Therapies for allergic inflammation: refining strategies to induce tolerance

Asthma phenotypes: the evolution from clinical to molecular approaches

Wenzel, S. E. (2012) · Nature Medicine · doi:10.1038/nm.2678 · Cited by 2,412

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

Haldar, P., Brightling, C. E., Hargadon, B., Gupta, S., Monteiro, W., Sousa, A., Marshall, R. P., Bradding, P., Green, R. H., Wardlaw, A. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808991 · Cited by 1,871

The development of allergic inflammation

Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839

Lebrikizumab Treatment in Adults with Asthma

Corren, J., Lemanske, R. F., Hanania, N. A., Korenblat, P. E., Parsey, M. V., Arron, J. R., Harris, J. M., Scheerens, H., Wu, L. C., Su, Z., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106469 · Cited by 1,514

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

Nair, P., Pizzichini, M. M. M., Kjarsgaard, M., Inman, M. D., Efthimiadis, A., Pizzichini, E., Hargreave, F. E., & O'Byrne, P. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805435 · Cited by 1,356

Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

Lötvall, J., Akdis, C. A., Bacharier, L. B., Bjermer, L., Casale, T. B., Custovic, A., Lemanske, R. F., Wardlaw, A. J., Wenzel, S. E., & Greenberger, P. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.037 · Cited by 1,160

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

Hammad, H., Chieppa, M., Perros, F., Willart, M. A., Germain, R. N., & Lambrecht, B. N. (2009) · Nature Medicine · doi:10.1038/nm.1946 · Cited by 1,139

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2426 · Cited by 1,120

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052

Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

Akdis, M., Verhagen, J., Taylor, A., Karamloo, F., Karagiannidis, C., Crameri, R., Thunberg, S., Deniz, G., Valenta, R., Fiebig, H., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032058 · Cited by 1,052

Competence and competition: the challenge of becoming a long-lived plasma cell

Radbruch, A., Muehlinghaus, G., Luger, E. O., Inamine, A., Smith, K. G. C., Dörner, T., & Hiepe, F. (2006) · Nature Reviews Immunology · doi:10.1038/nri1886 · Cited by 1,030

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

Dillon, S. R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S. R., Haugen, H. S., Maurer, M., Harder, B., Johnston, J., et al. (2004) · Nature Immunology · doi:10.1038/ni1084 · Cited by 1,015

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

van der Neut Kolfschoten, M., Schuurman, J., Losen, M., Bleeker, W. K., Martínez-Martínez, P., Vermeulen, E., den Bleker, T. H., Wiegman, L., Vink, T., Aarden, L. A., et al. (2007) · Science · doi:10.1126/science.1144603 · Cited by 975

Role of interleukin 10 in specific immunotherapy.

Akdis, C. A., Blesken, T., Akdis, M., Wüthrich, B., & Blaser, K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2250 · Cited by 973

IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

Jutel, M., Akdis, M., Budak, F., Aebischer‐Casaulta, C., Wrzyszcz, M., Blaser, K., & Akdis, C. A. (2003) · European Journal of Immunology · doi:10.1002/eji.200322919 · Cited by 915

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

Busse, W. W., Morgan, W. J., Gergen, P. J., Mitchell, H. E., Gern, J. E., Liu, A. H., Gruchalla, R. S., Kattan, M., Teach, S. J., Pongracic, J. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009705 · Cited by 884

Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma

Berry, M. A., Hargadon, B., Shelley, M., Parker, D., Shaw, D. E., Green, R. H., Bradding, P., Brightling, C. E., Wardlaw, A. J., & Pavord, I. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa050580 · Cited by 826

Eosinophil's Role Remains Uncertain as Anti–Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway

Flood-Page, P. T., Menzies-Gow, A. N., Kay, A. B., & Robinson, D. S. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-789oc · Cited by 808

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

Akdis, M., Burgler, S., Crameri, R., Eiwegger, T., Fujita, H., Gomez, E., Klunker, S., Meyer, N., O’Mahony, L., Palomares, O., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.050 · Cited by 778

