Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode
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Objective . As artificial prostheses become more refined, they are most often used as a therapeutic option for hand amputation. By contrast to extra- or intraneural interfaces, regenerative nerve electrodes are designed to enable electrical interfaces with regrowing axonal bundles of injured nerves, aiming to achieve high selectivity for recording and stimulation. However, most of the developed designs pose an obstacle to the regrowth mechanisms due to low transparency and cause impairment to the nerve regeneration. Approach . Here we present the double-aisle electrode, a new type of highly transparent, non-obstructive regenerative electrode. Using a double-side thin-film polyimide planar multi-contact electrode, two nerve fascicles can regenerate without physical impairment through two electrically isolated aisles. Main results . We show that this electrode can be used to selectively record and stimulate fascicles, acutely as well as chronically, and allow regeneration in nerve gaps of several millimeters without impairment. Significance . This multi-aisle regenerative electrode may be suitable for neuroprosthetic applications, such as prostheses, for the restoration of hand function after amputation or severe nerve injuries.
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In a double-aisle regenerative electrode, selective stimulation and recording of tibial and fibular nerve fascicles were possible both acutely and chronically, with a slight decrease in selectivity after 3 months.
“Selective stimulation and recording of the fascicles were possible both acutely and chronically, with a slight decrease in selectivity after 3 months.”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [124]
Section 3.2 reports selective stimulation and recording in acute tests, and section 3.4 reports that both capabilities were maintained three months after implantation. The timing of the decrease is imprecise: section 3.4 says selectivity was lower at six months than at three months, not that a decrease was observed at three months. The copy does not characterize the decrease as slight. (LLM, conf=0.85)
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Blasiak, A., Ng, K. A., Wong, M. D. S., Tsai, C.-W., Rusly, A., Gammad, G. G. L., Voges, K., Libedinsky, C., Yen, S., Thakor, N. V., et al. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3113653 · Cited by 4 · see citing works
Neural electrodes for long-term tissue interfaces
del Valle, J., Rodríguez‐Meana, B., & Navarro, X. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822828-9.00009-5 · Cited by 2 · see citing works
Self-citationRegenerative Electrodes for Peripheral Nerve Interfacing
Zellmer, E. R., & Moran, D. W. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_18 · Cited by 1 · see citing works
Silveira, C. R. A., Brunton, E., Spendiff, S., & Nazarpour, K. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8512751 · Cited by 1 · see citing works
The Potential of Artificial Intelligence in the Healthcare System
Gupta, M., & Kalra, R. (2023) · doi:10.1002/9781119792161.ch6
Giannotti, A., Santanché, R., Zinno, C., Carpaneto, J., Micera, S., & Riva, E. R. (2024) · Figshare · doi:10.6084/m9.figshare.26839025
Self-citation
- Authors
- Delgado-Martínez, I., Righi, M., Santos, D., Cutrone, A., Bossi, S., D’Amico, S., Del Valle, J., Micera, S., & Navarro, X.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Scuola Superiore Sant'Anna (IT)
- National Agency for New Technologies, Energy and Sustainable Economic Development (IT)
- Universitat Autònoma de Barcelona
- Corresponding author
- Navarro, X
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2017-05-12
- Volume
- 14
- Issue
- 4
- Pages
- 046003
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2604523147
- Cited by
- 35
- References
- 62
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 12 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 3
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- ENEA Open Archive (National Agency for New Technologies, Energy and Sustainable Economic Development) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- TERCEL (RD12/0019/0011)
- FEDER
- CIBERNED (CB06/05/1105)
- Seventh Framework Programme (280778)
- Instituto de Salud Carlos III
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- neurostimulation, nerve regeneration, transparent electrodes, hand amputation, neuroprosthetics, nerve injury, chronic electrode implantation
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Female, Microelectrodes, Miniaturization, Nerve Regeneration, Peripheral Nerves, Rats, Sprague-Dawley, Rats
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