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Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Open accessAbstract
Social behaviours in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. Although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviours, the neural mechanisms by which social reward is encoded by the brain are largely unknown. Here we demonstrate that in mice oxytocin acts as a social reinforcement signal within the nucleus accumbens core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons. Although the nucleus accumbens receives oxytocin-receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe nucleus, which provides serotonergic (5-hydroxytryptamine; 5-HT) innervation to the nucleus accumbens, abolishes the reinforcing properties of social interaction. Furthermore, oxytocin-induced synaptic plasticity requires activation of nucleus accumbens 5-HT1B receptors, the blockade of which prevents social reward. These results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the nucleus accumbens, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.
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In the citing paper
“Oxytocin induced LTD in nucleus accumbens medium spiny neurons (Figure 4b), as presynaptic oxytocin receptors on serotoninergic terminals lead to increased serotonin release onto medium spiny neurons and consequent LTD”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Dölen et al. 2013
The cited source says what the claim attributes to it.
In the citing paper
“Dölen et al. (2013) observed PVN oxytocin fibers innervating mouse nucleus accumbens, where oxytocin release was important for social-conditioned place preference and serotonin-dependent long-term depression (LTD).”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Dölen et al. 2013
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Dölen et al., 2013
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Dölen et al., 2013
Experimental — accuracy not yet measuredIn the citing paper
“In mice, formation of social reward requires coordinated activity of oxytocin and serotonin within the NAcc (Dölen et al., 2013).”
From Social functioning in major depressive disorder (2016) · cites this paper as Dölen et al., 2013
In the citing paper
“Recent research in mice has now shown that OT works in concert with the serotonin system in the NAcc of mice to modulate the rewarding aspects of social interaction (25).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [25]
In the citing paper
“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [3]
In the citing paper
“Preclinical studies have found that the neuropeptide, oxytocin, may regulate socialemotional functioning (Dölen et al., 2013;Hicks et al., 2012;Lim and Young, 2006;Lukas et al., 2011;Onaka et al., 2012).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Dölen et al., 2013
In the citing paper
“Social interactions can be rewarding and thereby recruit components of the brain’s reward circuitry, including the ventral tegmental area (VTA) dopamine (DA) neurons and the nucleus accumbens (NAc) (Dölen et al., 2013, Gunaydin et al., 2014, Robinson et al., 2002).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Dölen et al., 2013
In the citing paper
“In mice, both pharmacologic blockade and molecular ablation of presynaptic OXT receptors in the NAc impaired social reward processing, as assayed by social CPP [41].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [41]
In the citing paper
“More recently, modifications in the CPP assay have been made to expand its use to investigate the rewarding properties of prosocial interactions [40,41].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [41]
In the citing paper
“Additional experimental manipulations suggested that OXT induces 5-HT release from dorsal raphe (DR) inputs in the NAc, which acts on presynaptic 5-HT1b receptors that are also required for social reward [41].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [41]
In the citing paper
“This simple form of 5-HT1b receptor-triggered synaptic plasticity was subsequently found to be generated by bath application of OXT or MDMA [41,51], results consistent with the 5-HT releasing properties of these agents.”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [41]
In the citing paper
“Oxytocin promotes maternal nurturing and bonding, enhances social reward, and increases the salience of social stimuli.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [80]
In the citing paper
