JAMA · doi:10.1001/jama.282.7.637 · Cited by 3,366

Molecular basis of agonism and antagonism in the oestrogen receptor

Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,729

Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex

Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,687

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

Soule, H. D., Vazquez, J., Long, A., Albert, S., & Brennan, M. (1973) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/51.5.1409 · Cited by 2,449

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

Oñate, S. A., Tsai, S. Y., Tsai, M.-J., & O'Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,387

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J.-M., Argos, P., & Chambon, P. (1986) · Nature · doi:10.1038/320134a0 · Cited by 2,321

ERβ: Identification and characterization of a novel human estrogen receptor

Mosselman, S., Polman, J., & Dijkema, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00782-x · Cited by 2,269

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Hörlein, A. J., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,034

Mechanisms of Estrogen Action

Nilsson, S., Mäkelä, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., & Gustafsson, J.-Å. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1535 · Cited by 1,996

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,911

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science · doi:10.1126/science.277.5331.1508 · Cited by 1,861

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M. M., Guan, X.-Y., Sauter, G., Kallioniemi, O.-P., Trent, J. M., & Meltzer, P. S. (1997) · Science · doi:10.1126/science.277.5328.965 · Cited by 1,639

Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women

Delmas, P. D., Bjarnason, N. H., Mitlak, B. H., Ravoux, A.-C., Shah, A. S., Huster, W. J., Draper, M., & Christiansen, C. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712043372301 · Cited by 1,637

Functional domains of the human estrogen receptor

Kumar, V., Green, S., Stack, G., Berry, M., Jin, J.-R., & Chambon, P. (1987) · Cell · doi:10.1016/0092-8674(87)90581-2 · Cited by 1,316

Sequence and Expression of Human Estrogen Receptor Complementary DNA

Greene, G. L., Gilna, P., Waterfield, M., Baker, A., Hort, Y., & Shine, J. (1986) · Science · doi:10.1126/science.3753802 · Cited by 1,311

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

Berthois, Y., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2496 · Cited by 1,307

Steroid receptor coactivator-1 is a histone acetyltransferase

Spencer, T. E., Jenster, G., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Onate, S. A., Tsai, S. Y., Tsai, M.-J., et al. (1997) · Nature · doi:10.1038/38304 · Cited by 1,243

A MODIFICATION OF RECEPTOR THEORY

STEPHENSON, R. P. (1956) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1956.tb00006.x · Cited by 1,156

Molecular Determinants for the Tissue Specificity of SERMs

Shang, Y., & Brown, M. (2002) · Science · doi:10.1126/science.1068537 · Cited by 1,146

The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1

Hall, J. M., & McDonnell, D. P. (1999) · Endocrinology · doi:10.1210/endo.140.12.7179 · Cited by 1,075

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjöld, M., & Gustafsson, J.-A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4470 · Cited by 1,074

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk

Schairer, C. (2000) · JAMA · doi:10.1001/jama.283.4.485 · Cited by 1,048

A two-step mechanism for the interaction of estradiol with rat uterus.

Jensen, E. V., Suzuki, T., Kawashima, T., Stumpf, W. E., Jungblut, P. W., & DeSombre, E. R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.59.2.632 · Cited by 1,015

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial

Mulnard, R. A., Cotman, C. W., Kawas, C., van Dyck, C. H., Sano, M., Doody, R., Koss, E., Pfeiffer, E., Jin, S., Gamst, A., et al. (2000) · JAMA · doi:10.1001/jama.283.8.1007 · Cited by 991

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

Bunone, G., Briand, P. A., Miksicek, R. J., & Picard, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00571.x · Cited by 986

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

Pike, A. C. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4608 · Cited by 986

Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm

Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A., Scudiero, D. A., Rubinstein, L., Plowman, J., & Boyd, M. R. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.14.1088 · Cited by 967

Nuclear receptor coactivators and corepressors

Horwitz, K. B. (1996) · Molecular Endocrinology · doi:10.1210/me.10.10.1167 · Cited by 942

Role of CBP/P300 in nuclear receptor signalling

Chakravarti, D., LaMorte, V. J., Nelson, M. C., Nakajima, T., Schulman, I. G., Juguilon, H., Montminy, M., & Evans, R. M. (1996) · Nature · doi:10.1038/383099a0 · Cited by 930

Identification of a new class of steroid hormone receptors

Giguère, V., Yang, N., Segui, P., & Evans, R. M. (1988) · Nature · doi:10.1038/331091a0 · Cited by 867

The pharmacology and clinical uses of tamoxifen

Furr, B. J. A., & Jordan, V. C. (1984) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(84)90043-3 · Cited by 864

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

Tremblay, G. B., Tremblay, A., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Labrie, F., & Giguère, V. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.3.9902 · Cited by 864

The nuclear receptor ligand-binding domain: structure and function

Moras, D., & Gronemeyer, H. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80015-x · Cited by 843

The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture.

