Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

Nanocarriers as an emerging platform for cancer therapy

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Understanding biophysicochemical interactions at the nano–bio interface

Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

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Applications of magnetic nanoparticles in biomedicine

Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson, J. (2003) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/36/13/201 · Cited by 5,881

Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods

Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,436

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955

Particles as surfactants—similarities and differences

Binks, B. P. (2002) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(02)00008-0 · Cited by 3,691

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645

Heating magnetic fluid with alternating magnetic field

Rosensweig, R. E. (2002) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(02)00706-0 · Cited by 2,551

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D., Tolcher, A., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,505

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

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Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791

Superparamagnetism

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‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2612 · Cited by 1,681

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Prabhakar, U., Maeda, H., Jain, R. K., Sevick-Muraca, E. M., Zamboni, W., Farokhzad, O. C., Barry, S. T., Gabizon, A., Grodzinski, P., & Blakey, D. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4561 · Cited by 1,485

Progress in applications of magnetic nanoparticles in biomedicine

Pankhurst, Q. A., Thanh, N. T. K., Jones, S. K., & Dobson, J. (2009) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/42/22/224001 · Cited by 1,455

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

Verma, A., Uzun, O., Hu, Y., Hu, Y., Han, H.-S., Watson, N., Chen, S., Irvine, D. J., & Stellacci, F. (2008) · Nature Materials · doi:10.1038/nmat2202 · Cited by 1,266

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

Iversen, T.-G., Skotland, T., & Sandvig, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.02.003 · Cited by 1,239

Time Evolution of the Nanoparticle Protein Corona

Casals, E., Pfaller, T., Duschl, A., Oostingh, G. J., & Puntes, V. (2010) · ACS Nano · doi:10.1021/nn901372t · Cited by 1,211

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

Hrkach, J., Von Hoff, D., Ali, M. M., Andrianova, E., Auer, J., Campbell, T., De Witt, D., Figa, M., Figueiredo, M., Horhota, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003651 · Cited by 1,147

Selective Inductive Heating of Lymph Nodes

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Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

Zhang, L., Cao, Z., Bai, T., Carr, L., Ella-Menye, J.-R., Irvin, C., Ratner, B. D., & Jiang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2580 · Cited by 1,035

Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy

Hergt, R., Dutz, S., Müller, R., & Zeisberger, M. (2006) · Journal of Physics: Condensed Matter · doi:10.1088/0953-8984/18/38/s26 · Cited by 977

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2614 · Cited by 948

Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy

Hergt, R., & Dutz, S. (2007) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2006.10.1156 · Cited by 922

Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer

Bardhan, R., Lal, S., Joshi, A., & Halas, N. J. (2011) · Accounts of Chemical Research · doi:10.1021/ar200023x · Cited by 917

Minireview: Nanoparticles and the Immune System

Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

Deng, Z. J., Liang, M., Monteiro, M., Toth, I., & Minchin, R. F. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.250 · Cited by 893

Cell‐penetrating peptides: 20 years later, where do we stand?

Bechara, C., & Sagan, S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.031 · Cited by 857

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen, B., & Jordan, A. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802104757 · Cited by 829

Self-Assembly of Patchy Particles

Zhang, Z., & Glotzer, S. C. (2004) · Nano Letters · doi:10.1021/nl0493500 · Cited by 819

Janus Particle Synthesis and Assembly

Jiang, S., Chen, Q., Tripathy, M., Luijten, E., Schweizer, K. S., & Granick, S. (2010) · Advanced Materials · doi:10.1002/adma.200904094 · Cited by 803

Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme

Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldoefner, N., Felix, R., et al. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 775

Design considerations for tumour-targeted nanoparticles

Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

Cho, E. C., Zhang, Q., & Xia, Y. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.58 · Cited by 719

Measurements of particle size distribution parameters in ferrofluids

Chantrell, R., Popplewell, J., & Charles, S. (1978) · IEEE Transactions on Magnetics · doi:10.1109/tmag.1978.1059918 · Cited by 718

FDA-approved poly(ethylene glycol)–protein conjugate drugs

Alconcel, S. N. S., Baas, A. S., & Maynard, H. D. (2011) · Polymer Chemistry · doi:10.1039/c1py00034a · Cited by 643

Effect of local hyperthermia on blood flow and microenvironment: a review.

