Cited by 637Gut microbiota and healthEpigenetics and DNA MethylationTryptophan and brain disorders

The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., Cryan, J. F.·2014·Genes, Brain and Behavior

Open this paper in CoChat — free account

Abstract

To date, there is rapidly increasing evidence for host-microbe interaction at virtually all levels of complexity, ranging from direct cell-to-cell communication to extensive systemic signalling, and involving various organs and organ systems, including the central nervous system. As such, the discovery that differential microbial composition is associated with alterations in behaviour and cognition has significantly contributed to establishing the microbiota-gut-brain axis as an extension of the well-accepted gut-brain axis concept. Many efforts have been focused on delineating a role for this axis in health and disease, ranging from stress-related disorders such as depression, anxiety and irritable bowel syndrome to neurodevelopmental disorders such as autism. There is also a growing appreciation of the role of epigenetic mechanisms in shaping brain and behaviour. However, the role of epigenetics in informing host-microbe interactions has received little attention to date. This is despite the fact that there are many plausible routes of interaction between epigenetic mechanisms and the host-microbiota dialogue. From this new perspective we put forward novel, yet testable, hypotheses. Firstly, we suggest that gut-microbial products can affect chromatin plasticity within their host's brain that in turn leads to changes in neuronal transcription and eventually alters host behaviour. Secondly, we argue that the microbiota is an important mediator of gene-environment interactions. Finally, we reason that the microbiota itself may be viewed as an epigenetic entity. In conclusion, the fields of (neuro)epigenetics and microbiology are converging at many levels and more interdisciplinary studies are necessary to unravel the full range of this interaction.

Integrity signals

Registry

Crossref · 10.1111/gbb.12109

Cites

191 of 191 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
The human microbiome project
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Vaginal microbiome of reproductive-age women
Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 2×
“…Genes, Brain and Behavior (2014) 13: 69–86 T ab le 2: B io ch em ic al an d m ol ec ul ar al te ra tio ns w ith di ff er en tia lm ic ro bi ot a co m po si tio n Genes, Brain and Behavior (2014) 13: 69–86 73 a critical time window during adolescence (Clarke et al. 2013; Foster & Neufeld 2013).”
Background
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Self-citation
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
Induction of autophagy by spermidine promotes longevity
Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 3×
“…on different aspects ranging from basic microbiology to translational applications (e.g. see Bercik et al. 2012; Berer & Krishnamoorthy 2012; Collins et al. 2012b, 2013; Cryan & Dinan 2012; Cryan & O’Mahony 2011; Forsythe & Kunze 2013; Lyte 2011, 2013; Nicholson et al. 2012; Rhee et al.…”
Background
The role of microorganisms in coral health, disease and evolution
ROSENBERG, E. B., Koren, O., Reshef, L., Efrony, R., & Zilber‐Rosenberg, I. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1635 · Cited by 1,562
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515
Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 3×
“…ranging from basic microbiology to translational applications (e.g. see Bercik et al. 2012; Berer & Krishnamoorthy 2012; Collins et al. 2012b, 2013; Cryan & Dinan 2012; Cryan & O’Mahony 2011; Forsythe & Kunze 2013; Lyte 2011, 2013; Nicholson et al. 2012; Rhee et al. 2009; Sommer & Bäckhed 2013).”
Background
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192
Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123
The Inheritance of Epigenetic Defects
Holliday, R. (1987) · Science · doi:10.1126/science.3310230 · Cited by 1,096
Sodium butyrate inhibits histone deacetylation in cultured cells
Candido, E. (1978) · Cell · doi:10.1016/0092-8674(78)90305-7 · Cited by 1,036
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999
The microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952
Self-citation
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
Mellén, M., Ayata, P., Dewell, S., Kriaucionis, S., & Heintz, N. (2012) · Cell · doi:10.1016/j.cell.2012.11.022 · Cited by 943
Genomic variation landscape of the human gut microbiome
Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., et al. (2013) · Nature · doi:10.1038/nature11711 · Cited by 907
Microbiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
Szulwach, K. E., Li, X., Li, Y., Song, C., Wu, H., Dai, Q., Irier, H. A., Upadhyay, A. K., Gearing, M., Levey, A. I., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2959 · Cited by 843
Mom Knows Best: The Universality of Maternal Microbial Transmission
Funkhouser-Jones, L. J., & Bordenstein, S. R. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001631 · Cited by 837
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835
Influences of microbiota on intestinal immune system development.