Lippman, M. E., Bolan, G., & Huff, K. K. (1976) · PubMed · Cited by 810

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

Danielian, P. S., White, R., Lees, J. A., & Parker, M. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05141.x · Cited by 803

The effect of raloxifene on risk of breast cancer in postmenopausal women : results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation

Cummings, S. R. (1999) · Medical Entomology and Zoology · Cited by 797

A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

Lanz, R. B., McKenna, N. J., Onate, S. A., Albrecht, U., Wong, J., Tsai, S. Y., Tsai, M.-J., & O’Malley, B. W. (1999) · Cell · doi:10.1016/s0092-8674(00)80711-4 · Cited by 792

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

Berry, M., Metzger, D., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07469.x · Cited by 767

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

Cavaillès, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J., & Parker, M. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00044.x · Cited by 751

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains

Tanenbaum, D. M., Wang, Y., Williams, S. P., & Sigler, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5998 · Cited by 738

Cloning of the human estrogen receptor cDNA.

Walter, P., Green, S., Greene, G., Krust, A., Bornert, J. M., Jeltsch, J. M., Staub, A., Jensen, E., Scrace, G., & Waterfield, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7889 · Cited by 730

A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

Cole, M. P., Jones, C. T. A., & Todd, I. D. H. (1971) · British Journal of Cancer · doi:10.1038/bjc.1971.33 · Cited by 701

Basic Guide to the Mechanisms of Antiestrogen Action

Macgregor, J. I., & Jordan, V. C. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01358-9 · Cited by 694

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

Webb, P. (1995) · Molecular Endocrinology · doi:10.1210/me.9.4.443 · Cited by 693

Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women

Walsh, B. W. (1998) · JAMA · doi:10.1001/jama.279.18.1445 · Cited by 692

Estrogen Receptors α and β Form Heterodimers on DNA

Cowley, S. M., Hoare, S., Mosselman, S., & Parker, M. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19858 · Cited by 689

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

Toft, D., & Gorski, J. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.55.6.1574 · Cited by 680

Continued Breast Cancer Risk Reduction in Postmenopausal Women Treated with Raloxifene: 4-Year Results from the MORE Trial

Cauley, J. A., Norton, L., Lippman, M. E., Eckert, S., Krueger, K. A., Purdie, D. W., Farrerons, J., Karasik, A., Mellstrom, D., Ng, K. W., et al. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006478317173 · Cited by 678

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

Tzukerman, M. T. (1994) · Molecular Endocrinology · doi:10.1210/me.8.1.21 · Cited by 671

Establishment and characterization of a cell line of human breast carcinoma origin

Keydar, I., Chen, L., Karby, S., Weiss, F. R., Delarea, J., Radu, M., Chaitcik, S., & Brenner, H. J. (1979) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(79)90139-7 · Cited by 650

Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women.

Powles, T. J., Hickish, T., Kanis, J. A., Tidy, A., & Ashley, S. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.78 · Cited by 646

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C., & Brown, M. (1994) · Science · doi:10.1126/science.8197458 · Cited by 637

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

Black, L. J., Sato, M., Rowley, E. R., Magee, D. E., Bekele, A., Williams, D. C., Cullinan, G. J., Bendele, R., Kauffman, R. F., & Bensch, W. R. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116985 · Cited by 609

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

Pettersson, K., Grandien, K., Kuiper, G. G. J. M., & Gustafsson, J.-A. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9989 · Cited by 597

HORMONE REPLACEMENT THERAPY, HEART DISEASE, AND OTHER CONSIDERATIONS

Barrett-Connor, E., & Grady, D. (1998) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.19.1.55 · Cited by 590

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

Feng, W., Ribeiro, R. C. J., Wagner, R. L., Nguyen, H., Apriletti, J. W., Fletterick, R. J., Baxter, J. D., Kushner, P. J., & West, B. L. (1998) · Science · doi:10.1126/science.280.5370.1747 · Cited by 580

