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Cited by 272

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?

Open access
Pedersen, B. K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., Wolsk-Petersen, E., Febbraio, M.·2004·Proceedings of the Nutrition Society
DOI 10.1079/pns2004338
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Abstract

For most of the last century, researchers have searched for a muscle contraction-induced factor that mediates some of the exercise effects in other tissues such as the liver and the adipose tissue. It has been called the ‘work stimulus’, the ‘work factor’ or the ‘exercise factor’. In the search for such a factor, a cytokine, IL-6, was found to be produced by contracting muscles and released into the blood. It has been demonstrated that IL-6 has many biological roles such as: (1) induction of lipolysis; (2) suppression of TNF production; (3) stimulation of cortisol production. The IL-6 gene is rapidly activated during exercise, and the activation of this gene is further enhanced when muscle glycogen content is low. In addition, carbohydrate supplementation during exercise has been shown to inhibit the release of IL-6 from contracting muscle. Thus, it is suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines could be termed ‘myokines’.

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Metadata

Authors
Pedersen, B. K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., Wolsk-Petersen, E., & Febbraio, M.
Venue
Proceedings of the Nutrition Society
Publisher
Cambridge University Press (CUP)
Published
2004-05
Volume
63
Issue
2
Pages
263-267
ISSN
  • 0029-6651 (ISSN-L)
  • 1475-2719
DOI
10.1079/pns2004338
OpenAlex
W2109611332
Cited by
272
References
12
FWCI
11.95
Type
journal article
Language
en
Open access
bronze

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