Cebra, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1046s · Cited by 819
Fatal attraction in rats infected with Toxoplasma gondii
Berdoy, M., Webster, J. P., & Macdonald, D. W. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1182 · Cited by 731
Therapeutic Potential of Fecal Microbiota Transplantation
Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.058 · Cited by 717
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680
Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
Hargreaves, D. C., Horng, T., & Medzhitov, R. M. (2009) · Journal of End-to-End-testing · doi:10.1016/j.cell.2009.05.047 · Cited by 676
Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice
Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., Malinowski, P., Jackson, W., Blennerhassett, P., Neufeld, K. A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.063 · Cited by 674
Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
Waldecker, M., Kautenburger, T., Daumann, H., Busch, C., & Schrenk, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.002 · Cited by 615 · cited 2×
“In a similar IC50-range are certain polyphenol metabolites that are produced by gut bacteria (Waldecker et al. 2008, Table 3).”
Background
Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats
Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599
New insights into brain BDNF function in normal aging and Alzheimer disease
Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 589
Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors
Vyas, A., Kim, S.-K., Giacomini, N., Boothroyd, J. C., & Sapolsky, R. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608310104 · Cited by 580
Carpenter's Human Neuroanatomy
Parent, A., & Carpenter, M. B. (1996) · Medical Entomology and Zoology · Cited by 561
The Host Genotype Affects the Bacterial Community in the Human Gastronintestinal Tract
Zoetendal, A. D. L. A. E. G. (2001) · Microbial Ecology in Health and Disease · doi:10.1080/089106001750462669 · Cited by 558
Human gut microbiome: the second genome of human body
Zhu, B., Wang, X., & Li, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0093-z · Cited by 556
Probiotics function mechanistically as delivery vehicles for neuroactive compounds: microbial endocrinology in the design, and use of probiotics.
Lyte, M. (2011) · BioEssays · doi:10.1002/bies.201100024 · Cited by 549
Cesarean Versus Vaginal Delivery: Long-term Infant Outcomes and the Hygiene Hypothesis
Neu, J., & Rushing, J. (2011) · Clinics in Perinatology · doi:10.1016/j.clp.2011.03.008 · Cited by 548
Epigenetic mechanisms in cognition
Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510
DNA methylation and memory formation
Day, J. J., & Sweatt, J. D. (2010) · Nature Neuroscience · doi:10.1038/nn.2666 · Cited by 501
Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling
Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491
II. Stress and intestinal barrier function
Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction
Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T. T., Faull, K. F., Jaenisch, R., & Tsai, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.003 · Cited by 450
Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut
Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446
Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders
MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 438
Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress
Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415
The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality
Montiel-Castro, A. J., González-Cervantes, R. M., Bravo-Ruiseco, G., & Pacheco-López, G. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00070 · Cited by 413
TET1 Controls CNS 5-Methylcytosine Hydroxylation, Active DNA Demethylation, Gene Transcription, and Memory Formation
Kaas, G. A., Zhong, C., Eason, D. E., Ross, D. L., Vachhani, R., Ming, G., King, J. R., Song, H., & Sweatt, J. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.032 · Cited by 411
Gastrointestinal microbiology enters the metagenomics era
Frank, D. N., & Pace, N. R. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f2b0e8 · Cited by 410
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
Govindarajan, N., Agis-Balboa, R. C., Walter, J., Sananbenesi, F., & Fischer, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110080 · Cited by 405
The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription
LeRoy, G., Rickards, B., & Flint, S. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.018 · Cited by 397
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Gupta, V., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3512 · Cited by 376
Epigenetics and Bacterial InfectionsPreprint
Bierne, H., Hamon, M. A., & Cossart, P. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a010272 · Cited by 375
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 373
Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity.