Song, C. W. (1984) · PubMed · Cited by 628

Complement activation-related pseudoallergy: A new class of drug-induced acute immune toxicity

Szebeni, J. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.023 · Cited by 611

Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

Harrington, K. J., Mohammadtaghi, S., Uster, P. S., Glass, D. M., Peters, A. M., Vile, R. G., & Stewart, J. S. W. (2001) · PubMed · Cited by 575

Effects of Cell Culture Media on the Dynamic Formation of Protein−Nanoparticle Complexes and Influence on the Cellular Response

Maiorano, G., Sabella, S., Sorce, B., Brunetti, V., Malvindi, M. A., Cingolani, R., & Pompa, P. P. (2010) · ACS Nano · doi:10.1021/nn101557e · Cited by 573

Spontaneous assembly of subnanometre-ordered domains in the ligand shell of monolayer-protected nanoparticles

Jackson, A. M., Myerson, J. W., & Stellacci, F. (2004) · Nature Materials · doi:10.1038/nmat1116 · Cited by 569

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

Kedmi, R., Ben-Arie, N., & Peer, D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.027 · Cited by 546

Magnetic nanoparticle heating and heat transfer on a microscale: Basic principles, realities and physical limitations of hyperthermia for tumour therapy

Dutz, S., & Hergt, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.822993 · Cited by 522

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

Peer, D., Park, E. J., Morishita, Y., Carman, C. V., & Shimaoka, M. (2008) · Science · doi:10.1126/science.1149859 · Cited by 493

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R., & Muggia, F. M. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg374 · Cited by 479

Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery

Shin, J., Anisur, R. M., Ko, M. K., Im, G. H., Lee, J. H., & Lee, I. S. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802323 · Cited by 475

Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin

Cheng, K., Peng, S., Xu, C., & Sun, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903300f · Cited by 438

Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles

Riedinger, A., Guardia, P., Curcio, A., Garcia, M. A., Cingolani, R., Manna, L., & Pellegrino, T. (2013) · Nano Letters · doi:10.1021/nl400188q · Cited by 427

Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention

Szebeni, J., Muggia, F., Gabizon, A., & Barenholz, Y. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.017 · Cited by 423

Introduction to Magnetic Materials

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Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates

Ruiz-Hernández, E., Baeza, A., & Vallet-Regí, M. (2011) · ACS Nano · doi:10.1021/nn1029229 · Cited by 408

FePt@CoS2 Yolk−Shell Nanocrystals as a Potent Agent to Kill HeLa Cells

Gao, J., Liang, G., Zhang, B., Kuang, Y., Zhang, X., & Xu, B. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067785e · Cited by 403

Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

Liu, H.-L., Hua, M.-Y., Yang, H.-W., Huang, C.-Y., Chu, P.-C., Wu, J.-S., Tseng, I.-C., Wang, J.-J., Yen, T.-C., Chen, P.-Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003388107 · Cited by 395

Physics of heat generation using magnetic nanoparticles for hyperthermia

Dennis, C. L., & Ivkov, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.836758 · Cited by 391

Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent

Gao, J., Liang, G., Cheung, J. S., Pan, Y., Kuang, Y., Zhao, F., Zhang, B., Zhang, X., Wu, E. X., & Xu, B. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803920b · Cited by 366

Long term in vivo biotransformation of iron oxide nanoparticles

Levy, M., Luciani, N., Alloyeau, D., Elgrabli, D., Deveaux, V., Pechoux, C., Chat, S., Wang, G., Vats, N., Gendron, F., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.031 · Cited by 361

EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise

Creixell, M., Bohórquez, A. C., Torres-Lugo, M., & Rinaldi, C. (2011) · ACS Nano · doi:10.1021/nn201822b · Cited by 325

Magnetic resonance relaxation properties of superparamagnetic particles

Gossuin, Y., Gillis, P., Hocq, A., Vuong, Q. L., & Roch, A. (2009) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.36 · Cited by 319

Intracellular hyperthermia a biophysical approach to cancer treatment via intracellular temperature and biophysical alterations

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Remotely Triggered Release from Magnetic Nanoparticles

Derfus, A. M., von Maltzahn, G., Harris, T. J., Duza, T., Vecchio, K. S., Ruoslahti, E., & Bhatia, S. N. (2007) · Advanced Materials · doi:10.1002/adma.200700091 · Cited by 282

Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere−Serum Interface: Implications for Stealth Nanoparticle Engineering

Hamad, I., Al-Hanbali, O., Hunter, A. C., Rutt, K. J., Andresen, T. L., & Moghimi, S. M. (2010) · ACS Nano · doi:10.1021/nn101990a · Cited by 276

Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring

Lartigue, L., Alloyeau, D., Kolosnjaj-Tabi, J., Javed, Y., Guardia, P., Riedinger, A., Péchoux, C., Pellegrino, T., Wilhelm, C., & Gazeau, F. (2013) · ACS Nano · doi:10.1021/nn305719y · Cited by 274

Beyond the lipid-bilayer: interaction of polymers and nanoparticles with membranes

Schulz, M., Olubummo, A., & Binder, W. H. (2012) · Soft Matter · doi:10.1039/c2sm06999g · Cited by 258

Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging

Muro, E., Pons, T., Lequeux, N., Fragola, A., Sanson, N., Lenkei, Z., & Dubertret, B. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1005493 · Cited by 247

The State of Nanoparticle-Based Nanoscience and Biotechnology: Progress, Promises, and Challenges

Pelaz, B., Jaber, S., de Aberasturi, D. J., Wulf, V., Aida, T., de la Fuente, J. M., Feldmann, J., Gaub, H. E., Josephson, L., Kagan, C. R., et al. (2012) · ACS Nano · doi:10.1021/nn303929a · Cited by 233

On‐Demand Drug Release System for In Vivo Cancer Treatment through Self‐Assembled Magnetic Nanoparticles

Lee, J., Chen, K., Noh, S., Garcia, M. A., Wang, H., Lin, W., Jeong, H., Kong, B. J., Stout, D. B., Cheon, J., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207721 · Cited by 232

Magnetically Triggered Dual Functional Nanoparticles for Resistance‐Free Apoptotic Hyperthermia

Yoo, D., Jeong, H., Noh, S., Lee, J., & Cheon, J. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306557 · Cited by 230

Physicochemical Characteristics of Protein–NP Bioconjugates: The Role of Particle Curvature and Solution Conditions on Human Serum Albumin Conformation and Fibrillogenesis Inhibition

Goy-López, S., Juárez, J., Alatorre-Meda, M., Casals, E., Puntes, V. F., Taboada, P., & Mosquera, V. (2012) · Langmuir · doi:10.1021/la300402w · Cited by 214

ROLE OF COMPLEMENT ACTIVATION IN HYPERSENSITIVITY REACTIONS TO DOXIL AND HYNIC PEG LIPOSOMES: EXPERIMENTAL AND CLINICAL STUDIES

Szebeni, J., Baranyi, L., Savay, S., Milosevits, J., Bunger, R., Laverman, P., Metselaar, J. M., Storm, G., Chanan-Khan, A., Liebes, L., et al. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120004790 · Cited by 212

Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects

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Animal Models of Complement-Mediated Hypersensitivity Reactions to Liposomes and Other Lipid-Based Nanoparticles

Szebeni, J., Alving, C. R., Rosivall, L., Bünger, R., Baranyi, L., Bedöcs, P., Tóth, M., & Barenholz, Y. (2007) · Journal of Liposome Research · doi:10.1080/08982100701375118 · Cited by 199

Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties

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The Magnetization of Ferromagnetic Colloids

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Surface-structure-regulated penetration of nanoparticles across a cell membrane

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Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia‐Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions

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Recognition by Macrophages and Liver Cells of Opsonized Phospholipid Vesicles and Phospholipid Headgroups

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Poly(ethylene oxide)-graft-poly(L-lysine) copolymers to enhance the biocompatibility of poly(L-lysine)-alginate microcapsule membranes

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Homogeneous Conjugation of Peptides onto Gold Nanoparticles Enhances Macrophage Response

Bastús, N. G., Sànchez‐Tilló, E., Pujals, S., Farrera, C., López‐Iglesias, C., Giralt, E., Celada, A., Lloberas, J., & Puntes, V. (2009) · ACS Nano · doi:10.1021/nn8008273 · Cited by 157

Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis

Bhattacharyya, S., Bhattacharya, R., Curley, S. A., McNiven, M. A., & Mukherjee, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006507107 · Cited by 147

Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems

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Altering the immune response with lipid-based nanoparticles

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Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

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Hyperthermia in Cancer Treatment: A Primer

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Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

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The role of nanostructure in the wetting behavior of mixed-monolayer-protected metal nanoparticles

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DNA as a Molecular Local Thermal Probe for the Analysis of Magnetic Hyperthermia

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Repeated injections of PEG-PE liposomes generate anti-PEG antibodies.

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Detoxifying Antitumoral Drugs via Nanoconjugation: The Case of Gold Nanoparticles and Cisplatin

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Reshaping the Future of Nanopharmaceuticals: Ad Iudicium

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In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy

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