The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Effectiveness of Interventions to Improve Patient Compliance: A Meta-Analysis
Abstract
OBJECTIVES: This article summarizes the results of 153 studies published between 1977 and 1994 that evaluated the effectiveness of interventions to improve patient compliance with medical regimens. METHODS: The compliance interventions were classified by theoretical focus into educational, behavioral, and affective categories within which specific intervention strategies were further distinguished. The compliance indicators broadly represent five classes of compliance-related assessments: (1) health outcomes (eg, blood pressure and hospitalization), (2) direct indicators (eg, urine and blood tracers and weight change), (3) indirect indicators (eg, pill count and refill records), (4) subjective report (eg, patients' or others' reports), and (5) utilization (appointment making and keeping and use of preventive services). An effect size (ES) r, defined as Fisher's Z transformation of the Pearson correlation coefficient, representing the association between each intervention (intervention versus control) and compliance measure was calculated. Both an unweighted and weighted r were calculated because of large sample size variation, and a combined probability across studies was calculated. RESULTS: The interventions produced significant effects for all the compliance indicators (combined Z values more than 5 and less than 32), with the magnitude of effects ranging from small to large. The largest effects (unweighted) were evident for refill records and pill counts and in blood/urine and weight change studies. Although smaller in magnitude, compliance effects were evident for improved health outcomes and utilization. Chronic disease patients, including those with diabetes and hypertension, as well as cancer patients and those with mental health problems especially benefited from interventions. CONCLUSIONS: No single strategy or programmatic focus showed any clear advantage compared with another. Comprehensive interventions combining cognitive, behavioral, and affective components were more effective than single-focus interventions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lipsey, M. W., & Wilson, D. B. (1993) · American Psychologist · doi:10.1037/0003-066x.48.12.1181 · Cited by 2,033
Meta-analysis of correlates of provider behavior in medical encounters
Hall, J. A., Roter, D. L., & Katz, N. R. (1988) · Medical Care · doi:10.1097/00005650-198807000-00002 · Cited by 1,069
Self-citationPatient non-compliance: Deviance or reasoned decision-making?
Donovan, J. L., & Blake, D. R. (1992) · Social Science & Medicine · doi:10.1016/0277-9536(92)90206-6 · Cited by 785
Medication adherence behaviors in older adults: Effects of external cognitive supports.
Park, D. C., Morrell, R. W., Frieske, D., & Kincaid, D. (1992) · Psychology and Aging · doi:10.1037//0882-7974.7.2.252 · Cited by 147
Cited by
The functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416
Medication compliance and persistence: terminology and definitions
Cramer, J. A., Roy, A., Burrell, A., Fairchild, C. J., Fuldeore, M. J., Ollendorf, D. A., & Wong, P. K. (2008) · Value in Health · doi:10.1111/j.1524-4733.2007.00213.x · Cited by 2,220
Hillestad, R., Bigelow, J., Bower, A., Girosi, F., Meili, R., Scoville, R., & Taylor, R. (2005) · Health Affairs · doi:10.1377/hlthaff.24.5.1103 · Cited by 1,675
Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis
Robin DiMatteo, M., Giordani, P. J., Lepper, H. S., & Croghan, T. W. (2002) · Medical Care · doi:10.1097/00005650-200209000-00009 · Cited by 1,490