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

Kurokawa, R., Söderström, M., Hörlein, A., Halachmi, S., Brown, M., Rosenfeld, M. G., & Glass, C. K. (1995) · Nature · doi:10.1038/377451a0 · Cited by 547

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones

Katzenellenbogen, J. A. (1996) · Molecular Endocrinology · doi:10.1210/me.10.2.119 · Cited by 535

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

Xu, J., Liao, L., Ning, G., Yoshida-Komiya, H., Deng, C., & O'Malley, B. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120166297 · Cited by 534

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

McDonnell, D. P. (1995) · Molecular Endocrinology · doi:10.1210/me.9.6.659 · Cited by 526

Estrogen Replacement Therapy and Risk of Alzheimer Disease

Paganini‐Hill, A. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.19.2213 · Cited by 524

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

Dauvois, S., White, R., & Parker, M. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1377 · Cited by 522

The Complete Primary Structure of Human Estrogen Receptor β (hERβ) and Its Heterodimerization with ER αin Vivoandin Vitro

Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., & Muramatsu, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7893 · Cited by 510

A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY

JORDAN, V. C., COLLINS, M. M., ROWSBY, L., & PRESTWICH, G. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0750305 · Cited by 506

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

Rittinger, K., Walker, P. A., Eccleston, J. F., Smerdon, S. J., & Gamblin, S. J. (1997) · Nature · doi:10.1038/39651 · Cited by 490

Genomic organization of the human oestrogen receptor gene.

Ponglikitmongkol, M., Green, S., & Chambon, P. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03211.x · Cited by 485

The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L. W., & Horwitz, K. B. (1997) · Molecular Endocrinology · doi:10.1210/me.11.6.693 · Cited by 478

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

Dauvois, S., Danielian, P. S., White, R., & Parker, M. G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4037 · Cited by 465

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

Tremblay, A., Tremblay, G. B., Labrie, F., & Giguère, V. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80479-7 · Cited by 464

Molecular mechanics of calcium–myristoyl switches

Ames, J. B., Ishima, R., Tanaka, T., Gordon, J. I., Stryer, L., & Ikura, M. (1997) · Nature · doi:10.1038/38310 · Cited by 461

Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene

Couse, J. F. (1995) · Molecular Endocrinology · doi:10.1210/me.9.11.1441 · Cited by 461

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I

Aronica, S. M. (1993) · Molecular Endocrinology · doi:10.1210/me.7.6.743 · Cited by 456

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

Ogawa, S. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.15.3505 · Cited by 448

Television Viewing and Aggressive Behavior During Adolescence and Adulthood

Johnson, J. G., Cohen, P., Smailes, E. M., Kasen, S., & Brook, J. S. (2002) · Science · doi:10.1126/science.1062929 · Cited by 447

A NEW DERIVATIVE OF TRIPHENYLETHYLENE: EFFECT ON IMPLANTATION AND MODE OF ACTION IN RATS

HARPER, M. J. K., & WALPOLE, A. L. (1967) · Reproduction · doi:10.1530/jrf.0.0130101 · Cited by 445

AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

Font de Mora, J., & Brown, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5041-5047.2000 · Cited by 432

The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators

Wijayaratne, A. L., & McDonnell, D. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101097200 · Cited by 427

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

Gottardis, M. M., Robinson, S. P., SATYASWAROOP, P. G., & Jordan, V. C. (1988) · PubMed · Cited by 422

Biochemical pharmacology of antiestrogen action.

Jordan, V. C. (1984) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06650-5 · Cited by 417

The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

Onate, S. A., Boonyaratanakornkit, V., Spencer, T. E., Tsai, S. Y., Tsai, M.-J., Edwards, D. P., & O'Malley, B. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12101 · Cited by 417

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

Paige, L. A., Christensen, D. J., Grøn, H., Norris, J. D., Gottlin, E. B., Padilla, K. M., Chang, C.-Y., Ballas, L. M., Hamilton, P. T., McDonnell, D. P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3999 · Cited by 412

Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex

BEATO, M., & SÁNCHEZ-PACHECO, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-587 · Cited by 405

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

Osborne, C. K., Hobbs, K., & Clark, G. M. (1985) · PubMed · Cited by 402

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

Jacq, X., Brou, C., Lutz, Y., Davidson, I., Chambon, P., & Tora, L. (1994) · Cell · doi:10.1016/0092-8674(94)90404-9 · Cited by 401

Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

Saville, B., Wormke, M., Wang, F., Nguyen, T., Enmark, E., Kuiper, G., Gustafsson, J.-Å., & Safe, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5379 · Cited by 401

Endocrine Pharmacology of Antiestrogens as Antitumor Agents*

JORDAN, V. C., & MURPHY, C. S. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-4-578 · Cited by 400

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

vom Baur, E., Zechel, C., Heery, D., Heine, M. J., Garnier, J. M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., & Losson, R. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00339.x · Cited by 399

Relationship Between Estrogen Levels, Use of Hormone Replacement Therapy, and Breast Cancer

Colditz, G. A. (1998) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/90.11.814 · Cited by 399

p300 is a component of an estrogen receptor coactivator complex.

Hanstein, B., Eckner, R., DiRenzo, J., Halachmi, S., Liu, H., Searcy, B., Kurokawa, R., & Brown, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11540 · Cited by 396

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

Webb, P. M., Nguyen, P. T., Valentine, C. D., Lopez, G. N., Kwok, G. R., McInerney, E. M., Katzenellenbogen, B. S., Enmark, E., Gustafsson, J.-Α., Nilsson, S. V., et al. (1999) · Molecular Endocrinology · doi:10.1210/me.13.10.1672 · Cited by 396

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

Coezy, E. D., Borgna, J., & Rochefort, H. (1982) · PubMed · Cited by 394

Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

Ward, H. W. C. (1973) · BMJ · doi:10.1136/bmj.1.5844.13 · Cited by 375

Interaction of proteins with transcriptionally active estrogen receptors.

Cavaillès, V, Dauvois, S., Danielian, P. S., & Parker, M. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10009 · Cited by 375

The Orphan Nuclear Receptor Estrogen-Related Receptor α Is a Transcriptional Regulator of the Human Medium-Chain Acyl Coenzyme A Dehydrogenase Gene

Sladek, R., Bader, J.-A., & Giguère, V. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5400 · Cited by 374

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O’Brien, S. J., & Joyce, M. J. (1978) · PubMed · Cited by 373

Peptide Antagonists of the Human Estrogen Receptor

Norris, J. D., Paige, L. A., Christensen, D. J., Chang, C.-Y., Huacani, M. R., Fan, D., Hamilton, P. T., Fowlkes, D. M., & McDonnell, D. P. (1999) · Science · doi:10.1126/science.285.5428.744 · Cited by 373

Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

Jordan, V. C. (1976) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(76)90030-x · Cited by 371

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.

Korach, K. S., Couse, J. F., Curtis, S. W., Washburn, T. F., Lindzey, J. K., Kimbro, K. S., Eddy, E. M., Migliaccio, S., Snedeker, S. M., Lubahn, D. B., et al. (1996) · PubMed · Cited by 370

High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

Sutherland, R. L., Murphy, L. C., Foo, M. S., Green, M. D., Whybourne, A. M., & Krozowski, Z. S. (1980) · Nature · doi:10.1038/288273a0 · Cited by 362

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

Howell, A., DeFriend, D. J., Blamey, R. W., Robertson, J. F., & Walton, P. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91156-1 · Cited by 349

Structural Insights into the Mode of Action of a Pure Antiestrogen

Pike, A. C. W., Brzozowski, A. M., Walton, J., Hubbard, R. E., Thorsell, A.-G., Li, Y.-L., Gustafsson, J.-Å., & Carlquist, M. (2001) · Structure · doi:10.1016/s0969-2126(01)00568-8 · Cited by 347

Human breast carcinoma cells in continuous culture: a review.

Engel, L. W., & Young, N. A. (1978) · PubMed · Cited by 345

Ligand-independent activation of steroid hormone receptors

Weigel, N. L., & Zhang, Y. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050241 · Cited by 345

Induction of Ovulation with MRL/41: Preliminary Report

Greenblatt, R. B. (1961) · JAMA · doi:10.1001/jama.1961.03040410001001 · Cited by 343

Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha , but not by ERbeta

Vanacker, J.-M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4270 · Cited by 340

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

Ing, N. H., Beekman, J. M., Tsai, S. Y., Tsai, M. J., & O'Malley, B. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37087-5 · Cited by 336

Oestrogen-responsive human breast cancer in long term tissue culture

LIPPMAN, M. E., & BOLAN, G. (1975) · Nature · doi:10.1038/256592a0 · Cited by 335

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

HARPER, M. J. K., & WALPOLE, A. L. (1966) · Nature · doi:10.1038/212087a0 · Cited by 327

