The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Open accessAbstract
Social adaptation requires specific cognitive and emotional competences. Individuals with high-functioning autism or with Asperger syndrome cannot understand or engage in social situations despite preserved intellectual abilities. Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism. We investigated the behavioral effects of oxytocin in 13 subjects with autism. In a simulated ball game where participants interacted with fictitious partners, we found that after oxytocin inhalation, patients exhibited stronger interactions with the most socially cooperative partner and reported enhanced feelings of trust and preference. Also, during free viewing of pictures of faces, oxytocin selectively increased patients' gazing time on the socially informative region of the face, namely the eyes. Thus, under oxytocin, patients respond more strongly to others and exhibit more appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its action on a core dimension of autism.
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In the citing paper
“Animal model research points to a strong relationship between socially monogamous attachment behaviors and the expression of oxytocin within the brain—along with that of an affiliated peptide, vasopressin, and a suite of auxiliary hormones and neurotransmitters including dopamine.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [37]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Several trials have shown that a single dose of intranasal oxytocin enhanced performance on measures of social cognition10,11 or motivation,12–14 as compared with placebo, in persons with autism spectrum disorder.”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [13]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Infusing oxytocin into the brains of the females, and vasopressin into the brains of the males, significantly enhanced pair-bonding even in the absence of actual mating.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [37]
Experimental — accuracy not yet measuredIn the citing paper
“Indeed, IN-OT has been shown to acutely increase gaze to the eye region of human faces in autistic populations (65,66), although the benefit of chronic or developmental OT exposure is only beginning to be explored (67,68).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [65]
In the citing paper
“within the ASD literature there is evidence that improved facial emotion recognition is due, in part, to participants spending more time looking at the eye area of faces (e.g., Andari et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Andari et al., 2010
In the citing paper
“Nevertheless, our results are consistent with evidence from ASD literature suggesting that OXT increases attention to socially relevant stimuli, and specifically for the eye-region (e.g., Andari et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Andari et al., 2010
In the citing paper
“A second study [16] also found significantly elevated plasma OT concentrations at 10 minutes post-administration.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [16]
In the citing paper
“It appears that the enhanced prosocial effects of intranasally administered OT are especially pronounced for individuals suffering from socio-emotional deficits, as is the case for individuals with Asperger syndrome (Andari et al., 2010) or high alexithymia (Luminet et al., 2011).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Andari et al., 2010
In the citing paper
“In individuals with autism, intranasal OT was shown to increase emotion recognition (13) and to increase feelings of trust and willingness to interact socially (16).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [16]
In the citing paper
“OT administration has been shown to improve social decision-making (Andari et al., 2010; Hollander et al., 2007)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“promote visual scanning of faces (Andari et al., 2010)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Similar doses of OT have been administered to subjects in previous studies of social functioning (Andari et al., 2010; Feifel et al., 2010; Guastella et al., 2008; Hollander et al., 2007; Ditzen et al., 2009).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Previous studies have employed simulated social games (Andari et al., 2010; Kosfeld et al., 2005), and static social photographs (Guastella et al., 2008) to evaluate the effects of OT on social behaviors.”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Other research suggests that the effect of oxytocin on cooperative behavior depends on characteristics of the individual (Andari et al. 2010; Bartz et al. 2010a; Bartz et al. 2011).”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Andari et al. 2010
In the citing paper
“For example, oxytocin has been shown to increase gazing time on the eye region33, and to improve performance on the Reading the Mind in the Eyes Task in adults and adolescents with ASD48,49.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [33]
In the citing paper
“Moreover, in subjects diagnosed with autism, a single intranasal administration of OXT might be able to improve, at least temporarily, emotion recognition abilities in the Reading the Mind in the Eyes test and the patients' ability to process socially relevant cues in a computer-based game (Andari et al, 2010;Green and Hollander, 2010;Guastella et al, 2010).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Andari et al, 2010
In the citing paper
“While most randomized clinical trials have found some oxytocin effects on ASD symptoms33,50–52 and brain function50–52,80,81, not all trials have reported effects82.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [33]
In the citing paper
“Studies in our lab and others have found that OT plasma concentration is significantly lower in patients with ASD than in healthy subjects (Andari et al. 2010; Modahl et al. 1998).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Andari et al. 2010
In the citing paper
“In terms of exogenous effects of OT, we showed that intranasal administration (24 IU) of OT to adults with ASD (men between 18 and 45 years old) enhanced their attention to faces and improved the social recognition of implicit cues within an interactive social game in a within subject placebo-controlled study (Andari et al. 2010).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Andari et al. 2010
In the citing paper
“Intranasal OT also increases attention to the eyes in individuals with social deficits. Individuals with autism, for example, spend more time attending to the eye region of faces following intranasal OT compared to placebo (Andari et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Andari et al., 2010
In the citing paper
“two studies have found lower average levels of blood plasma concentrations of oxytocin in individuals with ASD relative to controls [166,167]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [166]
In the citing paper
“increases cooperative behaviors, trust, and attention to socially informative stimuli (for example, eyes) [166]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [166]
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Citations
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555 · cited 1×
“On formal tests of social cognitive skill, they show specific impairments in understanding the intentions of others (1, 5) and lack of fast intuitive judgments about social contexts (4).”
