Adipose tissue as an endocrine and paracrine organ

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.171 · Cited by 791

Does central obesity reflect “Cushing's disease of the omentum”?

Bujalska, I. J., Kumar, S., & Stewart, P. M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)11222-8 · Cited by 753

Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function

Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-575 · Cited by 632

Effect of fatty acids on energy coupling processes in mitochondria

Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363

Evidence for a Novel Peripheral Action of Leptin as a Metabolic Signal to the Adrenal Gland: Leptin Inhibits Cortisol Release Directly

Bornstein, S. R., Uhlmann, K., Haidan, A., Ehrhart-Bornstein, M., & Scherbaum, W. A. (1997) · Diabetes · doi:10.2337/diab.46.7.1235 · Cited by 344

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, N., & Skoda, R. C. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9907 · Cited by 326

Effects of body fat distribution on regional lipolysis in obesity.

Martin, M. L., & Jensen, M. D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115345 · Cited by 252

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755

Pathophysiology of human visceral obesity: an update

Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526

Elevated C-reactive protein levels in overweight and obese adults

Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494

Adipokines: inflammation and the pleiotropic role of white adipose tissue

Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775

Adipose Tissue as an Endocrine Organ

Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

Park, H. S., Park, J. Y., & Yu, R. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.11.007 · Cited by 964

Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance

Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753

Adipose tissue as a buffer for daily lipid flux

Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752

Sarcopenic obesity and inflammation in the InCHIANTI study

Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575

The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X

Black, P. H. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00048-5 · Cited by 502

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

O’Connor, M.-F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., Hoyt, M. A., Martin, J. L., Robles, T. F., Sloan, E. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.005 · Cited by 500

The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss

Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461

Obesity and inflammation: the effects of weight loss

Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4485 · Cited by 364

Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases

Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318

Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity

Chung, J.-Y., Kang, H.-T., Lee, D.-C., Lee, H.-R., & Lee, Y.-J. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.09.007 · Cited by 283

Caloric Restriction and Aging: Studies in Mice and Monkeys

Anderson, R. M., Shanmuganayagam, D., & Weindruch, R. (2009) · Toxicologic Pathology · doi:10.1177/0192623308329476 · Cited by 276

Regulation of leptin production: sympathetic nervous system interactions

Rayner, D. V., & Trayhurn, P. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100198 · Cited by 250

Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression

Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M.-G., Steffensen, K. R., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3430-3444.2004 · Cited by 250

Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

Anderson, H. D. I., Rahmutula, D., & Gardner, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309552200 · Cited by 186

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity

Wunderlich, C. M., Hövelmeyer, N., & Wunderlich, F. T. (2013) · JAK-STAT · doi:10.4161/jkst.23878 · Cited by 176

Interleukin‐6 production in human subcutaneous abdominal adipose tissue: the effect of exercise

Lyngsø, D., Simonsen, L., & Bülow, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019380 · Cited by 155

Obesity, Visceral Fat, and NAFLD: Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease

Mirza, M. S. (2011) · ISRN Gastroenterology · doi:10.5402/2011/592404 · Cited by 148

Attachment avoidance predicts inflammatory responses to marital conflict

Gouin, J.-P., Glaser, R., Loving, T. J., Malarkey, W. B., Stowell, J., Houts, C., & Kiecolt-Glaser, J. K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.016 · Cited by 133

Metabolic effects of interleukin-6 in human splanchnic and adipose tissue

Lyngsø, D., Simonsen, L., & Bülow, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.021022 · Cited by 119

Abdominal obesity and lung cancer risk: Systematic review and meta-analysis of prospective studies

Hidayat, K., Du, X., Chen, G., Shi, M., & Shi, B. (2016) · Nutrients · doi:10.3390/nu8120810 · Cited by 114

Sleep duration and circulating adipokine levels

Hayes, A. L., Xu, F., Babineau, D., & Patel, S. R. (2011) · Sleep · doi:10.1093/sleep/34.2.147 · Cited by 114

The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity

van Harmelen, V, Elizalde, M., Ariapart, P., Bergstedt-Lindqvist, S., Reynisdottir, S., Hoffstedt, J., Lundkvist, I., Bringman, S., & Arner, P. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801217 · Cited by 114

Adipose tissue as an endocrine organ

Prins, J. B. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0222 · Cited by 121

Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism

De Boer, H., Verschoor, L., Ruinemans‐Koerts, J., & Jansen, M. (2005) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00397.x · Cited by 108

Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery

Tussing‐Humphreys, L. M., Nemeth, E., Fantuzzi, G., Freels, S., Holterman, A. L., Galvani, C., Ayloo, S., Vitello, J., & Braunschweig, C. (2010) · Obesity · doi:10.1038/oby.2009.490 · Cited by 105

Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder

Pike, J. L., & Irwin, M. R. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.05.004 · Cited by 101

Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Blouin, K., Richard, C., Brochu, G., Hould, F.-S., Lebel, S., Marceau, S., Biron, S., Luu-The, V., & Tchernof, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06365 · Cited by 90

Adiponectin and energy homeostasis: consensus and controversy

Dridi, S., & Taouis, M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.003 · Cited by 85

Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women

Blouin, K., Blanchette, S., Richard, C., Dupont, P., Luu-The, V., & Tchernof, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2004 · Cited by 67

Omega-3 fatty acid epa improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation

Saini, A., Sharples, A. P., Al-Shanti, N., & Stewart, C. E. (2017) · Biogerontology · doi:10.1007/s10522-016-9667-3 · Cited by 53

The prospective association of socioeconomic status with C-reactive protein levels in the CARDIA study

Deverts, D. J., Cohen, S., Kalra, P., & Matthews, K. A. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.017 · Cited by 44

Adrenergic and glucocorticoid modulation of the sterile inflammatory response

Cox, S. S., Speaker, K. J., Beninson, L. A., Craig, W. C., Paton, M. M., & Fleshner, M. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.018 · Cited by 35

Optimism, pessimism, cynical hostility, and biomarkers of metabolic function in the Women's Health Initiative: 妇女健康倡议研究中的乐观情绪、悲观情绪、愤世嫉俗型敌意与代谢功能生物标志物

Tindle, H. A., Duncan, M. S., Liu, S., Kuller, L. H., Fugate Woods, N., Rapp, S. R., Kroenke, C. H., Coday, M., Loucks, E. B., Lamonte, M. J., et al. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12584 · Cited by 20

Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass spectrometric methods

Wang, F., Koskela, A., Hämäläinen, E., Turpeinen, U., Savolainen-Peltonen, H., Mikkola, T. S., Vihma, V., Adlercreutz, H., & Tikkanen, M. J. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.01.014 · Cited by 18