Effects of anti-estrogens on bone in castrated and intact female rats

Jordan, V. C., Phelps, E., & Lindgren, J. U. (1987) · Breast Cancer Research and Treatment · doi:10.1007/bf01806132 · Cited by 324

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

Zwijsen, R. M. L., Buckle, R. S., Hijmans, E. M., Loomans, C. J. M., & Bernards, R. (1998) · Genes & Development · doi:10.1101/gad.12.22.3488 · Cited by 305

Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3

Hong, H., Yang, L., & Stallcup, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22618 · Cited by 303

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

Pace, P., Taylor, J., Suntharalingam, S., Coombes, R. C., & Ali, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25832 · Cited by 298

Aromatase Inhibitors in the Treatment and Prevention of Breast Cancer

Goss, P. E., & Strasser, K. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.3.881 · Cited by 298

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

Montano, M. M., Ekena, K., Delage-Mourroux, R., Chang, W., Martini, P., & Katzenellenbogen, B. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6947 · Cited by 296

Identification of two transactlvation domains in the mouse oestrogen receptor

Lees, J. A., Fawell, S. E., & Parker, M. G. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.14.5477 · Cited by 295

Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3

Greschik, H., Wurtz, J.-M., Sanglier, S., Bourguet, W., van Dorsselaer, A., Moras, D., & Renaud, J.-P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00444-6 · Cited by 291

Recovery after intravenous barbiturate anesthesia.

Cj, E., Green, R., Th, H., et al. (1962) · PubMed · Cited by 288

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women After 5 Years of Treatment

Love, R. R., Wiebe, D. A., Feyzi, J. M., Newcomb, P. A., & Chappell, R. J. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.20.1534 · Cited by 278

Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats

Sato, M., Rippy, M. K., & Bryant, H. U. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.8.8666168 · Cited by 277

Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines.

Pink, J. J., & Jordan, V. C. (1996) · PubMed · Cited by 276

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras1

McInerney, E. M., Weis, K. E., Sun, J., Mosselman, S., & Katzenellenbogen, B. S. (1998) · Endocrinology · doi:10.1210/endo.139.11.6298 · Cited by 269

4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ

Coward, P., Lee, D., Hull, M. V., & Lehmann, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151244398 · Cited by 265

Growth Regulation of Estrogen Receptor-Negative Breast Cancer Cells Transfected With Complementary DNAs for Estrogen Receptor

Jiang, S.-Y., & Jordan, V. C. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.8.580 · Cited by 261

Heart and Estrogen/progestin Replacement Study (HERS)

Grady, D., Applegate, W., Bush, T., Furberg, C., Riggs, B., & Hulley, S. B. (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(98)00010-5 · Cited by 260

Risks of breast and endometrial cancer after estrogen and estrogen–progestin replacement

Persson, I., Weiderpass, E., Bergkvist, L., Bergström, R., & Schairer, C. (1999) · Cancer Causes & Control · doi:10.1023/a:1008909128110 · Cited by 258

Tamoxifen, Raloxifene, and the Prevention of Breast Cancer*

Jordan, V. C., & Morrow, M. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0368 · Cited by 258

Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ

Tremblay, G. B., Kunath, T., Bergeron, D., Lapointe, L., Champigny, C., Bader, J.-A., Rossant, J., & Giguère, V. (2001) · Genes & Development · doi:10.1101/gad.873401 · Cited by 255

Allosteric Regulation of Estrogen Receptor Structure, Function, and Coactivator Recruitment by Different Estrogen Response Elements

Hall, J. M. (2002) · Molecular Endocrinology · doi:10.1210/me.16.3.469 · Cited by 253

Tourette Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding

Wolf, S. S., Jones, D. W., Knable, M. B., Gorey, J. G., Lee, K. S., Hyde, T. M., Coppola, R., & Weinberger, D. R. (1996) · Science · doi:10.1126/science.273.5279.1225 · Cited by 252

A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer

Powles, T., Hardy, Jr., Ashley, S., Farrington, G., Cosgrove, D., Davey, J., Dowsett, M., McKinna, J., Nash, A., Sinnett, H., et al. (1989) · British Journal of Cancer · doi:10.1038/bjc.1989.235 · Cited by 246

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists

Montano, M. M. (1995) · Molecular Endocrinology · doi:10.1210/me.9.7.814 · Cited by 246