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

Ling, E. M., Smith, T., Nguyen, X. D., Pridgeon, C., Dallman, M., Arbery, J., Carr, V. A., & Robinson, D. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15592-x · Cited by 747

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

Galli, S. J., Grimbaldeston, M., & Tsai, M. (2008) · Nature Reviews Immunology · doi:10.1038/nri2327 · Cited by 738

Reslizumab for Poorly Controlled, Eosinophilic Asthma: A Randomized, Placebo-controlled Study

Castro, M., Mathur, S., Hargreave, F., Boulet, L.-P., Xie, F., Young, J., Wilkins, H. J., Henkel, T., & Nair, P. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201103-0396oc · Cited by 716

Sublingual immunotherapy for allergic rhinitis: systematic review and meta‐analysis*

Wilson, D. R., Torres Lima, M., & Durham, S. R. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00699.x · Cited by 660

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

Gevaert, P., Van Bruaene, N., Cattaert, T., Van Steen, K., Van Zele, T., Acke, F., De Ruyck, N., Blomme, K., Sousa, A. R., Marshall, R. P., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.07.056 · Cited by 629

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

Straumann, A., Conus, S., Grzonka, P., Kita, H., Kephart, G., Bussmann, C., Beglinger, C., Smith, D. A., Patel, J., Byrne, M., et al. (2010) · Gut · doi:10.1136/gut.2009.178558 · Cited by 598

Orchestrating the orchestrators: chemokines in control of T cell traffic

Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 593

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

Wenzel, S., Wilbraham, D., Fuller, R., Getz, E. B., & Longphre, M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61600-6 · Cited by 588

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab

Rothenberg, M. E., Klion, A. D., Roufosse, F. E., Kahn, J. E., Weller, P. F., Simon, H.-U., Schwartz, L. B., Rosenwasser, L. J., Ring, J., Griffin, E. F., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070812 · Cited by 583

Immunotherapy with a Ragweed–Toll-Like Receptor 9 Agonist Vaccine for Allergic Rhinitis

Creticos, P. S., Schroeder, J. T., Hamilton, R. G., Balcer-Whaley, S. L., Khattignavong, A. P., Lindblad, R., Li, H., Coffman, R., Seyfert, V., Eiden, J. J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052916 · Cited by 562

Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial

Spergel, J. M., Rothenberg, M. E., Collins, M. H., Furuta, G. T., Markowitz, J. E., Fuchs, G., O’Gorman, M. A., Abonia, J. P., Young, J., Henkel, T., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.044 · Cited by 556

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

Balachandran, V. P., Cavnar, M. J., Zeng, S., Bamboat, Z. M., Ocuin, L. M., Obaid, H., Sorenson, E. C., Popow, R., Ariyan, C., Rossi, F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2438 · Cited by 521

Allergen-specific immunotherapy with recombinant grass pollen allergens

Jutel, M., Jaeger, L., Suck, R., Meyer, H., Fiebig, H., & Cromwell, O. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.06.004 · Cited by 519

Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy

Karlsson, M. R., Rugtveit, J., & Brandtzaeg, P. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032121 · Cited by 506

Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study

Kips, J. C., O'Connor, B. J., Langley, S. J., Woodcock, A., Kerstjens, H. A. M., Postma, D. S., Danzig, M., Cuss, F., & Pauwels, R. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-525oc · Cited by 494

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

Wilhelm, C., Hirota, K., Stieglitz, B., Van Snick, J., Tolaini, M., Lahl, K., Sparwasser, T., Helmby, H., & Stockinger, B. (2011) · Nature Immunology · doi:10.1038/ni.2133 · Cited by 481

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

Wenzel, S. E., Barnes, P. J., Bleecker, E. R., Bousquet, J., Busse, W., Dahlén, S.-E., Holgate, S. T., Meyers, D. A., Rabe, K. F., Antczak, A., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1512oc · Cited by 460

Omalizumab-induced reductions in mast cell FcεRI expression and function

Beck, L. A., Marcotte, G. V., MacGlashan, D., Togias, A., & Saini, S. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.06.032 · Cited by 456

Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom☆☆☆★★★

Müller, U., Akdis, C. A., Fricker, M., Akdis, M., Blesken, T., Bettens, F., & Blaser, K. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70402-6 · Cited by 456