Cowansage, K., LeDoux, J., & Monfils, M.-H. (2010) · Current Molecular Pharmacology · doi:10.2174/1874467211003010012 · Cited by 372 · cited 2×
“a number of psychiatric and neurodegenerative diseases (Cowansage et al. 2010; Tapia-Arancibia et al. 2008; Walker et al. 2012).”
Background
Targeting the correct HDAC(s) to treat cognitive disorders
Fischer, A., Sananbenesi, F., Mungenast, A. E., & Tsai, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.09.003 · Cited by 365
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365
The human gut microbiome: current knowledge, challenges, and future directions
Dave, M., Higgins, P., Middha, S., & Rioux, K. P. (2012) · Translational research · doi:10.1016/j.trsl.2012.05.003 · Cited by 357
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Latham, T., Mackay, C. L., Sproul, D., Karim, M., Culley, J., Harrison, D. J., Hayward, L., Langridge‐Smith, P. R. R., Gilbert, N., & Ramsahoye, B. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks066 · Cited by 340
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336
Epigenetic sources of behavioral differences in mice
Francis, D. D., Szegda, K. L., Campbell, G., Martin, W. D., & Insel, T. R. (2003) · Nature Neuroscience · doi:10.1038/nn1038 · Cited by 334
Programming infant gut microbiota: influence of dietary and environmental factors
Marques, T. M., Wall, R., Ross, R. P., Fitzgerald, G. F., Ryan, C. A., & Stanton, C. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.03.020 · Cited by 326
The Emerging Field of Neuroepigenetics
Sweatt, J. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.023 · Cited by 324
Chemokines: a new class of neuromodulator?
Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2255 · Cited by 321
Suppression of the antiviral response by an influenza histone mimic
Marazzi, I., Ho, J., Kim, J., Manicassamy, B., Dewell, S. B., Albrecht, R. A., Seibert, C. W., Schaefer, U., Jeffrey, K. L., Prinjha, R. K., et al. (2012) · Nature · doi:10.1038/nature10892 · Cited by 320
Distinct antimicrobial peptide expression determines host species-specific bacterial associations
Franzenburg, S., Walter, J., Künzel, S., Wang, J., Baines, J. F., Bosch, T. C. G., & Fraune, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304960110 · Cited by 320
Long noncoding RNAs in development and disease of the central nervous system
Ng, S., Lin, L., Soh, B.-S., & Stanton, L. W. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.03.002 · Cited by 314
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
Santos, J., Yang, P.-C., Söderholm, J. D., Benjamin, M., & Perdue, M. H. (2001) · Gut · doi:10.1136/gut.48.5.630 · Cited by 313
Brain function and chromatin plasticity
Dulac, C. G. (2010) · Nature · doi:10.1038/nature09231 · Cited by 312
Two Time Periods of Hippocampal mRNA Synthesis Are Required for Memory Consolidation of Fear-Motivated Learning
Igaz, L. M., Vianna, M. R. M. R., Medina, J. H., & Izquierdo, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06781.2002 · Cited by 309
Altered colonic function and microbiota profile in a mouse model of chronic depression
Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 306
Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
Collins, L. M., Toulouse, A., Connor, T. J., & Nolan, Y. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.028 · Cited by 306
The Potential of HDAC Inhibitors as Cognitive Enhancers
Gräff, J., & Tsai, L. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140216 · Cited by 306
The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse
McVey Neufeld, K. A., Mao, Y. K., Bienenstock, J., Foster, J. A., & Kunze, W. A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12049 · Cited by 299
Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment
Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 291
Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome–gut–brain axis
Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation
Weng, N.-P., Araki, Y., & Subedi, K. (2012) · Nature Reviews Immunology · doi:10.1038/nri3173 · Cited by 290
Introduction to intestinal microecology
Luckey, T. D. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.12.1292 · Cited by 288
Epigenetics of Host–Pathogen Interactions: The Road Ahead and the Road Behind
