The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index; none of the 177 sources its claims cite is checked for support yet.
Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development
Open accessAbstract
The Social Determinants of Health, a set of social factors including socioeconomic status, community context, and neighborhood safety among others, are well-known predictors of mental and physical health across the lifespan. Recent research has begun to establish the importance of these social factors at the earliest points of brain development, including during the prenatal period. Prenatal socioeconomic status, perceived stress, and neighborhood safety have all been reported to impact neonatal brain structure and function, with exploratory work suggesting subsequent effects on infant and child behavior. Secondary effects of the Social Determinants of Health, such as maternal sleep and psychopathology during pregnancy, have also been established as important predictors of infant brain development. This research not only establishes prenatal Social Determinants of Health as important predictors of future outcomes but may be effectively applied even before birth. Future research replicating and extending the effects in this nascent literature has great potential to produce more specific and mechanistic understanding of the social factors that shape early neurobehavioral development. IMPACT: This review synthesizes the research to date examining the effects of the Social Determinants of Health during the prenatal period and neonatal brain outcomes. Structural, functional, and diffusion-based imaging methodologies are included along with the limited literature assessing subsequent infant behavior. The degree to which results converge between studies is discussed, in combination with the methodological and sampling considerations that may contribute to divergence in study results. Several future directions are identified, including new theoretical approaches to assessing the impact of the Social Determinants of Health during the perinatal period.
Overview
CoChat Summary
TL;DR
This narrative review summarizes evidence that prenatal social determinants of health—especially socioeconomic status, maternal stress, and neighborhood safety—are associated with neonatal brain structure, function, and connectivity. It also reviews secondary maternal factors such as sleep and psychopathology and calls for larger, longitudinal, and more mechanistic research.
Key findings
- In the eLABE sample of 280 term-born infants, prenatal social disadvantage was associated with smaller total gray, total subcortical gray, and total white matter volumes; mean gyrification index and bilateral amygdala/hippocampus volumes were also negatively associated, though amygdala and hippocampus effects were not significant after adjustment for total brain volume.
- Higher social risk was associated with lower fractional anisotropy in tracts including the frontolimbic uncinate fasciculus, posterior thalamic radiation, internal and external capsules, and corona radiata; prenatal social disadvantage was associated with lower mean diffusivity in the bilateral cingulum, bilateral uncinate, and right fornix.
- Maternal stress and psychopathology showed links to limbic connectivity: greater prenatal perceived stress was associated with smaller left hippocampus volume; prenatal depression was associated with increased amygdala functional connectivity with emotion regulation, sensory, and memory-related regions in one study (N=24 after motion exclusions); racial discrimination was associated with weaker amygdala–medial/anterior prefrontal cortex and stronger amygdala–fusiform connectivity.
- Neighborhood crime exposure was associated with widespread neonatal functional connectivity differences, including weaker thalamus–anterior default mode network, thalamus–anterior frontoparietal network, amygdala–hippocampus, and amygdala–anterior default mode network connectivity; violent and property crime were positively associated with externalizing symptoms at ages 1 and 2 years.
Methods
- Narrative review surveying literature linking prenatal SDoH to neonatal brain structure and function, including only studies with SDoH predictors before delivery and brain imaging completed within the first two months of life.
- Literature search used Google Scholar and PubMed between November 2023 and January 2024 without systematic search terms; example terms included “prenatal social determinants of health,” “structural MRI,” “functional MRI,” “functional connectivity,” “diffusion MRI,” “socioeconomic status,” “psychosocial stress,” “neighborhood safety,” and “maternal psychopathology.”
- Studies were grouped by prenatal exposure type and imaging modality; the review referenced SANRA and SWiM reporting standards.
Limitations
- The authors state this was not a systematic survey, so it is only a summary of included literature rather than an authoritative synthesis, and it may miss studies with null findings due to file-drawer effects or secondary MRI outcomes not identified in the search.
- The review states that the extant neonatal imaging literature has inconsistent image processing pipelines, small sample sizes, and a limited set of regions of interest examined.
