Cellular cholesterol trafficking and compartmentalization

Functional rafts in cell membranes

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Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

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Structure and lipid transport mechanism of a StAR-related domain

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Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

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Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

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Rapid regulation of steroidogenesis by mitochondrial protein import

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Intracellular cholesterol transport

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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria

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Applying systems-level spectral imaging and analysis to reveal the organelle interactome

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Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

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Cholesterol metabolism and homeostasis in the brain

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

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Cytosolic lipolysis and lipophagy: two sides of the same coin

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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

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Cholesterol metabolism in neurons and astrocytes

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Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

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Cholesterol transport in steroid biosynthesis: Role of protein–protein interactions and implications in disease states

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25-Hydroxycholesterols in innate and adaptive immunity

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Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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Cholesterol in brain disease: Sometimes determinant and frequently implicated

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Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

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Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

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Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

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Androgens in pregnancy: roles in parturition

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Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

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The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity

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The crosstalk: exosomes and lipid metabolism

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Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

Paunovska, K., Da Silva Sanchez, A. J., Sago, C. D., Gan, Z., Lokugamage, M. P., Islam, F. Z., Kalathoor, S., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201807748 · Cited by 205

Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

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Cholesterol in myelin biogenesis and hypomyelinating disorders

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Colorimetric detection of cholesterol based on highly efficient peroxidase mimetic activity of graphene quantum dots

Nirala, N. R., Abraham, S., Kumar, V., Bansal, A., Srivastava, A., & Saxena, P. S. (2015) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2015.04.091 · Cited by 180

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

Wang, H., Ma, Q., Qi, Y., Dong, J., Du, X., Rae, J., Wang, J., Wu, W.-F., Brown, A. J., Parton, R. G., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.014 · Cited by 175

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

Naito, T., Ercan, B., Krshnan, L., Triebl, A., Koh, D. H. Z., Wei, F.-Y., Tomizawa, K., Torta, F. T., Wenk, M. R., & Saheki, Y. (2019) · eLife · doi:10.7554/elife.51401 · Cited by 171

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

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Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

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Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

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Lipid sorting and multivesicular endosome biogenesis

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Cholesterol: A Novel Regulatory Role in Myelin Formation

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Untitled work

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Cell cholesterol homeostasis: Mediation by active cholesterol

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Molecular Pathways Underlying Cholesterol Homeostasis

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Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

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Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function

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Mitochondria-associated ER membranes and Alzheimer disease

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Apolipoprotein E4 genotype compromises brain exosome production

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Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

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NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

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An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread

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Intracellular Cholesterol Synthesis and Transport

Shi, Q., Chen, J., Zou, X., & Tang, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.819281 · Cited by 73

Stability and Stoichiometry of Bilayer Phospholipid–Cholesterol Complexes: Relationship to Cellular Sterol Distribution and Homeostasis

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Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation

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ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease

Marchi, C., Adorni, M. P., Caffarra, P., Ronda, N., Spallazzi, M., Barocco, F., Galimberti, D., Bernini, F., & Zimetti, F. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p091033 · Cited by 64

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake

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The ABCs of Sterol Transport

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Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism

Riegelhaupt, J. J., Waase, M. P., Garbarino, J., Cruz, D. E., & Breslow, J. L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003095 · Cited by 52

Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution

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HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective

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SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP

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The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

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Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols

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Astrocytic microRNAs and transcription factors in Alzheimer’s disease and therapeutic interventions

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Brain cholesterol homeostasis and its association with neurodegenerative diseases

Gao, Y., Ye, S., Tang, Y., Tong, W., & Sun, S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105635 · Cited by 38

Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia

Brouwers, M. C. G. J., Konrad, R. J., van Himbergen, T. M., Isaacs, A., Otokozawa, S., Troutt, J. S., Schaefer, E. J., van Greevenbroek, M. M. J., Stalenhoef, A. F. H., & de Graaf, J. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.11.008 · Cited by 24

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Qian, L., Scott, N. A., Capell-Hattam, I. M., Draper, E. A., Fenton, N. M., Luu, W., Sharpe, L. J., & Brown, A. J. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100362 · Cited by 23

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis

Mercer, J. L., Argus, J. P., Crabtree, D. M., Keenan, M. M., Wilks, M. Q., Chi, J.-T. A., Bensinger, S. J., Lavau, C. P., & Wechsler, D. S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0129776 · Cited by 17

Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women

Kalantarian, S., Rimm, E. B., Herrington, D. M., & Mozaffarian, D. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.01.001 · Cited by 8

Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition.

Adachi, C., Otsuka, S., & Inoue, T. (2022) · iScience · doi:10.1016/j.isci.2022.105138 · Cited by 7