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Cited by 267

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Synaptic influences on rat ganglion‐cell photoreceptors

Open access
Wong, Kwoon Y., Dunn, Felice A., Graham, Dustin M., Berson, David M.·2007·The Journal of Physiology
DOI 10.1113/jphysiol.2007.133751
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Abstract

The intrinsically photosensitive retinal ganglion cells (ipRGCs) provide a conduit through which rods and cones can access brain circuits mediating circadian entrainment, pupillary constriction and other non‐image‐forming visual functions. We characterized synaptic inputs to ipRGCs in rats using whole‐cell and multielectrode array recording techniques. In constant darkness all ipRGCs received spontaneous excitatory and inhibitory synaptic inputs. Light stimulation evoked in all ipRGCs both synaptically driven (‘extrinsic’) and autonomous melanopsin‐based (‘intrinsic’) responses. The extrinsic light responses were depolarizing, about 5 log units more sensitive than the intrinsic light response, and transient near threshold but sustained to brighter light. Pharmacological data showed that ON bipolar cells and amacrine cells make the most prominent direct contributions to these extrinsic light responses, whereas OFF bipolar cells make a very weak contribution. The spatial extent of the synaptically driven light responses was comparable to that of the intrinsic photoresponse, suggesting that synaptic contacts are made onto the entire dendritic field of the ipRGCs. These synaptic influences increase the sensitivity of ipRGCs to light, and also extend their temporal bandpass to higher frequencies. These extrinsic ipRGC light responses can explain some of the previously reported properties of circadian photoentrainment and other non‐image‐forming visual behaviours.

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Crossref · 10.1113/jphysiol.2007.133751

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Metadata

Authors
Wong, K. Y., Dunn, F. A., Graham, D. M., & Berson, D. M.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2007-06-25
Volume
582
Issue
1
Pages
279-296
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2007.133751
OpenAlex
W1479926654
Cited by
267
References
90
FWCI
6.12
Type
journal article
Language
en
Open access
green

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