- The text also makes evident heterogeneity and mixed results across studies, including inconsistent regional brain volume findings, differing directions of connectivity effects, and limited investigation of distal factors such as intimate partner violence, green space, local health systems, and societal attitudes toward prenatal care.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 Valid · 1 Not valid · 128 Not checked · 49 Own results and interpretations
A result the paper states — it cites no source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Secondary effects of the Social Determinants of Health, such as maternal sleep and psychopathology during pregnancy, have also been established as important predictors of infant brain development.”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Abstract
boostedstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper states — it cites no source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Prenatal socioeconomic status, perceived stress, and neighborhood safety have all been reported to impact neonatal brain structure and function, with exploratory work suggesting subsequent effects on infant and child behavior.”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Abstract
hedgedstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper states — it cites no source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, many of the associations between prenatal maternal environments and infant brain structure reported to date have been identified in brain regions known to be sensitive to stress hormones.”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Methods > Mechanisms Underlying SDoH Effects on Perinatal Brain Development
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper states — it cites no source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Prenatal socioeconomic status, perceived stress, and neighborhood safety have all been reported to impact neonatal brain structure and function, with exploratory work suggesting subsequent effects on infant and child behavior.”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Abstract
hedgedstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper states — it cites no source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Prenatal socioeconomic status, perceived stress, and neighborhood safety have all been reported to impact neonatal brain structure and function, with exploratory work suggesting subsequent effects on infant and child behavior.”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Abstract
hedgedstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
128 more claims
Create a free account to see all 178 claims and to verify the 175 references still open.
- The quote only partly states this claim. 2
- Probably not a substantial claim. 14
- It may state two separate claims as one. 35
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Environmental and social adversity can become biologically embedded, influencing physiological trajectories across the lifespan 2,3 as proposed by the Developmental Origins of Health and Diseases (DOHaD) framework.”
From Environmental roots of neonatal health: how social and structural exposures shape early-life outcomes (2026) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Abstract
“the aim of this review is to survey the literature that reports the effects of prenatal SDoH on infant brain structure and function within the first six weeks of life”
§ Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development > Methods
“including only studies that investigated SDoH predictors prior to infant delivery and brain imaging completed within the first two months of life.”
Citations
Cites
Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline
Campbell, M., McKenzie, J. E., Sowden, A., Katikireddi, S. V., Brennan, S. E., Ellis, S., Hartmann-Boyce, J., Ryan, R., Shepperd, S., Thomas, J., et al. (2020) · BMJ · doi:10.1136/bmj.l6890 · Cited by 4,628 · cited 1×
“Both the Scale for the Assessment of Narrative Review Articles (SANRA) 14 and Synthesis Without Meta-analysis (SWiM) 15 reporting standards were referenced in the preparation of this review.”
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
SANRA—a scale for the quality assessment of narrative review articles
Baethge, C., Goldbeck-Wood, S., & Mertens, S. (2019) · Research Integrity and Peer Review · doi:10.1186/s41073-019-0064-8 · Cited by 3,469
Levels of racism: a theoretic framework and a gardener's tale
(2000) · American Journal of Public Health · doi:10.2105/ajph.90.8.1212 · Cited by 2,626
Socioeconomic inequalities in depression: a meta-analysis
Lorant, V. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf182 · Cited by 2,603
Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Family income, parental education and brain structure in children and adolescents
Noble, K. G., Houston, S. M., Brito, N. H., Bartsch, H., Kan, E., Kuperman, J. M., Akshoomoff, N., Amaral, D. G., Bloss, C. S., Libiger, O., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3983 · Cited by 1,423
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386
Killing Me Softly: The Fetal Origins Hypothesis
