The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
Abstract
In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient (Lep ob /Lep ob ) mice and leptin treatment in adulthood does not reverse these neuroanatomical defects. However, treatment of Lep ob /Lep ob neonates with exogenous leptin rescues the development of ARH projections, and leptin promotes neurite outgrowth from ARH neurons in vitro. These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Cited by
Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · American Journal of Human Biology · doi:10.1002/ajhb.20590 · Cited by 1,006
Obesity Pathogenesis: An Endocrine Society Scientific Statement
Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727
Childhood maltreatment and obesity: systematic review and meta-analysis
Danese, A., & Tan, M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.54 · Cited by 709
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710
Leptin and the endocrine control of energy balance
Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661
The role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604
Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0040 · Cited by 583
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575
Leptin targets in the mouse brain
Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22025 · Cited by 484
Developmental programming of obesity in mammals
Taylor, P. D., & Poston, L. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.032854 · Cited by 473
Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain.
Fowler, S. P., Williams, K., Resendez, R. G., Hunt, K. J., Hazuda, H. P., & Stern, M. P. (2008) · Obesity · doi:10.1038/oby.2008.284 · Cited by 464
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
Foukas, L. C., Claret, M., Pearce, W., Okkenhaug, K., Meek, S., Peskett, E., Sancho, S., Smith, A. J. H., Withers, D. J., & Vanhaesebroeck, B. (2006) · Nature · doi:10.1038/nature04694 · Cited by 463
Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457
Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging
Lieb, W. (2009) · JAMA · doi:10.1001/jama.2009.1836 · Cited by 428
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour
Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403
Sixteen years and counting: an update on leptin in energy balance
Gautron, L., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45888 · Cited by 367
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Millington, G. W. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-18 · Cited by 345
Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes
Lenard, N. R., & Berthoud, H. (2008) · Obesity · doi:10.1038/oby.2008.511 · Cited by 338
Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons
Briggs, D. I., Enriori, P. J., Lemus, M. B., Cowley, M. A., & Andrews, Z. B. (2010) · Endocrinology · doi:10.1210/en.2010-0556 · Cited by 320
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
Hyperleptinemia Is Required for the Development of Leptin Resistance
Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311
Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308
Maternal Undernutrition Influences Placental-Fetal Development1
Belkacemi, L., Nelson, D. M., Desai, M., & Ross, M. G. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.084517 · Cited by 299
The omniscient placenta: Metabolic and epigenetic regulation of fetal programming
Nugent, B. M., & Bale, T. L. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.09.001 · Cited by 222
Critical role of STAT3 in leptin's metabolic actions
Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228
Developmental programming of hypothalamic feeding circuits
Bouret, S., & Simerly, R. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00684.x · Cited by 227
Self-citationPTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214
Minireview: Leptin and Development of Hypothalamic Feeding Circuits
Bouret, S. G., & Simerly, R. B. (2004) · Endocrinology · doi:10.1210/en.2004-0231 · Cited by 210
Self-citationGarza, J. C., Guo, M., Zhang, W., & Lu, X.-Y. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.161 · Cited by 209
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208
Coupé, B., Ishii, Y., Dietrich, M. O., Komatsu, M., Horvath, T. L., & Bouret, S. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.016 · Cited by 174
Self-citationParent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171
Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.001 · Cited by 173
Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157
Self-citationBrain Adipocytokine Action and Metabolic Regulation
Ahima, R. S., Qi, Y., Singhal, N. S., Jackson, M. B., & Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-s018 · Cited by 150
Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons
Cristino, L., Busetto, G., Imperatore, R., Ferrandino, I., Palomba, L., Silvestri, C., Petrosino, S., Orlando, P., Bentivoglio, M., Mackie, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219485110 · Cited by 143
Steculorum, S. M., & Bouret, S. G. (2011) · Endocrinology · doi:10.1210/en.2011-1279 · Cited by 140
Self-citationJousse, C., Parry, L., Lambert‐Langlais, S., Maurin, A., Averous, J., Bruhat, A., Carraro, V., Tost, J., Letteron, P., Chen, P., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181792 · Cited by 139
Obesity, leptin, and Alzheimer's disease
Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126
Kabahizi, A., Wallace, B., Lieu, L., Chau, D., Dong, Y., Hwang, E., & Williams, K. W. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15682 · Cited by 126
Early-Life Exposure to Testosterone Programs the Hypothalamic Melanocortin System
Nohara, K., Zhang, Y., Waraich, R. S., Laque, A., Tiano, J. P., Tong, J., Münzberg, H., & Mauvais-Jarvis, F. (2011) · Endocrinology · doi:10.1210/en.2010-1288 · Cited by 120
Molecular physiology of weight regulation in mice and humans
Leibel, R. L. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.245 · Cited by 120
Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity
Roth, C. L., Eslamy, H., Werny, D., Elfers, C., Shaffer, M. L., Pihoker, C., Ojemann, J., & Dobyns, W. B. (2015) · Obesity · doi:10.1002/oby.21067 · Cited by 96
Salomäki, H., Vähätalo, L. H., Laurila, K., Jäppinen, N. T., Penttinen, A.-M., Ailanen, L., Ilyasizadeh, J., Pesonen, U., & Koulu, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056594 · Cited by 92
Jung, J., Lee, S. M., Lee, M.-J., Ryu, J.-S., Song, J.-H., Lee, J.-E., Kang, G., Kwon, O. S., & Park, J.-Y. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.02.003 · Cited by 84
Varcoe, T. J., Boden, M. J., Voultsios, A., Salkeld, M. D., Rattanatray, L., & Kennaway, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053800 · Cited by 78
Nohara, K., Waraich, R. S., Liu, S., Ferron, M., Waget, A., Meyers, M. S., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2012 · Cited by 77
Bagias, C., Sukumar, N., Weldeselassie, Y., Oyebode, O., & Saravanan, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041897 · Cited by 72
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Neuroendocrine and metabolic effects of adipocyte-derived hormones
Jackson, M. B., & Ahima, R. S. (2006) · Clinical Science · doi:10.1042/cs20050243 · Cited by 68
Salomäki, H., Heinäniemi, M., Vähätalo, L. H., Ailanen, L., Eerola, K., Ruohonen, S. T., Pesonen, U., & Koulu, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115778 · Cited by 63
Alonge, K. M., Mirzadeh, Z., Scarlett, J. M., Logsdon, A. F., Brown, J. M., Cabrales, E., Chan, C. K., Kaiyala, K. J., Bentsen, M. A., Banks, W. A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00275-6 · Cited by 63
Lutz, T. A. (2022) · Appetite · doi:10.1016/j.appet.2022.105965 · Cited by 59
Josefson, J. L., Scholtens, D. M., Kuang, A., Catalano, P. M., Lowe, L. P., Dyer, A. R., Petito, L. C., Lowe, W. L., Metzger, B. E., HAPO Follow-up Study Cooperative Research Group, et al. (2021) · Diabetes Care · doi:10.2337/dc20-2398 · Cited by 55
Tam, J., Fukumura, D., & Jain, R. K. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.005 · Cited by 52
Leibel, R. L., Seeley, R. J., Darsow, T., Berg, E. G., Smith, S. R., & Ratner, R. (2015) · Diabetes · doi:10.2337/db15-0004 · Cited by 52
Organizational actions of metabolic hormones
Bouret, S. G. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.01.001 · Cited by 52
Self-citationVargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51
Lecoutre, S., Oger, F., Pourpe, C., Butruille, L., Marousez, L., Dickes-Coopman, A., Laborie, C., Guinez, C., Lesage, J., Vieau, D., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.010 · Cited by 49
Schurgin, S., Canavan, B., Koutkia, P., DePaoli, A. M., & Grinspoon, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1102 · Cited by 48
The central melanocortin system and the regulation of energy balance
Lee, M. (2007) · Frontiers in Bioscience · doi:10.2741/2366 · Cited by 45
Acquired hypothalamic obesity: A clinical overview and update
Roth, C. L., & McCormack, S. E. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15530 · Cited by 42
The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease
Hamilton, K., & Harvey, J. (2021) · Pharmaceuticals · doi:10.3390/ph14010052 · Cited by 36
Pang, Z. P., & Han, W. (2012) · Bioscience Reports · doi:10.1042/bsr20120026 · Cited by 34
Zhuo, Y., Zhou, D., Che, L., Fang, Z., Lin, Y., & Wu, D. (2014) · Nutrition · doi:10.1016/j.nut.2013.12.019 · Cited by 33
Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice
Nohara, K., Liu, S., Meyers, M. S., Waget, A., Ferron, M., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0230 · Cited by 28
Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development
Poling, M. C., & Kauffman, A. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00150 · Cited by 27
Chigr, F., Rachidi, F., Tardivel, C., Najimi, M., & Moyse, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00198 · Cited by 21
Vargas, V. E., Gurung, S., Grant, B., Hyatt, K., Singleton, K., Myers, S. M., Saunders, D., Njoku, C., Towner, R., & Myers, D. A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185272 · Cited by 16
Developmental androgenization programs metabolic dysfunction in adult mice: Clinical implications
Mauvais-Jarvis, F. (2014) · Adipocyte · doi:10.4161/adip.27746 · Cited by 15
Early life programming of energy balance
Cripps, R. L., Archer, Z. A., Mercer, J. G., & Ozanne, S. E. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351203 · Cited by 9
Metadata
- Authors
- Bouret, S. G., Draper, S. J., & Simerly, R. B.
- Venue
- Science
- Published
- 2004-04-02
- Volume
- 304
- Issue
- 5667
- Pages
- 108-110
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972275518
- Cited by
- 1,218
- References
- 2
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.