Gómez‐Díaz, E., Jordà, M., Peinado, M. A., & Rivero, A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003007 · Cited by 277
The gut microbiome: the role of a virtual organ in the endocrinology of the host
Evans, J. M., Morris, L. S., & Marchesi, J. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0131 · Cited by 273
A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection
Eskandarian, H. A., Impens, F., Nahori, M., Soubigou, G., Coppée, J., Cossart, P., & Hamon, M. A. (2013) · Science · doi:10.1126/science.1238858 · Cited by 268
ASSOCIATION OF GERMFREE MICE WITH BACTERIA ISOLATED FROM NORMAL MICE
Schaedler, R. W., Dubos, R. J., & Costello, R. L. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.1.77 · Cited by 268
The Gut Microbiome: A New Frontier in Autism Research
Mulle, J. G., Sharp, W. G., & Cubells, J. F. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-012-0337-0 · Cited by 262
Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication
Rolando, M., Sanulli, S., Rusniok, C., Gómez-Valero, L., Bertholet, C., Sahr, T., Margueron, R., & Buchrieser, C. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.03.004 · Cited by 260
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
Alenghat, T., Osborne, L. C., Saenz, S. A., Kobuley, D. E., Ziegler, C. G. K., Mullican, S. E., Choi, I., Grunberg, S., Sinha, R., Wynosky-Dolfi, M. A., et al. (2013) · Nature · doi:10.1038/nature12687 · Cited by 255
Long Noncoding RNAs Usher In a New Era in the Biology of Enhancers
Ørom, U. A., & Shiekhattar, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.028 · Cited by 254
Autism Spectrum Disorders and Epigenetics
Grafodatskaya, D., Chung, B., Szatmari, P., & Weksberg, R. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.005 · Cited by 235
How and why Toxoplasma makes us crazy
Jaroslav Flegr, A. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.01.007 · Cited by 235
Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study
Ming, X., Stein, T. P., Barnes, V., Rhodes, N., & Guo, L. (2012) · Journal of Proteome Research · doi:10.1021/pr300910n · Cited by 234
Genotype Is a Stronger Determinant than Sex of the Mouse Gut Microbiota
Kovacs, A., Ben-Jacob, N., Tayem, H., Halperin, E., Iraqi, F. A., & Gophna, U. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9787-2 · Cited by 226
The Distribution of Toxoplasma gondii Cysts in the Brain of a Mouse with Latent Toxoplasmosis: Implications for the Behavioral Manipulation Hypothesis
Berenreiterová, M., Jaroslav Flegr, A., Kuběna, A. A., & Němec, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028925 · Cited by 223
Histone Modifications and Chromatin Remodeling during Bacterial Infections
Hamon, M. A., & Cossart, P. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.07.009 · Cited by 222
Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria
Clarke, G. A., Cryan, J. F., Dinan, T. G., & Quigley, E. M. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04965.x · Cited by 221
The immunology of neurodegeneration
Czirr, E., & Wyss‐Coray, T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58656 · Cited by 218
Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour
Webster, J. P. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01459-9 · Cited by 216
The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications
Collins, S. M., Kassam, Z., & Berčík, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.004 · Cited by 214
Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management
de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 212
Effect of Intestinal Microbial Ecology on the Developing Brain
Douglas‐Escobar, M., Elliott, E. C., & Neu, J. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.497 · Cited by 211
MicroRNAs in learning, memory, and neurological diseases: Figure 1.Preprint
Wang, W., Kwon, E. J., & Tsai, L. (2012) · Learning & Memory · doi:10.1101/lm.026492.112 · Cited by 210
The hologenome theory of evolution contains Lamarckian aspects within a Darwinian framework
Rosenberg, E., Sharon, G., & Zilber‐Rosenberg, I. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01995.x · Cited by 210
Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings
Gondalia, S. V., Palombo, E. A., Knowles, S. R., Cox, S. B., Meyer, D., & Austin, D. W. (2012) · Autism Research · doi:10.1002/aur.1253 · Cited by 208