Interleukin-4 Receptor in Moderate Atopic Asthma: A Phase I/II Randomized, Placebo-controlled Trial

BORISH, L. C., NELSON, H. S., LANZ, M. J., CLAUSSEN, L., WHITMORE, J. B., AGOSTI, J. M., & GARRISON, L. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9808146 · Cited by 418

Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma

Hellings, P. W., Kasran, A., Liu, Z., Vandekerckhove, P., Wuyts, A., Overbergh, L., Mathieu, C., & Ceuppens, J. L. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4832 · Cited by 417

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

Meiler, F., Zumkehr, J., Klunker, S., Rückert, B., Akdis, C. A., & Akdis, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080193 · Cited by 411

Origins of CD4+ effector and central memory T cells

Pepper, M., & Jenkins, M. K. (2011) · Nature Immunology · doi:10.1038/ni.2038 · Cited by 400

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

Gri, G., Piconese, S., Frossi, B., Manfroi, V., Merluzzi, S., Tripodo, C., Viola, A., Odom, S., Rivera, J., Colombo, M. P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.018 · Cited by 391

Effect of Omalizumab on Symptoms of Seasonal Allergic Rhinitis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

Casale, T. B. (2001) · JAMA · doi:10.1001/jama.286.23.2956 · Cited by 377

Vaccination with genetically engineered allergens prevents progression of allergic disease

Niederberger, V., Horak, F., Vrtala, S., Spitzauer, S., Krauth, M.-T., Valent, P., Reisinger, J., Pelzmann, M., Hayek, B., Kronqvist, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404735101 · Cited by 376

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

Ballantyne, S. J., Barlow, J. L., Jolin, H. E., Nath, P., Williams, A. S., Chung, K. F., Sturton, G., Wong, S. H., & McKenzie, A. N. J. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.051 · Cited by 368

Treatment of cat allergy with T-cell reactive peptides.

Norman, P. S., Ohman, J. L., Long, A. A., Creticos, P. S., Gefter, M. A., Shaked, Z., Wood, R. A., Eggleston, P. A., Hafner, K. B., Rao, P., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.6.8970345 · Cited by 365

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial

Senti, G., Prinz Vavricka, B. M., Erdmann, I., Diaz, M. I., Markus, R., McCormack, S. J., Simard, J. J., Wüthrich, B., Crameri, R., Graf, N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803725105 · Cited by 364

Long-term clinical efficacy in grass pollen–induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet

Durham, S. R., Emminger, W., Kapp, A., Colombo, G., de Monchy, J. G. R., Rak, S., Scadding, G. K., Andersen, J. S., Riis, B., & Dahl, R. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.035 · Cited by 352

Omalizumab treatment downregulates dendritic cell FcεRI expression

Prussin, C., Griffith, D. T., Boesel, K. M., Lin, H., Foster, B., & Casale, T. B. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.10.003 · Cited by 349

Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial

Oldfield, W., Larché, M., & Kay, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09332-7 · Cited by 347

Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies

James, L. K., Shamji, M. H., Walker, S. M., Wilson, D. R., Wachholz, P. A., Francis, J. N., Jacobson, M. R., Kimber, I., Till, S. J., & Durham, S. R. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1080 · Cited by 342

Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy

Bufe, A., Eberle, P., Franke-Beckmann, E., Funck, J., Kimmig, M., Klimek, L., Knecht, R., Stephan, V., Tholstrup, B., Weißhaar, C., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.044 · Cited by 336

Grass pollen immunotherapy induces Foxp3-expressing CD4+CD25+ cells in the nasal mucosa

Radulovic, S., Jacobson, M. R., Durham, S. R., & Nouri-Aria, K. T. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.013 · Cited by 333

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

Rickel, E. A., Siegel, L. A., Yoon, B.-R. P., Rottman, J. B., Kugler, D. G., Swart, D. A., Anders, P. M., Tocker, J. E., Comeau, M. R., & Budelsky, A. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4299 · Cited by 321

Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.