“For example, Dölen et al (80), using elegant circuit manipulations, demonstrated that PVN OXT and DR serotonin projections to the nucleus accumbens (NAcc) are required for social reward in mice.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [80]
In the citing paper
“Oxytocin mediates a broad spectrum of prosocial behaviors such as empathy, pair bonding, mating and social reward (Dölen et al., 2013; L. W. Hung et al., 2017; Insel and Young, 2001; Nakajima et al., 2014; Rogers-Carter et al., 2018).”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Dölen et al., 2013
In the citing paper
“the nucleus accumbens (NAc), dorsal raphe nucleus (dRph), and ventral tegmental area (VTA) receive direct or indirect projections from hypothalamic OT neurons (Beier et al., 2015; Dölen et al., 2013; Hung et al., 2017; Nardou et al., 2019)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as Dölen et al., 2013
In the citing paper
“The hippocampus projects back to basolateral amygdala and nucleus accumbens (NAc), where oxytocinergic, dopaminergic, and serotonergic innervation from the hypothalamic paraventricular nucleus, ventral tegmental area, and dorsal raphe nucleus, respectively, are necessary for social reward learning [21,22].”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [22]
In the citing paper
“Previously, we have shown that changes in locomotor activity are unlikely to account for differences in sCPP across a variety of experimental manipulations (Dölen et al., 2013; Nardou et al., 2019)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as Dölen et al., 2013
In the citing paper
“Prior investigations in rodents and primates, for example, have provided evidence for the presence of neurons that encode information about other individuals, demonstrating changes in activity when the animals observe another’s appetitive or aversive experiences 1–11.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [3]
In the citing paper
“Previous investigations have provided insight into how discrete aspects of another animal’s experience, such as receipt of reward, may be encoded by cells 1–7,9.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [3]
In the citing paper
“The use of microdialysis to measure regionally-specific neuronal release of neuropeptides has provided important mechanistic insights into neuropeptide modulation in a variety of species and a host of social contexts, including maternal behavior, social recognition, social preference, social reward, social memory, and social buffering (Bosch and Neumann, 2012; Dölen et al., 2013; Dumais et al., 20”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Dölen et al., 2013
In the citing paper
“In an elegant study, authors showed that mice form a preference for social bedding compared to the isolated bedding (Dolen et al. 2013).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Dolen et al. 2013
In the citing paper
“Moreover, mice treated with an OT antagonist within the NAcc did not form this preference.”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Dolen et al. 2013
In the citing paper
“This neuropeptide is crucial in many aspects of social behavior, including affiliation6 and reward.7”
From Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment (2016) · cites this paper as [7]
In the citing paper
“OT regulates neuronal activities in multiple neural circuits, such as sensory cortices (Marlin et al., 2015), nucleus accumbens (Dölen et al., 2013), and prefrontal cortex (Nakajima et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Dölen et al., 2013
In the citing paper
“Brain regions responding to naturally rewarding stimuli, including the ventral tegmental area (VTA) and the nucleus accumbens (NAc), are crucially involved in social behaviors (Dolen et al., 2013; Gunaydin et al., 2014; Huang and Hessler, 2008).”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Dolen et al., 2013
In the citing paper
“There are also signs of support for the view that 5-HT and oxytocin interplay in the nucleus accumbens significantly mediate the rewarding aspects of social behavior (Dolen et al., 2013).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Dolen et al., 2013
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Cites
Wickersham, I. R., Sullivan, H., & Seung, H. (2010) · Nature Protocols · doi:10.1038/nprot.2009.248 · Cited by 4,905
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,505
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300
Self-citationConcurrent activation of striatal direct and indirect pathways during action initiation
