Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, Derek C., Linde-Zwirble, Walter T., Lidicker, Jeffrey, Clermont, Gilles, Carcillo, Joseph, Pinsky, Michael R.·2001·Critical Care Medicine

Cited by (155)

Items 101–155 of 155

  1. Endothelial Permeability and Hemostasis in Septic Shock
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  2. Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data
    Fleischmann-Struzek, Carolin, Thomas-Rüddel, Daniel O., Schettler, Anna, Schwarzkopf, Daniel, Stacke, Angelika, Seymour, Christopher W., Haas, Christoph, Dennler, Ulf, Reinhart, Konrad · 2018 · PLOS ONE
  3. Impaired adrenal stress response in Toll-like receptor 2-deficient mice
    Bornstein, Stefan R., Zacharowski, Paula, Schumann, Ralf R., Barthel, Andreas, Tran, Nguyen, Papewalis, Claudia, Rettori, Valeria, McCann, Samuel M., Schulze-Osthoff, Klaus, Scherbaum, Werner A. et al. · 2004 · Proceedings of the National Academy of Sciences
  4. Reduction in Mortality Associated with Statin Therapy in Patients with Severe Sepsis
    Dobesh, Paul P., Klepser, Donald G., McGuire, Timothy R., Morgan, Craig W., Olsen, Keith M. · 2009 · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
  5. Glucocorticoid resistance as a major drive in sepsis pathology
    Dendoncker, Karen, Libert, Claude · 2017 · Cytokine & Growth Factor Reviews
  6. Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons*
    Rhee, Chanu, Jentzsch, Maximilian S., Kadri, Sameer S., Seymour, Christopher W., Angus, Derek C., Murphy, David J., Martin, Greg S., Dantes, Raymund B., Epstein, Lauren, Fiore, Anthony E. et al. · 2019 · Critical Care Medicine
  7. Evaluation of lactate, white blood cell count, neutrophil count, procalcitonin and immature granulocyte count as biomarkers for sepsis in emergency department patients
    Karon, Brad S., Tolan, Nicole V., Wockenfus, Amy M., Block, Darci R., Baumann, Nikola A., Bryant, Sandra C., Clements, Casey M. · 2017 · Clinical Biochemistry
  8. A risk score for identifying methicillin-resistant Staphylococcus aureus in patients presenting to the hospital with pneumonia
    Shorr, Andrew F, Myers, Daniela E, Huang, David B, Nathanson, Brian H, Emons, Matthew F, Kollef, Marin H · 2013 · BMC Infectious Diseases
  9. Statins and sepsis.
    Gao, F, Linhartova, L, Johnston, A.McD., Thickett, D.R. · 2008 · British Journal of Anaesthesia
  10. The 2008 ESPEN Sir David Cuthbertson Lecture: fatty acids and inflammation–from the membrane to the nucleus and from the laboratory bench to the clinic
    Calder, Philip C. · 2010 · Clinical Nutrition
  11. Top 10 pearls for the recognition, evaluation, and management of maternal sepsis
    Shields, Andrea, de Assis, Viviana, Halscott, Torre · 2021 · Obstetrics & Gynecology
  12. Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay
    Guerrero, Julia, Gatica, Héctor A, Rodríguez, Margarita, Estay, Roberto, Goecke, Irmgadt Annelise · 2013 · Critical Care
  13. Application of a framework to assess the usefulness of alternative sepsis criteria
    Seymour, Christopher W., Coopersmith, Craig M., Deutschman, Clifford S., Gesten, Foster, Klompas, Michael, Levy, Mitchell, Martin, Gregory S., Osborn, Tiffany M., Rhee, Chanu, Warren, David K. et al. · 2016 · Critical Care Medicine
  14. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients
    Stefanova, Deborah, Raychev, Antoan, Deville, Jaime, Humphries, Romney, Campeau, Shelley, Ruchala, Piotr, Nemeth, Elizabeta, Ganz, Tomas, Bulut, Yonca · 2018 · Infection and Immunity
