Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

Synthesis of Proteins by Native Chemical Ligation

Dawson, P. E., Muir, T. W., Clark-Lewis, I., & Kent, S. B. H. (1994) · Science · doi:10.1126/science.7973629 · Cited by 4,131

The possible role of hydrogen sulfide as an endogenous neuromodulator

Abe, K., & Kimura, H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01066.1996 · Cited by 2,239

Hydrogen sulphide and its therapeutic potential

Szabó, C. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2425 · Cited by 2,038

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

Wang, R. (2012) · Physiological Reviews · doi:10.1152/physrev.00017.2011 · Cited by 1,939

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

Zhao, W. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6008 · Cited by 1,936

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

Chan, J., Dodani, S. C., & Chang, C. J. (2012) · Nature Chemistry · doi:10.1038/nchem.1500 · Cited by 1,883

Hydrogen Sulfide and Cell Signaling

Li, L., Rose, P., & Moore, P. K. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100505 · Cited by 1,296

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

Paulsen, C. E., & Carroll, K. S. (2013) · Chemical Reviews · doi:10.1021/cr300163e · Cited by 1,278

H 2 S Signals Through Protein S-Sulfhydration

Mustafa, A. K., Gadalla, M. M., Sen, N., Kim, S., Mu, W., Gazi, S. K., Barrow, R. K., Yang, G., Wang, R., & Snyder, S. H. (2009) · Science Signaling · doi:10.1126/scisignal.2000464 · Cited by 1,231

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

Shibuya, N., Tanaka, M., Yoshida, M., Ogasawara, Y., Togawa, T., Ishii, K., & Kimura, H. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2253 · Cited by 919

Hydrogen sulfide mediates the vasoactivity of garlic

Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., Darley-Usmar, V. M., Doeller, J. E., & Kraus, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705710104 · Cited by 886

Hydrogen sulfide protects neurons from oxidative stress

Kimura, Y., & Kimura, H. (2004) · The FASEB Journal · doi:10.1096/fj.04-1815fje · Cited by 874

Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation

Zanardo, R. C. O., Brancaleone, V., Distrutti, E., Fiorucci, S., Cirino, G., Wallace, J. L., Zanardo, R. C. O., Brancaleone, V., Distrutti, E., Fiorucci, S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6270fje · Cited by 859

H2S signalling through protein sulfhydration and beyond

Paul, B. D., & Snyder, S. H. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3391 · Cited by 853

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide

Li, L., Whiteman, M., Guan, Y. Y., Neo, K. L., Cheng, Y., Lee, S. W., Zhao, Y., Baskar, R., Tan, C.-H., & Moore, P. K. (2008) · Circulation · doi:10.1161/circulationaha.107.753467 · Cited by 839

H 2 S Induces a Suspended Animation-Like State in Mice

Blackstone, E., Morrison, M., & Roth, M. B. (2005) · Science · doi:10.1126/science.1108581 · Cited by 802

Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

Li, L., Bhatia, M., Zhu, Y. Z., Zhu, Y. C., Ramnath, R. D., Wang, Z. J., Anuar, F. B. M., Whiteman, M., Salto‐Tellez, M., & Moore, P. K. (2005) · The FASEB Journal · doi:10.1096/fj.04-3583fje · Cited by 773

Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells

Lippert, A. R., New, E. J., & Chang, C. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203661j · Cited by 760

Redox Biochemistry of Hydrogen Sulfide

Kabil, O., & Banerjee, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.128363 · Cited by 744

Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling

Calvert, J. W., Jha, S., Gundewar, S., Elrod, J. W., Ramachandran, A., Pattillo, C. B., Kevil, C. G., & Lefer, D. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.199919 · Cited by 723

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

Sen, N., Paul, B. D., Gadalla, M. M., Mustafa, A. K., Sen, T., Xu, R., Kim, S., & Snyder, S. H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.10.021 · Cited by 719

Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial

Schnitzer, T. J., Burmester, G. R., Mysler, E., Hochberg, M. C., Doherty, M., Ehrsam, E., Gitton, X., Krammer, G., Mellein, B., Matchaba, P., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16893-1 · Cited by 701

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

Kimura, Y., Goto, Y.-I., & Kimura, H. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2282 · Cited by 685

Clarifying the real bioactive constituents of garlic

Amagase, H. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.3.716s · Cited by 680

Development of a Highly Selective Fluorescence Probe for Hydrogen Sulfide

Sasakura, K., Hanaoka, K., Shibuya, N., Mikami, Y., Kimura, Y., Komatsu, T., Ueno, T., Terai, T., Kimura, H., & Nagano, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207851s · Cited by 661

A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood

Peng, H., Cheng, Y., Dai, C., King, A. L., Predmore, B. L., Lefer, D. J., & Wang, B. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104236 · Cited by 637

Capture and Visualization of Hydrogen Sulfide by a Fluorescent Probe

Liu, C., Pan, J., Li, S., Zhao, Y., Wu, L. Y., Berkman, C. E., Whorton, A. R., & Xian, M. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104305 · Cited by 578

Hydrogen Sulfide Protects Against Cellular Senescence via S -Sulfhydration of Keap1 and Activation of Nrf2

Yang, G., Zhao, K., Ju, Y., Mani, S., Cao, Q., Puukila, S., Khaper, N., Wu, L., & Wang, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4645 · Cited by 563

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., & Kimura, H. (2013) · Nature Communications · doi:10.1038/ncomms2371 · Cited by 558

Selective fluorescent probes for live-cell monitoring of sulphide

Qian, Y., Karpus, J., Kabil, O., Zhang, S.-Y., Zhu, H.-L., Banerjee, R., Zhao, J., & He, C. (2011) · Nature Communications · doi:10.1038/ncomms1506 · Cited by 506

Use of Lawesson's Reagent in Organic Syntheses

Ozturk, T., Ertas, E., & Mert, O. (2007) · Chemical Reviews · doi:10.1021/cr040650b · Cited by 500

Hydrogen sulfide as a gasotransmitter

Gadalla, M. M., & Snyder, S. H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06580.x · Cited by 498

Hydrogen sulfide chemical biology: pathophysiological roles and detection

Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480

Polysulfides Link H 2 S to Protein Thiol Oxidation

Greiner, R., Pálinkás, Z., Bäsell, K., Becher, D., Antelmann, H., Nagy, P., & Dick, T. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5041 · Cited by 468

H 2 S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

Krishnan, N., Fu, C., Pappin, D. J., & Tonks, N. K. (2011) · Science Signaling · doi:10.1126/scisignal.2002329 · Cited by 446

Hydrogen Sulfide in Biochemistry and Medicine

Predmore, B. L., Lefer, D. J., & Gojon, G. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4612 · Cited by 393

Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species

Fukuto, J. M., Carrington, S. J., Tantillo, D. J., Harrison, J. G., Ignarro, L. J., Freeman, B. A., Chen, A., & Wink, D. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx2005234 · Cited by 389

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

Lee, Z. W., Zhou, J., Chen, C.-S., Zhao, Y., Tan, C.-H., Li, L., Moore, P. K., & Deng, L.-W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021077 · Cited by 382

The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages

Whiteman, M., Li, L., Rose, P., Tan, C.-H., Parkinson, D. B., & Moore, P. K. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2899 · Cited by 367

Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues

Doeller, J. E., Isbell, T. S., Benavides, G., Koenitzer, J., Patel, H., Patel, R. P., Lancaster, J. R., Darley-Usmar, V. M., & Kraus, D. W. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.03.024 · Cited by 367

Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative

Li, L., Rossoni, G., Sparatore, A., Lee, L. C., Del Soldato, P., & Moore, P. K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.011 · Cited by 345

Sulfhydration mediates neuroprotective actions of parkin

Vandiver, M. S., Paul, B. D., Xu, R., Karuppagounder, S., Rao, F., Snowman, A. M., Seok Ko, H., Il Lee, Y., Dawson, V. L., Dawson, T. M., et al. (2013) · Nature Communications · doi:10.1038/ncomms2623 · Cited by 343