Comparative Analyses of Mechanistic Differences Among Antiestrogens1

Wijayaratne, A. L., Nagel, S. C., Paige, L. A., Christensen, D. J., Norris, J. D., Fowlkes, D. M., & McDonnell, D. P. (1999) · Endocrinology · doi:10.1210/endo.140.12.7164 · Cited by 244

Biological Activities of Steroids in Relation to Cancer

(1961) · Pediatrics · doi:10.1542/peds.27.5.754 · Cited by 244

Molecular determinants of tissue selectivity in estrogen receptor modulators

Grese, T. A., Sluka, J. P., Bryant, H. U., Cullinan, G. J., Glasebrook, A. L., Jones, C. D., Matsumoto, K., Palkowitz, A. D., Sato, M., Termine, J. D., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14105 · Cited by 243

The reaction between acetyl choline and muscle cells

Clark, A. J. (1926) · The Journal of Physiology · doi:10.1113/jphysiol.1926.sp002314 · Cited by 242

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

Black, L. J., Jones, C. D., & Falcone, J. F. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90935-9 · Cited by 239

SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.

Chen, J. D., Umesono, K., & Evans, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7567 · Cited by 237

Subnuclear Trafficking of Estrogen Receptor-α and Steroid Receptor Coactivator-1

Stenoien, D. L., Mancini, M. G., Patel, K., Allegretto*, E. A., Smith, C. L., & Mancini, M. A. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.4.0436 · Cited by 237

Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients.

Speirs, V., Malone, C. M., Walton, D. S., Kerin, M. J., & Atkin, S. L. (1999) · PubMed · Cited by 237

Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.

Borgna, J., & Rochefort, H. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70058-1 · Cited by 234

Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

Speirs, V., Parkes, A., Kerin, M. J., Walton, D. S., Carleton, P. J., Fox, J. N., & Atkin, S. L. (1999) · PubMed · Cited by 234

A NON-STEROIDAL ESTROGEN ANTAGONIST l-(p-2-DIETHYLAMINOETHOXYPHENYLH-PHENYL-2-p-METHOXYPHENYL ETHANOL

LERNER, L. J., HOLTHAUS, F. J., & THOMPSON, C. R. (1958) · Endocrinology · doi:10.1210/endo-63-3-295 · Cited by 233

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

Metzger, D., Ali, S., Bornert, J.-M., & Chambon, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9535 · Cited by 231

In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity.

Bautista, S., Valles, H., Walker, R. L., Anzick, S. L., Zeillinger, R., Meltzer, P. S., & Theillet, C. G. (1998) · PubMed · Cited by 231

A receptor molecule for estrogens: studies using a cell-free system.

Toft, D., Shyamala, G., & Gorski, J. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.6.1740 · Cited by 224

Tamoxifen Inhibits Osteoclast-Mediated Resorption of Trabecular Bone in Ovarian Hormone-Deficient Rats*

TURNER, R. T., WAKLEY, G. K., HANNON, K. S., & BELL, N. H. (1988) · Endocrinology · doi:10.1210/endo-122-3-1146 · Cited by 224

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

Jordan, V. C., & Allen (née Naylor), K. E. (1980) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(80)90156-5 · Cited by 214

Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors.

Greene, G. L., Fitch, F. W., & Jensen, E. V. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.157 · Cited by 206

Estrogen-related Receptor, hERR1, Modulates Estrogen Receptor-mediated Response of Human Lactoferrin Gene Promoter

Yang, N., Shigeta, H., Shi, H., & Teng, C. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5795 · Cited by 200

Effect of Tamoxifen on Lumbar Spine Bone Mineral Density in Postmenopausal Women After 5 Years

Love, R. R. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.154.22.2585 · Cited by 199

Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer

Turken, S., Siris, E., Seldin, D., Flaster, E., Hyman, G., & Lindsay, R. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.14.1086 · Cited by 194

Estrogen control of prolactin synthesis in vitro.

Lieberman, M. E., Maurer, R. A., & Gorski, J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.5946 · Cited by 189

Human ERRγ, a Third Member of the Estrogen Receptor-Related Receptor (ERR) Subfamily of Orphan Nuclear Receptors: Tissue-Specific Isoforms Are Expressed during Development and in the Adult

Heard, D. J., Norby, P. L., Holloway, J., & Vissing, H. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.3.0431 · Cited by 188

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

Wrenn, C. K., & Katzenellenbogen, B. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80497-9 · Cited by 186

Antiestrogen-Binding Sites Distinct from the Estrogen Receptor: Subcellular Localization, Ligand Specificity, and Distribution in Tissues of the Rat*

SUDO, K., MONSMA, F., & KATZENELLENBOGEN, B. S. (1983) · Endocrinology · doi:10.1210/endo-112-2-425 · Cited by 183

Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.