Almond, D., & Currie, J. (2011) · Journal of Economic Perspectives · doi:10.1257/jep.25.3.153 · Cited by 1,241
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy
Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988
Buss, C., Davis, E. P., Shahbaba, B., Pruessner, J. C., Head, K., & Sandman, C. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201295109 · Cited by 652
Racial and Ethnic Health Disparities Related to COVID-19
Lopez, L., Hart, L. H., & Katz, M. H. (2021) · JAMA · doi:10.1001/jama.2020.26443 · Cited by 642
State of the Art Review: Poverty and the Developing Brain
Johnson, S. B., Riis, J. L., & Noble, K. G. (2016) · Pediatrics · doi:10.1542/peds.2015-3075 · Cited by 624
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
O’Donnell, K. J., & Meaney, M. J. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020138 · Cited by 608
Meta-analysis: Exposure to Early Life Stress and Risk for Depression in Childhood and Adolescence
LeMoult, J., Humphreys, K. L., Tracy, A., Hoffmeister, J.-A., Ip, E., & Gotlib, I. H. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.10.011 · Cited by 576
Placental 11β‐hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure
Benediktsson, R., Calder, A. A., Edwards, C. R. W., & Seckl, J. R. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.1230939.x · Cited by 536
Rich-Edwards, J. W., Kleinman, K., Abrams, A., Harlow, B. L., McLaughlin, T. J., Joffe, H., & Gillman, M. W. (2006) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2005.039370 · Cited by 489
Sandman, C. A., Glynn, L., Schetter, C. D., Wadhwa, P., Garite, T., Chicz-DeMet, A., & Hobel, C. (2006) · Peptides · doi:10.1016/j.peptides.2005.10.002 · Cited by 411
Prenatal developmental origins of future psychopathology: mechanisms and pathways
Monk, C., Lugo-Candelas, C., & Trumpff, C. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095539 · Cited by 388
Gao, W., Alcauter, S., Elton, A., Hernandez-Castillo, C. R., Smith, J. K., Ramirez, J., & Lin, W. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu088 · Cited by 380
Prenatal stress: Effects on fetal and child brain development
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.11.002 · Cited by 326
Health equity among black women in the United States
Chinn, J. J., Martin, I. K., & Redmond, N. (2021) · Journal of Women's Health · doi:10.1089/jwh.2020.8868 · Cited by 320
Monk, C., Feng, T., Lee, S., Krupska, I., Champagne, F. A., & Tycko, B. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15091171 · Cited by 304
Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants
Qiu, A., Anh, T. T., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., Kwek, K., Saw, S.-M., Chong, Y.-S., Gluckman, P. D., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.3 · Cited by 282
Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.
Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.019 · Cited by 258
The Wellcome Foundation Lecture, 1994. The fetal origins of adult disease
Barker, D. J. (1995) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1995.0173 · Cited by 255
Neighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248
Warland, J., Dorrian, J., Morrison, J. L., & O'Brien, L. M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.004 · Cited by 224 · cited 1×
“65,66 69 Evidence from the eLABE study suggests that disrupted sleep during pregnancy, associated with prenatal social disadvantage, is also associated with neonatal brain structure.”
Gumusoglu, S. B., & Stevens, H. E. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.008 · Cited by 220
Sandman, C. A., Buss, C., Head, K., & Davis, E. P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.025 · Cited by 219
Wu, Y., Lu, Y.-C., Jacobs, M., Pradhan, S., Kapse, K., Zhao, L., Niforatos-Andescavage, N., Vezina, G., du Plessis, A. J., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.19940 · Cited by 218
Maternal anxiety and infants’ hippocampal development: timing matters.
Qiu, A., Rifkin-Graboi, A., Chen, H., Chong, Y.-S., Kwek, K., Gluckman, P. D., Fortier, M. V., & Meaney, M. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.79 · Cited by 214
Graham, A. M., Rasmussen, J. M., Entringer, S., Ben Ward, E., Rudolph, M. D., Gilmore, J. H., Styner, M., Wadhwa, P. D., Fair, D. A., & Buss, C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.023 · Cited by 203
Pavlides, C., Ogawa, S., Kimura, A., & McEwen, B. S. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00776-7 · Cited by 199
Intergenerational Effect of Maternal Exposure to Childhood Maltreatment on Newborn Brain Anatomy
Moog, N. K., Entringer, S., Rasmussen, J. M., Styner, M., Gilmore, J. H., Kathmann, N., Heim, C. M., Wadhwa, P. D., & Buss, C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.009 · Cited by 189
Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression
Posner, J., Cha, J., Roy, A. K., Peterson, B. S., Bansal, R., Gustafsson, H. C., Raffanello, E., Gingrich, J., & Monk, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.146 · Cited by 184 · cited 1×
“79 The authors also reported decreased structural connectivity between right amygdala and ventral PFC in neonates whose mothers experienced prenatal depression (see Fig.”