Polysulfides are possible H 2 S‐derived signaling molecules in rat brain

Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J., & Kimura, H. (2013) · The FASEB Journal · doi:10.1096/fj.12-226415 · Cited by 342

Chemical Characterization of the Smallest S -Nitrosothiol, HSNO; Cellular Cross-talk of H 2 S and S -Nitrosothiols

Filipovic, M. R., Miljkovic, J. L., Nauser, T., Royzen, M., Klos, K., Shubina, T., Koppenol, W. H., Lippard, S. J., & Ivanović-Burmazović, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3009693 · Cited by 336

Celecoxib Versus Naproxen and Diclofenac in Osteoarthritis Patients: SUCCESS-I Study

Singh, G., Fort, J. G., Goldstein, J. L., Levy, R. A., Hanrahan, P. S., Bello, A. E., Andrade-Ortega, L., Wallemark, C., Agrawal, N. M., Eisen, G. M., et al. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.054 · Cited by 335

Chemical foundations of hydrogen sulfide biology

Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334

Hydrogen sulfide-releasing anti-inflammatory drugs

Wallace, J. L. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.003 · Cited by 328

The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia–reperfusion injury☆☆☆

Sodha, N. R., Clements, R. T., Feng, J., Liu, Y., Bianchi, C., Horvath, E. M., Szabo, C., & Sellke, F. W. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2008.01.047 · Cited by 321

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

Kashfi, K., & Olson, K. R. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.10.019 · Cited by 318

Novel Insights Into Hydrogen Sulfide–Mediated Cytoprotection

Calvert, J. W., Coetzee, W. A., & Lefer, D. J. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2882 · Cited by 314

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

Whiteman, M., Le Trionnaire, S., Chopra, M., Fox, B., & Whatmore, J. (2011) · Clinical Science · doi:10.1042/cs20110267 · Cited by 310

Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats

Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308

A two-photon fluorescent probe with near-infrared emission for hydrogen sulfide imaging in biosystems

Sun, W., Fan, J., Hu, C., Cao, J., Zhang, H., Xiong, X., Wang, J., Cui, S., Sun, S., & Peng, X. (2013) · Chemical Communications · doi:10.1039/c3cc41244j · Cited by 303

Hydrogen sulfide‐induced apoptosis of human aorta smooth muscle cells via the activation of mitogen‐activated protein kinases and caspase‐3

Yang, G., Sun, X., & Wang, R. (2004) · The FASEB Journal · doi:10.1096/fj.04-2279fje · Cited by 295

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

Calvert, J. W., Elston, M., Nicholson, C. K., Gundewar, S., Jha, S., Elrod, J. W., Ramachandran, A., & Lefer, D. J. (2010) · Circulation · doi:10.1161/circulationaha.109.920991 · Cited by 294

Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

Xuan, W., Sheng, C., Cao, Y., He, W., & Wang, W. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107025 · Cited by 294

Hydrogen Sulfide Is a Signaling Molecule and a Cytoprotectant

Kimura, H., Shibuya, N., & Kimura, Y. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4345 · Cited by 291

Detection of Protein S‐Sulfhydration by a Tag‐Switch Technique

Zhang, D., Macinkovic, I., Devarie‐Baez, N. O., Pan, J., Park, C., Carroll, K. S., Filipovic, M. R., & Xian, M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201305876 · Cited by 287

Sulfur signaling: Is the agent sulfide or sulfane?