  15. The Neuroprotective Effect of Short Chain Fatty Acids Against Sepsis-Associated Encephalopathy in Mice
    Liu, Jiaming, Jin, Yangjie, Ye, Yanglie, Tang, Yahui, Dai, Shanshan, Li, Mengfang, Zhao, Guangju, Hong, Guangliang, Lu, Zhong-Qiu · 2021 · Frontiers in Immunology
  16. Altered functions of platelets during aging
    Montenont, Emilie, Rondina, Matthew T., Campbell, Robert A. · 2019 · Current Opinion in Hematology
  17. MicroRNAs and miRceptors: a new mechanism of action for intercellular communication
    Fabbri, Muller · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
  18. P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction
    Savio, Luiz Eduardo Baggio, Andrade, Mariana G. Juste, de Andrade Mello, Paola, Santana, Patrícia Teixeira, Moreira-Souza, Aline Cristina Abreu, Kolling, Janaína, Longoni, Aline, Feldbrügge, Linda, Wu, Yan, Wyse, Angela T. S. et al. · 2017 · Molecular Neurobiology
  19. Nationwide survey on resource availability for implementing current sepsis guidelines in Mongolia.
    Bataar, Otgon, Lundeg, Ganbold, Tsenddorj, Ganbat, Jochberger, Stefan, Grander, Wilhelm, Baelani, Inipavudu, Wilson, Iain, Baker, Tim, Dünser, Martin W · 2010 · Bulletin of the World Health Organization
  20. Prognostic value of timing of antibiotic administration in patients with septic shock treated with early quantitative resuscitation.
    Ryoo, Seung Mok, Kim, Won Young, Sohn, Chang Hwan, Seo, Dong Woo, Oh, Bum Jin, Lim, Kyoung Soo, Koh, Jae Woong · 2015 · The American Journal of the Medical Sciences
  21. Machine learning and artificial intelligence: applications in healthcare epidemiology
    Hamilton, Alisa J., Strauss, Alexandra T., Martinez, Diego A., Hinson, Jeremiah S., Levin, Scott, Lin, Gary, Klein, Eili Y. · 2021 · Antimicrobial Stewardship & Healthcare Epidemiology
  22. Association of neighborhood socioeconomic status with risk of infection and sepsis.
    Donnelly, John P, Lakkur, Sindhu, Judd, Suzanne E, Levitan, Emily B, Griffin, Russell, Howard, George, Safford, Monika M, Wang, Henry E · 2018 · Clinical Infectious Diseases
  23. Erythropoietin ameliorates renal dysfunction during endotoxaemia
    Mitra, A., Bansal, S., Wang, W., Falk, S., Zolty, E., Schrier, R. W. · 2007 · Nephrology Dialysis Transplantation
  24. Statin (cerivastatin) protects mice against sepsis-related death via reduced proinflammatory cytokines and enhanced bacterial clearance.
    Chaudhry, Mohammad Z., Wang, Jiang Huai, Blankson, Siobhan, Redmond, H. Paul · 2008 · Surgical Infections
  25. Screening for sepsis in general hospitalized patients: a systematic review
    Alberto, L., Marshall, A.P., Walker, R., Aitken, L.M. · 2017 · Journal of Hospital Infection
  26. The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial
    Chelkeba, Legese, Ahmadi, Arezoo, Abdollahi, Mohammad, Najafi, Atabak, Ghadimi, Mohammad Hosein, Mosaed, Reza, Mojtahedzadeh, Mojtaba · 2015 · Annals of Intensive Care
  27. Prospective evaluation of an automated method to identify patients with severe sepsis or septic shock in the emergency department
    Brown, Samuel M., Jones, Jason, Kuttler, Kathryn Gibb, Keddington, Roger K., Allen, Todd L., Haug, Peter · 2016 · BMC Emergency Medicine
  28. Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates
    Bouza, C., Lopez-Cuadrado, T., Amate-Blanco, J. M. · 2016 · Critical Care
  29. Early infectious disease consultation is associated with lower mortality in patients with severe sepsis or septic shock who complete the 3-hour sepsis treatment bundle.
