The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory
Abstract
Autobiographical memory relies on complex interactions between episodic memory contents, associated emotions and a sense of self-continuity along the time axis of one's life history. The neural correlates underlying autobiographical memory are known to primarily comprise areas of prefrontal cortex, medial and lateral temporal cortex, as well as posterior cingulate and retrosplenial cortex. By contrast, the effect of encoding and/or storage parameters such as the emotional tone of the memories retrieved or the length of the time-interval between the initial encoding of information and retrieval remains to be clarified. Using blocked design functional MRI and statistical parametric mapping, we investigated the impact of remoteness (factor 1: recent, remote) and emotional valence (factor 2: positive, negative) on the neural correlates of autobiographical memory retrieval. Changes in neural activity (P < 0.05, corrected) related to autobiographical memory retrieval (irrespective of remoteness and emotional tone) relative to baseline were observed bilaterally in medial and lateral temporal, temporal-occipital, posterior cingulate and frontal cortices. Recent (relative to remote) memories were associated with differentially increased neural activity bilaterally in the retrosplenial cortex and the hippocampal region, whereas remote (relative to recent) memories did not show any statistically significant differential neural activations. Positive (relative to negative) memories bilaterally activated the orbitofrontal cortex, the temporal pole, as well as medial temporal areas, with the activation peak being in the entorhinal region. By contrast, negative (relative to positive) memories differentially increased neural activity in the right middle temporal gyrus only. The data suggest differential functional roles for temporal, prefrontal and retrosplenial regions during autobiographical memory retrieval depending on the remoteness and the emotional valence of the memories retrieved. In particular, our findings support the 'classic' model of long-term memory processing, which suggests a time-limited differential involvement of the hippocampus in memory consolidation. Interestingly, the observation of such a time-dependent involvement of the hippocampal region in memory consolidation corresponds to the course of retrograde amnesia observed in demented patients, with the loss of recent memories appearing during early stages of the disease when conspicuous neurofibrillary changes are restricted mainly to the hippocampal and parahippocampal regions. Only during later stages, as the neurofibrillary changes spread out to neocortical association areas, do remote memories also become impaired. We conclude that the brain regions involved in autobiographical memory retrieval are influenced by the triggered memories' emotional significance and their relationship to the individual time axis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924
Neuroanatomical correlates of pleasant and unpleasant emotion
Lane, R. D., Reiman, E. M., Bradley, M. M., Lang, P. J., Ahern, G. L., Davidson, R. J., & Schwartz, G. E. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00070-5 · Cited by 830 · cited 3×
“These coordinates are well within the range of coordinates for activations of the hippocampal region reported in previous studies (e.g. Lane et al., 1997).”
BackgroundMethodResultCerebral Representation of One’s Own Past: Neural Networks Involved in Autobiographical Memory
Fink, G. R., Markowitsch, H. J., Reinkemeier, M., Bruckbauer, T., Kessler, J., & Heiss, W.-D. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04275.1996 · Cited by 803
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., & Menon, R. S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1920 · Cited by 521
Memory for places learned long ago is intact after hippocampal damage
Teng, E., & Squire, L. R. (1999) · Nature · doi:10.1038/23276 · Cited by 372
Self-recognition and the right hemisphere
Keenan, J. P., Nelson, A., O'Connor, M., & Pascual-Leone, A. (2001) · Nature · doi:10.1038/35053167 · Cited by 321
Cited by
Self-referential processing in our brain—A meta-analysis of imaging studies on the self
Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., & Panksepp, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.002 · Cited by 2,792
Spreng, R. N., Mar, R. A., & Kim, A. S. N. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21029 · Cited by 2,143
Addis, D. R., Wong, A. T., & Schacter, D. L. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.10.016 · Cited by 1,949
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834
The functional neuroanatomy of autobiographical memory: a meta-analysis
Svoboda, E., McKinnon, M. C., & Levine, B. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.05.023 · Cited by 1,274
Moscovitch, M., Rosenbaum, R. S., Gilboa, A., Addis, D. R., Westmacott, R., Grady, C., McAndrews, M. P., Levine, B., Black, S., Winocur, G., et al. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00421.x · Cited by 893
Functional neuroimaging of autobiographical memory
Cabeza, R., & St Jacques, P. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.02.005 · Cited by 736
Squire, L. R., Genzel, L., Wixted, J. T., & Morris, R. G. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021766 · Cited by 700
Neural correlates of the first-person-perspective
Vogeley, K., & Fink, G. R. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)00003-7 · Cited by 611
Neural Correlates of First-Person Perspective as One Constituent of Human Self-Consciousness
Vogeley, K., May, M., Ritzl, A., Falkai, P., Zilles, K., & Fink, G. R. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/089892904970799 · Cited by 548
Self-citationEmotion and autobiographical memory
Holland, A. C., & Kensinger, E. A. (2010) · Physics of Life Reviews · doi:10.1016/j.plrev.2010.01.006 · Cited by 540
Winocur, G., Moscovitch, M., & Bontempi, B. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.016 · Cited by 486
Cytology and functionally correlated circuits of human posterior cingulate areas
Vogt, B. A., Vogt, L., & Laureys, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.048 · Cited by 484
What is self-specific? Theoretical investigation and critical review of neuroimaging results
Legrand, D., & Ruby, P. (2009) · Psychological Review · doi:10.1037/a0014172 · Cited by 470
Recollective qualities modulate hippocampal activation during autobiographical memory retrieval
Addis, D. R., Moscovitch, M., Crawley, A. P., & McAndrews, M. P. (2004) · Hippocampus · doi:10.1002/hipo.10215 · Cited by 383
Autobiographical and episodic memory—one and the same?