Toohey, J. I. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.01.044 · Cited by 275

The biology of reactive sulfur species (RSS)

Gruhlke, M. C. H., & Slusarenko, A. J. (2012) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2012.03.016 · Cited by 274

Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals

Caliendo, G., Cirino, G., Santagada, V., & Wallace, J. L. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901638j · Cited by 272

Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat

Wallace, J. L., Caliendo, G., Santagada, V., Cirino, G., & Fiorucci, S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.042 · Cited by 271

Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation

Esechie, A., Kiss, L., Olah, G., Horváth, E. M., Hawkins, H., Szabo, C., & Traber, D. L. (2008) · Clinical Science · doi:10.1042/cs20080021 · Cited by 267

Fluorescent probes for sensing and imaging biological hydrogen sulfide

Lin, V. S., & Chang, C. J. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.07.014 · Cited by 260

Fluorescent Probes Based on Nucleophilic Substitution–Cyclization for Hydrogen Sulfide Detection and Bioimaging

Peng, B., Chen, W., Liu, C., Rosser, E. W., Pacheco, A., Zhao, Y., Aguilar, H. C., & Xian, M. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201303757 · Cited by 259

Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices

Tangerman, A. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.05.026 · Cited by 257

Is hydrogen sulfide a circulating “gasotransmitter” in vertebrate blood?

Olson, K. R. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.03.019 · Cited by 254

Sulphane sulphur in biological systems: a possible regulatory role

Toohey, J. I. (1989) · Biochemical Journal · doi:10.1042/bj2640625 · Cited by 246

SUSPENDED ANIMATION-LIKE STATE PROTECTS MICE FROM LETHAL HYPOXIA

Blackstone, E., & Roth, M. B. (2007) · Shock · doi:10.1097/shk.0b013e31802e27a0 · Cited by 237

Phosphorodithioate DNA as a Potential Therapeutic Drug

Marshall, W. S., & Caruthers, M. H. (1993) · Science · doi:10.1126/science.7681216 · Cited by 223

Reaction Based Fluorescent Probes for Hydrogen Sulfide

Liu, C., Peng, B., Li, S., Park, C.-M., Whorton, A. R., & Xian, M. (2012) · Organic Letters · doi:10.1021/ol3008183 · Cited by 222

Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest

Carballal, S., Trujillo, M., Cuevasanta, E., Bartesaghi, S., Möller, M. N., Folkes, L. K., García-Bereguiaín, M. A., Gutiérrez-Merino, C., Wardman, P., Denicola, A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.705 · Cited by 221

In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe

Wan, Q., Song, Y., Li, Z., Gao, X., & Ma, H. (2013) · Chem. Commun. · doi:10.1039/c2cc37725j · Cited by 219

Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications

Szabo, C. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4451 · Cited by 217

Recent developments of fluorescent probes for the detection of gasotransmitters (NO, CO and H2S)

Kumar, N., Bhalla, V., & Kumar, M. (2013) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2013.02.028 · Cited by 216

Hydrogen sulfide: a gasotransmitter of clinical relevance

Vandiver, M. S., & Snyder, S. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0873-4 · Cited by 207

A Practical Look at the Chemistry and Biology of Hydrogen Sulfide

Olson, K. R. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4401 · Cited by 206

Hydrogen Sulfide: Neurophysiology and Neuropathology

Hu, L.-F., Lu, M., Hon Wong, P. T., & Bian, J.-S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3517 · Cited by 205

The reaction of H2S with oxidized thiols: generation of persulfides and implications to H2S biology

Francoleon, N. E., Carrington, S. J., & Fukuto, J. M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.09.015 · Cited by 199

THE TOXICITY OF HYDROGEN SULPHIDE AND OTHER SULPHIDES

Evans, C. L. (1967) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1967.sp001909 · Cited by 187

Persulfide Reactivity in the Detection of Protein S-Sulfhydration

Pan, J., & Carroll, K. S. (2013) · ACS Chemical Biology · doi:10.1021/cb4001052 · Cited by 185

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

Martelli, A., Testai, L., Citi, V., Marino, A., Pugliesi, I., Barresi, E., Nesi, G., Rapposelli, S., Taliani, S., Da Settimo, F., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400239a · Cited by 179

Passive loss of hydrogen sulfide in biological experiments

DeLeon, E. R., Stoy, G. F., & Olson, K. R. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2011.10.016 · Cited by 176