Lu, D., Kiriyama, Y., Lee, K. Y., & Giguère, V. (2001) · PubMed · Cited by 182

Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice.

SATYASWAROOP, P. G., Zaino, R. J., & Mortel, R. (1984) · PubMed · Cited by 178

Expression of wild-type estrogen receptor beta and variant isoforms in human breast cancer.

Fuqua, S. A. W., Schiff, R., Parra, I., Friedrichs, W. E., Su, J. L., McKee, D. D., Slentz‐Kesler, K., Moore, L. B., Willson, T. M., & Moore, J. T. (1999) · PubMed · Cited by 177

Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels

Clemens, J. A., Bennett, D. R., Black, L. J., & Jones, C. D. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90323-5 · Cited by 176

A molecular basis for drug action

Ariëns, E. J., & Simonis, A. M. (1964) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1964.tb07437.x · Cited by 175

Estrogenic activity of phenol red

Welshons, W. V., Wolf, M. F., Murphy, C. S., & Jordan, V. C. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90072-x · Cited by 173

Raloxifene preserves bone strength and bone mass in ovariectomized rats

Turner, C. H. (1994) · Endocrinology · doi:10.1210/en.135.5.2001 · Cited by 173

Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic Acid

Anzano, M. A., Peer, C. W., Smith, J. M., Mullen, L. T., Shrader, M. W., Logsdon, D. L., Driver, C. L., Brown, C. C., Roberts, A. B., & Sporn, M. B. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.123 · Cited by 170

Estrogen-Related Receptor α1 Functionally Binds as a Monomer to Extended Half-Site Sequences Including Ones Contained within Estrogen-Response Elements

Johnston, S. D., Liu, X., Zuo, F., Eisenbraun, T. L., Wiley, S. R., Kraus, R. J., & Mertz, J. E. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.3.9897 · Cited by 170

Constitutive Activation of Transcription and Binding of Coactivator by Estrogen-Related Receptors 1 and 2

Xie, W., Hong, H., Yang, N., Lin, R. J., Simon, C. M., Stallcup, M. R., & Evans, R. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0381 · Cited by 158

Transcriptional Activators Differ in Their Responses to Overexpression of TATA-Box-Binding Protein

Sadovsky, Y., Webb, P., Lopez, G. N., Baxter, J. D., Fitzpatrick, P. M., Gizang-Ginsberg, E., Cavaillès, V., Parker, M. G., & Kushner, P. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1554 · Cited by 157

Selective estrogen receptor modulation: a personal perspective.

Jordan, V. C. (2001) · PubMed · Cited by 156

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain

Wolf, D. M., & Jordan, V. C. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00689683 · Cited by 155

Selective oestrogen receptor modulation

Levenson, A. S., & Jordan, V. C. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00297-x · Cited by 152

The ERR-1 Orphan Receptor Is a Transcriptional Activator Expressed During Bone Development

Bonnelye, E., Vanacker, J. M., Dittmar, T., Begue, A., Desbiens, X., Denhardt, D. T., Aubin, J. E., Laudet, V., & Fournier, B. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.7.9948 · Cited by 147

Effects of raloxifene hydrochloride on the endometrium of postmenopausal women

Boss, S. M., Huster, W. J., Neild, J. A., Glant, M. D., Eisenhut, C. C., & Draper, M. W. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70091-7 · Cited by 144

A realistic clinical perspective of tamoxifen and endometrial carcinogenesis

Assikis, V. J., Neven, P., Jordan, V. C., et al. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00184-0 · Cited by 142

Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

Tremblay, G. B., Tremblay, A., Labrie, F., & Giguère, V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1919 · Cited by 141

Remodeling the estrogen receptor model

Gorski, J., Welshons, W. V., & Sakai, D. D. (1984) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(84)90079-0 · Cited by 141

Isolation of a Gene Encoding a Novel Member of the Nuclear Receptor Superfamily from the Critical Region of Usher Syndrome Type IIa at 1q41

Eudy, J. D., Yao, S., Weston, M. D., Ma-Edmonds, M., Talmadge, C. B., Cheng, J. J., Kimberling, W. J., & Sümegi, J. (1998) · Genomics · doi:10.1006/geno.1998.5345 · Cited by 140

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.