Akdis, C. A., Akdis, M., Blesken, T., Wymann, D., Alkan, S. S., Müller, U., & Blaser, K. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118963 · Cited by 312

Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll‐like receptors

Meiler, F., Klunker, S., Zimmermann, M., Akdis, C. A., & Akdis, M. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01774.x · Cited by 302

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

Corren, J., Busse, W., Meltzer, E. O., Mansfield, L., Bensch, G., Fahrenholz, J., Wenzel, S. E., Chon, Y., Dunn, M., Weng, H. H., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1448oc · Cited by 299

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

Busse, W. W., Katial, R., Gossage, D., Sari, S., Wang, B., Kolbeck, R., Coyle, A. J., Koike, M., Spitalny, G. L., Kiener, P. A., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.005 · Cited by 278

Omalizumab rapidly decreases nasal allergic response and FcεRI on basophils

Lin, H., Boesel, K. M., Griffith, D. T., Prussin, C., Foster, B., Romero, F. A., Townley, R., & Casale, T. B. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.11.044 · Cited by 269

Efficacy and Safety of Subcutaneous Omalizumab vs Placebo as Add-on Therapy to Corticosteroids for Children and Adults With Asthma

Rodrigo, G. J., Neffen, H., & Castro-Rodriguez, J. A. (2011) · Chest · doi:10.1378/chest.10-1194 · Cited by 268

Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3‐expressing cells and elevated allergen‐specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E‐facilitated allergen binding to B cells

Scadding, G. W., Shamji, M. H., Jacobson, M. R., Lee, D. I., Wilson, D., Lima, M. T., Pitkin, L., Pilette, C., Nouri‐Aria, K., & Durham, S. R. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03462.x · Cited by 258

Anti-CD20 (rituximab) treatment improves atopic eczema

Simon, D., Hösli, S., Kostylina, G., Yawalkar, N., & Simon, H.-U. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.11.016 · Cited by 255

TNFα blockade in human diseases: An overview of efficacy and safety

Lin, J., Ziring, D., Desai, S., Kim, S., Wong, M., Korin, Y., Braun, J., Reed, E., Gjertson, D., & Singh, R. R. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.08.012 · Cited by 244

Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma

Massanari, M., Nelson, H., Casale, T., Busse, W., Kianifard, F., Geba, G. P., & Zeldin, R. K. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.11.022 · Cited by 230

Unmet needs in severe chronic upper airway disease (SCUAD)

Bousquet, J., Bachert, C., Canonica, G. W., Casale, T. B., Cruz, A. A., Lockey, R. J., & Zuberbier, T. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.06.027 · Cited by 227

Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2–IL-33 Pathway

Kearley, J., Buckland, K. F., Mathie, S. A., & Lloyd, C. M. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-666oc · Cited by 227

Inhibition of complement activation by IgG4 antibodies.

van der Zee, J. S., van Swieten, P., & Aalberse, R. C. (1986) · PubMed · Cited by 223

A randomized, double‐blind, placebo‐controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

Barnes, N., Pavord, I., Chuchalin, A., Bell, J., Hunter, M., Lewis, T., Parker, D., Payton, M., Collins, L. P., Pettipher, R., et al. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03813.x · Cited by 218

Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression

Campbell, J. D., Buckland, K. F., McMillan, S. J., Kearley, J., Oldfield, W. L. G., Stern, L. J., Grönlund, H., van Hage, M., Reynolds, C. J., Boyton, R. J., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082901 · Cited by 208

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

Seshasayee, D., Lee, W. P., Zhou, M., Shu, J., Suto, E., Zhang, J., Diehl, L., Austin, C. D., Meng, Y. G., Tan, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33559 · Cited by 207

Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma

HART, T. K., BLACKBURN, M. N., BRIGHAM-BURKE, M., DEDE, K., AL-MAHDI, N., ZIA-AMIRHOSSEINI, P., & COOK, R. M. (2002) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2002.01973.x · Cited by 201

Anti‐interleukin‐31‐antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

Grimstad, Ø., Sawanobori, Y., Vestergaard, C., Bilsborough, J., Olsen, U. B., Grønhøj‐Larsen, C., & Matsushima, K. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00766.x · Cited by 200