Cui, G., Jun, S. B., Jin, X., Pham, M. D., Vogel, S. S., Lovinger, D. M., & Costa, R. M. (2013) · Nature · doi:10.1038/nature11846 · Cited by 1,245
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
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Sorted by citations
Items 101–200 of 1,000
Smith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143
Molecular Profiling of Neurons Based on Connectivity
Ekstrand, M. I., Nectow, A. R., Knight, Z. A., Latcha, K. N., Pomeranz, L. E., & Friedman, J. M. (2014) · Cell · doi:10.1016/j.cell.2014.03.059 · Cited by 143
Neural Circuits for Social Cognition: Implications for Autism
Fernández, M. C., Mollinedo-Gajate, I., & Peñagarikano, O. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.013 · Cited by 143
Resendez, S. L., Namboodiri, V. M. K., Otis, J. M., Eckman, L. E. H., Rodriguez-Romaguera, J., Ung, R. L., Basiri, M. L., Kosyk, O., Rossi, M. A., Dichter, G. S., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1515-18.2020 · Cited by 142
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
Duque-Wilckens, N., Torres, L. Y., Yokoyama, S., Minie, V. A., Tran, A. M., Petkova, S. P., Hao, R., Ramos-Maciel, S., Rios, R. A., Jackson, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011890117 · Cited by 139
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139
Kirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 140
Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships
Hurlemann, R., & Scheele, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.013 · Cited by 136
Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits
Rothwell, P. E., Hayton, S. J., Sun, G. L., Fuccillo, M. V., Lim, B. K., & Malenka, R. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.035 · Cited by 135
Self-citationSocial trauma engages lateral septum circuitry to occlude social reward
Li, L., Durand-de Cuttoli, R., Aubry, A. V., Burnett, C. J., Cathomas, F., Parise, L. F., Chan, K. L., Morel, C., Yuan, C., Shimo, Y., et al. (2023) · Nature · doi:10.1038/s41586-022-05484-5 · Cited by 134
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 133
Yang, C.-J., Tan, H.-P., & Du, Y.-J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.021 · Cited by 132
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131
Zhang, B., Qiu, L., Xiao, W., Ni, H., Chen, L., Wang, F., Mai, W., Wu, J., Bao, A., Hu, H., et al. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.032 · Cited by 131
Oxytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130
The neuroscience of social feelings: mechanisms of adaptive social functioning
Eslinger, P. J., Anders, S., Ballarini, T., Boutros, S., Krach, S., Mayer, A. V., Moll, J., Newton, T. L., Schroeter, M. L., de Oliveira-Souza, R., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.028 · Cited by 130
Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity
Becker, J. A. J., Clesse, D., Spiegelhalter, C., Schwab, Y., Merrer, J. L., & Kieffer, B. L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.59 · Cited by 128
Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives
Vitale, E. M., & Smith, A. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.846315 · Cited by 127
Whole-brain wiring diagram of oxytocin system in adult mice
Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y.-T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C., & Kim, Y. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0307-22.2022 · Cited by 125
Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence
Choe, H. K., Reed, M. D., Benavidez, N., Montgomery, D., Soares, N., Yim, Y. S., & Choi, G. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.022 · Cited by 124
Meerkats: Cooperative breeding in the Kalahari
Clutton-Brock, T. H., & Manser, M. B. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107338357.018 · Cited by 124
Wei, D., Dinh, D., Lee, D., Li, D., Anguren, A., Moreno-Sanz, G., Gall, C. M., & Piomelli, D. (2016) · Cannabis and Cannabinoid Research · doi:10.1089/can.2015.0008 · Cited by 122
An insular view of the social decision-making network
Rogers-Carter, M. M., & Christianson, J. P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.005 · Cited by 121
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Bethlehem, R. A. I., Baron-Cohen, S., van Honk, J., Auyeung, B., & Bos, P. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00048 · Cited by 120
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120
Self-citationNetser, S., Meyer, A., Magalnik, H., Zylbertal, A., Haskal, S., Briller, M., Bizer, A., Grinevich, V., & Wagner, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19569-0 · Cited by 120
