A comprehensive study of whole-brain functional connectivity in children and young adults
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Over the past decade, examination of functional connectivity using functional magnetic resonance imaging has become an important tool to investigate functional changes in patient populations, healthy aging, and recently also child development. Most prior developmental studies focused on functional connectivity between brain regions important for cognitive or emotional control and the so-called "default-mode network." In the present study, we investigated whole-brain functional connectivity in children (11-13 years; N = 19) and young adults (19-25 years; N = 29), without a priori restrictions to specific regions. We found similar patterns of functionally connected regions in children and young adults, but there were differences in the size of functionally connected regions (i.e., the number of voxels), as well as in the strength of functional connectivity (i.e., the correlation value) between brain regions. This indicates that functional connectivity continues to change during adolescence. Developmental differences were found across the whole brain, but the effects differed for functional connectivity patterns associated with higher cognitive or emotional functions and functional connectivity patterns associated with basic visual and sensorimotor functions. Finally, we showed that the majority of functional connectivity differences could not be explained on the basis of gray matter density alone.
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Developmental differences in functional connectivity patterns are associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.
“Thus, functional connectivity continues to change during and after adolescence, and these developmental differences in functional connectivity patterns were associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.”
From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [34]
Functional connectivity continues to change during and after adolescence.
“Thus, functional connectivity continues to change during and after adolescence, and these developmental differences in functional connectivity patterns were associated with higher cognitive or emotional functions and basic visual and sensorimotor functions.”
From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [34]
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- Authors
- Jolles, D. D., van Buchem, M. A., Crone, E. A., & Rombouts, S. A. R. B.
- Affiliations
- Leiden University (NL)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-11
- Volume
- 21
- Issue
- 2
- Pages
- 385-391
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2115718505
- Cited by
- 181
- References
- 81
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 6 · 2020: 13 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 10 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 12
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91786368, 452-07-011)
- Gratama Stichting
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- whole-brain functional connectivity, brain development, adolescence, children, young adults, default mode network, gray matter density
- MeSH terms
- Adolescent, Adult, Aging, Brain, Brain Mapping, Child, Child Development, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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