McDermott, C. L., Seidlitz, J., Nadig, A., Liu, S., Clasen, L. S., Blumenthal, J. D., Reardon, P. K., Lalonde, F., Greenstein, D., Patel, R., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1808-18.2018 · Cited by 177
Dismantling Structural Racism in Psychiatry: A Path to Mental Health Equity
Shim, R. S. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21060558 · Cited by 173
V. THE NEUROBIOLOGICAL TOLL OF EARLY HUMAN DEPRIVATION
Nelson, C. A., Bos, K., Gunnar, M. R., & Sonuga-Barke, E. J. S. (2011) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.2011.00630.x · Cited by 162
Structuring Poverty: How Racism Shapes Child Poverty and Child and Adolescent Health
Heard‐Garris, N., Boyd, R. W., Kan, K., Pérez-Cardona, L., Heard, N. J., & Johnson, T. J. (2021) · Academic Pediatrics · doi:10.1016/j.acap.2021.05.026 · Cited by 149
The fetal origins of adult disease
Barker, D. J. P. (1994) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539500001005 · Cited by 142
Luby, J. L., Belden, A., Harms, M. P., Tillman, R., & Barch, D. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601443113 · Cited by 142
Rifkin-Graboi, A., Meaney, M. J., Chen, H., Bai, J., Hameed, W. B., Tint, M. T., Broekman, B. F. P., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., et al. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.01.013 · Cited by 139
Dean, D. C., Planalp, E. M., Wooten, W., Kecskemeti, S. R., Adluru, N., Schmidt, C. K., Frye, C., Birn, R. M., Burghy, C. A., Schmidt, N. L., et al. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.2132 · Cited by 138
Appleton, A. A., Armstrong, D. A., Lesseur, C., Lee, J., Padbury, J. F., Lester, B. M., & Marsit, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074691 · Cited by 134
Prenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost, D., Kwon, S. H., Lacadie, C., Sze, G., Sinha, R., Constable, R. T., & Ment, L. R. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2016.08.010 · Cited by 130
Gee, D. G., & Cohodes, E. M. (2021) · Current Directions in Psychological Science · doi:10.1177/09637214211015673 · Cited by 119
Qiu, A., Shen, M., Buss, C., Chong, Y.-S., Kwek, K., Saw, S.-M., Gluckman, P. D., Wadhwa, P. D., Entringer, S., Styner, M., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx065 · Cited by 114
Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood
Davis, E. P., Head, K., Buss, C., & Sandman, C. A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.005 · Cited by 110
COMT Haplotypes Modulate Associations of Antenatal Maternal Anxiety and Neonatal Cortical Morphology
Qiu, A., Tuan, T. A., Ong, M. L., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., Kwek, K., Saw, S.-M., Chong, Y.-S., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14030313 · Cited by 100
Maternal-Fetal Circadian Communication During Pregnancy
Bates, K., & Herzog, E. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00198 · Cited by 97
Betancourt, L. M., Avants, B., Farah, M. J., Brodsky, N. L., Wu, J., Ashtari, M., & Hurt, H. (2016) · Developmental Science · doi:10.1111/desc.12344 · Cited by 89
Prenatal Maternal Stress, Child Cortical Thickness, and Adolescent Depressive Symptoms
Davis, E. P., Hankin, B. L., Glynn, L. M., Head, K., Kim, D. J., & Sandman, C. A. (2020) · Child Development · doi:10.1111/cdev.13252 · Cited by 87
Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity
De Asis-Cruz, J., Krishnamurthy, D., Zhao, L., Kapse, K., Vezina, G., Andescavage, N., Quistorff, J., Lopez, C., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.22349 · Cited by 81
Association of Prenatal Exposure to Early-Life Adversity With Neonatal Brain Volumes at Birth
Triplett, R. L., Lean, R. E., Parikh, A., Miller, J. P., Alexopoulos, D., Kaplan, S., Meyer, D., Adamson, C., Smyser, T. A., Rogers, C. E., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.7045 · Cited by 80