Visualizing an emotional valence map in the limbic forebrain by TAI-FISH
Xiu, J., Zhang, Q., Zhou, T., Zhou, T.-T., Chen, Y., & Hu, H. (2014) · Nature Neuroscience · doi:10.1038/nn.3813 · Cited by 119
Bowton, E., Saunders, C., Reddy, I. A., Campbell, N. G., Hamilton, P. J., Henry, L. K., Coon, H. H., Sakrikar, D. S., Veenstra-VanderWeele, J. M., Blakely, R., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.90 · Cited by 119
Endocannabinoid Signaling in the Control of Social Behavior
Don, W., Allsop, S. A., Tye, K. M., & Piomelli, D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.005 · Cited by 120
The zebrafish subcortical social brain as a model for studying social behavior disorders
Geng, Y., & Peterson, R. T. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039446 · Cited by 119
Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis
Borland, J. M., Rilling, J. K., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0129-2 · Cited by 116
Golden, S. A., Jin, M., Heins, C., Vènniro, M., Michaelides, M., & Shaham, Y. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2409-18.2019 · Cited by 116
Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115
μ opioid receptor, social behaviour and autism spectrum disorder: reward matters
Pellissier, L. P., Gandía, J., Laboute, T., Becker, J. A. J., & Merrer, J. L. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13808 · Cited by 115
An affective neuroscience model of boosting resilience in adults
Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 115
Williams, A. V., Duque‐Wilckens, N., Ramos-Maciel, S., Campi, K. L., Bhela, S. K., Xu, C. K., Jackson, K., Chini, B., Pesavento, P. A., & Trainor, B. C. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0657-4 · Cited by 114
Borroto‐Escuela, D. O., Ambrogini, P., Chruścicka, B., Lindskog, M., Crespo‐Ramírez, M., Hernández-Mondragón, J. C., de la Mora, M. P., Schellekens, H., & Fuxé, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041927 · Cited by 114
Oxytocin receptors modulate a social salience neural network in male prairie voles
Johnson, Z. V., Walum, H., Xiao, Y., Riefkohl, P. C., & Young, L. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.009 · Cited by 113
The transition to motherhood: linking hormones, brain and behaviour
Servin-Barthet, C., Martínez‐Garcia, M., Pretus, C., Paternina-Die, M., Soler, A., Khymenets, O., Pozo, Ó. J., Leuner, B., Vilarroya, Ó., & Carmona, S. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00733-6 · Cited by 112
Presynaptic long-term depression mediated by Gi/o-coupled receptors
Atwood, B. K., Lovinger, D. M., & Mathur, B. N. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.010 · Cited by 111
Oxytocin in learning and addiction: From early discoveries to the present
Sarnyai, Z., & Kovács, G. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.019 · Cited by 110
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior
Collins, A. L., Aitken, T. J., Huang, I.-W., Shieh, C., Greenfield, V. Y., Monbouquette, H. G., Ostlund, S. B., & Wassum, K. M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.014 · Cited by 110
The Moral brain: a multidisciplinary perspective
Decety, J., & Wheatley, T. (2015) · Choice Reviews Online · doi:10.5860/choice.192126 · Cited by 110
Ciranna, L., & Catania, M. V. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00250 · Cited by 109
Tendler, A., & Wagner, S. (2015) · eLife · doi:10.7554/elife.03614 · Cited by 109
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Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 106
Priel, A., Djalovski, A., Zagoory‐Sharon, O., & Feldman, R. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12880 · Cited by 106
Steinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105
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Yoshihara, C., Numan, M., & Kuroda, K. O. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_11 · Cited by 104
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Edsinger, E., & Dölen, G. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.061 · Cited by 104
Self-citationThe role of brain reward pathways in stress resilience and health
Dutcher, J. M., & Creswell, J. D. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.014 · Cited by 105
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
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Benekareddy, M., Stachniak, T. J., Bruns, A., Knoflach, F., von Kienlin, M., Künnecke, B., & Ghosh, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.032 · Cited by 103
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Song, Z., Borland, J. M., Larkin, T. E., O’Malley, M., & Albers, H. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.001 · Cited by 101
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100
Prosocial Choice in Rats Depends on Food-Seeking Behavior Displayed by Recipients
Márquez, C., Rennie, S. M., Costa, D. F., & Moita, M. A. P. (2015) · Current Biology · doi:10.1016/j.cub.2015.05.018 · Cited by 100
Cardi, V., Tchanturia, K., & Treasure, J. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180118100028 · Cited by 98
Adolescent sleep shapes social novelty preference in mice
Bian, W.-J., Brewer, C. L., Kauer, J. A., & de Lecea, L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01076-8 · Cited by 99
Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area
Borland, J. M., Aiani, L. M., Norvelle, A., Grantham, K. N., O’Laughlin, K., Terranova, J. I., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0262-y · Cited by 97
The Protective Action Encoding of Serotonin Transients in the Human Brain
Moran, R., Kishida, K. T., Lohrenz, T. M., Sáez, I., Laxton, A. W., Witcher, M. R., Tatter, S. B., Ellis, T. L., Phillips, P. E. M., Dayan, P., et al. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.304 · Cited by 97
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction
Li, Y., Simmler, L. D., van Zessen, R., Flakowski, J., Wan, J., Deng, F., Li, Y., Nautiyal, K. M., Pascoli, V., & Lüscher, C. (2021) · Science · doi:10.1126/science.abi9086 · Cited by 97
Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand
Cox, B. M., Bentzley, B. S., Regen-Tuero, H. C., See, R. E., Reichel, C. M., & Aston‐Jones, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.011 · Cited by 98
Berg, E. L., Copping, N. A., Rivera, J. K., Pride, M. C., Careaga, M., Bauman, M. D., Berman, R. F., Lein, P. J., Harony‐Nicolas, H., Buxbaum, J. D., et al. (2018) · Autism Research · doi:10.1002/aur.1925 · Cited by 96
The Role of the Oxytocin System in Anxiety Disorders
Yoon, S., & Kim, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_7 · Cited by 96
Western Diet Consumption During Development: Setting the Stage for Neurocognitive Dysfunction
Tsan, L., Décarie-Spain, L., Noble, E. E., & Kanoski, S. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.632312 · Cited by 97
Consolidating the Circuit Model for Addiction
Lüscher, C., & Janak, P. H. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092920-123905 · Cited by 94
Bolis, D., & Schilbach, L. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.01.009 · Cited by 94
A neural circuit for male sexual behavior and reward
Bayless, D. W., Davis, C.-H. O., Yang, R., Wei, Y., Carvalho, V. M. D. A., Knoedler, J. R., Yang, T., Livingston, O., Lomvardas, A., Martins, G. J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.021 · Cited by 94
Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders
Grissom, N. M., McKee, S. E., Schoch, H., Bowman, N., Havekes, R., O'Brien, W. T., Mahrt, E., Siegel, S., Commons, K., Portfors, C., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.184 · Cited by 92
Schiavi, S., Iezzi, D., Manduca, A., Leone, S., Melancia, F., Carbone, C., Petrella, M., Mannaioni, G., Masi, A., & Trezza, V. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00479 · Cited by 90
How the brain codes intimacy: The neurobiological substrates of romantic touch
Kreuder, A.-K., Scheele, D., Wassermann, L., Wollseifer, M., Stoffel-Wagner, B., Lee, M. R., Hennig, J., Maier, W., & Hurlemann, R. (2017) · Human Brain Mapping · doi:10.1002/hbm.23679 · Cited by 89
A hypothalamic circuit underlying the dynamic control of social homeostasis
Liu, D., Rahman, M., Johnson, A., Amo, R., Tsutsui‐Kimura, I., Sullivan, Z. A., Pena, N., Talay, M., Logeman, B. L., Finkbeiner, S., et al. (2025) · Nature · doi:10.1038/s41586-025-08617-8 · Cited by 89
Pérez‐Fernández, J., Stephenson‐Jones, M., Suryanarayana, S. M., Robertson, B., & Grillner, S. E. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23639 · Cited by 89
Calcagnoli, F., de Boer, S. F., Beiderbeck, D. I., Althaus, M., Koolhaas, J. M., & Neumann, I. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.050 · Cited by 88
Rebalancing the Addicted Brain: Oxytocin Interference with the Neural Substrates of Addiction
Bowen, M. T., & Neumann, I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.003 · Cited by 87
A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain
Ino, D., Tanaka, Y., Hibino, H., & Nishiyama, M. (2022) · Nature Methods · doi:10.1038/s41592-022-01597-x · Cited by 87
