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Extending Healthy Life Span—From Yeast to Humans
Open accessAbstract
Eat Less, Live Long: Studies in several model organisms have shown that dietary restriction without malnutrition, or manipulation of nutrient-sensing pathways through mutations or drugs, can increase life span and reduce age-related disease. Fontana et al. (p. 321 ) review the ways in which nutrient-sensing pathways are central to aging. Studies of yeast, worms, rodents, and primates show that these pathways are conserved during evolution. Although data on the effects of dietary restriction in primates are very limited, in humans, the protective effects of dietary restriction against cancer, cardiovascular disease, and diabetes must be judged against potentially negative long-term effects. More work is needed to determine whether dietary restriction and the modulation of anti-aging pathways through drugs can extend life span and reduce pathologies in humans.
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“Caloric restriction has been demonstrated to be the most effective strategy to lengthen healthspan and lifespan, and is efficacious in a range of species from yeast to primates255.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [255]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fontana et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including unicellular and multicellular organisms of several distinct phyla, including non-human primates”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Genetic polymorphisms or mutations that reduce the functions of GH, IGF-1 receptor, insulin receptor or downstream intracellular effectors such as AKT, mTOR and FOXO, have been linked to longevity, both in humans and in model organisms”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Multiple genetic manipulations that attenuate signaling intensity at different levels of the IIS pathway consistently extend the lifespan of worms, flies and mice”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
Experimental — accuracy not yet measured
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“Remarkably, the IIS pathway is the most conserved aging-controlling pathway in evolution”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Collectively, current available evidence strongly supports the idea that anabolic signaling accelerates aging, and decreased nutrient signaling extends longevity”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“Genetic analyses indicate that this pathway mediates part of the beneficial effects of DR on longevity in worms and flies”
From The Hallmarks of Aging (2013) · cites this paper as Fontana et al., 2010
In the citing paper
“Dietary, genetic, and pharmacological (rapamycin) inhibition of mTOR extends life span in multiple model organisms (83).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [83]
In the citing paper
“The IIS pathway informs cells of glucose levels and is the most conserved aging-controlling pathway in evolution.207”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [207]
In the citing paper
“Suppression of the insulin–insulin-like growth factor 1 (IGF1) signalling (IIS) pathway dramatically extends lifespan in multiple organisms, which suggests that it is an evolutionarily conserved mechanism16.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [16]
In the citing paper
“Additional interest on how nutrient scarcity modulates mitochondrial function comes from the fact that CR is the most consistent physiological intervention to improve health and extend lifespan across a wide range of organisms (Fontana et al, 2010; Houtkooper et al, 2010b).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Fontana et al, 2010
In the citing paper
“The data infer the mutations cause a physiological state similar to that experienced during periods of reduced calorie intake (206).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [206]
In the citing paper
“Caloric restriction reduces the generation of growth hormone, insulin, IGF1, and other growth factors, all of which have been shown to hasten aging and increase mortality in a number of species (see Figure 3) (206).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [206]
In the citing paper
“Several genetic mutations, such as in the C. elegans DAF-16 transcription signaling pathway, involving nutrient-sensing pathways have been described and linked to a role in extending lifespan.”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [206]
In the citing paper
“Furthermore, caloric restriction has been found to extend the life span of several organisms including S. cerevisiae (yeast), C. elegans, fish, rodents, and rhesus monkeys (206, 207).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [206]
In the citing paper