Self-citationPrenatal stress affects the developmental trajectory of the rat amygdala
Kraszpulski, M., Dickerson, P. A., & Salm, A. K. (2006) · Stress · doi:10.1080/10253890600798109 · Cited by 77
Thompson, D. K., Kelly, C. E., Chen, J., Beare, R., Alexander, B., Seal, M. L., Lee, K., Matthews, L. G., Anderson, P. J., Doyle, L. W., et al. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.031 · Cited by 77
Lautarescu, A., Pecheva, D., Nosarti, C., Nihouarn, J., Zhang, H., Victor, S., Craig, M., Edwards, A. D., & Counsell, S. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.010 · Cited by 74
Brain connectivity and socioeconomic status at birth and externalizing symptoms at age 2 years
Ramphal, B., Whalen, D. J., Kenley, J. K., Yu, Q., Smyser, C. D., Rogers, C. E., & Sylvester, C. M. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100811 · Cited by 70
Self-citationHumphreys, K. L., Camacho, M. C., Roth, M. C., & Estes, E. C. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100877 · Cited by 67
Aberrant resting-state co-activation network dynamics in major depressive disorder
An, Z., Tang, K., Xie, Y., Tong, C., Liu, J., Tao, Q., DIRECT Consortium, Yan, C.-G., Chen, X., Cao, L.-P., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02722-w · Cited by 66
Moog, N. K., Nolvi, S., Kleih, T. S., Styner, M., Gilmore, J. H., Rasmussen, J. M., Heim, C. M., Entringer, S., Wadhwa, P. D., & Buss, C. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100368 · Cited by 65
Spann, M. N., Bansal, R., Hao, X., Rosen, T. S., & Peterson, B. S. (2020) · Child Neuropsychology · doi:10.1080/09297049.2019.1648641 · Cited by 64
Association Between Socioeconomic Status and In Utero Fetal Brain Development
Lu, Y.-C., Kapse, K., Andersen, N., Quistorff, J., Lopez, C., Fry, A., Cheng, J., Andescavage, N., Wu, Y., Espinosa, K., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.3526 · Cited by 63
Bernard, K., Lee, A. H., & Dozier, M. (2017) · Child Maltreatment · doi:10.1177/1077559517691126 · Cited by 62
Stoye, D. Q., Blesa, M., Sullivan, G., Galdi, P., Lamb, G. J., Black, G. S., Quigley, A. J., Thrippleton, M. J., Bastin, M. E., Reynolds, R. M., et al. (2020) · eLife · doi:10.7554/elife.60729 · Cited by 62
Low Socioeconomic Status Negatively Affects Sleep in Pregnant Women
Okun, M. L., Tolge, M., & Hall, M. (2014) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/1552-6909.12295 · Cited by 60
Lean, R. E., Smyser, C. D., Brady, R. G., Triplett, R. L., Kaplan, S., Kenley, J. K., Shimony, J. S., Smyser, T. A., Miller, J. P., Barch, D. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204135119 · Cited by 59
Self-citationKalmbach, D. A., Cheng, P., Sangha, R., O'Brien, L. M., Swanson, L. M., Palagini, L., Bazan, L. F., Roth, T., & Drake, C. L. (2019) · Nature and Science of Sleep · doi:10.2147/nss.s226291 · Cited by 56
Pires, G. N., Benedetto, L., Cortese, R., Gozal, D., Gulia, K. K., Kumar, V. M., Tufik, S., & Andersen, M. L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13135 · Cited by 56
Neighborhood Violent Crime and Perceived Stress in Pregnancy
Shannon, M. M., Clougherty, J. E., McCarthy, C., Elovitz, M. A., Nguemeni Tiako, M. J., Melly, S. J., & Burris, H. H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155585 · Cited by 53
Maternal Anxiety and Depression during Late Pregnancy and Newborn Brain White Matter Development
Graham, R. M., Jiang, L., McCorkle, G., Bellando, B. J., Sorensen, S. T., Glasier, C. M., Ramakrishnaiah, R. H., Rowell, A. C., Coker, J. L., & Ou, X. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6759 · Cited by 52
Wang, C., Shen, M., Guillaume, B., Chong, Y.-S., Chen, H., Fortier, M. V., Meaney, M. J., & Qiu, A. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.232 · Cited by 51
