The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Sarcopenic obesity: definition, cause and consequences
Open accessAbstract
PURPOSE OF REVIEW: Older obese persons with decreased muscle mass or strength are at special risk for adverse outcomes. We discuss potential pathways to muscle impairment in obese individuals and the consequences that joint obesity and muscle impairment may have on health and disability. Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition. RECENT FINDINGS: Excess energy intake, physical inactivity, low-grade inflammation, insulin resistance and changes in hormonal milieu may lead to the development of so-called 'sarcopenic obesity'. It was originally believed that the culprit of age-related muscle weakness was a reduction in muscle mass, but it is now clear that changes in muscle composition and quality are predominant. We propose that the risk of adverse outcomes, such as functional limitation and mortality, is better estimated by considering jointly obesity and muscle strength rather than obesity and muscle mass and the term 'sarcopenic obesity' should be revisited. SUMMARY: Recognition of obese patients who have associated muscle problems is an essential goal for clinicians. Further research is needed to identify new target for prevention and cure of this important geriatric syndrome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A number of mechanisms might explain the reduction of muscle mass and strength in sarcopenic obesity, including type II muscle fibre atrophy, reduction in motor neurons, collagen deposition and fibre necrosis67–70.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [70]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function.”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [2]
Experimental — accuracy not yet measuredIn the citing paper
“Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people.”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [2]
In the citing paper
“The proportions of visceral fat and intramuscular fat also increase with age, reaching a peak between 60 and 75 years old, as the proportion of subcutaneous fat decreases.[ 9 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [9]
In the citing paper
“Therefore, it is reasonable to speculate when muscle damage and obesity coexist, they act synergistically on the risk of mortality, metabolic disorders, and quality of life (47, 51).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [51]
In the citing paper
“Of note, not all older adults with obesity will exhibit sarcopenia, as excess body weight usually stimulates muscle (and bone) mechanoreceptors, triggering growth factor synthesis that leads to muscle formation11.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [11]
In the citing paper
“In patients with physical inactivity sarcopenic obesity is frequently observed due to muscle loss and a sedentary lifestyle.[ 8 ]”
From Exercise approaches in obese individuals with physical limitations (2026) · cites this paper as [8]
In the citing paper
“Twelve weeks of resistance training in sarcopenic obesity can increase muscle mass by up to 8%.”
From Exercise approaches in obese individuals with physical limitations (2026) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2000) · PubMed · Cited by 13,173
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Osteoporosis Prevention, Diagnosis, and Therapy
NIH Consensus Development Panel on Osteoporosis Prevention, D. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.6.785 · Cited by 5,529
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Self-citationExcess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,811
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606
Sarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090
Lauretani, F., Russo, C. R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A. M., Rantanen, T., Guralnik, J. M., & Ferrucci, L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00246.2003 · Cited by 1,946
Self-citationInvited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692
Self-citationAging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E., & Klein, S. (2007) · Diabetes · doi:10.2337/db06-1656 · Cited by 1,417
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Self-citationVisser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Self-citationRosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,234
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
Self-citationHouston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214
Self-citationBody Composition in Healthy Aging
BAUMGARTNER, R. N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06498.x · Cited by 1,078
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047
Self-citationSarcopenia: alternative definitions and associations with lower extremity function
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51534.x · Cited by 981
Self-citationMorley, J. E., Baumgartner, R., Roubenoff, R., Mayer, J., & Nair, K. S. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.113504 · Cited by 964
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly
Baumgartner, R. N., Wayne, S. J., Waters, D. L., Janssen, I., Gallagher, D., & Morley, J. E. (2004) · Obesity Research · doi:10.1038/oby.2004.250 · Cited by 937
HUGHES, V. A., Frontera, W. R., Wood, M., Evans, W. J., Dallal, G. E., Roubenoff, R., & Singh, M. A. F. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b209 · Cited by 935
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845