BackgroundBaron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Wing, L., & Gould, J. (1979) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531288 · Cited by 2,587 · cited 1×
“Different authors have suggested that patients with autism may display different social interaction styles (15, 22).”
BackgroundRELATIVE AND ABSOLUTE STRENGTH OF RESPONSE AS A FUNCTION OF FREQUENCY OF REINFORCEMENT 1, 2
Herrnstein, R. J. (1961) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1961.4-267 · Cited by 2,281
Cyberostracism: effects of being ignored over the Internet
Williams, K. D., Cheung, C. K. T., & Choi, W. (2000) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.79.5.748 · Cited by 2,276
Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.809 · Cited by 2,120
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851
Self-citationOxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602
Self-citationGaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
When inclusion costs and ostracism pays, ostracism still hurts.
van Beest, I., & Williams, K. D. (2006) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.91.5.918 · Cited by 567
A neurobiological basis of social attachment.
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.726 · Cited by 553
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Emanuel Miller lecture: Confusions and controversies about Asperger syndrome
Frith, U. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00262.x · Cited by 439
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · cited 1×
“It has been proposed that oxytocin enhances affiliation partly by reducing fear of social unfaithfulness and by suppressing avoidance behavior (14) and that it reduces the activity of the amygdala, resulting in a decrease of fear responses (14, 24, 25).”
BackgroundOxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404
Oxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352
A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311
Gillberg, C., Gillberg, C., Råstam, M., & Wentz, E. (2001) · Autism · doi:10.1177/1362361301005001006 · Cited by 309
Post-learning intranasal oxytocin modulates human memory for facial identity
Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262
Neurofunctional mechanisms in autism
Waterhouse, L., Fein, D., & Modahl, C. (1996) · Psychological Review · doi:10.1037/0033-295x.103.3.457 · Cited by 218
Hansson, S. L., Svanströmröjvall, A., Rastam, M., Gillberg, C., Gillberg, C., & Anckarsäter, H. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.3.262 · Cited by 208
Research works printed but not linked: 1
- FR Volkmar, A Klin Asperger’s syndrome, eds A Klin, F Volkmar, SS Sparrow (Guilford, New York), pp. 25–71 (2000).
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Oxytocin enables maternal behaviour by balancing cortical inhibition
Marlin, B. J., Mitre, M., D’amour, J. A., Chao, M. V., & Froemke, R. C. (2015) · Nature · doi:10.1038/nature14402 · Cited by 744
Metadata
- Authors
- Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre de Neuroscience Cognitive, Unité Mixte de Recherche 5229, Centre National de la Recherche Scientifique, 69675 Bron, France; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-02-16
- Volume
- 107
- Issue
- 9
- Pages
- 4389-4394
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2840168
- OpenAlex
- W2034453108
- Cited by
- 941
- References
- 32
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 25 · 2023: 44 · 2022: 37 · 2021: 44 · 2020: 91 · 2019: 48 · 2018: 51 · 2017: 72 · 2016: 68 · 2015: 81 · 2014: 100 · 2013: 89 · 2012: 74
- FWCI
- 109.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation FondaMental
- Fondation Orange
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- oxytocin, autism spectrum disorder, Asperger syndrome, social behavior, social cognition, trust, gaze behavior, face processing, social interaction, social dysfunction
- MeSH terms
- Administration, Inhalation, Adolescent, Adult, Autistic Disorder, Emotions, Female, Humans, Male, Oxytocin, Social Behavior, Young Adult
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