“Importantly, CR-mediated longevity in eukaryotes seems to be governed by a set of conserved nutrient signaling pathways (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Among them are the insulin and the TOR/S6K pathways, whose inhibition upon CR eventually confer stress resistance and promote survival during aging.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Since then, CR has been shown to prolong mean and maximum lifespan in dogs, rodents, worms, flies, yeasts, and prokaryotes (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“CR reduces the release of growth factors like growth hormone, insulin and insulin-like growth factor 1 (IGF1), which have been shown to accelerate aging and increase mortality in many organisms (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Stress-related transcription factors represent the common effectors in yeast, flies, worms, and mammals (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Accumulating evidence suggests that protein restriction is necessary and sufficient for depletion of serum IGF1 in humans (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Female rats subjected to prolonged CR become infertile in a reversible fashion (Martin et al., 2007), and moderate CR may be harmful to lean human beings (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“CR changes many parameters in the aging human body, including the transcriptome, the hormonal status (in particular the serum concentration of IGF-1 and thyroid hormones), oxidative stress, inflammation, mitochondrial function, and glucose homeostasis (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
In the citing paper
“Hence, exercise training can have a beneficial impact against diseases and metabolic disorders that typically accompany aging, notably cardiovascular diseases, diabetes and osteoporosis (Fontana et al., 2010).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fontana et al., 2010
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Cites
1 retracted
Bonkowski, M. S., Dominici, F. P., Arum, O., Rocha, J. S., Al-Regaiey, K., Westbrook, R., Spong, A., Panici, J. A., Masternak, M. M., Kopchick, J. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004567 · Cited by 125
RetractedRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120
Self-citationMechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057
Self-citationExtension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982
Cited by
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Items 201–300 of 1,019
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Weiss, E. P., & Fontana, L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00685.2011 · Cited by 198
Self-citationReynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20790-0 · Cited by 199
Slack, C., Foley, A., & Partridge, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047699 · Cited by 199
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Barnes, P. J. (2015) · European Respiratory Journal · doi:10.1183/09031936.00229714 · Cited by 204
Dietary restriction impacts health and lifespan of genetically diverse mice
Francesco, A. D., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L. L., Garland, G., Donato, H., Vincent, M. J., Schott, W., et al. (2024) · Nature · doi:10.1038/s41586-024-08026-3 · Cited by 216
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · doi:10.1101/2023.11.28.568901 · Cited by 194
The Mitochondrial Free Radical Theory of Aging
Barja, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00001-5 · Cited by 198
Aging, Atherosclerosis, and IGF-1
Higashi, Y., Sukhanov, S., Anwar, A., Shai, S., & Delafontaine, P. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls102 · Cited by 195
Metabolism and Colorectal Cancer
Sedlak, J. C., Yilmaz, Ö. H., & Roper, J. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-041113 · Cited by 208
Stenesen, D., Suh, J. M., Seo, J. H., Yu, K., Lee, K., Kim, J.-S., Min, K., & Graff, J. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.006 · Cited by 210
Villareal, D. T., Fontana, L., Das, S. K., Redman, L., Smith, S. R., Saltzman, E., Bales, C., Rochon, J., Pieper, C., Huang, M., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2701 · Cited by 191
“Caloric restriction (CR) is the most promising intervention for extending healthy life span of humans.((1)) Data from CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) phase 1 suggested that CR is feasible and could confer ample health benefits.”
BackgroundSelf-citationGodar, R. J., Ma, X., Liu, H., Murphy, J. T., Weinheimer, C. J., Kovács, A. D., Crosby, S. D., Säftig, P., & Diwan, A. (2015) · Autophagy · doi:10.1080/15548627.2015.1063768 · Cited by 189
Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K. L., Säftig, P., Marshall, C. A., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1368596 · Cited by 194
Ageing and the border between health and disease
MacNee, W., Rabinovich, R., & Choudhury, G. (2014) · European Respiratory Journal · doi:10.1183/09031936.00134014 · Cited by 198
Nagpal, R., Neth, B. J., Wang, S., Mishra, S. P., Craft, S., & Yadav, H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102950 · Cited by 197
Ocampo, A., Liu, J., Schroeder, E. A., Shadel, G. S., & Barrientos, A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.013 · Cited by 188