Self-citationFerrucci, L., Bandinelli, S., Benvenuti, E., Iorio, A. D., Macchi, C., Harris, T. B., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03873.x · Cited by 797
Self-citationAccelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Strotmeyer, E. S., Kuller, L. H., Broudeau, R., Kammerer, C., de Rekeneire, N., Harris, T. B., Schwartz, A. V., Tylavsky, F. A., et al. (2007) · Diabetes Care · doi:10.2337/dc06-2537 · Cited by 766
Self-citationAnorexia of aging: physiologic and pathologic
Morley, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.760 · Cited by 761
Normal Human Aging: The Baltimore Longitudinal Study on Aging
Shock, N. W., Greulich, R. C., Costa, P. T., Andres, R., Lakatta, E. G., Arenberg, D., & Tobin, J. D. (1984) · University Libraries (University of Maryland) · doi:10.13016/sclw-iccq · Cited by 757
Grip strength, body composition, and mortality
Galé, C. R., Martyn, C., Cooper, C. C., & Sayer, A. A. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl224 · Cited by 740
Physiological changes in ageing muscles
Campbell, M. J., McComas, A. J., & Petito, F. (1973) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.36.2.174 · Cited by 738
Goodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.885 · Cited by 707
Rantanen, T., Volpato, S., Luigi Ferrucci, M., Eino Heikkinen, M., Fried, L. P., & Guralnik, J. M. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1600-0579.2003.00207.x · Cited by 661
Self-citationHealth consequences of obesity in the elderly: a review of four unresolved questions
Zamboni, M. M., Mazzali, G., Zoico, E., Harris, T. B., Meigs, J. B., Francesco, V. D., Fantin, F., Bissoli, L., & Bosello, O. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803005 · Cited by 654
Self-citationMuscle strength and body mass index as long-term predictors of mortality in initially healthy men
Rantanen, T., Harris, T., Leveille, S. G., Visser, M., Foley, D., Masaki, K., & Guralnik, J. M. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.3.m168 · Cited by 647
Self-citationGoodpaster, B. H., Krishnaswami, S., Resnick, H., Kelley, D. E., Haggerty, C., Harris, T. B., Schwartz, A. V., Kritchevsky, S., & Newman, A. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.372 · Cited by 619
Self-citationSarcopenic obesity and inflammation in the InCHIANTI study
Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594
Self-citationEnzi, G., Gasparo, M., Biondetti, P., Fiore, D., Semisa, M., & Zurlo, F. (1986) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/44.6.739 · Cited by 547
Review Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521
Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442
Davison, K. K., Ford, E. S., Cogswell, M. E., & Dietz, W. H. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50508.x · Cited by 435
Cesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 432
Self-citationThe changing relationship of obesity and disability, 1988–2004
Alley, D. E., & Chang, V. W. (2007) · JAMA · doi:10.1001/jama.298.17.2020 · Cited by 414
Zoico, E., Di Francesco, V, Guralnik, J. M., Mazzali, G., Bortolani, A., Guariento, S., Sergi, G., Bosello, O., & Zamboni, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802552 · Cited by 392
Larsson, L., Li, X., & Frontera, W. R. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.2.c638 · Cited by 367
Grip strength changes over 27 yr in Japanese-American men
Rantanen, T., Masaki, K., Foley, D., Izmirlian, G., White, L. R., & Guralnik, J. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.6.2047 · Cited by 364
Self-citationEffects of Ageing on the Motor Unit: A Brief Review
Doherty, T. J., Vandervoort, A. A., & Brown, W. F. (1993) · Canadian Journal of Applied Physiology · doi:10.1139/h93-029 · Cited by 359
Cesari, M., Kritchevsky, S. B., Baumgartner, R., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.428 · Cited by 345
Self-citationVisser, M., Deeg, D. J. H., Lips, P., Harris, T. B., & Bouter, L. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04694.x · Cited by 323
Self-citationThe Effect of Obesity on Disability vs Mortality in Older Americans
Snih, S. A. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.8.774 · Cited by 307
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2002 · Cited by 303
Self-citationFat and protein redistribution with aging: metabolic considerations
Beaufrère, B., & Morio, B. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601025 · Cited by 295
Attrition in the Longitudinal Aging Study Amsterdam
Deeg, D. J. H., van Tilburg, T. G., Smit, J. H., & de Leeuw, E. D. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00475-9 · Cited by 286
Sarcopenia: Effects on Body Composition and Function
Roubenoff, R. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.11.m1012 · Cited by 282
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Grady, J. J., & Volpi, E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00271.2005 · Cited by 278
Dyck, D. J., Heigenhauser, G. J. F., & Bruce, C. R. (2005) · Acta Physiologica · doi:10.1111/j.1748-1716.2005.01502.x · Cited by 275
Predictors of 6‐minute walk test results in lean, obese and morbidly obese women
Hulens, M., Vansant, G. A. A. M., Claessens, A., Lysens, R., & Muls, E. (2003) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2003.10273.x · Cited by 266
Neural control of aging skeletal muscle
Delbono, O. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00011.x · Cited by 248
Insulin resistance: a contributing factor to age-related muscle mass loss?