Diagnosis and management of drug hypersensitivity reactions

Romano, A., Torres, M. J., Castells, M., Sanz, M. L., & Blanca, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.047 · Cited by 199

Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults

Kündig, T. M., Senti, G., Schnetzler, G., Wolf, C., Prinz Vavricka, B. M., Fulurija, A., Hennecke, F., Sladko, K., Jennings, G. T., & Bachmann, M. F. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.040 · Cited by 199

Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course – a randomized, placebo‐controlled and double blind pilot study

Heil, P. M., Maurer, D., Klein, B., Hultsch, T., & Stingl, G. (2010) · JDDG: Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07497.x · Cited by 197

Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

Melendez, A. J., Harnett, M. M., Pushparaj, P. N., Wong, W. F., Tay, H. K., McSharry, C. P., & Harnett, W. (2007) · Nature Medicine · doi:10.1038/nm1654 · Cited by 196

Therapeutic manipulation of immune tolerance in allergic disease

Akdis, M., & Akdis, C. A. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2653 · Cited by 195

A novel human immunoglobulin Fcγ–Fcɛ bifunctional fusion protein inhibits FcɛRI-mediated degranulation

Zhu, D., Kepley, C. L., Zhang, M., Zhang, K., & Saxon, A. (2002) · Nature Medicine · doi:10.1038/nm0502-518 · Cited by 195

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells

Klunker, S., Chong, M. M. W., Mantel, P.-Y., Palomares, O., Bassin, C., Ziegler, M., Rückert, B., Meiler, F., Akdis, M., Littman, D. R., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090596 · Cited by 193

Infliximab in the treatment of moderate to severe atopic dermatitis

Jacobi, A., Antoni, C., Manger, B., Schuler, G., & Hertl, M. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.11.022 · Cited by 192

A chimeric human-cat fusion protein blocks cat-induced allergy

Zhu, D., Kepley, C. L., Zhang, K., Terada, T., Yamada, T., & Saxon, A. (2005) · Nature Medicine · doi:10.1038/nm1219 · Cited by 188

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

Holz, O., Khalilieh, S., Ludwig-Sengpiel, A., Watz, H., Stryszak, P., Soni, P., Tsai, M., Sadeh, J., & Magnussen, H. (2010) · European Respiratory Journal · doi:10.1183/09031936.00048509 · Cited by 183

Inhibition of human interleukin‐13‐induced respiratory and oesophageal inflammation by anti‐human‐interleukin‐13 antibody (CAT‐354)

Blanchard, C., Mishra, A., Saito‐Akei, H., Monk, P., Anderson, I., & Rothenberg, M. E. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02299.x · Cited by 181

Allergy and hypersensitivity

Akdis, C. A. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.016 · Cited by 175

Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy

Worm, M., Lee, H.-H., Kleine-Tebbe, J., Hafner, R. P., Laidler, P., Healey, D., Buhot, C., Verhoef, A., Maillère, B., Kay, A. B., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.029 · Cited by 173

Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis

Carter, M. C., Robyn, J. A., Bressler, P. B., Walker, J. C., Shapiro, G. G., & Metcalfe, D. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.032 · Cited by 172

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

Doherty, T. A., Soroosh, P., Khorram, N., Fukuyama, S., Rosenthal, P., Cho, J. Y., Norris, P. S., Choi, H., Scheu, S., Pfeffer, K., et al. (2011) · Nature Medicine · doi:10.1038/nm.2356 · Cited by 171

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

Palomares, O., Rückert, B., Jartti, T., Kücüksezer, U. C., Puhakka, T., Gomez, E., Fahrner, H. B., Speiser, A., Jung, A., Kwok, W. W., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.031 · Cited by 167

Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells

Allam, J.-P., Peng, W.-M., Appel, T., Wenghoefer, M., Niederhagen, B., Bieber, T., Bergé, S., & Novak, N. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.045 · Cited by 163

IL-4 Receptor α Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets

Andrews, A.-L., Holloway, J. W., Holgate, S. T., & Davies, D. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7456 · Cited by 162

Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.