Genetics and epigenetics of aging and longevity
Moskalev, A., Aliper, A. M., Smit‐McBride, Z., Buzdin, A. A., & Zhavoronkov, A. A. (2014) · Cell Cycle · doi:10.4161/cc.28433 · Cited by 189
Molecular and phenotypic biomarkers of aging
Xia, X., Chen, W., McDermott, J., & Han, J.-D. J. (2017) · F1000Research · doi:10.12688/f1000research.10692.1 · Cited by 188
Guidelines and recommendations on yeast cell death nomenclature
Carmona‐Gutiérrez, D., Bauer, M. A., Zimmermann, A., Aguilera, A., Austriaco, N. P. G., Ayscough, K. R., Balzan, R., Bar‐Nun, S., Barrientos, A., Belenky, P. A., et al. (2017) · Microbial Cell · doi:10.15698/mic2018.01.607 · Cited by 193
The impact of dietary macronutrient intake on cognitive function and the brain
Muth, A.-K., & Park, S. Q. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.043 · Cited by 213
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction
Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184
Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites
Kaczanowski, S., Sajid, M., & Reece, S. E. (2011) · Parasites & Vectors · doi:10.1186/1756-3305-4-44 · Cited by 182
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis
Catalina-Rodriguez, O., Kolukula, V. K., Tomita, Y. A., Preet, A., Palmieri, F., Wellstein, A., Byers, S. W., Giaccia, A. J., Glasgow, E. F., Albanese, C., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.714 · Cited by 190
Gut microbiota mediates the anti-obesity effect of calorie restriction in mice
Wang, S., Huang, M., You, X., Zhao, J., Chen, L., Wang, L., Luo, Y., & Chen, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-31353-1 · Cited by 189
Dietary habits, lifestyle factors and neurodegenerative diseases
Popa‐Wagner, A., Dumbrava, D., Dumitrascu, D., Căpitănescu, B., Petcu, E. B., Surugiu, R., & Fang, W.-H. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266045 · Cited by 190
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Rafalski, V. A., Mancini, E., & Brunet, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.114827 · Cited by 181
Common methods of biological age estimation
Jia, L., Zhang, W., & Chen, X. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s134921 · Cited by 196
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 181
High-throughput analysis of yeast replicative aging using a microfluidic system
Jo, M. C., Liu, W., Gu, L., Dang, W., & Qin, L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510328112 · Cited by 189
FOXO Transcriptional Factors and Long‐Term Living
Murtaza, G., Khan, A. K., Rashid, R., Muneer, S., Hasan, S. M. F., & Chen, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3494289 · Cited by 182
SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
Chakrabarti, P., English, T., Karki, S., Qiang, L., Tao, R., Kim, J., Luo, Z., Farmer, S. R., & Kandror, K. V. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014647 · Cited by 182
Caloric restriction and the aging process: a critique
Sohal, R. S., & Forster, M. J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.015 · Cited by 187
Anti-senescence compounds: A potential nutraceutical approach to healthy aging
Gurău, F., Baldoni, S., Prattichizzo, F., Espinosa, E., Amenta, F., Procopio, A. D., Albertini, M. C., Bonafè, M., & Olivieri, F. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.001 · Cited by 179
The impact of dietary protein intake on longevity and metabolic health
Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.005 · Cited by 175
“CR without malnutrition has been shown to extend the lifespan and improvemetabolic health in organisms [1].”
BackgroundThe role of nutrition in enhancing immunity in aging.
Pae, M., Meydani, S. N., & Wu, D. (2012) · Europe PMC (PubMed Central) · Cited by 180
Vernochet, C., Damilano, F., Mourier, A., Bézy, O., Mori, M. A., Smyth, G., Rosenzweig, A., Larsson, N., & Kahn, C. R. (2014) · The FASEB Journal · doi:10.1096/fj.14-253971 · Cited by 173
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173
Steinbrenner, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.016 · Cited by 177
Human mortality improvement in evolutionary context
Bürger, O., Baudisch, A., & Vaupel, J. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215627109 · Cited by 172
Dietary restriction with and without caloric restriction for healthy aging
Lee, C. D., & Longo, V. D. (2016) · F1000Research · doi:10.12688/f1000research.7136.1 · Cited by 178
Self-citationThe role of oxidative and nitrosative stress in accelerated aging and major depressive disorder
Maurya, P. K., Noto, C. D. S., Rizzo, L. B., Rios, A. C., Nunes, S. O. V., Barbosa, D. S., Sethi, S., Zeni‐Graiff, M., Mansur, R. B., Maes, M. H. J., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.016 · Cited by 174
Renal Protective Effects of Resveratrol
Kitada, M., & Koya, D. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/568093 · Cited by 174
Söderberg, J. A. E., Carlsson, M. A., & Nässel, D. R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00109 · Cited by 182