Guillet, C., & Boirie, Y. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(05)73648-x · Cited by 245
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232
Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults
FRIMEL, T. N., SINACORE, D. R., & VILLAREAL, D. T. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816a85ce · Cited by 230
Total energy expenditure in the elderly
Elia, M., Ritz, P., & Stubbs, R. J. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601030 · Cited by 223
Exercise capacity in lean versus obese women
Hulens, M., Vansant, G. A. A. M., Lysens, R., Claessens, A., & Muls, E. (2001) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2001.110509.x · Cited by 223
Effects of age on body fat distribution and cardiovascular risk factors in women
Zamboni, M. M., Armellini, F., Harris, T. B., Turcato, E., Micciolo, R., Bergamo-Andreis, I., & Bosello, O. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.1.111 · Cited by 213
Self-citationGender variations of body composition, muscle strength and power output in morbid obesity
Lafortuna, C. L., Maffiuletti, N. A., Agosti, F., & Sartório, A. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802955 · Cited by 210
Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus
Kelley, D., Slasky, B., & Janosky, J. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.509 · Cited by 206
Association of IGF-I levels with muscle strength and mobility in older women
Cappola, A. R., Bandeen-Roche, K., Wand, G. S., Volpato, S., & Fried, L. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7868 · Cited by 205
Change in height, weight and body mass index: Longitudinal data from the HUNT Study in Norway
Drøyvold, W. B., Nilsen, T. I. L., Krüger, Ø., Holmen, T. L., Krokstad, S., Midthjell, K., & Holmen, J. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803178 · Cited by 191
Resistance Training and Type 2 Diabetes
Eves, N. D., & Plotnikoff, R. C. (2006) · Diabetes Care · doi:10.2337/dc05-1981 · Cited by 190
The Cardiometabolic Syndrome and Sarcopenic Obesity in Older Persons
Dominguez, L. J., & Barbagallo, M. (2007) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2007.06673.x · Cited by 185
Friedmann, J. M., Elasy, T. A., & Jensen, G. L. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49082.x · Cited by 176
Hung, J., McQuillan, B., Thompson, P. L., & Beilby, J. P. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803793 · Cited by 175
Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk
LaMonte, M. J., & Blair, S. N. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241662.92642.08 · Cited by 171
Schaap, L. A., Pluijm, S. M. F., Smit, J. H., Van Schoor, N. M., Visser, M., Gooren, L. J. G., & Lips, P. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02315.x · Cited by 168
Self-citationFat metabolism in human obesity
Campbell, P. J., Carlson, M. G., & Nurjhan, N. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.4.e600 · Cited by 153
Effect of Sarcopenia on Cardiovascular Disease Risk Factors in Obese Postmenopausal Women
Aubertin‐Leheudre, M., Lord, C., Goulet, É. D. B., Khalil, A., & Dionne, I. J. (2006) · Obesity · doi:10.1038/oby.2006.267 · Cited by 151
Effects of birth cohort and age on body composition in a sample of community-based elderly