The Phosphonation of Aromatic Compounds with Phosphorus Pentasulfide

Lecher, H. Z., Greenwood, R. A., Whitehouse, K. C., & Chao, T. H. (1956) · Journal of the American Chemical Society · doi:10.1021/ja01600a058 · Cited by 174

Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury

Zhao, Y., Bhushan, S., Yang, C., Otsuka, H., Stein, J. D., Pacheco, A., Peng, B., Devarie-Baez, N. O., Aguilar, H. C., Lefer, D. J., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400090d · Cited by 170

Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress

Wen, Y.-D., Wang, H., Kho, S.-H., Rinkiko, S., Sheng, X., Shen, H.-M., & Zhu, Y.-Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053147 · Cited by 169

Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner

Peake, B. F., Nicholson, C. K., Lambert, J. P., Hood, R. L., Amin, H., Amin, S., & Calvert, J. W. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00796.2012 · Cited by 166

Assay methods and biological roles of labile sulfur in animal tissues

Ubuka, T. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00623-2 · Cited by 165

Hydrogen sulphide: novel opportunity for drug discovery

Martelli, A., Testai, L., Breschi, M. C., Blandizzi, C., Virdis, A., Taddei, S., & Calderone, V. (2012) · Medicinal Research Reviews · doi:10.1002/med.20234 · Cited by 163

Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation

Collman, J. P., Ghosh, S., Dey, A., & Decréau, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904082106 · Cited by 159

THIATION WITH 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4- DITHIADIPHOSPHETANE 2,4-DISULFIDE: N-METHYLTHIOPYRROLIDONE

(1984) · Organic Syntheses · doi:10.15227/orgsyn.062.0158 · Cited by 151

A near-infrared reversible and ratiometric fluorescent probe based on Se-BODIPY for the redox cycle mediated by hypobromous acid and hydrogen sulfide in living cells

Wang, B., Li, P., Yu, F., Chen, J., Qu, Z., & Han, K. (2013) · Chemical Communications · doi:10.1039/c3cc42313a · Cited by 150

Hydrogen sulfide‐induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells

Baskar, R., Li, L., & Moore, P. K. (2006) · The FASEB Journal · doi:10.1096/fj.06-6255com · Cited by 145

5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5 H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

Distrutti, E., Sediari, L., Mencarelli, A., Renga, B., Orlandi, S., Russo, G., Caliendo, G., Santagada, V., Cirino, G., Wallace, J. L., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106435 · Cited by 144

Light-Induced Hydrogen Sulfide Release from “Caged” gem-Dithiols

Devarie‐Baez, N. O., Bagdon, P. E., Peng, B., Zhao, Y., Park, C., & Xian, M. (2013) · Organic Letters · doi:10.1021/ol401118k · Cited by 144

Prodrugs of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), More Than Meets the Eye: A Critical Review

Qandil, A. M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131217244 · Cited by 134

Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

Chattopadhyay, M., Kodela, R., Nath, N., Dastagirzada, Y. M., Velázquez‐Martínez, C. A., Boring, D. L., & Kashfi, K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.018 · Cited by 131

Cardioprotective effects of hydrogen sulfide

Szabo, G. B., Veres, G., Radovits, T., et al. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.11.001 · Cited by 120

Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes

Xue, R., Hao, D.-D., Sun, J., Li, W., Zhao, M., Li, X., Chen, Y., Zhu, Y., Ding, Y.-J., Liu, J., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5024 · Cited by 117

Dithiolethiones for cancer chemoprevention: where do we stand?