    Madaline, Theresa, Wadskier Montagne, Francis, Eisenberg, Ruth, Mowrey, Wenzhu, Kaur, Jaskiran, Malik, Maria, Gendlina, Inessa, Guo, Yi, White, Deborah, Pirofski, Liise-Anne et al. · 2019 · Open Forum Infectious Diseases
  30. Time to antibiotics and the outcome of patients with septic shock: A propensity score analysis.
    Ko, Byuk Sung, Choi, Sung-Hyuk, Kang, Gu Hyun, Shin, Tae Gun, Kim, Kyuseok, Jo, You Hwan, Ryoo, Seung Mok, Kim, Youn-Jung, Park, Yoo Seok, Kwon, Woon Yong et al. · 2020 · The American Journal of Medicine
  31. Lifetime modulation of the pain system via neuroimmune and neuroendocrine interactions
    Zouikr, Ihssane, Karshikoff, Bianka · 2017 · Frontiers in Immunology
  32. Sepsis-induced alterations in sleep of rats
    Baracchi, Francesca, Ingiosi, Ashley M., Raymond, Richard M., Opp, Mark R. · 2011 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  33. Nitrite regulation of shock
    Cauwels, A., Brouckaert, P. · 2011 · Cardiovascular Research
  34. Selective activation of cholinergic neurotransmission from the medial septal nucleus to hippocampal pyramidal neurones improves sepsis-induced cognitive deficits in mice
    Yin, Lu, Zhang, Jinming, Ma, Hongwei, Zhang, Xinxin, Fan, Zhongmin, Yang, Yongheng, Li, Mengyun, Han, Jing, Zhang, Xijing · 2023 · British Journal of Anaesthesia
  35. Effective Treatment of Mouse Sepsis With an Inhibitory Antibody Targeting Integrin αvβ5*
    Su, George, Atakilit, Amha, Li, John T., Wu, Nanyan, Luong, Jacky, Chen, Robert, Bhattacharya, Mallar, Sheppard, Dean · 2013 · Critical Care Medicine
  36. Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities
    Liu, Jiaming, Jin, Yangjie, Li, Haijun, Yu, Jiaheng, Gong, Tianyu, Gao, Xinxin, Sun, Jing · 2020 · Journal of Agricultural and Food Chemistry
  37. Intensive insulin therapy for septic patients: A meta-analysis of randomized controlled trials.
    Song, Fang, Zhong, Liu-Jun, Han, Liang, Xie, Guo-Hao, Xiao, Cheng, Zhao, Bing, Hu, Yao-Qin, Wang, Shu-Yan, Qin, Chao-Jin, Zhang, Yan et al. · 2014 · BioMed Research International
  38. Crossing the handover chasm: Clinicians’ perceptions of barriers to the early detection and timely management of severe sepsis and septic shock.
    Matthaeus-Kraemer, Claudia T., Thomas-Rueddel, Daniel O., Schwarzkopf, Daniel, Rueddel, Hendrik, Poidinger, Bernhard, Reinhart, Konrad, Bloos, Frank · 2016 · Journal of Critical Care
  39. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
    Thabet, Pierre, Joshi, Anchal, MacDonald, Erika, Hutton, Brian, Cheng, Wei, Stevens, Adrienne, Kanji, Salmaan · 2021 · PLOS ONE
  40. IMPOSE (IMProving Outcomes after Sepsis)—the effect of a multidisciplinary follow-up service on health-related quality of life in patients postsepsis syndromes—a double-blinded randomised controlled trial: protocol
    Paratz, Jennifer D, Kenardy, Justin, Mitchell, Geoffrey, Comans, Tracy, Coyer, Fiona, Thomas, Peter, Singh, Sunil, Luparia, Louise, Boots, Robert J · 2014 · BMJ Open
  41. Early sepsis mortality prediction model based on interpretable machine learning approach: development and validation study
    Wang, Yiping, Gao, Zhihong, Zhang, Yang, Lu, Zhongqiu, Sun, Fangyuan · 2025 · Internal and Emergency Medicine
  42. Hypothyroidism and Adrenal Insufficiency in Sepsis and Hemorrhagic Shock
    Ho, Hao Chih · 2004 · Archives of Surgery
  43. Transferability and interpretability of the sepsis prediction models in the intensive care unit
    Chen, Qiyu, Li, Ranran, Lin, ChihChe, Lai, Chiming, Chen, Dechang, Qu, Hongping, Huang, Yaling, Lu, Wenlian, Tang, Yaoqing, Li, Lei · 2022 · BMC Medical Informatics and Decision Making
  44. The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils
    Fung, Yoke Lin, Fraser, John F., Wood, Peter, Minchinton, Robyn M., Silliman, MD,, Christopher C. · 2008 · Journal of Critical Care
