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Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
Abstract
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)–secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell–independent expression of IgA and gut-homing receptors on B cells. GALT-DC–derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC–derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.
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Metadata
- Authors
- Mora, J. R., Iwata, M., Eksteen, B., Song, S.-Y., Junt, T., Senman, B., Otipoby, K. L., Yokota, A., Takeuchi, H., Ricciardi-Castagnoli, P., Rajewsky, K., Adams, D. H., & von Andrian, U. H.
- Venue
- Science
- Published
- 2006-11-17
- Volume
- 314
- Issue
- 5802
- Pages
- 1157-1160
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050417626
- Cited by
- 1,011
- References
- 1
- FWCI
- 21.33
- Type
- journal article
- Language
- en
- Open access
- closed
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