Ding, J., Kritchevsky, S. B., Newman, A. B., Taaffe, D. R., Nicklas, B. J., Visser, M., Lee, J. S., Nevitt, M. C., Tylavsky, F. A., Rubin, S. M., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.405 · Cited by 148
Self-citationDietary protein and resistance training effects on muscle and body composition in older persons
Campbell, W. W., & Leidy, H. J. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719650 · Cited by 148
Reexamining the Sarcopenia Hypothesis: Muscle Mass versus Muscle Strength
VISSER, M., NEWMAN, A. B., NEVITT, M. C., KRITCHEVSKY, S. B., STAMM, E. B., GOODPASTER, B. H., HARRIS, T. B., & FOR THE HEALTH, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06500.x · Cited by 141
Self-citationLongitudinal Changes in Selected Physical Capabilities: Muscle Strength, Flexibility and Body Size
Bassey, E. J. (1998) · Age and Ageing · doi:10.1093/ageing/27.suppl_3.12 · Cited by 138
Insulin resistance and muscle strength in older persons
Abbatecola, A. M., Ferrucci, L., Ceda, G., Russo, C. R., Lauretani, F., Bandinelli, S., Barbieri, M., Valenti, G., & Paolisso, G. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.10.1278 · Cited by 135
Self-citationOverweight and anthropometric changes in adulthood: a prospective study of 17,000 Finns.
Rissanen, A., Heliövaara, M., & Aromaa, A. (1988) · PubMed · Cited by 131
Effect of sex and age on bone mass, body composition and fuel metabolism in humans
Horber, F., Gruber, B., Thomi, F., Jensen, E. X., & Jaeger, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00031-2 · Cited by 122
Role of Protein and Amino Acids in the Pathophysiology and Treatment of Sarcopenia
Dreyer, H. C., & Volpi, E. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719455 · Cited by 115
Inflammatory factors in age-related muscle wasting
Roth, S. M., Metter, E. J., Ling, S. M., & Ferrucci, L. (2006) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000245722.10136.6d · Cited by 115
Self-citationThe role of waist circumference in predicting disability in periretirement age adults
Angleman, S. B., Harris, T. B., & Melzer, D. R. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803130 · Cited by 112
Self-citationWaters, D. L., Qualls, C. R., Dorin, R. I., Veldhuis, J. D., & Baumgartner, R. N. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.5.536 · Cited by 112
Stenholm, S., Rantanen, T., Heliövaara, M., & Koskinen, S. V. P. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01567.x · Cited by 111
Self-citationDiagnosis and epidemiology of osteoporosis
Dennison, E. M., Cole, Z. A., & Cooper, C. C. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000166384.80777.0d · Cited by 106
Wang, X., Miller, G. D., Messier, S. P., & Nicklas, B. J. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.8.866 · Cited by 91
Clinical implications of the reduced activity of the GH-IGF-I axis in older men.
Ceda, G. P., Dall’Aglio, E., Maggio, M. G., et al. (2005) · PubMed · Cited by 87
Duvigneaud, N., Matton, L., Wijndaele, K., Deriemaeker, P., Lefevre, J., Philippaerts, R. M., Thomis, M. A., Delecluse, C., & Duquet, W. (2008) · PubMed · Cited by 86
Skeletal Muscle Lipid and Its Association with Insulin Resistance: What Is the Role for Exercise?