Lacro, J. P., Dunn, L. B., Dolder, C. R., Leckband, S. G., & Jeste, D. V. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1007 · Cited by 1,383
Long-term persistence in use of statin therapy in elderly patients
Benner, J. S. (2002) · JAMA · doi:10.1001/jama.288.4.455 · Cited by 1,232
Patient Medication Adherence: Measures in Daily Practice
Jimmy, B., & Jose, J. (2011) · Oman Medical Journal · doi:10.5001/omj.2011.38 · Cited by 956
Interventions to Enhance Medication Adherence in Chronic Medical Conditions: A Systematic Review
Kripalani, S., Yao, X., & Haynes, R. B. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.6.540 · Cited by 810
Viswanathan, M., Golin, C. E., Jones, C. D., Ashok, M., Blalock, S. J., Wines, R. C. M., Coker-Schwimmer, E. J. L., Rosen, D. L., Sista, P., & Lohr, K. N. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-11-201212040-00538 · Cited by 754
Patient-centered care and adherence: definitions and applications to improve outcomes
Robinson, J. H., Callister, L. C., Berry, J. A., & Dearing, K. A. (2008) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2008.00360.x · Cited by 721
Halpern, J. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.21017.x · Cited by 710
Guidelines for improving the care of the older person with diabetes mellitus
California Healthcare Foundation/American Geriatrics Society, C. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.51.5s.1.x · Cited by 651
Patient adherence to medical treatment: a review of reviews
van Dulmen, S., Sluijs, E., van Dijk, L., de Ridder, D., Heerdink, R., & Bensing, J. (2007) · BMC Health Services Research · doi:10.1186/1472-6963-7-55 · Cited by 627
Gottfredson, L. S. (2004) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.86.1.174 · Cited by 580
Development and Testing of the Hill‐Bone Compliance to High Blood Pressure Therapy Scale
Kim, M. T., Hill, M. N., Bone, L. R., & Levine, D. M. (2000) · Progress in Cardiovascular Nursing · doi:10.1111/j.1751-7117.2000.tb00211.x · Cited by 514
Garber, M. C., Nau, D. P., Erickson, S. R., Aikens, J. E., & Lawrence, J. B. (2004) · Medical Care · doi:10.1097/01.mlr.0000129496.05898.02 · Cited by 519
Canale, S. D., Louis, D. Z., Maio, V., Wang, X., Rossi, G., Hojat, M., & Gonnella, J. S. (2012) · Academic Medicine · doi:10.1097/acm.0b013e3182628fbf · Cited by 512
Interventions to Support Behavioral Self-Management of Chronic Diseases
Allegrante, J. P., Wells, M. T., & Peterson, J. C. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040218-044008 · Cited by 502
Zuckerbrot, R. A., Cheung, A., Jensen, P. S., Stein, R. E. K., Laraque, D., GLAD-PC STEERING GROUP, Levitt, A., Birmaher, B., Campo, J., Clarke, G., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-4081 · Cited by 446
Lutfey, K., & Freese, J. (2005) · American Journal of Sociology · doi:10.1086/428914 · Cited by 425
Physician communication when prescribing new medications
Tarn, D. M., Heritage, J., Paterniti, D. A., Hays, R. D., Kravitz, R. L., & Wenger, N. S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1855 · Cited by 400
Medication adherence outcomes of 771 intervention trials: Systematic review and meta-analysis
Conn, V. S., & Ruppar, T. M. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.03.008 · Cited by 367
“…possible explanations exist for the modest magnitude 0.290 standardized mean difference effect size, which is consistent with effect sizes reported by previous smaller and more narrowly focused meta-analyses (Demonceau et al., 2013; Mullen et al., 1985; Peterson et al., 2003; Roter et al., 1998).”
BackgroundResultInfluentialAssessing Medication Adherence in the Elderly: Which Tools to Use in Clinical Practice?