Zhang, Y., & Munday, R. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0625 · Cited by 114

Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfide

Olson, K. R., Donald, J. A., Dombkowski, R. A., & Perry, S. F. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.04.004 · Cited by 113

Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite

Filipović, M. R., Miljković, J. L., Allgäuer, A., Chaurio, R. A., Shubina, T. E., i, M. H., & Ivanović‐Burmazović, I. (2011) · Biochemical Journal · doi:10.1042/bj20111389 · Cited by 113

Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca 2+ -activated K + channels and smooth muscle Ca 2+ sparks

Jackson‐Weaver, O., Osmond, J. M., Riddle, M. A., Naik, J. S., Bosc, L. V. G., Walker, B. R., & Kanagy, N. L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00506.2012 · Cited by 112

Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K+ATP Channel Activation

Spiller, F., Orrico, M. I. L., Nascimento, D. C., Czaikoski, P. G., Souto, F. O., Alves-Filho, J. C., de Freitas, A., Carlos, D., Montenegro, M. F., Neto, A. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1145oc · Cited by 108

Oxidative acylation using thioacids

Liu, R., & Orgel, L. E. (1997) · Nature · doi:10.1038/37944 · Cited by 103

Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides

Bruce King, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.005 · Cited by 103

H2S induced hypometabolism in mice is missing in sedated sheep

Haouzi, P. A., Notet, V., Chenuel, B. J., Chalon, B., Sponne, I., Ogier, V., & Bihain, B. E. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.09.001 · Cited by 101

Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments

Chan, M. V., & Wallace, J. L. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00169.2013 · Cited by 98

Epimerization‐Free Block Synthesis of Peptides from Thioacids and Amines with the Sanger and Mukaiyama Reagents

Crich, D., & Sharma, I. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805782 · Cited by 97

Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

Fukushima, N., Ieda, N., Sasakura, K., Nagano, T., Hanaoka, K., Suzuki, T., Miyata, N., & Nakagawa, H. (2013) · Chemical Communications · doi:10.1039/c3cc47421f · Cited by 97

Electron paramagnetic resonance spin trapping investigation into the kinetics of glutathione oxidation by the superoxide radical: re-evaluation of the rate constant

Jones, C. M., Lawrence, A. D., Wardman, P., & Burkitt, M. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00791-8 · Cited by 84

Inhibition of Hydrogen Sulfide Synthesis Attenuates Chemokine Production and Protects Mice Against Acute Pancreatitis and Associated Lung Injury

Tamizhselvi, R., Moore, P. K., & Bhatia, M. (2008) · Pancreas · doi:10.1097/mpa.0b013e31816857bb · Cited by 81

Therapeutic potential of new hydrogen sulfide-releasing hybrids

Sparatore, A., Santus, G., Giustarini, D., Rossi, R., & Soldato, P. D. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.122 · Cited by 81

Controlled Growth of Monodisperse Self-Supported Superparamagnetic Nanostructures of Spherical and Rod-Like CoFe2O4 Nanocrystals

Bao, N., Shen, L., Wang, Y. A., Ma, J., Mazumdar, D., & Gupta, A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905811h · Cited by 80

Therapeutic Effect of Hydrogen Sulfide-Releasing L-Dopa Derivative ACS84 on 6-OHDA-Induced Parkinson’s Disease Rat Model

Xie, L. H., Hu, L., Teo, X. Q., Tiong, C. X., Tazzari, V., Sparatore, A., Soldato, P. D., Dawe, G. S., & Bian, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060200 · Cited by 79

Perspective on Recent Developments on Sulfur-Containing Agents and Hydrogen Sulfide Signaling

Jacob, C., Anwar, A., & Burkholz, T. (2008) · Planta Medica · doi:10.1055/s-0028-1088299 · Cited by 78

Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury

King, A. L., & Lefer, D. J. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.059725 · Cited by 78

Hydrogen Sulfide Preconditioning Protects Rat Liver against Ischemia/Reperfusion Injury by Activating Akt-GSK-3β Signaling and Inhibiting Mitochondrial Permeability Transition

Zhang, Q., Fu, H., Zhang, H., Xu, F., Zou, Z., Liu, M., Wang, Q., Miao, M., & Shi, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074422 · Cited by 76

Promising General Solution to the Problem of Ligating Peptides and Glycopeptides

Wang, P., & Danishefsky, S. J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1084628 · Cited by 75