Lehtola, S. J., Tuulari, J. J., Scheinin, N. M., Karlsson, L., Parkkola, R., Merisaari, H., Lewis, J. D., Fonov, V. S., Louis Collins, D., Evans, A., et al. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102380 · Cited by 51
The Effects of Prenatal Exposure to Neighborhood Crime on Neonatal Functional Connectivity
Brady, R. G., Rogers, C. E., Prochaska, T., Kaplan, S., Lean, R. E., Smyser, T. A., Shimony, J. S., Slavich, G. M., Warner, B. B., Barch, D. M., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.020 · Cited by 50
Self-citationOldenburg, K. S., O'Shea, T. M., & Fry, R. C. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101115 · Cited by 46
Association of Preterm Birth and Socioeconomic Status With Neonatal Brain Structure
Mckinnon, K., Galdi, P., Blesa-Cábez, M., Sullivan, G., Vaher, K., Corrigan, A., Hall, J., Jiménez-Sánchez, L., Thrippleton, M., Bastin, M. E., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.16067 · Cited by 40
Impact of Demographic and Obstetric Factors on Infant Brain Volumes: A Population Neuroscience Study
Knickmeyer, R. C., Xia, K., Lu, Z., Ahn, M., Jha, S. C., Zou, F., Zhu, H., Styner, M., & Gilmore, J. H. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw331 · Cited by 37
Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life
Luby, J. L., Herzberg, M. P., Hoyniak, C. P., Tillman, R., Lean, R. E., Brady, R. G., Triplett, R. L., Alexopoulos, D. K., Loseille, D., Smyser, T. A., et al. (2024) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2024.0143 · Cited by 36
Self-citationHoyniak, C. P., Whalen, D. J., Luby, J. L., Barch, D. M., Miller, J. P., Zhao, P., Triplett, R. L., Ju, Y., Smyser, C. D., Warner, B., et al. (2024) · Developmental Science · doi:10.1111/desc.13456 · Cited by 34
Self-citationChronodisruption: An untimely cause of preterm birth?
Reschke, L., McCarthy, R., Herzog, E. D., Fay, J. C., Jungheim, E. S., & England, S. K. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.08.001 · Cited by 31
Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development
Lautarescu, A., Bonthrone, A. F., Pietsch, M., Batalle, D., Cordero-Grande, L., Tournier, J.-D., Christiaens, D., Hajnal, J. V., Chew, A., Falconer, S., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02073-y · Cited by 29
Sanders, A. F. P., Tirado, B. A., Seider, N. A., Triplett, R. L., Lean, R. E., Neil, J. J., Miller, J. P., Tillman, R., Smyser, T. A., Barch, D. M., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02782-6 · Cited by 27
Self-citationLater sleep timing is associated with an increased risk of preterm birth in nulliparous women
Facco, F. L., Parker, C. B., Hunter, S., Reid, K. J., Zee, P. P., Silver, R. M., Pien, G., Chung, J. H., Louis, J. M., Haas, D. M., et al. (2019) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2019.100040 · Cited by 26
Neurobehavioral Consequences of Fetal Exposure to Gestational Stress
Sandman, C. A., Glynn, L. M., & Davis, E. P. (2016) · Fetal Development · doi:10.1007/978-3-319-22023-9_13 · Cited by 24
Maternal Childhood Adversity Associates With Frontoamygdala Connectivity in Neonates
Hendrix, C. L., Dilks, D. D., McKenna, B. G., Dunlop, A. L., Corwin, E. J., & Brennan, P. A. (2021) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.11.003 · Cited by 24
van den Heuvel, M. I., Monk, C., Hendrix, C. L., Hect, J., Lee, S., Feng, T., & Thomason, M. E. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.03.020 · Cited by 23
Hendrix, C. L., Srinivasan, H., Feliciano, I., Carré, J. M., & Thomason, M. E. (2022) · Life · doi:10.3390/life12070943 · Cited by 21 · cited 1×
“93 Further, total maternal cortisol output was positively associated with hippocampus-dorsal In this investigation, the functional and structural connectivity of the amygdala in infants whose mothers who experienced prenatal depression (PMD) were compared to those whose mothers had not experienced…”
