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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction

Schaefer, Anne, Im, Heh-In, Venø, Morten T., Fowler, Christie D., Min, Alice, Intrator, Adam, Kjems, Jørgen, Kenny, Paul J., O’Carroll, Donal, Greengard, Paul·2010·Journal of Experimental Medicine
DOI 10.1084/jem.20100451PMC PMC2931161
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Abstract

Cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mRNA translation, and metabolism within medium spiny neurons in the striatum. The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine. Here, we provide evidence for a key role of miRNAs in cocaine addiction. We show that Argonaute 2 (Ago2), which plays an important role in miRNA generation and execution of miRNA-mediated gene silencing, is involved in regulation of cocaine addiction. Deficiency of Ago2 in dopamine 2 receptor (Drd2)–expressing neurons greatly reduces the motivation to self-administer cocaine in mice. We identified a distinct group of miRNAs that is specifically regulated by Ago2 in the striatum. Comparison of miRNAs affected by Ago2 deficiency with miRNAs that are enriched and/or up-regulated in Drd2-neurons in response to cocaine identified a set of miRNAs that are likely to play a role in cocaine addiction.

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  • Previous studies have confirmed that when expressed in the mouse brain, FLAG-Ago2 carries an extensive range of miRNAs representative of the functional miRNA pool.

    “Previous studies have confirmed that when expressed in the mouse brain, FLAG-Ago2 carries an extensive range of miRNAs representative of the functional miRNA pool (Schaefer et al., 2010; Tan et al., 2013; Brennan et al., 2020).”

    From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Schaefer et al., 2010

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Research works printed but not linked: 28

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Metadata

Authors
Schaefer, A., Im, H.-I., Venø, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O’Carroll, D., & Greengard, P.
Affiliations
  • Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065 1
  • Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, FL 33458 2
  • Department of Molecular Biology, Faculty of Science, Aarhus University, DK-8000 Aarhus, Denmark 3
  • European Molecular Biology Laboratory Monterotondo, 00015 Monterotondo, Italy 4
Venue
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2010-07-19
Volume
207
Issue
9
Pages
1843-1851
ISSN
  • 1540-9538
  • 0022-1007
DOI
10.1084/jem.20100451
PMC
PMC2931161
Cited by
139
References
7
Language
en

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