Deep Sequencing Identifies Ethnicity-Specific Bacterial Signatures in the Oral Microbiome
Mason, M. R., Nagaraja, H. N., Camerlengo, T., Joshi, V., & Kumar, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077287 · Cited by 205
Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis
Pennini, M. E., Perrinet, S., Dautry‐Varsat, A., & Subtil, A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000995 · Cited by 205
The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat
McKernan, D. P., Fitzgerald, P., Dinan, T. G., & Cryan, J. F. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01520.x · Cited by 205
Manipulation of Host Behavior by Parasitic Insects and Insect Parasites
Libersat, F., Delago, A., & Gal, R. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.54.110807.090556 · Cited by 202
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders
Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200
Host manipulation by parasites: a multidimensional phenomenon
Frédéric Thomas, A., Poulin, R., & Jacques Brodeur, B. (2010) · Oikos · doi:10.1111/j.1600-0706.2009.18077.x · Cited by 178
Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons
Mao, Y.-K., Kasper, D. L., Wang, B., Forsythe, P., Bienenstock, J., & Kunze, W. A. (2013) · Nature Communications · doi:10.1038/ncomms2478 · Cited by 178
The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders
Critchfield, J. W., van Hemert, S., Ash, M. E., Mulder, L. H. C., & Ashwood, P. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/161358 · Cited by 178
Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability
Jochems, J., Boulden, J., Lee, B. G., Blendy, J. A., Jarpe, M. B., Mazitschek, R., van Duzer, J. H., Jones, S. S., & Berton, O. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.207 · Cited by 175
Toxoplasma gondiiinfection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?
Webster, J. P., Kaushik, M., Bristow, G. C., & McConkey, G. A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.074716 · Cited by 175
THE ROLES OF HOST EVOLUTIONARY RELATIONSHIPS (GENUS: NASONIA) AND DEVELOPMENT IN STRUCTURING MICROBIAL COMMUNITIES
Brucker, R. M., & Bordenstein, S. R. (2011) · Evolution · doi:10.1111/j.1558-5646.2011.01454.x · Cited by 170
When bacteria target the nucleus: the emerging family of nucleomodulins
Bierne, H., & Cossart, P. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01758.x · Cited by 163
HDAC6 Regulates Glucocorticoid Receptor Signaling in Serotonin Pathways with Critical Impact on Stress Resilience
Espallergues, J., Teegarden, S. L., Veerakumar, A., Boulden, J., Challis, C., Jochems, J., Chan, M., Petersen, T. L., Deneris, E. S., Matthias, P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5634-11.2012 · Cited by 151
The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease
Stilling, R. M., & Fischer, A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.002 · Cited by 144
Transgenerational Epigenetic Effects on Brain Functions
Bohacek, J., Gapp, K., Saab, B. J., & Mansuy, I. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.019 · Cited by 142
SLC5A8 Triggers Tumor Cell Apoptosis through Pyruvate-Dependent Inhibition of Histone Deacetylases
Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E., & Ganapathy, V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1950 · Cited by 140
Epigenetics and Evolution
Mendizabal, I., Keller, T. E., Zeng, J., & Yi, S. V. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu040 · Cited by 139
Cognitive neuroepigenetics: A role for epigenetic mechanisms in learning and memory
Day, J. J., & Sweatt, J. D. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.12.008 · Cited by 137
Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression
O’Connor, R. M., Dinan, T. G., & Cryan, J. F. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.162 · Cited by 135
HDAC3 and the molecular brake pad hypothesis
McQuown, S. C., & Wood, M. A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.005 · Cited by 126
Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress
Tran, L., Chaloner, A., Sawalha, A. H., & van-Meerveld, B. G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.016 · Cited by 124
Host-manipulation by parasites with complex life cycles: adaptive or not?