Fan, J. D., Wagner, B. L., & McDonnell, D. P. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.12.8961270 · Cited by 139

Transcriptional Activities of the Orphan Nuclear Receptor ERR (Estrogen Receptor-Related Receptor- )

Vanacker, J.-M., Bonnelye, E., Delannoy, S., Delmarre, C., Cavaillès, V., & Laudet, V. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.5.0281 · Cited by 138

Estrogen Receptor-related Receptor α1 Interacts with Coactivator and Constitutively Activates the Estrogen Response Elements of the Human Lactoferrin Gene

Zhang, Z., & Teng, C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001880200 · Cited by 138

Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.

Holtkamp, D. E., GRESLIN, J. G., Root, C. A., & Lerner, L. J. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-105-26054 · Cited by 138

Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism

Gangloff, M., Ruff, M., Eiler, S., Duclaud, S., Wurtz, J., & Moras, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009870200 · Cited by 136

Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex

Zamir, I., Dawson, J., Lavinsky, R. M., Glass, C. K., Rosenfeld, M. G., & Lazar, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14400 · Cited by 135

Estrogen receptor-beta messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins.

Dotzlaw, H., Leygue, E., Watson, P. H., & Murphy, L. C. (1999) · PubMed · Cited by 134

Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice

Black, L. J., & Goode, R. L. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90049-1 · Cited by 134

Ribozyme Targeting Demonstrates That the Nuclear Receptor Coactivator AIB1 Is a Rate-limiting Factor for Estrogen-dependent Growth of Human MCF-7 Breast Cancer Cells

List, H.-J., Lauritsen, K. J., Reiter, R., Powers, C., Wellstein, A., & Riegel, A. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102397200 · Cited by 134

Suppression of Mouse Mammary Tumorigenesis by Long-Term Tamoxifen Therapy

Jordan, V. C., Lababidi, M. K., & Langan-Fahey, S. M. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.7.492 · Cited by 134

RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites

L’Horset, F., Dauvois, S., Heery, D. M., Cavaillès, V., & Parker, M. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6029 · Cited by 133

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro.

Lieberman, M. E., Gorski, J., & Jordan, V. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32484-0 · Cited by 132

Coactivator Peptides Have a Differential Stabilizing Effect on the Binding of Estrogens and Antiestrogens with the Estrogen Receptor

Gee, A. C., Carlson, K. E., Martini, P. G. V., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.11.0373 · Cited by 130

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat

Jordan, V. C., DIX, C. J., Rowsby, L., & Prestwich, G. (1977) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(77)90066-1 · Cited by 129

New Synthetic Agent for the Induction of Ovulation: Preliminary Trials in Women

Klopper, A. I., & Hall, M. (1971) · BMJ · doi:10.1136/bmj.1.5741.152 · Cited by 129

Species-specific pharmacology of antiestrogens: role of metabolism.

Jordan, V. C., & Robinson, S. P. (1987) · PubMed · Cited by 125

Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.

Yang, C., Zhou, D., & Chen, S. (1998) · PubMed · Cited by 121

Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red

Bindal, R. D., Carlson, K. E., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90352-4 · Cited by 115

Transcription and Translation of Estrogen Receptor- in the Male Reproductive Tract of Estrogen Receptor- Knock-Out and Wild-Type Mice

Rosenfeld, C. S., Ganjam, V. K., Taylor, J. A., Yuan, X., Stiehr, J. R., Hardy, M. P., & Lubahn, D. B. (1998) · Endocrinology · doi:10.1210/endo.139.6.6028 · Cited by 113

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Paterni, I., Granchi, C., Katzenellenbogen, J. A., & Minutolo, F. (2014) · Steroids · doi:10.1016/j.steroids.2014.06.012 · Cited by 721

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

Huang, P., Chandra, V., & Rastinejad, F. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135917 · Cited by 533

Resveratrol as an anticancer nutrient: molecular basis, open questions and promises

Signorelli, P., & Ghidoni, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.01.017 · Cited by 489

Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Chwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., & Elger, W. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0001 · Cited by 310

Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry

Chalmers, M. J., Busby, S. A., Pascal, B. D., He, Y., Hendrickson, C. L., Marshall, A. G., & Griffin, P. R. (2006) · Analytical Chemistry · doi:10.1021/ac051294f · Cited by 301