New Biologically Active Hydrogen Sulfide Donors

Roger, T., Raynaud, F., Bouillaud, F., Ransy, C., Simonet, S., Crespo, C., Bourguignon, M., Villeneuve, N., Vilaine, J., Artaud, I., et al. (2013) · ChemBioChem · doi:10.1002/cbic.201300552 · Cited by 67

Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors

Park, C., Zhao, Y., Zhu, Z., Pacheco, A., Peng, B., Devarie‐Baez, N. O., Bagdon, P. E., Zhang, H., & Xian, M. (2013) · Molecular BioSystems · doi:10.1039/c3mb70145j · Cited by 65

Hydrogen Sulfide: Potent Regulator of Vascular Tone and Stimulator of Angiogenesis

Gollasch, M., Huang, Y., Köhn, C., et al. (2012) · International Journal of Biomedical Science · doi:10.59566/ijbs.2012.8081 · Cited by 61

Facile Amide Formation via S-Nitrosothioacids

Pan, J. H., Devarie‐Baez, N. O., & Xian, M. (2011) · Organic Letters · doi:10.1021/ol1031393 · Cited by 55

Hydrogen Sulphide: Biopharmacological Roles in the Cardiovascular System and Pharmaceutical Perspectives

Martelli, A., Testai, L., Marino, A., Breschi, M. C., Settimo, F. D., & Calderone, V. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801215928 · Cited by 51

The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury (Review)

Dongó, E., Hornyák, I., Benkő, Z., & Kiss, L. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.4.1 · Cited by 51

Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects

Derwall, M., Francis, R. C. E., Kida, K., Bougaki, M., Crimi, E., Adrie, C., Zapol, W. M., & Ichinose, F. (2011) · Critical Care · doi:10.1186/cc10016 · Cited by 49

Peptide−Small Molecule Hybrids via Orthogonal Deprotection−Chemoselective Conjugation to Cysteine-Anchored Scaffolds. A Model Study

Smith, A. B., Savinov, S. N., Manjappara, U. V., & CHAIKEN, I. M. (2002) · Organic Letters · doi:10.1021/ol026736d · Cited by 48

A hydrogen sulfide‐releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury

Campolo, M., Esposito, E., Ahmad, A., Paola, R. D., Wallace, J. L., & Cuzzocrea, S. (2013) · The FASEB Journal · doi:10.1096/fj.13-234716 · Cited by 46

Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2

Kloesch, B., Liszt, M., Steiner, G. E., & Broell, J. (2010) · Rheumatology International · doi:10.1007/s00296-010-1682-0 · Cited by 45

Synthesis and Preliminary Pharmacological Evaluation of Aryl Dithiolethiones with Cyclooxygenase-2-Selective Inhibitory Activity and Hydrogen Sulfide-Releasing Properties

Zanatta, S. D., Jarrott, B., & Williams, S. J. (2010) · Australian Journal of Chemistry · doi:10.1071/ch09517 · Cited by 37

Hydrogen sulfide oxidation and the arterial chemoreflex: Effect of methemoglobin

Haouzi, P. A., Bell, H. J., & Philmon, M. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.04.025 · Cited by 36

Effects of H2S on Myogenic Responses in Rat Cerebral Arterioles

Liu, L., Liu, H., Sun, D., Qiao, W., Qi, Y.-J., Sun, H., & Yan, C. (2012) · Circulation Journal · doi:10.1253/circj.cj-11-0890 · Cited by 21

Distribution of Ion Species and Formation of Ion Pairs in Concentrated Polysulfide Solutions in Photoelectrochemical Transducers

Vorobets, V. S., Kovach, S. K., & Kolbasov, G. Y. (2002) · Russian Journal of Applied Chemistry · doi:10.1023/a:1016152117662 · Cited by 12

Of mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)

Wagner, K., Georgieff, M., Asfar, P., Calzia, E., Knöferl, M. W., & Radermacher, P. (2011) · Critical Care · doi:10.1186/cc10079 · Cited by 11

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683

Chemical Biology of H2S Signaling through Persulfidation

Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046