Cézilly, F., Frédéric Thomas, A., Médoc, V., & Perrot‐Minnot, M. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.03.009 · Cited by 114
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease
Walker, M. P., LaFerla, F. M., Oddo, S., & Brewer, G. J. (2012) · AGE · doi:10.1007/s11357-011-9375-5 · Cited by 112
Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory
Kennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2014) · Psychological Medicine · doi:10.1017/s0033291713002171 · Cited by 106
Ingestion of mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice
Matthews, D. M., & Jenks, S. M. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.02.007 · Cited by 105
Microbes' roadmap to neurons
Kristensson, K. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3029 · Cited by 104
The Human Gut Bacteria Bacteroides thetaiotaomicron and Fusobacterium varium Produce Putrescine and Spermidine in Cecum of Pectin-Fed Gnotobiotic Rats
Noack, J., Dongowski, G., Hartmann, L., & Blaut, M. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1225 · Cited by 101
The gut microbiota—a clinical perspective on lessons learned
Shanahan, F. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.145 · Cited by 100
New mechanisms in memory storage: piRNAs and epigenetics
Landry, C. D., Kandel, E. R., & Rajasethupathy, P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.004 · Cited by 96
IBS: an epigenetic perspective
Dinan, T. G., Cryan, J. F., Shanahan, F., Keeling, P. W. N., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.99 · Cited by 91
Pathogenesis of Human Enterovirulent Bacteria: Lessons from Cultured, Fully Differentiated Human Colon Cancer Cell Lines
Moal, V. L.-L., & Servin, A. L. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-12 · Cited by 88
Gene, environment, and brain‐gut interactions in irritable bowel syndrome
Fukudo, S., & Kanazawa, M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06631.x · Cited by 87
Physicochemical analysis of electrostatic foundation for DNA–protein interactions in chromatin transformations
Korolev, N., Vorontsova, O. V., & Nordenskiöld, L. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.11.003 · Cited by 84
Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes
Soliman, M. L., Combs, C. K., & Rosenberger, T. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9426-4 · Cited by 84
Commensal gut flora and brain autoimmunity: a love or hate affair?
Berer, K., & Krishnamoorthy, G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0949-9 · Cited by 82
Does the Human Gut Microbiota Contribute to the Etiology of Autism Spectrum Disorders?
Louis, P. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2286-1 · Cited by 81
Basic Pathophysiologic Mechanisms in Irritable Bowel Syndrome
Mayer, E. A., Naliboff, B. D., & Chang, L. (2001) · Digestive Diseases · doi:10.1159/000050682 · Cited by 81
Language: Disputed definitions
Ledford, H. K. (2008) · Nature · doi:10.1038/4551023a · Cited by 78
Epigenetic regulation of genomic integrity
Deem, A. K., Li, X., & Tyler, J. K. (2012) · Chromosoma · doi:10.1007/s00412-011-0358-1 · Cited by 78
Microbe-induced epigenetic alterations in host cells: The coming era of patho-epigenetics of microbial infections
Minárovits, J. (2009) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/amicr.56.2009.1.1 · Cited by 73
Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory
da Silva, W. C. F. N., Bonini, J. S., Bevilaqua, L. R., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Hippocampus · doi:10.1002/hipo.20362 · Cited by 70
Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics
Kosik, K. S., Rapp, P. R., Raz, N., Small, S. A., Sweatt, J. D., & Tsai, L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls110 · Cited by 67
An observational study of cognitive function in patients with irritable bowel syndrome and inflammatory bowel disease
Berrill, J. W., Gallacher, J., Hood, K., Green, J. T., Matthews, S. B., Campbell, A. K., & Smith, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12219 · Cited by 62
THE PURE‐CULTURE CONCEPT AND GNOTOBIOTICS
Reyniers, J. A. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb53091.x · Cited by 56
Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes
Chen, J., Ghazawi, F. M., & Li, Q. (2010) · Epigenetics · doi:10.4161/epi.5.6.12224 · Cited by 55
Microbial Endocrinology
Lyte, M., & Freestone, P. P. E. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5576-0 · Cited by 55
Epigenomic control of the innate immune response
Stender, J. D., & Glass, C. K. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.06.002 · Cited by 50
Neural parasitology: how parasites manipulate host behaviour
Adamo, S. A., & Webster, J. P. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.082511 · Cited by 49
Epigenetics and Evolution
Saunders, P. T. (2017) · Human Development · doi:10.1159/000477993 · Cited by 48
The capacious hologenome
Brucker, R. M., & Bordenstein, S. R. (2013) · Zoology · doi:10.1016/j.zool.2013.08.003 · Cited by 46
Microbial–immune cross‐talk and regulation of the immune system
Cahenzli, J., Balmer, M. L., & McCoy, K. D. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03624.x · Cited by 44
Gene expression during memory formation
Igaz, L. M., Bekinschtein, P., Vianna, M. R. M. R., Izquierdo, I., & Medina, J. H. (2004) · Neurotoxicity Research · doi:10.1007/bf03033221 · Cited by 41
Microbial endocrinology and nutrition: A perspective on new mechanisms by which diet can influence gut-to-brain communication
Lyte, M. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2012.11.002 · Cited by 40
Do gut microbial communities differ in pediatric IBS and health?