MacLaughlin, E. J., Raehl, C. L., Treadway, A. K., Sterling, T. L., Zoller, D. P., & Bond, C. A. (2005) · Drugs & Aging · doi:10.2165/00002512-200522030-00005 · Cited by 363
Interventions to improve adherence to lipid-lowering medication
van Driel, M. L., Morledge, M. D., Ulep, R., Shaffer, J. P., Davies, P., & Deichmann, R. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004371.pub4 · Cited by 333
In principle obstacles for empathic AI: why we can’t replace human empathy in healthcare
Montemayor, C., Halpern, J., & Fairweather, A. (2022) · AI & SOCIETY · doi:10.1007/s00146-021-01230-z · Cited by 293
Improving patient adherence: a three-factor model to guide practice
DiMatteo, M. R., Haskard-Zolnierek, K. B., & Martin, L. R. (2012) · Health Psychology Review · doi:10.1080/17437199.2010.537592 · Cited by 288
Patient Satisfaction with Physician–Patient Communication During Telemedicine
Agha, Z., Schapira, R. M., Laud, P. W., McNutt, G., & Roter, D. L. (2009) · Telemedicine and e-Health · doi:10.1089/tmj.2009.0030 · Cited by 252
Self-citationPatient Centered Experiences in Breast Cancer: Predicting Long-Term Adherence to Tamoxifen Use
Kahn, K. L., Schneider, E. C., Malin, J. L., Adams, J. L., & Epstein, A. M. (2007) · Medical Care · doi:10.1097/01.mlr.0000257193.10760.7f · Cited by 245
Miaskowski, C., Dodd, M., West, C., Schumacher, K., Paul, S. M., Tripathy, D., & Koo, P. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.140 · Cited by 240
Translating what we have learned into practice
Glasgow, R. E., Goldstein, M. G., Ockene, J. K., & Pronk, N. P. (2004) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2004.04.019 · Cited by 239
Conn, V. S., Hafdahl, A. R., Cooper, P. S., Ruppar, T. M., Mehr, D. R., & Russell, C. L. (2009) · The Gerontologist · doi:10.1093/geront/gnp037 · Cited by 227
Nicolson, P. J. A., Bennell, K. L., Dobson, F. L., Van Ginckel, A., Holden, M. A., & Hinman, R. S. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096458 · Cited by 209
Duijts, S. F. A., van Beurden, M., Oldenburg, H. S. A., Hunter, M. S., Kieffer, J. M., Stuiver, M. M., Gerritsma, M. A., Menke-Pluymers, M. B. E., Plaisier, P. W., Rijna, H., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.8525 · Cited by 220
Interventions for enhancing adherence with physiotherapy: A systematic review
McLean, S. M., Burton, M., Bradley, L., & Littlewood, C. (2010) · Manual Therapy · doi:10.1016/j.math.2010.05.012 · Cited by 204
George, J., Elliott, R. A., & Stewart, D. C. (2008) · Drugs & Aging · doi:10.2165/00002512-200825040-00004 · Cited by 191
Miller, C. K., Kristeller, J. L., Headings, A., Nagaraja, H., & Miser, W. F. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.07.036 · Cited by 179
van Eijken, M., Tsang, S., Wensing, M., de Smet, P. A. G. M., & Grol, R. P. T. M. (2003) · Drugs & Aging · doi:10.2165/00002512-200320030-00006 · Cited by 184
From idealized clinical empathy to empathic communication in medical care
Halpern, J. (2014) · Medicine, Health Care and Philosophy · doi:10.1007/s11019-013-9510-4 · Cited by 181
McKay, J. R., Lynch, K. G., Shepard, D. S., & Pettinati, H. M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.199 · Cited by 177
Bissonnette, J. M. (2008) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2008.04745.x · Cited by 172
Efficacy of therapeutic patient education in chronic diseases and obesity
Lagger, G., Pataky, Z., & Golay, A. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2010.03.015 · Cited by 176
AI chatbots cannot replace human interactions in the pursuit of more inclusive mental healthcare
Brown, J. E. H., & Halpern, J. (2021) · SSM - Mental Health · doi:10.1016/j.ssmmh.2021.100017 · Cited by 139