Ong, M., Tuan, T. A., Poh, J., Teh, A. L., Chen, L., Pan, H., MacIsaac, J. L., Kobor, M. S., Chong, Y. S., Kwek, K., et al. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12576 · Cited by 20
Spann, M. N., Alleyne, K., Holland, C. M., Davids, A., Pierre-Louis, A., Bang, C., Oyeneye, V., Kiflom, R., Shea, E., Cheng, B., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01765-3 · Cited by 20
Brady, R. G., Leverett, S. D., Mueller, L., Ruscitti, M., Latham, A. R., Smyser, T. A., Gerstein, E. D., Warner, B. B., Barch, D. M., Luby, J. L., et al. (2024) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.09.547 · Cited by 15
Self-citationLautarescu, A., Hadaya, L., Craig, M. C., Makropoulos, A., Batalle, D., Nosarti, C., Edwards, A. D., Counsell, S. J., & Victor, S. (2021) · PLOS ONE · doi:10.1371/journal.pone.0250413 · Cited by 12
Herzberg, M. P., Triplett, R., McCarthy, R., Kaplan, S., Alexopoulos, D., Meyer, D., Arora, J., Miller, J. P., Smyser, T. A., Herzog, E. D., et al. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.03.002 · Cited by 11
Self-citationHerzberg, M. P., Nielsen, A. N., Brady, R., Kaplan, S., Alexopoulos, D., Meyer, D., Arora, J., Miller, J. P., Smyser, T. A., Barch, D. M., et al. (2024) · Developmental Psychology · doi:10.1037/dev0001708 · Cited by 11
Self-citation
Research works printed but not linked: 1
- Nielsen, A. N. et al. Prenatal exposure to social disadvantage is evident in functional networks at birth. Preprint at (Under Review).
Cited by
Brain health equity and the influence of social determinants across the life cycle
Bach, A., Peeler, M., Caunca, M. R., Olusanya, B. O., Rosendale, N., & Gano, D. L. (2024) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2024.101553 · Cited by 18
Gutiérrez, V. B., Bozhilova, L. V., Darko, N., Georgieva, A., & O'Hara, K. P. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-07765-z · Cited by 4
Sandre, A., Troller‐Renfree, S. V., Amarante, M., Dettmer, A. M., Meyer, J. S., & Noble, K. G. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101611 · Cited by 3
Social Determinants of Health and Early Brain Development
Anaya, B., Triplett, R. L., Rogers, C. E., & Smyser, C. D. (2025) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2025.05.013 · Cited by 2
Self-citationNawaz, K., Babata, K., Scheid, L., Bitar, L., Ortiz, N. V., Kota, S., & Chalak, L. F. (2026) · Pediatric Research · doi:10.1038/s41390-026-05139-5 · Cited by 1
Metadata
- Authors
- Herzberg, M. P., & Smyser, C. D.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Smyser, Christopher D.
- Venue
- Pediatric Research
- Published
- 2024-07-03
- Volume
- 96
- Issue
- 6
- Pages
- 1417-1428
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- PMC
- PMC12013378
- OpenAlex
- W4400309621
- Cited by
- 22
- References
- 96
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 3
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- March of Dimes Foundation
- National Institutes of Health
- Intellectual and Developmental Disabilities Research Center (P50HD103525)
- National Institute of Mental Health (R01MH113883)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD103525)
- Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine in St. Louis (P50 HD103525)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Keywords
- social determinants of health, intrauterine environment, neonatal brain development, socioeconomic status, perceived stress, neighborhood safety, maternal sleep, maternal psychopathology, infant behavior, neurobehavioral development, diffusion MRI
- MeSH terms
- Brain, Child Development, Female, Humans, Infant, Newborn, Pregnancy, Social Environment, Social Determinants of Health
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-11-13, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-11-13 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
