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Cited by 470

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

Nanoparticle-Based Immunotherapy for Cancer

Open access
Shao, Kun, Singha, Santiswarup, Clemente-Casares, Xavier, Tsai, Sue, Yang, Yang, Santamaria, Pere·2015·ACS Nano
DOI 10.1021/nn5062029
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Abstract

The design of nanovaccines capable of triggering effective antitumor immunity requires an understanding of how the immune system senses and responds to threats, including pathogens and tumors. Equally important is an understanding of the mechanisms employed by tumor cells to evade immunity and an appreciation of the deleterious effects that antitumor immune responses can have on tumor growth, such as by skewing tumor cell composition toward immunologically silent tumor cell variants. The immune system and tumors engage in a tug-of-war driven by competition where promoting antitumor immunity or tumor cell death alone may be therapeutically insufficient. Nanotechnology affords a unique opportunity to develop therapeutic compounds than can simultaneously tackle both aspects, favoring tumor eradication. Here, we review the current status of nanoparticle-based immunotherapeutic strategies for the treatment of cancer, ranging from antigen/adjuvant delivery vehicles (to professional antigen-presenting cell types of the immune system) to direct tumor antigen-specific T-lymphocyte-targeting compounds and their combinations thereof.

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Metadata

Authors
Shao, K., Singha, S., Clemente-Casares, X., Tsai, S., Yang, Y., & Santamaria, P.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2014-12-23
Volume
9
Issue
1
Pages
16-30
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/nn5062029
OpenAlex
W2102284924
Cited by
470
References
121
FWCI
12.19
Type
journal article
Language
en
Open access
hybrid

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