Effect of late medication non-compliance on outcome after heart transplantation: A 5-year follow-up
Dobbels, F., De Geest, S., van Cleemput, J., Droogne, W., & Vanhaecke, J. (2004) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2003.09.016 · Cited by 122
Nglazi, M. D., Bekker, L.-G., Wood, R., Hussey, G. D., & Wiysonge, C. S. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-566 · Cited by 119
Márquez Contreras, E., de la Figuera von Wichmann, M., Gil Guillén, V., Ylla-Catalá, A., Figueras, M., Balaña, M., & Naval, J. (2004) · Atención Primaria · doi:10.1016/s0212-6567(04)78922-2 · Cited by 115
Telemedicine technologies for confronting COVID-19 pandemic: a review
Bahl, S., Singh, R. P., Javaid, M., Khan, I. H., Vaishya, R., & Suman, R. (2020) · Journal of Industrial Integration and Management · doi:10.1142/s2424862220300057 · Cited by 112
Park, J. Y. E., Li, J., Howren, A., Tsao, N. W., & De Vera, M. (2019) · JMIR mHealth and uHealth · doi:10.2196/11919 · Cited by 106
Koelewijn-van Loon, M. S., van der Weijden, T., Ronda, G., van Steenkiste, B., Winkens, B., Elwyn, G., & Grol, R. (2010) · Preventive Medicine · doi:10.1016/j.ypmed.2009.11.007 · Cited by 105
A review of interventions used to improve adherence to medication in older people
Banning, M. (2009) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2009.03.011 · Cited by 98
Nhavoto, J. A., Grönlund, Å., & Klein, G. O. (2017) · PLOS ONE · doi:10.1371/journal.pone.0176051 · Cited by 91
Petrilla, A. A., Benner, J. S., Battleman, D. S., Tierce, J. C., & Hazard, E. H. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2005.00704.x · Cited by 89
Wens, J., Vermeire, E., Hearnshaw, H., Lindenmeyer, A., Biot, Y., & Van Royen, P. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.06.006 · Cited by 81
Fox, S., & Chesla, C. (2008) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2007.00295.x · Cited by 65
Physician Alerts to Increase Antidepressant Adherence: Fax or Fiction?
Bambauer, K. Z., Adams, A. S., Zhang, F., Minkoff, N., Grande, A., Weisblatt, R., Soumerai, S. B., & Ross-Degnan, D. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.5.498 · Cited by 51
Tamblyn, R., Reidel, K., Huang, A., Taylor, L., Winslade, N., Bartlett, G., Grad, R., Jacques, A., Dawes, M., Larochelle, P., et al. (2010) · Medical Decision Making · doi:10.1177/0272989x09342752 · Cited by 44
Ezzat, A. M., MacPherson, K., Leese, J., & Li, L. C. (2015) · Musculoskeletal Care · doi:10.1002/msc.1084 · Cited by 38
Assessing Empathy in Large Language Models with Real-World Physician-Patient Interactions
Luo, M., Warren, C. J., Cheng, L., Abdul-Muhsin, H. M., & Banerjee, I. (2024) · 2024 IEEE International Conference on Big Data (BigData) · doi:10.1109/bigdata62323.2024.10825307 · Cited by 36
From Physician to Consumer: The Effectiveness of Strategies to Manage Health Care Utilization
Flynn, K. E., Smith, M. A., & Davis, M. K. (2002) · Medical Care Research and Review · doi:10.1177/107755802237811 · Cited by 36
A Multi-faceted Approach to Promote Comprehension of Online Health Information Among Older Adults
Chin, J., Moeller, D. D., Johnson, J., Duwe, E. A. G., Graumlich, J. F., Murray, M. D., & Morrow, D. G. (2018) · The Gerontologist · doi:10.1093/geront/gnw254 · Cited by 28
Nglazi, M. D., Bekker, L.-G., Wood, R., Hussey, G. D., & Wiysonge, C. S. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-6 · Cited by 19
Metadata
- Authors
- Roter, D. L., Hall, J. A., Merisca, R., Nordstrom, B., Cretin, D., & Svarstad, B.
- Venue
- Medical Care
- Published
- 1998-08
- Volume
- 36
- Issue
- 8
- Pages
- 1138-1161
- ISSN
- 0025-7079 (ISSN-L)
- OpenAlex
- W1989252935
- Cited by
- 995
- References
- 4
- FWCI
- 27.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.