The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The caloric restriction paradigm: Implications for healthy human aging
Abstract
Underlying the importance of research on the biology of aging is the fact that many nations face the demographic reality of a rapidly aging populace and the looming healthcare challenges that it brings. This reality is a result of aging itself being the most significant risk factor for a range of the most prevalent diseases, including many cancers, cardiovascular disease, and diabetes. Accordingly, interventions are sorely needed that would be able to delay or prevent diseases and disorders associated with the aging process and thereby increase the period of time that aging individuals are in good health (the health‐span). Caloric restriction (CR) has emerged as a model of major interest as it is widely agreed that CR is the most potent environmental intervention that delays the onset of aging and extends life span in diverse experimental organisms. A better understanding of the mechanisms by which CR delays aging will reveal new insights into the aging process and the underlying causes of disease vulnerability with age. These novel insights will allow the development of novel treatments and preventive measures for age‐associated diseases and disorders. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Caloric restriction is established to increase healthy lifespan in multiple species.
“and is established to increase healthy lifespan in multiple species8,9.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047
Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580
Self-citationAGEMAP: A Gene Expression Database for Aging in Mice
Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030201 · Cited by 431
Long-term caloric restriction ameliorates the decline in diastolic function in humans
Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.069 · Cited by 383
Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms
CARTWRIGHT, M., TCHKONIA, T., & KIRKLAND, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.003 · Cited by 318 · cited 1×
“Indeed, aging is also associated with adverse alterations in body fat distribution as well as deregulated WAT function (Cartwright et al., 2007; Clement and Langin, 2007; Das et al., 2004; Fig.”
BackgroundEffect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution
Redman, L. M., Heilbronn, L. K., Martin, C. K., Alfonso, A., Smith, S. R., Ravussin, E., & for the Pennington CALERIE Team (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2184 · Cited by 293
Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Lefevre, M., Redman, L. M., Heilbronn, L. K., Smith, J. V., Martin, C. K., Rood, J. C., Greenway, F. L., Williamson, D. A., Smith, S. R., & Ravussin, E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.036 · Cited by 217
Higami, Y., Pugh, T. D., Page, G. P., Allison, D. B., Prolla, T. A., & Weindruch, R. (2004) · The FASEB Journal · doi:10.1096/fj.03-0678fje · Cited by 173
Self-citationPutman, C. T., Kiricsi, M., Pearcey, J., MacLean, I. M., Bamford, J. A., Murdoch, G. K., Dixon, W. T., & Pette, D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040691 · Cited by 110
Lessons learned from gene expression profile studies of aging and caloric restriction
Park, S.-K., & Prolla, T. A. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2004.09.003 · Cited by 106
Regulation of inflammation-related genes in human adipose tissue
Clement, K., & Langin, D. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01851.x · Cited by 98
Flagged first, then by citations
Research works printed but not linked: 49
- 10.1016/j.tem.2009.11.005 · DOI
- 10.1016/j.exger.2008.06.013 · DOI
- 10.1093/gerona/56.3.B98 · DOI
- 10.1093/gerona/58.3.B212 · DOI
- 10.1080/07315724.1997.10718679 · DOI
- 10.1126/science.1173635 · DOI · Paper page
- 10.1016/S8756-3282(98)00147-1 · DOI
- 10.1093/gerona/54.7.B283 · DOI
- 10.1111/j.1467-789X.2004.00115.x · DOI · Paper page
- 10.1093/carcin/bgr107 · DOI
- 10.1093/bioinformatics/btp073 · DOI · Paper page
- 10.1016/S0140-6736(05)66378-7 · DOI
- 10.1093/gerona/53A.6.B443 · DOI
- 10.1016/j.tcb.2007.04.001 · DOI · Paper page
- 10.1073/pnas.0308291101 · DOI · Paper page
- 10.1152/ajpendo.00102.2007 · DOI
- 10.1152/ajpendo.2001.281.4.E757 · DOI
- 10.1001/jama.295.13.1539 · DOI · Paper page
- 10.1093/jn/136.2.343 · DOI · Paper page
- 10.1038/nature05485 · DOI · Paper page
- 10.1016/S0168-9525(00)02119-3 · DOI
- 10.1158/0008-5472.CAN-07-6721 · DOI
- 10.1016/0091-7435(78)90246-3 · DOI