Principles of pharmacological research of nutraceuticals
Andrew, R., & Izzo, A. A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13779 · Cited by 175
Nutrient sensing modulates malaria parasite virulence
Mancio-Silva, L., Slavic, K., Grilo Ruivo, M. T., Grosso, A. R., Modrzynska, K. K., Vera, I. M., Sales-Dias, J., Gomes, A. R., MacPherson, C. R., Crozet, P., et al. (2017) · Nature · doi:10.1038/nature23009 · Cited by 169
Dietary protein, aging and nutritional geometry
Simpson, S. J., Le Couteur, D. G., Raubenheimer, D., Solon-Biet, S. M., Cooney, G. J., Cogger, V. C., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.001 · Cited by 169
Self-citationKapan, N., Lushchak, O. V., Luo, J., & Nässel, D. R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1097-z · Cited by 169
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 170
Ketone bodies mimic the life span extending properties of caloric restriction
Veech, R. L., Bradshaw, P. C., Clarke, K., Curtis, W., Pawlosky, R. J., & King, M. T. (2017) · IUBMB Life · doi:10.1002/iub.1627 · Cited by 171
Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168
A causal role for hyperinsulinemia in obesity
Templeman, N. M., Skovsø, S., Page, M. M., Lim, G. E., & Johnson, J. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0449 · Cited by 168
Fontana, L., Villareal, D. T., Das, S. K., Smith, S. R., Meydani, S. N., Pittas, A. G., Klein, S., Bhapkar, M. V., Rochon, J., Ravussin, É., et al. (2015) · Aging Cell · doi:10.1111/acel.12400 · Cited by 181
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Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D. T., Hotamışlıgil, G. S., Holloszy, J. O., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.042 · Cited by 174
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Huan, T., Chen, G., Liu, C., Bhattacharya, A., Rong, J., Chen, B. H., Seshadri, S. S., Tanrıverdi, K., Freedman, J. E., Larson, M. G., et al. (2017) · Aging Cell · doi:10.1111/acel.12687 · Cited by 171
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163
Tryptophan metabolism: entering the field of aging and age-related pathologies
van der Goot, A. T., & Nollen, E. A. A. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.02.007 · Cited by 166
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
The blue zones: Areas of exceptional longevity around the world
Poulain, M., Herm, A., & Pes, G. (2014) · Vienna Yearbook of Population Research · doi:10.1553/populationyearbook2013s87 · Cited by 162
Calorie restriction mimetics: Can you have your cake and eat it, too?
Ingram, D. K., & Roth, G. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.005 · Cited by 164
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza, W., Veronese, N., & Fontana, L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.11.002 · Cited by 168
Self-citationDistinct longevity mechanisms across and within species and their association with aging
Tyshkovskiy, A., Ma, S., Shindyapina, A. V., Tikhonov, S., Lee, S.-G., Bozaykut, P., Castro, J. P., Seluanov, A., Schork, N. J., Gorbunova, V., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.002 · Cited by 162
Karnewar, S., Neeli, P. K., Panuganti, D., Kotagiri, S., Mallappa, S., Jain, N., Jerald, M. K., & Kotamraju, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.018 · Cited by 161
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models
Johansson, J. U., Woodling, N. S., Wang, Q., Panchal, M., Liang, X., Trueba-Saiz, A., Brown, H. D., Mhatre, S. D., Loui, T., & Andreasson, K. I. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77487 · Cited by 161
Signaling networks determining life span
Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161
Jenwitheesuk, A., Nopparat, C., Mukda, S., Wongchitrat, P., & Govitrapong, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916848 · Cited by 164
van Heemst, D. (2010) · Europe PMC (PubMed Central) · Cited by 160
Fasting Therapy - an Expert Panel Update of the 2002 Consensus Guidelines
de Toledo, F. W., Buchinger, A., Burggrabe, H., Hölz, G., Kuhn, C., Lischka, E., Lischka, N., Lützner, H., May, W., Ritzmann-Widderich, M., et al. (2013) · Complementary Medicine Research · doi:10.1159/000357602 · Cited by 158
Optimal body weight for health and longevity: bridging basic, clinical, and population research
Fontana, L., & Hu, F. B. (2014) · Aging Cell · doi:10.1111/acel.12207 · Cited by 157
Self-citationA null mutation in SERPINE1 protects against biological aging in humans
Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., et al. (2017) · Science Advances · doi:10.1126/sciadv.aao1617 · Cited by 157
FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging
Oellerich, M. F., & Potente, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.246488 · Cited by 161
Qiao, J., Wang, Z., Feng, H.-L., Miao, Y., Wang, Q., Yu, Y., Wei, Y., Yan, J., Wang, W., Shen, W., et al. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.06.001 · Cited by 158
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
Obata, F., & Miura, M. (2015) · Nature Communications · doi:10.1038/ncomms9332 · Cited by 157