  45. An evaluation of sepsis Web sites for patient and family education.
    Oermann, Marilyn H., McInerney, Sean M. · 2007 · Plastic Surgical Nursing
  46. Disease Outcome and Brain Metabolomics of Cyclophilin-D Knockout Mice in Sepsis
    Kobayashi, Takayuki, Uchino, Hiroyuki, Elmér, Eskil, Ogihara, Yukihiko, Fujita, Hidetoshi, Sekine, Shusuke, Ishida, Yusuke, Saiki, Iwao, Shibata, Shoichiro, Kawachi, Aya · 2022 · International Journal of Molecular Sciences
  47. Enhancing sepsis management through machine learning techniques: A review
    Ocampo-Quintero, N., Vidal-Cortés, P., del Río Carbajo, L., Fdez-Riverola, F., Reboiro-Jato, M., Glez-Peña, D. · 2022 · Medicina Intensiva
  48. The Relationship Between Index Hospitalizations, Sepsis, and Death or Transition to Hospice Care During 30-Day Hospital Readmissions
    Dietz, Brett W., Jones, Tiffanie K., Small, Dylan S., Gaieski, David F., Mikkelsen, Mark E. · 2017 · Medical Care
  49. Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis
    Baby, Sheon, Reljic, Tea, Villalba, Nuria, Kumar, Ambuj, Yuan, Sarah Y. · 2023 · PLOS ONE
  50. On Missingness Features in Machine Learning Models for Critical Care: Observational Study
    Singh, Janmajay, Sato, Masahiro, Ohkuma, Tomoko · 2021 · JMIR Medical Informatics
  51. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients
    Siner, Jonathan M., Pisani, Margaret A. · 2007 · Clinics in Chest Medicine
  52. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.
    Dellinger, R Phillip, Levy, Mitchell M., Carlet, Jean M., Bion, Julian, Parker, Margaret M., Jaeschke, Roman, Reinhart, Konrad, Angus, Derek C., Brun-Buisson, Christian, Beale, Richard et al. · 2008 · Critical Care Medicine
  53. Downregulation of high mobility group box 1 attenuates the severity of acute lung injury in endotoxemic mice
    ZHANG, XIAOJUAN, LUAN, ZHENGGANG, LIANG, YINGJIAN, LIU, YINA, MA, XIAOCHUN · 2015 · Molecular Medicine Reports
  54. Incidence and determinants of maternal sepsis in Ghana in the midst of a pandemic
    Noora, Charles Lwanga, Manu, Adom, Addo-Lartey, Adolphina, Mohammed, Abdul Gafaru, Ameme, Donne Kofi, Kenu, Ernest, Torpey, Kwasi, Adanu, Richard · 2022 · BMC Pregnancy and Childbirth
  55. Risk of subsequent sepsis within 90 days after a hospital stay by type of antibiotic exposure.
    Baggs, James, Jernigan, John A, Halpin, Alison Laufer, Epstein, Lauren, Hatfield, Kelly M, McDonald, L Clifford · 2018 · Clinical Infectious Diseases