- Kemnitz JW, 1994, Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys, Am J Physiol, 266, E540
- 10.1007/s00018-007-6470-y · DOI
- 10.1016/j.cytogfr.2007.04.007 · DOI
- Lane MA, 1995, Diet restriction in rhesus monkeys lowers fasting and glucose‐stimulated glucoregulatory end points, Am J Physiol, 268, E941
- 10.1073/pnas.232308999 · DOI · Paper page
- 10.1126/science.285.5432.1390 · DOI · Paper page
- 10.1038/77046 · DOI · Paper page
- 10.1016/j.cell.2006.07.002 · DOI · Paper page
- Mattison JA, 2007, Dietary restriction in aging nonhuman primates, Interdiscip Top Gerontol, 35, 137
- 10.1093/jn/10.1.63 · DOI · Paper page
- 10.1016/j.exger.2010.09.011 · DOI
- 10.1016/j.cmet.2008.06.011 · DOI · Paper page
- 10.1111/j.1469-7793.2003.00169.x · DOI
- 10.1093/gerona/61.9.943 · DOI · Paper page
- 10.1016/j.febslet.2007.11.034 · DOI · Paper page
- 10.1038/sj.ejcn.1601020 · DOI
- 10.1016/j.mad.2005.03.019 · DOI
- 10.1111/j.1440-6047.2001.00219.x · DOI
- 10.1016/j.cmet.2011.10.002 · DOI · Paper page
- 10.1093/jn/116.4.641 · DOI
- 10.1093/geronj/43.2.B40 · DOI · Paper page
- 10.1093/ajcn/84.5.1033 · DOI · Paper page
- 10.1097/01.ASN.0000141966.69934.21 · DOI
- 10.1016/S0092-8674(00)80611-X · DOI · Paper page
- 10.1016/j.cell.2006.01.016 · DOI · Paper page
- 10.1111/j.1474-9726.2010.00563.x · DOI · Paper page
Cited by
Sorted by citations
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
Hebert, A. S., Dittenhafer-Reed, K. E., Yu, W., Bailey, D. J., Selen, E. S., Boersma, M. D., Carson, J. J., Tonelli, M., Balloon, A. J., Higbee, A. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.024 · Cited by 636
Replicative and chronological aging in Saccharomyces cerevisiae
Longo, V. D., Shadel, G. S., Kaeberlein, M., & Kennedy, B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.002 · Cited by 595
Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet
Willcox, D. C., Scapagnini, G., & Willcox, B. J. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.002 · Cited by 273
Sirtuin catalysis and regulation
Feldman, J. L., Dittenhafer-Reed, K. E., & Denu, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.378877 · Cited by 248
Waziry, R., Ryan, C. P., Corcoran, D. L., Huffman, K. M., Kobor, M. S., Kothari, M., Graf, G. H., Kraus, V. B., Kraus, W. E., Lin, D. T. S., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00357-y · Cited by 217
Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential
Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148
Self-citationTranslating advances from the basic biology of aging into clinical application
Kirkland, J. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.014 · Cited by 128
NAD+ flux is maintained in aged mice despite lower tissue concentrations
McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.09.001 · Cited by 112
Recent advances in calorie restriction research on aging
Chung, K. W., Kim, D. H., Park, M. H., Choi, Y. J., Kim, N. D., Lee, J., Yu, B. P., & Chung, H. Y. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.007 · Cited by 108
The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing
Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105
Willcox, B. J., & Willcox, D. C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000019 · Cited by 92
Translating the Science of Aging into Therapeutic Interventions
Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78
Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Hullinger, R., & Puglielli, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.008 · Cited by 68
Nutrition modulation of human aging: The calorie restriction paradigm
Das, S. K., Balasubramanian, P., & Weerasekara, Y. K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.011 · Cited by 51
Yzydorczyk, C., Li, N., Rigal, E., Chehade, H., Mosig, D., Armengaud, J. B., Rolle, T., Krishnasamy, A., Orozco, E., Siddeek, B., et al. (2019) · Nutrients · doi:10.3390/nu11112796 · Cited by 24
Jiang, Z., Wang, J., Imai, D., Snider, T., Klug, J., Mangalindan, R., Morton, J., Zhu, L., Salmon, A. B., Wezeman, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11229-1 · Cited by 21
Does Short-Term Fasting Promote Pathological Eating Patterns?
Schaumberg, K., Anderson, D. A., Reilly, E. E., & Anderson, L. M. (2015) · Eating Behaviors · doi:10.1016/j.eatbeh.2015.09.005 · Cited by 23
Metadata
- Authors
- Anderson, R. M., & Weindruch, R.
- Venue
- American Journal of Human Biology
- Publisher
- Wiley
- Published
- 2012-01-30
- Volume
- 24
- Issue
- 2
- Pages
- 101-106
- ISSN
- 1042-0533
- 1520-6300
- PMC
- PMC3705772
- Cited by
- 125
- References
- 18
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