Kubrak, O. I., Kučerová, L., Theopold, U., & Nässel, D. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113051 · Cited by 156
Fasting and Caloric Restriction in Cancer Prevention and Treatment
Brandhorst, S., & Longo, V. D. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_12 · Cited by 166
Self-citationNutrition and human health from a sex–gender perspective
Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 159
Tipping the metabolic scales towards increased longevity in mammals
Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153
Owusu-Ansah, E., & Perrimon, N. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.012989 · Cited by 156
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
Blackwell, T. K., Sewell, A. K., Wu, Z., & Han, M. (2019) · Genetics · doi:10.1534/genetics.119.302504 · Cited by 148
Ding, J., & Sullivan, D. A. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.020 · Cited by 155
Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates
Pifferi, F., Terrien, J., Marchal, J., Dal‐Pan, A., Djelti, F., Hardy, I., Chahory, S., Cordonnier, N., Desquilbet, L., Hurion, M., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0024-8 · Cited by 167
Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.01.014 · Cited by 150
Mitochondrial response to nutrient availability and its role in metabolic disease
Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148
Fusco, S., Ripoli, C., Podda, M. V., Ranieri, S. C., Leone, L., Toietta, G., McBurney, M. W., Schütz, G., Riccio, A., Grassi, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109237109 · Cited by 148
Testa, G., Biasi, F., Poli, G., & Chiarpotto, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660699 · Cited by 153
Linking Lipid Metabolism to Chromatin Regulation in Aging
Papsdorf, K., & Brunet, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.09.004 · Cited by 155
Teodoro, J. S., Nunes, S., Rolo, A. P., Reis, F., & Palmeira, C. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01857 · Cited by 150
Increased transsulfuration mediates longevity and dietary restriction in Drosophila
Kabil, H., Kabil, Ö., Banerjee, R. V., Harshman, L. G., & Pletcher, S. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102008108 · Cited by 147
Fok, W. C., Chen, Y., Bokov, A. F., Zhang, Y., Salmon, A. B., Diaz, V., Javors, M. A., Wood, W. H., Zhang, Y., Becker, K. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083988 · Cited by 147
The caloric restriction paradigm: Implications for healthy human aging
Anderson, R. M., & Weindruch, R. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22243 · Cited by 125
Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease
Brandhorst, S., & Longo, V. D. (2019) · Circulation Research · doi:10.1161/circresaha.118.313352 · Cited by 148
Self-citationDelgado‐Morales, R., Agís‐Balboa, R. C., Esteller, M., & Berdasco, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0365-z · Cited by 147
Luo, A., Yan, J., Tang, X., Zhao, Y., Zhou, B., & Li, S. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00559-0 · Cited by 146
Circulating Proteomic Signatures of Chronological Age
Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu121 · Cited by 144
Lettieri‐Barbato, D., Tatulli, G., Aquilano, K., & Ciriolo, M. R. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.404 · Cited by 151
Rallis, C., Codlin, S., & Bähler, J. (2013) · Aging Cell · doi:10.1111/acel.12080 · Cited by 140
mTORC1 signaling: what we still don't know
Wang, X., & Proud, C. G. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq038 · Cited by 150
Metadata
- Authors
- Fontana, L., Partridge, L., & Longo, V. D.
- Affiliations
- Washington University in St. Louis (US)
- University College London (GB)
- University of Southern California (US)
- Corresponding author
- Fontana, Luigi
- Partridge, Linda
- Longo, Valter D.
- Venue
- Science
- Published
- 2010-04-16
- Volume
- 328
- Issue
- 5976
- Pages
- 321-326
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3607354
- OpenAlex
- W2080094749
- Cited by
- 3,023
- References
- 75
- Citations by year
- 2026: 135 · 2025: 168 · 2024: 160 · 2023: 145 · 2022: 194 · 2021: 221 · 2020: 229 · 2019: 194 · 2018: 191 · 2017: 213 · 2016: 174 · 2015: 197 · 2014: 195 · 2013: 207 · 2012: 188
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- National Institute on Aging (AG20642, R01AG020642, AG025135, R01AG025135)
- National Institute of General Medical Sciences (R01GM075308, GM075308)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
- National Center for Research Resources (UL1RR024992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, healthspan, aging, nutrient-sensing pathways, growth hormone receptor, age-related diseases, cancer, neurodegeneration, diabetes mellitus, rhesus monkeys, evolution of aging, healthy aging
- MeSH terms
- Aging, Animals, Haplorhini, Drosophila, Eating, Humans, Longevity, Saccharomyces cerevisiae, Signal Transduction, Caenorhabditis elegans, Caloric Restriction, Mice
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