Goodpaster, F. H., & Brown, F. F. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200507000-00008 · Cited by 84
Sipilä, S., & Suominen, H. (1994) · Clinical Physiology · doi:10.1111/j.1475-097x.1994.tb00402.x · Cited by 83
Sonnenberg, C., Deeg, D. J. H., Comijs, H. C., van Tilburg, W., & Beekman, A. T. F. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.03.009 · Cited by 81
Houston, D. K., Stevens, J., & Cai, J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803043 · Cited by 78
Body composition, metabolic syndrome and testosterone in ageing men
Allan, C. A., Strauss, B. J. G., & McLachlan, R. I. (2007) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901552 · Cited by 67
Stenholm, S., Sainio, P., Rantanen, T., Alanen, E., & Koskinen, S. V. P. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324702 · Cited by 64
Self-citationMuscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study
NOMURA, T., IKEDA, Y., NAKAO, S., ITO, K., ISHIDA, K., SUEHIRO, T., & HASHIMOTO, K. (2007) · Endocrine Journal · doi:10.1507/endocrj.k07-055 · Cited by 61
Body composition, physical exercise, growth hormone and obesity.
WELTMAN, A. L., Weltman, J. Y., Veldhuis, J. D., & Hartman, M. L. (2001) · PubMed · Cited by 37
Chu, L., Tam, S., Kung, A. W. C., Lo, S. S. T., Fan, S., Wong, R. L. C., Morley, J. E., & Lam, K. S. L. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01746.x · Cited by 36
Sytze van Dam, P., Smid, H. E. C., de Vries, W. R., Niesink, M., Bolscher, E., Waasdorp, E. J., Dieguez, C., Casanueva, F. F., & Koppeschaar, H. P. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7087 · Cited by 32
True osteoporosis and frailty-related osteopenia: two different clinical entities
Russo, C. R., Ricca, M., & Ferrucci, L. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03895.x · Cited by 21
Self-citationRisk factors and health determinants in older Italians
the ILSA Group, Farchi, G., Brescianini, S., et al. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324525 · Cited by 16
The quality of bone: a "magic natural alloy".
Maggi, S., Lauretani, F., Ferrucci, L., et al. (2004) · PubMed · Cited by 7
Self-citation
Research works printed but not linked: 7
- Rissanen, 1988, Int J Obes, 12, 391
- Duvigneaud, 2008, J Sports Med Phys Fitness, 48, 201
- Bastard, 2006, Eur Cytokine Netw, 17, 4
- Guillet, 2, Spec No, 5S, 20
- Campbell, 1994, Am J Physiol, 266, E600
- Weltman, 2001, Eat Weight Disord, 6, 28
- Ceda, 2005, J Endocrinol Invest, 28, 96
Cited by
Sorted by citations
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
ESPEN guidelines on definitions and terminology of clinical nutrition
Cederholm, T., Barazzoni, R., Austin, P., Ballmer, P., Biolo, G., Bischoff, S. C., Compher, C., Correia, I., Higashiguchi, T., Holst, M., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.004 · Cited by 2,560
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
Metadata
- Authors
- Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L.
- Affiliations
- National Institute on Aging (US)
- National Institutes of Health (US)
- University of Jyväskylä (FI)
- Amsterdam Public Health (NL)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Ferrucci, Luigi
- ORCID
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2008-11
- Volume
- 11
- Issue
- 6
- Pages
- 693-700
- ISSN
- 1363-1950 (ISSN-L)
- PMC
- PMC2633408
- OpenAlex
- W2157300817
- Cited by
- 1,070
- References
- 112
- Citations by year
- 2026: 16 · 2025: 38 · 2024: 63 · 2023: 80 · 2022: 74 · 2021: 94 · 2020: 83 · 2019: 77 · 2018: 68 · 2017: 62 · 2016: 70 · 2015: 87 · 2014: 66 · 2013: 75 · 2012: 46
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Ministero della Salute
- National Institutes of Health
- National Institute on Aging (N01AG-821336, N01[AG]916413, Z01AG000015, P30AG021332)
- National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336, R01MD009164)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- sarcopenic obesity, muscle weakness, muscle mass, muscle quality, muscle composition, older adults, obesity, physical inactivity, insulin resistance, low-grade inflammation, functional limitations, mortality, geriatric syndromes
- MeSH terms
- Aged, Aging, Female, Health Status, Humans, Male, Muscular Atrophy, Obesity, Risk Factors, Exercise, Comorbidity, Muscle, Skeletal, Muscle Strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