Shankar, V., Agans, R., Holmes, B., Raymer, M. G., & Paliy, O. (2013) · Gut Microbes · doi:10.4161/gmic.24827 · Cited by 36
Effects of polyamines on in vitro phosphorylation and acetylation of histones of the cerebral cortex of rats of various ages
Das, R., & Kanungo, M. S. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)91885-0 · Cited by 25
Nuclear microbiology—bacterial assault on the nucleolus
Bierne, H. (2013) · EMBO Reports · doi:10.1038/embor.2013.105 · Cited by 15
Treatment of Severe Constipation Improves Parkinsonʼs Disease (PD) Symptoms
Borody, T. J., Torres, M., Campbell, J., Hills, L., & Ketheeswaran, S. (2009) · The American Journal of Gastroenterology · doi:10.14309/00000434-200910003-00999 · Cited by 15
Role of probiotics as memory enhancer
Medhi, B., & Misra, S. (2013) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.111917 · Cited by 11
Germfrec Vertebrates
Reyniers, J. A. (1960) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196003000-00073 · Cited by 9
[Observations of the behavior of gnotobiotic piglets].
Kh, B. (1970) · PubMed · Cited by 6
Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health
Lyte, M., & Lambris, J. D. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-20215-0 · Cited by 4
Clinical Vignettes - Functional Bowel Disorders
(2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.492_14 · Cited by 2
Untitled work
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Stress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150
Butyrate: A Double-Edged Sword for Health?
Liu, H., Wang, J., He, T., Becker, S. R., Zhang, G., Li, D., & Ma, X. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx009 · Cited by 1,185

See all 637

Authors: Stilling, R. M., Dinan, T. G., & Cryan, J. F.
Affiliations: APC Microbiome Institute (IE)
University College Cork (IE)
Corresponding author: Cryan, J. F.
ORCID: Stilling, R. M.
Dinan, T. G.
Cryan, J. F.
Venue: Genes, Brain and Behavior
Publisher: Wiley
Published: 2013-12-27
Volume: 13
Issue: 1
Pages: 69-86
ISSN: 1601-183X (ISSN-L)
1601-1848
DOI: 10.1111/gbb.12109
OpenAlex: W1490861410
Cited by: 637
References: 191
Citations by year: 2026: 36 · 2025: 44 · 2024: 46 · 2023: 47 · 2022: 65 · 2021: 59 · 2020: 68 · 2019: 45 · 2018: 50 · 2017: 55 · 2016: 50 · 2015: 47 · 2014: 25
FWCI: 3.83
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Genes Brain & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: microbiota-gut-brain axis, gut-brain axis, epigenetics, host-microbe interactions, chromatin plasticity, gene-environment interaction, depression, anxiety, irritable bowel syndrome, autism spectrum disorder, neurodevelopmental disorders, microbial metabolites, behavior
MeSH terms: Animals, Brain, Genes, Bacterial, Humans, Intestines, Stress, Psychological, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Host-Pathogen Interactions, Gene-Environment Interaction, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks