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Brain metabolism dictates the polarity of astrocyte control over arterioles
Open accessAbstract
Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the mechanism for how these opposite astrocyte influences provide appropriate changes in vessel tone within an environment that has dynamic metabolic requirements remains unclear. Here we show that the ability of astrocytes to induce vasodilations over vasoconstrictions relies on the metabolic state of the rat brain tissue. When oxygen availability is lowered and astrocyte calcium concentration is elevated, astrocyte glycolysis and lactate release are maximized. External lactate attenuates transporter-mediated uptake from the extracellular space of prostaglandin E2, leading to accumulation and subsequent vasodilation. In conditions of low oxygen concentration extracellular adenosine also increases, which blocks astrocyte-mediated constriction, facilitating dilation. These data reveal the role of metabolic substrates in regulating brain blood flow and provide a mechanism for differential astrocyte control over cerebrovascular diameter during different states of brain activation.
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Cites
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. D., & Helmchen, F. (2004) · Nature Methods · doi:10.1038/nmeth706 · Cited by 784
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742
Astrocyte glycogen and brain energy metabolism
Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586
Cited by
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Self-citationThe Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Synaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Sugar for the brain: the role of glucose in physiological and pathological brain function
Mergenthaler, P., Lindauer, U., Dienel, G. A., & Meisel, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.07.001 · Cited by 1,612
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243
The neurovascular unit - concept review
Muoio, V., Persson, P. B., & Sendeski, M. M. (2014) · Acta Physiologica · doi:10.1111/apha.12250 · Cited by 564
Glucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513
Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
Hung, Y. P., Albeck, J. G., Tantama, M., & Yellen, G. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.012 · Cited by 509
Brain lactate metabolism: the discoveries and the controversies
Dienel, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479
Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451
Astrocyte Ca2+ signalling: an unexpected complexity
Volterra, A., Liaudet, N., & Savtchouk, I. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3725 · Cited by 446
Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.11.004 · Cited by 411
Self-citationRole of Astrocytes in Neurovascular Coupling
Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409
Three-dimensional Ca 2+ imaging advances understanding of astrocyte biology
Bindocci, E., Savtchouk, I., Liaudet, N., Becker, D., Carriero, G., & Volterra, A. (2017) · Science · doi:10.1126/science.aai8185 · Cited by 342
The Translational Significance of the Neurovascular Unit
McConnell, H. L., Kersch, C. N., Woltjer, R. L., & Neuwelt, E. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.760215 · Cited by 314
The neurovascular unit in brain function and disease: The neurovascular unit function
Lecrux, C., & Hamel, E. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02256.x · Cited by 251
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241
Astrocyte Endfeet in Brain Function and Pathology: Open Questions
Díaz-Castro, B., Robel, S., & Mishra, A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-031205 · Cited by 238
Hamby, M. E., Coppola, G., Ao, Y., Geschwind, D. H., Khakh, B. S., & Sofroniew, M. V. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1256-12.2012 · Cited by 228
Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone
Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W., & Kim, K. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.064 · Cited by 222
Aamand, R., Dalsgaard, T., Jensen, F. B., Simonsen, U., Roepstorff, A., & Fago, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2009 · Cited by 213
The energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205
Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons
Descalzi, G., Gao, V., Steinman, M. Q., Suzuki, A., & Alberini, C. M. (2019) · Communications Biology · doi:10.1038/s42003-019-0495-2 · Cited by 188
Mapping oxygen concentration in the awake mouse brain
Lyons, D. G., Parpaleix, A., Roche, M., & Charpak, S. (2016) · eLife · doi:10.7554/elife.12024 · Cited by 165
Blood-Brain Glucose Transfer in Alzheimer’s disease: Effect of GLP-1 Analog Treatment
Gejl, M., Brock, B., Egefjord, L., Vang, K., Rungby, J., & Gjedde, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17718-y · Cited by 163
Gandhi, G. K., Cruz, N. F., Ball, K. K., & Dienel, G. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06333.x · Cited by 162
Brain energy metabolism: Astrocytes in neurodegenerative diseases.
Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13982 · Cited by 153
The physiology of developmental changes in BOLD functional imaging signals
Harris, J. J., Reynell, C., & Attwell, D. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.001 · Cited by 142
Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina
Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P., & Newman, E. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1782-16.2016 · Cited by 144
Ion channel networks in the control of cerebral blood flow
Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137
Unraveling the complex metabolic nature of astrocytes
Bouzier-Sore, A.-K., & Pellerin, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00179 · Cited by 134
Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease
Zhang, X., Alshakhshir, N., & Zhao, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.662242 · Cited by 134
Heterogeneity of Astrocytes in Grey and White Matter
Köhler, S., Winkler, U., & Hirrlinger, J. (2021) · Neurochemical Research · doi:10.1007/s11064-019-02926-x · Cited by 123
Shibasaki, K., Ikenaka, K., Tamalu, F., Tominaga, M., & Ishizaki, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.557132 · Cited by 118
Stobart, J. L. L., Lu, L., Anderson, H. D. I., Mori, H., & Anderson, C. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215929110 · Cited by 113
Adapting brain metabolism to myelination and long‐range signal transduction
Hirrlinger, J., & Nave, K. (2014) · Glia · doi:10.1002/glia.22737 · Cited by 109
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105
Shuttleworth, C. W. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.015 · Cited by 104
At least eighty percent of brain grey matter is modifiable by physical activity: A review study
Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92
Kreft, M., Bak, L. K., Waagepetersen, H. S., & Schousboe, A. (2012) · ASN Neuro · doi:10.1042/an20120007 · Cited by 88
Sonnay, S., Gruetter, R., & Duarte, J. M. N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00288 · Cited by 74
Boillat, Y., Xin, L., van der Zwaag, W., & Gruetter, R. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19831022 · Cited by 58
Hertz, L., Gibbs, M. E., & Dienel, G. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00261 · Cited by 58
Wells, J. A., Christie, I. N., Hosford, P. S., Huckstepp, R. T. R., Angelova, P. R., Vihko, P., Cork, S. C., Abramov, A. Y., Teschemacher, A. G., Kasparov, S., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3787-14.2015 · Cited by 57
Yoo, I. D., Park, M. W., Cha, H. W., Yoon, S., Boonpraman, N., Yi, S. S., & Moon, J.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217862 · Cited by 51
Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal
Hammett, S. T., Wall, M. B., Edwards, T. C., & Smith, A. T. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.054 · Cited by 38
Metadata
- Authors
- Gordon, G. R. J., Choi, H. B., Rungta, R. L., Ellis-Davies, G. C. R., & MacVicar, B. A.
- Venue
- Nature
- Published
- 2008-10-29
- Volume
- 456
- Issue
- 7223
- Pages
- 745-749
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1971285535
- Cited by
- 744
- References
- 8
- FWCI
- 27.53
- Type
- journal article
- Language
- en
- Open access
- green
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