Cited by 181Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and Applications

A comprehensive study of whole-brain functional connectivity in children and young adults

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Jolles, D. D., van Buchem, M. A., Crone, E. A., Rombouts, S. A. R. B.·2011·Cerebral Cortex

Abstract

Over the past decade, examination of functional connectivity using functional magnetic resonance imaging has become an important tool to investigate functional changes in patient populations, healthy aging, and recently also child development. Most prior developmental studies focused on functional connectivity between brain regions important for cognitive or emotional control and the so-called "default-mode network." In the present study, we investigated whole-brain functional connectivity in children (11-13 years; N = 19) and young adults (19-25 years; N = 29), without a priori restrictions to specific regions. We found similar patterns of functionally connected regions in children and young adults, but there were differences in the size of functionally connected regions (i.e., the number of voxels), as well as in the strength of functional connectivity (i.e., the correlation value) between brain regions. This indicates that functional connectivity continues to change during adolescence. Developmental differences were found across the whole brain, but the effects differed for functional connectivity patterns associated with higher cognitive or emotional functions and functional connectivity patterns associated with basic visual and sensorimotor functions. Finally, we showed that the majority of functional connectivity differences could not be explained on the basis of gray matter density alone.

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  • Developmental differences in functional connectivity patterns are associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.

    “Thus, functional connectivity continues to change during and after adolescence, and these developmental differences in functional connectivity patterns were associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.”

    From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [34]

  • Functional connectivity continues to change during and after adolescence.

    “Thus, functional connectivity continues to change during and after adolescence, and these developmental differences in functional connectivity patterns were associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.”

    From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [34]

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Authors
Jolles, D. D., van Buchem, M. A., Crone, E. A., & Rombouts, S. A. R. B.
Affiliations
Leiden University (NL)
Venue
Cerebral Cortex
Published
2010-06-11
Volume
21
Issue
2
Pages
385-391
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2115718505
Cited by
181
References
81
Citations by year
2026: 5 · 2025: 11 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 6 · 2020: 13 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 10 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 12
FWCI
6.96
Type
journal article
Language
en
Open access
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91786368, 452-07-011)
  • Gratama Stichting
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
whole-brain functional connectivity, brain development, adolescence, children, young adults, default mode network, gray matter density
MeSH terms
Adolescent, Adult, Aging, Brain, Brain Mapping, Child, Child Development, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Young Adult

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