Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Schreiber, S. L. (1991) · Science · doi:10.1126/science.1702904 · Cited by 1,494

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S. A., Mannella, C. A., & Korsmeyer, S. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00116-2 · Cited by 1,072

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

Sabers, C. J., Martin, M. M., Brunn, G. J., Williams, J. M., Dumont, F. J., Wiederrecht, G., & Abraham, R. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.815 · Cited by 887

A second class of chemosensory receptors in the olfactory epithelium

Liberles, S. D., & Buck, L. B. (2006) · Nature · doi:10.1038/nature05066 · Cited by 791

The mitochondrial permeability transition from in vitro artifact to disease target

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627

Calcineurin is required for virulence of Cryptococcus neoformans

Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

Chiu, M. I., Katz, H., & Berlin, V (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12574 · Cited by 481

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

Lieberman, D. N., & Mody, I. (1994) · Nature · doi:10.1038/369235a0 · Cited by 480

Chemically induced proximity in biology and medicine

Stanton, B. Z., Chory, E. J., & Crabtree, G. R. (2018) · Science · doi:10.1126/science.aao5902 · Cited by 475

Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

Stathopoulos, A. M., & Cyert, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.24.3432 · Cited by 442

Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae

Yoshimoto, H., Saltsman, K., Gasch, A. P., Li, H. X., Ogawa, N., Botstein, D., Brown, P. O., & Cyert, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202718200 · Cited by 404

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

Ishida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., & Takeya, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205063200 · Cited by 377

Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons

Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., & Crabtree, G. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00390-8 · Cited by 379

The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37038-2 · Cited by 350

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

Chang, C.-P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004) · Cell · doi:10.1016/j.cell.2004.08.010 · Cited by 331

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

Vang, T., Torgersen, K. M., Sundvold, V., Saxena, M., Levy, F. O., Skålhegg, B. S., Hansson, V., Mustelin, T., & Taskén, K. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.497 · Cited by 330

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

Steinbach, W. J., Reedy, J. L., Cramer, R. A., Perfect, J. R., & Heitman, J. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1680 · Cited by 313

Protein phosphatase type 2B (calcineurin)‐mediated, FK506‐sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

Nakamura, T., Liu, Y., Hirata, D., Namba, H., Harada, S., Hirokawa, T., & Miyakawa, T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06090.x · Cited by 270

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Asfaw, Y. G., Sauer, T. C., Najvar, L. K., Kirkpatrick, W. R., Patterson, T. F., Benjamin, D. K., Heitman, J., et al. (2006) · Eukaryotic Cell · doi:10.1128/ec.00139-06 · Cited by 264

Signaling pathways in Th2 development

Mowen, K. A., & Glimcher, L. H. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00209.x · Cited by 255

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

Almawi, W., & Melemedjian, O. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0280069 · Cited by 242

Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

Stathopoulos-Gerontides, A., Guo, J. J., & Cyert, M. S. (1999) · Genes & Development · doi:10.1101/gad.13.7.798 · Cited by 240

Calcineurin: Structure, function, and inhibition

Hemenway, C. S., & Heitman, J. (1999) · Cell Biochemistry and Biophysics · doi:10.1007/bf02737887 · Cited by 227

The mitochondrial permeability transition

Bernardi, P., Colonna, R., Costantini, P., Eriksson, O., Fontaine, E., Ichas, F., Massari, S., Nicolli, A., Petronilli, V., & Scorrano, L. (1998) · BioFactors · doi:10.1002/biof.5520080315 · Cited by 183

Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans

Fox, D. S., Cruz, M. C., Sia, R. A. L., Ke, H., Cox, G. M., Cardenas, M. E., & Heitman, J. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02295.x · Cited by 175

FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition

Baughman, G., Wiederrecht, G. J., Campbell, N. F., Martin, M. M., & Bourgeois, S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4395 · Cited by 173

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

Cramer, R. A., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00086-08 · Cited by 172

Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6

Kuhara, A., Inada, H., Katsura, I., & Mori, I. (2002) · Neuron · doi:10.1016/s0896-6273(02)00607-4 · Cited by 153