Marshall, J. S., Leal‐Berumen, I., Nielsen, L., Glibetić, M., & Jordana, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118506 · Cited by 159

Epicutaneous allergen-specific immunotherapy ameliorates grass pollen–induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study

Senti, G., von Moos, S., Tay, F., Graf, N., Sonderegger, T., Johansen, P., & Kündig, T. M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.08.036 · Cited by 158

Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels

Belloni, B., Ziai, M., Lim, A., Lemercier, B., Sbornik, M., Weidinger, S., Andres, C., Schnopp, C., Ring, J., Hein, R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.060 · Cited by 157

Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma

Parker, J. M., Oh, C. K., LaForce, C., Miller, S. D., Pearlman, D. S., Le, C., Robbie, G. J., White, W. I., White, B., & Molfino, N. A. (2011) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-11-14 · Cited by 150

Allergens and their role in the allergic immune response

Platts‐Mills, T. A. E., & Woodfolk, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01021.x · Cited by 148

Daclizumab Improves Asthma Control in Patients with Moderate to Severe Persistent Asthma

Busse, W. W., Israel, E., Nelson, H. S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1200oc · Cited by 147

IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

Wilson, M. S., Elnekave, E., Mentink-Kane, M. M., Hodges, M. G., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., Kamanaka, M., Flavell, R. A., Keane-Myers, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31546 · Cited by 137

Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding

Klunker, S., Saggar, L. R., Seyfert-Margolis, V., Asare, A. L., Casale, T. B., Durham, S. R., & Francis, J. N. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.05.034 · Cited by 129

Differentiation and functional analysis of human TH17 cells

Bürgler, S., Ouaked, N., Bassin, C., Basinski, T. M., Mantel, P., Siegmund, K., Meyer, N., Akdiş, C. A., & Schmidt‐Weber, C. B. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.017 · Cited by 128

CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung

Mionnet, C., Buatois, V., Kanda, A., Milcent, V., Fleury, S., Lair, D., Langelot, M., Lacoeuille, Y., Hessel, E. M., Coffman, R. L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2253 · Cited by 128

Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1

Zhou, Y., Kawasaki, H., Hsu, S., Lee, R. T., Xu, Y., Plunkett, B., Fu, J., Yang, K. D., Lee, Y. C., & Huang, S. K. (2010) · Nature Medicine · doi:10.1038/nm.2201 · Cited by 126

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis

Zimmermann, M., Koreck, A., Meyer, N., Basinski, T. M., Meiler, F., Bürgler, S., Woehrl, S., Moritz, K. B., Eiwegger, T., Schmid‐Grendelmeier, P., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.005 · Cited by 126

Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-γ production of T cells

Pierkes, M., Bellinghausen, I., Hultsch, T., et al. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70509-9 · Cited by 121

Evidence that vitamin D3 promotes mast cell–dependent reduction of chronic UVB-induced skin pathology in mice

Biggs, L., Yu, C., Fedoric, B., Lopez, A. F., Galli, S. J., & Grimbaldeston, M. A. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091725 · Cited by 116

What targeting eosinophils has taught us about their role in diseases

Bochner, B. S., & Gleich, G. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.026 · Cited by 115

Cost-effectiveness of omalizumab in adults with severe asthma: Results from the Asthma Policy Model

Wu, A. C., Paltiel, A. D., Kuntz, K. M., Weiss, S. T., & Fuhlbrigge, A. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.055 · Cited by 111

Steroid‐sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis

Zirbes, J. M., & Milla, C. E. (2008) · Pediatric Pulmonology · doi:10.1002/ppul.20804 · Cited by 109

A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS

Niespodziana, K., Focke‐Tejkl, M., Linhart, B., Civaj, V., Blatt, K., Valent, P., van Hage, M., Grönlund, H., & Valenta, R. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.004 · Cited by 104

Measurement of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy

van Ree, R., LEEUWEN, W. A. V., Dieges, P. H., van Wijk, R. G., de Jong, N. W., BREWCZYSKI, P. Z., Kroon, A. M., Schilte, P. P. M., Tan, K. Y., SIMON‐LICHT, I. F., et al. (1997) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1997.d01-416.x · Cited by 100

Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses

Angeli, V., Staumont-Sallé, D., Charbonnier, A.-S., Hammad, H., Gosset, P., Pichavant, M., Lambrecht, B. N., Capron, M., Dombrowicz, D., & Trottein, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3822 · Cited by 94

A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy

Kussebi, F., Karamloo, F., Rhyner, C., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.041 · Cited by 91

Anti-CD20 (rituximab) treatment for atopic eczema

Šedivá, A., Kayserová, J., Vernerová, E., Poloučková, A., Čapková, Š., Špíšek, R., & Bartůňková, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.007 · Cited by 89

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

Busse, W. W., Morgan, W. J., Gergen, P. J., Mitchell, H., Gern, J. E., Liu, A. H., Gruchalla, R. S., Kattan, M., Teach, S. J., Pongracic, J. A., et al. (2012) · Survey of Anesthesiology · doi:10.1097/01.sa.0000410631.09026.a4 · Cited by 87

Successful treatment of 3 patients with recurrent idiopathic angioedema with omalizumab

Sands, M. F., Blume, J. W., & Schwartz, S. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.041 · Cited by 79

CD4+CD25+ Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection

Turner, J. D., Jenkins, G. R., Hogg, K., Aynsley, S. A., Paveley, R. A., Cook, P. C., Coles, M. C., & Mountford, A. P. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001269 · Cited by 79

Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes

Karamloo, F., Schmid‐Grendelmeier, P., Kussebi, F., Akdiş, M., Salagianni, M. L., von Beust, B. R., Reimers, A., Zumkehr, J., Soldatova, L., Marković-Housley, Z., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200425522 · Cited by 78

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions

Hitomi, K., Tahara‐Hanaoka, S., Someya, S., Fujiki, A., Tada, H., Sugiyama, T., Shibayama, S., Shibuya, K., & Shibuya, A. (2010) · Nature Immunology · doi:10.1038/ni.1886 · Cited by 75

A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells

Zhang, F., Huang, G., Hu, B., Song, Y., & Shi, Y. P. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04328.x · Cited by 74

Immunomodulators for allergic respiratory disorders

Casale, T. B., & Stokes, J. R. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.11.040 · Cited by 70

Basophil Interleukin 4 and Interleukin 13 Production Is Suppressed during the Early Phase of Rush Immunotherapy

Plewako, H., Wosińska, K., Arvidsson, M., Björkander, J., Skov, P. S., Håkansson, L., & Rak, S. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000095461 · Cited by 68

Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen‐specific immunotherapy

Asturias, J. A., Ibarrola, I., Arilla, M., Vidal, C., Ferrer, A., Gamboa, P. M., Viñuela, J. E., Sanz, M. L., Andréu, C., & Martı́nez, A. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03264.x · Cited by 68

Dual nature of T cell–epithelium interaction in chronic rhinosinusitis

Basinski, T. M., Holzmann, D., Eiwegger, T., Zimmermann, M., Klunker, S., Meyer, N., Schmid‐Grendelmeier, P., Jutel, M., & Akdiş, C. A. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.04.019 · Cited by 67

Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization *

Eberlein-König, B., Ullmann, S., THOMAS, P. A., & Przybilla, B. (1995) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1995.tb00007.x · Cited by 66

The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge

Nicholson, G. C., Kariyawasam, H. H., Tan, A. J., Hohlfeld, J. M., Quinn, D. A., Walker, C., Rodman, D. M., Westwick, J. K., Jurčević, S., Kon, O. M., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.013 · Cited by 63

Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children

Rosewich, M., Schulze, J., Eickmeier, O., Telles, T., Rose, M. A., Schubert, R., & Zielen, S. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04106.x · Cited by 58

Bypassing IgE and targeting T cells for specific immunotherapy of allergy

Akdiş, C. A., & Blaser, K. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01862-2 · Cited by 57

Churg-Strauss Vasculitis in a Patient Treated with Omalizumab

Bargagli, E., Madioni, C., Olivieri, C., Penza, F., & Rottoli, P. (2008) · Journal of Asthma · doi:10.1080/02770900701767704 · Cited by 56

Analysis of Epitope-Specific Immune Responses Induced by Vaccination with Structurally Folded and Unfolded Recombinant Bet v 1 Allergen Derivatives in Man

Pree, I., Reisinger, J., Focke, M., Vrtala, S., Pauli, G., van Hage, M., Cromwell, O., Gadermaier, E., Egger, C., Reider, N., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5309 · Cited by 55

Tracking Antigen-Specific T-Cells during Clinical Tolerance Induction in Humans

Aslam, A., Chan, H., Warrell, D. A., Misbah, S., & Ogg, G. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011028 · Cited by 55

Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation

Vlad, G., Ho, E. K., Vasilescu, E. R., Fan, J., Liu, Z., Cai, J. W., Jin, Z., Burke, E. M., Deng, M. C.-H. K., Cadeiras, M., et al. (2007) · Transplant Immunology · doi:10.1016/j.trim.2007.03.001 · Cited by 50

Prolonged antigen‐exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice

Thunberg, S., Neimert-Andersson, T., Cheng, Q., Wermeling, F., Bergström, U., Swedin, L., Dahlén, S., Arnér, E. S. J., Scheynius, A., Karlsson, M. C. I., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01905.x · Cited by 43

Rituximab and Omalizumab in Severe, Refractory Insulin Allergy

Yong, P. F. K., Malik, R., Arif, S., Peakman, M., Amiel, S. A., Ibrahim, M. A. A., & Gough, A. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0808282 · Cited by 41

Association between CD4+CD25high T cells and atopy in children

Jartti, T. T., Burmeister, K. A., Seroogy, C. M., Jennens-Clough, M. L., Tisler, C. J., Salazar, L. P., DaSilva, D. F., Evans, M. D., Vrtis, R. F., Wallace, P. K., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.008 · Cited by 32

Multitargeted Approach Using Antisense Oligonucleotides for the Treatment of Asthma

Allakhverdi, Z., ALLAM, M., GUIMOND, A., FERRARI, N., ZEMZOUMI, K., Seguin, R. M., Paquet, L., & RENZI, P. M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.047 · Cited by 31

A follow‐up study of immunotherapy‐treated birch‐allergic patients: effect on the expression of chemokines in the nasal mucosa

Plewako, H., Holmberg, K., Oancea, I., Gotlib, T., Samolinski, B. K., & Rak, S. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03005.x · Cited by 27

Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma.

Antoniu, S. A. (2010) · PubMed · Cited by 26

Inhibitory Effect of the New Orally Active CCR4 Antagonist K327 on CCR4+CD4+ T Cell Migration into the Lung of Mice with Ovalbumin-Induced Lung Allergic Inflammation

Sato, T., Komai, M., Iwase, M., Kobayashi, K., Tahara, H., Ohshima, E., Arai, H., & Miki, I. (2008) · Pharmacology · doi:10.1159/000235748 · Cited by 23

Modular antigen-translocation as a novel vaccine strategy for allergen-specific immunotherapy

Crameri, R., Kündig, T. M., & Akdiş, C. A. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283310fdf · Cited by 22

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Akdis, C. A., Bachert, C., Cingi, C., Dykewicz, M. S., Hellings, P. W., Naclerio, R. M., Schleimer, R. P., & Ledford, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.036 · Cited by 538

Noncoding RNAs, cytokines, and inflammation-related diseases

Marques-Rocha, J. L., Samblas, M., Milagro, F. I., Bressan, J., Martínez, J. A., & Marti, A. (2015) · The FASEB Journal · doi:10.1096/fj.14-260323 · Cited by 477

A biodiversity hypothesis

Haahtela, T. (2019) · Allergy · doi:10.1111/all.13763 · Cited by 407

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

Palomares, O., Martín-Fontecha, M., Lauener, R., Traidl-Hoffmann, C., Cavkaytar, O., Akdis, M., & Akdis, C. A. (2014) · Genes & Immunity · doi:10.1038/gene.2014.45 · Cited by 347

The Unique Properties of IgG4 and Its Roles in Health and Disease

Rispens, T., & Huijbers, M. G. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00871-z · Cited by 282