Challis, C., & Berton, O. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00007 · Cited by 87
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety
Yu, X., Zhu, Y., Sun, Q., Deng, F., Wan, J., Zheng, D., Gong, W., Xie, S., Shen, C.-J., Fu, J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01200-8 · Cited by 89
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 86
Links between the neurobiology of oxytocin and human musicality
Harvey, A. R. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00350 · Cited by 85
Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice
Beny, Y., Zilkha, N., Lavi‐Avnon, Y., Bezalel, N., Rogachev, I., Brandis, A. S., Dayan, M., & Kimchi, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.062 · Cited by 85
Liu, L., Xu, H., Wang, J., Li, J., Tian, Y., Zheng, J., He, M., Xu, T., Wu, Z., Li, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4073 · Cited by 85
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 86
Stoop, R. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.012 · Cited by 84
Zhang, X., Peng, S., Shen, L.-P., Zhuang, Q., Li, B., Xie, S.-T., Li, Q.-X., Shi, M.-R., Ma, T.-Y., Zhang, Q., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008456117 · Cited by 85
Potential of Oxytocin in the Treatment of Schizophrenia
Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 84
Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons
Xiao, L., Priest, M. F., & Kozorovitskiy, Y. (2018) · eLife · doi:10.7554/elife.33892 · Cited by 83
The role of social cognition in parasite and pathogen avoidance
Kavaliers, M., & Choleris, E. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0206 · Cited by 83
Sampedro‐Piquero, P., de Guevara‐Miranda, D. L., Pavón, F. J., Serrano, A., Suárez, J., de Fonseca, F. R., Santín, L. J., & Castilla‐Ortega, E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.015 · Cited by 85
Hartl, C., Ramaswami, G., Pembroke, W. G., Muller, S., Pintacuda, G., Saha, A., Parsana, P., Battle, A. J., Lage, K., & Geschwind, D. H. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00887-5 · Cited by 86
Beery, A. K., McEwen, L. M., MacIsaac, J. L., Francis, D. D., & Kobor, M. S. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.022 · Cited by 81
Specificity in Sociality: Mice and Prairie Voles Exhibit Different Patterns of Peer Affiliation
Beery, A. K., Christensen, J. D., Lee, N. S., & Blandino, K. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00050 · Cited by 81
Noncanonical Genomic Imprinting Effects in Offspring
Bonthuis, P. J., Huang, W.-C., Hörndli, C. S., Ferris, E., Cheng, T., & Gregg, C. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.017 · Cited by 81
Pinto, D. F. C., Yang, H., Dorocic, I. P., de Jong, J. W., Han, V. J., Peck, J. R., Zhu, Y., Liu, C. J., Beier, K. T., Smidt, M. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12392-2 · Cited by 80
Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice
Otero‐García, M., Agustín‐Pavón, C., Lanuza, E., & Martínez‐Garciá, F. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1111-y · Cited by 80
The multiple faces of the oxytocin and vasopressin systems in the brain
Grinevich, V., & Ludwig, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13004 · Cited by 80
Metadata
- Authors
- Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Nature
- Published
- 2013-09
- Volume
- 501
- Issue
- 7466
- Pages
- 179-184
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4091761
- OpenAlex
- W2099168883
- Cited by
- 1,161
- References
- 49
- Citations by year
- 2026: 72 · 2025: 107 · 2024: 86 · 2023: 87 · 2022: 124 · 2021: 118 · 2020: 119 · 2019: 77 · 2018: 95 · 2017: 75 · 2016: 84 · 2015: 62 · 2014: 45 · 2013: 9
- FWCI
- 100.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Drug Abuse (R21DA032955, P01DA008227)
- National Institute of Neurological Disorders and Stroke (NS069375, P30NS069375)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social reward, oxytocin, serotonin, nucleus accumbens core, dorsal raphe nucleus, 5-HT1B receptor, medium spiny neurons, social reinforcement, synaptic plasticity, autism spectrum disorder, social dysfunction
- MeSH terms
- Animals, Autistic Disorder, Conditioning, Psychological, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Neurons, Nucleus Accumbens, Oxytocin, Raphe Nuclei, Reward, Serotonin, Social Behavior, Gene Deletion, Presynaptic Terminals, Receptors, Oxytocin, Mice, Knockout, Long-Term Synaptic Depression, Receptor, Serotonin, 5-HT1B, Mice
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