Dendritic epidermal T cells regulate skin antimicrobial barrier function

MacLeod, A. S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D. A., & Havran, W. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70064 · Cited by 152

Refined structure of the FKBP12–rapamycin–FRB ternary complex at 2.2 Å resolution

Liang, J., Choi, J., & Clardy, J. (1999) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998014747 · Cited by 148

Activity regulates cell death within cortical interneurons through a Calcineurin-dependent mechanism

Priya, R., Paredes, M. F., Karayannis, T., Yusuf, N., Liu, X., Jaglin, X., Graef, I., Alvarez-Buylla, A., & Fishell, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.007 · Cited by 127

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

Breuder, T., Hemenway, C. S., Movva, N. R., Cardenas, M. E., & Heitman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5372 · Cited by 135

Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site

Boustany, L. M., & Cyert, M. S. (2002) · Genes & Development · doi:10.1101/gad.967602 · Cited by 115

Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.

Ferreira, A., Kincaid, R., & Kosik, K. S. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1225 · Cited by 110

Recent Approaches to Antifungal Therapy for Invasive Mycoses

Mathew, B. P., & Nath, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200800353 · Cited by 105

Signal-transduction cascades as targets for therapeutic intervention by natural products

Cardenas, M. E., Sanfridson, A., Cutler, N. S., & Heitman, J. (1998) · Trends in Biotechnology · doi:10.1016/s0167-7799(98)01239-6 · Cited by 101

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

Renoir, J. M., Mercier-Bodard, C., Hoffmann, K., Le Bihan, S., Ning, Y. M., Sanchez, E. R., Handschumacher, R. E., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4977 · Cited by 94

Zinc Finger Protein Prz1 Regulates Ca2+ but Not Cl− Homeostasis in Fission Yeast

Hirayama, S., Sugiura, R., Lu, Y., Maeda, T., Kawagishi, K., Yokoyama, M., Tohda, H., Giga-Hama, Y., Shuntoh, H., & Kuno, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212900200 · Cited by 87

Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence

Reedy, J. L., Filler, S. G., & Heitman, J. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.09.002 · Cited by 76

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

Carraro, M., Carrer, A., Urbani, A., & Bernardi, P. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.014 · Cited by 71

Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p

Polizotto, R. S., & Cyert, M. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104078 · Cited by 63

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

Stanford, S. M., Krishnamurthy, D., Falk, M. D., Messina, R., Debnath, B., Li, S., Liu, T., Kazemi, R., Dahl, R., He, Y., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101202j · Cited by 59

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

Juvvadi, P. R., Gehrke, C., Fortwendel, J. R., Lamoth, F., Soderblom, E. J., Cook, E. C., Hast, M. A., Asfaw, Y. G., Moseley, M. A., Creamer, T. P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003564 · Cited by 57

Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp

Weisz Hubsman, M., Volinsky, N., Manser, E., Yablonski, D., & Aronheim, A. (2007) · Biochemical Journal · doi:10.1042/bj20061696 · Cited by 56

Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.

Tai, P.-K. K., Albers, M. W., McDonnell, D. P., Chang, H., Schreiber, S. L., & Faber, L. E. (1994) · Biochemistry · doi:10.1021/bi00201a014 · Cited by 52

Calcium‐ and FK506‐independent interaction between the immunophilin FKBP51 and calcineurin*

Li, T., Baksh, S., Cristillo, A. D., & Bierer, B. E. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10026 · Cited by 40

Treatment of Breast Cancer-Related Lymphedema With Topical Tacrolimus: A Prospective, Open-Label, Single-Arm, Phase II Pilot Trial

Gulmark Hansen, F. C., Jørgensen, M. G., & Sørensen, J. A. (2023) · Journal of Breast Cancer · doi:10.4048/jbc.2023.26.e2 · Cited by 25

Analysis of FK506, timcodar (VX‐853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

Hinds, T. D., Stechschulte, L. A., Elkhairi, F., & Sanchez, E. R. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.76 · Cited by 20