Isogenic strain construction and gene mapping in Candida albicans.

Fonzi, W A, Irwin, M Y·1993·Genetics

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Abstract

Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. Recessive mutations are not expressed when heterozygous and undesired mutations introduced in the course of random mutagenesis cannot be removed by genetic back-crossing. To circumvent these problems, we developed a genotypic screen that permitted identification of a heterozygous recessive mutation at the URA3 locus. The mutation was introduced by targeted mutagenesis, homologous integration of transforming DNA, to avoid introduction of extraneous mutations. The ura3 mutation was rendered homozygous by a second round of transformation resulting in a Ura- strain otherwise isogenic with the parental clinical isolate. Subsequent mutation of the Ura- strain was achieved by targeted mutagenesis using the URA3 gene as a selectable marker. URA3 selection was used repeatedly for the sequential introduction of mutations by flanking the URA3 gene with direct repeats of the Salmonella typhimurium hisG gene. Spontaneous intrachromosomal recombination between the flanking repeats excised the URA3 gene restoring a Ura- phenotype. These Ura- segregants were selected on 5-fluoroorotic acid-containing medium and used in the next round of mutagenesis. To permit the physical mapping of disrupted genes, the 18-bp recognition sequence of the endonuclease I-SceI was incorporated into the hisG repeats. Site-specific cleavage of the chromosome with I-SceI revealed the position of the integrated sequences.

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N-cadherin Mediates Endocytosis of Candida albicans by Endothelial Cells
Phan, Q. T., Fratti, R. A., Prasadarao, N. V., Edwards, J. E., & Filler, S. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412592200 · Cited by 113
Msb2 Signaling Mucin Controls Activation of Cek1 Mitogen-Activated Protein Kinase in Candida albicans
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Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to Candida albicans
Marchetti, O., Entenza, J. M., Sanglard, D., Bille, J., Glauser, M. P., & Moreillon, P. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.2932-2938.2000 · Cited by 113
Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole
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Characterization of the gene family encoding alternative oxidase from Candida albicans
HUH, W.-K., & KANG, S.-O. (2001) · Biochemical Journal · doi:10.1042/bj3560595 · Cited by 113
Potent Synergistic Effect of Doxycycline with Fluconazole against Candida albicans Is Mediated by Interference with Iron Homeostasis
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Yang, F., Teoh, F., Tan, A. S. M., Cao, Y., Pavelka, N., & Berman, J. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz104 · Cited by 101
Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi
Mansfield, B. E., Oltean, H. N., Oliver, B. G., Hoot, S. J., Leyde, S. E., Hedstrom, L., & White, T. C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001126 · Cited by 111
Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation†
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Oh, S.-H., Cheng, G., Nuessen, J. A., Jajko, R., Yeater, K. M., Zhao, X., Pujol, C., Soll, D. R., & Hoyer, L. L. (2005) · Microbiology · doi:10.1099/mic.0.27680-0 · Cited by 108
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Chen, Y.-L., Brand, A., Morrison, E. L., Silao, F. G. S., Bigol, U. G., Malbas, F. F., Nett, J. E., Andes, D. R., Solis, N. V., Filler, S. G., et al. (2011) · Eukaryotic Cell · doi:10.1128/ec.00310-10 · Cited by 107
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A G1 Cyclin Is Necessary for Maintenance of Filamentous Growth in Candida albicans
Loeb, J. D. J., Sepulveda-Becerra, M., Hazan, I., & Liu, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4019 · Cited by 105
The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans
Alonso-Monge, R., Carvaihlo, S., Nombela, C., Rial, E., & Pla, J. (2009) · Microbiology · doi:10.1099/mic.0.023309-0 · Cited by 105
Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm‐blooded animals
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Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall
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Molecular cloning and characterization of chitinase genes from Candida albicans.
McCreath, K. J., Specht, C. A., & Robbins, P. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2544 · Cited by 101
Isolation of a Putative Candida albicans Transcriptional Regulator Involved in Pleiotropic Drug Resistance by Functional Complementation of a pdr1 pdr3 Mutation in Saccharomyces cerevisiae
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Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro
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Characterization and Functional Analysis of the Siderophore-Iron Transporter CaArn1p in Candida albicans
Hu, C.-J., Bai, C., Zheng, X.-D., Wang, Y.-M., & Wang, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204545200 · Cited by 97
Heme Oxygenase in Candida albicans Is Regulated by Hemoglobin and Is Necessary for Metabolism of Exogenous Heme and Hemoglobin to α-Biliverdin
Pendrak, M. L., Chao, M. P., Yan, S. S., & Roberts, D. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311550200 · Cited by 97
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Selvaggini, S., Munro, C. A., Paschoud, S., Sanglard, D., & Gow, N. A. R. (2004) · Microbiology · doi:10.1099/mic.0.26661-0 · Cited by 93
Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans
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Munro, C. A., Whitton, R. K., Bleddyn Hughes, H., Rella, M., Selvaggini, S., & Gow, N. A. R. (2003) · Fungal Genetics and Biology · doi:10.1016/s1087-1845(03)00083-5 · Cited by 91
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Yan, L., Li, M., Cao, Y., Gao, P., Cao, Y., Wang, Y., & Jiang, Y. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp273 · Cited by 89
Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans
Swoboda, R. K., Bertram, G., Budge, S., Gooday, G. W., Gow, N. A., & Brown, A. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4506-4514.1995 · Cited by 89
Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa
Brand, A., Barnes, J. D., Mackenzie, K. S., Odds, F. C., & Gow, N. A. R. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01301.x · Cited by 86
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Ardon, O., Bussey, H., Philpott, C., Ward, D. M., Davis-Kaplan, S., Verroneau, S., Jiang, B., & Kaplan, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108701200 · Cited by 68
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Hameed, S., Dhamgaye, S., Singh, A., Goswami, S. K., & Prasad, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018684 · Cited by 69
Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance
Niimi, M., Niimi, K., Takano, Y., Holmes, A. R., Fischer, F. J., Uehara, Y., & Cannon, R. D. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh456 · Cited by 69
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Potrykus, J., Stead, D., MacCallum, D. M., Urgast, D. S., Raab, A., van Rooijen, N., Feldmann, J., & Brown, A. J. P. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003676 · Cited by 66
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Sun, L.-M., Liao, K., Liang, S., Yu, P.-H., & Wang, D.-Y. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12737 · Cited by 67
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Huh, W.-K., & Kang, S.-O. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.13.4098-4102.1999 · Cited by 66
diskImageR: quantification of resistance and tolerance to antimicrobial drugs using disk diffusion assays
Gerstein, A. C., Rosenberg, A., Hecht, I., & Berman, J. (2016) · Microbiology · doi:10.1099/mic.0.000295 · Cited by 63
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Jia, N., Arthington-Skaggs, B., Lee, W., Pierson, C. A., Lees, N. D., Eckstein, J., Barbuch, R., & Bard, M. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.4.947-957.2002 · Cited by 61
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Chiang, L. Y., Sheppard, D. C., Bruno, V. M., Mitchell, A. P., Edwards, J. E., & Filler, S. G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00784.x · Cited by 59
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Authors: Fonzi, W. A., & Irwin, M. Y.
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1993-07-01
Volume: 134
Issue: 3
Pages: 717-728
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/134.3.717
OpenAlex: W2140935709
Cited by: 1,687
References: 0
FWCI: 5.87
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)

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Isogenic strain construction and gene mapping in Candida albicans.

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