Gilboa, A. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.02.014 · Cited by 367
Daselaar, S. M., Rice, H. J., Greenberg, D. L., Cabeza, R., LaBar, K. S., & Rubin, D. C. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm048 · Cited by 341
The Role of Odor-Evoked Memory in Psychological and Physiological Health
Herz, R. (2016) · Brain Sciences · doi:10.3390/brainsci6030022 · Cited by 310
Greenberg, D. L., Rice, H. J., Cooper, J. J., Cabeza, R., Rubin, D. C., & LaBar, K. S. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.09.002 · Cited by 273
Irish, M., Hornberger, M., Lah, S., Miller, L., Pengas, G., Nestor, P. J., Hodges, J. R., & Piguet, O. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.05.017 · Cited by 223
Hardt, O., Einarsson, E. Ö., & Nader, K. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100455 · Cited by 211
Grimm, S., Schmidt, C. F., Bermpohl, F., Heinzel, A., Dahlem, Y., Wyss, M., Hell, D., Boesiger, P., Boeker, H., & Northoff, G. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.006 · Cited by 195
Savoring the past: Positive memories evoke value representations in the striatum
Speer, M. E., Bhanji, J. P., & Delgado, M. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.028 · Cited by 194
Neural basis of interpersonal traits in neurodegenerative diseases
Sollberger, M., Stanley, C. M., Wilson, S. M., Gyurak, A., Beckman, V., Growdon, M., Jang, J., Weiner, M. W., Miller, B. L., & Rankin, K. P. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.06.006 · Cited by 167
Sugiura, M., Shah, N. J., Zilles, K., & Fink, G. R. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929053124956 · Cited by 167
de Sousa, A. F., Cowansage, K. K., Zutshi, I., Cardozo, L. M., Yoo, E. J., Leutgeb, S., & Mayford, M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818432116 · Cited by 138
The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words
Arshamian, A., Iannilli, E., Gerber, J. C., Willander, J., Persson, J., Seo, H.-S., Hummel, T., & Larsson, M. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.10.023 · Cited by 148
Ecphory of autobiographical memories: an fMRI study of recent and remote memory retrieval.
Steinvorth, S., Corkin, S., & Halgren, E. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.025 · Cited by 148
Self-awareness and the left inferior frontal gyrus: Inner speech use during self-related processing
Morin, A., & Michaud, J. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.06.013 · Cited by 141
Measuring attachment representation in an fMRI environment: a pilot study
Buchheim, A., Erk, S., George, C., Kächele, H., Ruchsow, M., Spitzer, M., Kircher, T., & Walter, H. (2006) · Psychopathology · doi:10.1159/000091800 · Cited by 141
Caria, A., Venuti, P., & de Falco, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr084 · Cited by 118
Distinct brain systems underlie the processing of valence and arousal of affective pictures
Nielen, M. M. A., Heslenfeld, D. J., Heinen, K., Van Strien, J. W., Witter, M. P., Jonker, C., & Veltman, D. J. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.05.007 · Cited by 114
Carhart-Harris, R. L., Wall, M. B., Erritzoe, D., Kaelen, M., Ferguson, B., De Meer, I., Tanner, M., Bloomfield, M., Williams, T. M., Bolstridge, M., et al. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001405 · Cited by 108
Understanding the self: a cultural neuroscience approach
Han, S., & Northoff, G. (2009) · Progress in Brain Research · doi:10.1016/s0079-6123(09)17814-7 · Cited by 96
Tsukiura, T., & Cabeza, R. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.03.013 · Cited by 90
King, M. J., MacDougall, A. G., Ferris, S. M., Levine, B., MacQueen, G. M., & McKinnon, M. C. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803391003781874 · Cited by 81
Morin, A., & Hamper, B. (2012) · The Open Neuroimaging Journal · doi:10.2174/1874440001206010078 · Cited by 80
Lenzi, D., Trentini, C., Pantano, P., Macaluso, E., Lenzi, G. L., & Ammaniti, M. (2013) · Human Brain Mapping · doi:10.1002/hbm.21520 · Cited by 68
Irish, M., Landin-Romero, R., Mothakunnel, A., Ramanan, S., Hsieh, S., Hodges, J. R., & Piguet, O. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.03.014 · Cited by 65
Raber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62
Oddo, S., Lux, S., Weiss, P. H., Schwab, A., Welzer, H., Markowitsch, H. J., & Fink, G. R. (2010) · Cortex · doi:10.1016/j.cortex.2008.07.003 · Cited by 54
Samara, Z., Evers, E. A. T., Peeters, F., Uylings, H. B. M., Rajkowska, G., Ramaekers, J. G., & Stiers, P. (2018) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.01.004 · Cited by 40
Irish, M., Lawlor, B. A., O′Mara, S. M., & Coen, R. F. (2008) · Behavioural Neurology · doi:10.1155/2008/691925 · Cited by 39
Bertoux, M., Flanagan, E. C., Hobbs, M., Ruiz-Tagle, A., Delgado, C., Miranda, M., Ibáñez, A., Slachevsky, A., & Hornberger, M. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170771 · Cited by 28
Buckwalter, J. A., Schumann, C. M., & Van Hoesen, G. W. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1203-x · Cited by 26
Metadata
- Authors
- Piefke, M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-01
- Volume
- 126
- Issue
- 3
- Pages
- 650-668
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2139068530
- Cited by
- 393
- References
- 15
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
