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Motor skill learning requires active central myelination
Open accessAbstract
Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In this work, we study the function of these late-forming cells and the myelin they produce. Learning a new motor skill (such as juggling) alters the structure of the brain’s white matter, which contains many OLs, suggesting that late-born OLs might contribute to motor learning. Consistent with this idea, we show that production of newly formed OLs is briefly accelerated in mice that learn a new skill (running on a “complex wheel” with irregularly spaced rungs). By genetically manipulating the transcription factor myelin regulatory factor in OL precursors, we blocked production of new OLs during adulthood without affecting preexisting OLs or myelin. This prevented the mice from mastering the complex wheel. Thus, generation of new OLs and myelin is important for learning motor skills.
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“In the mouse, motor learning or motor behavioral improvements require proliferation and differentiation of oligodendrocyte precursor cells (OPCs) in the white matter and motor cortex (Gibson et al., 2014 ; McKenzie et al., 2014 ; Xiao et al., 2016 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“We focused on the primary motor cortex (M1), as the proliferation and differentiation of M1 OPCs is accelerated, and the activity of M1 cortical neurons dynamically changes during motor learning (Huber et al., 2012 ; Masamizu et al., 2014 ; McKenzie et al., 2014 ; Peters, Chen, & Komiyama, 2014 ; Xiao et al., 2016 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In such a case, the synchronous input of myelinated long‐range axons connecting distant areas, and information processes with a high signal‐to‐noise ratio, may be important (Gibson et al., 2014 ; McKenzie et al., 2014 ; Xiao et al., 2016 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These assessed motor learning ability using a running wheel with irregularly spaced rungs, in which the mice had to coordinate many parts of the body to avoid missing their step, even in the first session.”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“running on the wheel leads to an increase in the number of proliferating OPCs after 4 days, followed by an increase in oligodendrocytes after 8 days (20).”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [20]
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“increased motor skills were already apparent after 2 days in wild type mice, but not in mutant mice that were unable to synthesize new myelin (20)”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“the density of BCAS1+ oligodendrocytes in the cortex remains high throughout life—in stark contrast to the white matter—supporting a physiological role in neuronal function, e.g. as effectors of adaptive cortical myelination and circuit modulation.49,50”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [50]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“It is now known that task learning can alter dMRI attributes (Hofstetter et al., 2013; McKenzie et al., 2014; Sampaio-Baptista et al., 2013; Xiao et al., 2016)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as McKenzie et al., 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Recent evidence in animal models indicates that ongoing myelin remodeling throughout life may be important for learning, behavior, and cognition throughout adulthood (Liu et al., 2012; McKenzie et al., 2014).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as McKenzie et al., 2014
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“Genetic deletion of myelin regulatory factor causes deficient maturation of OPCs in mature mice, resulting in impaired motor learning (McKenzie et al., 2014 ; Xiao et al., 2016 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
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“In contrast to our results, the effect of impaired myelin regulation was detected from the beginning of motor training in other studies (McKenzie et al., 2014 ; Xiao et al., 2016 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as McKenzie et al., 2014
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“a process that requires active myelination (20).”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [20]
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“suggesting that oligodendrocyte lineage cells contribute to learning already within the first 2 days.”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [20]
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“Indeed, the growing realisation that experience can alter white matter microstructure (Metzler-Baddeley et al., 2017; (McKenzie et al., 2014) Zatorre et al., 2012) highlights the problems of separating cause from effect.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as McKenzie et al., 2014
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Cites
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Training induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
Cognitive Neuroscience and the Study of Memory
Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,335
Extensive piano practicing has regionally specific effects on white matter development
Bengtsson, S. L., Nagy, Z., Skare, S., Forsman, L., Forssberg, H., & Ullén, F. (2005) · Nature Neuroscience · doi:10.1038/nn1516 · Cited by 1,193
A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
Hippenmeyer, S., Pecho‐Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D. R., & Arber, S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030159 · Cited by 1,111
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Self-citationA critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922
Biological Pattern Generation: The Cellular and Computational Logic of Networks in Motion
Grillner, S. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.008 · Cited by 920
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
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Marques, S., Zeisel, A., Codeluppi, S., van Bruggen, D., Mendanha Falcão, A., Xiao, L., Li, H., Häring, M., Hochgerner, H., Romanov, R. A., et al. (2016) · Science · doi:10.1126/science.aaf6463 · Cited by 1,132
“In this paradigm, running on the wheel leads to an increase in the number of proliferating OPCs after 4 days, followed by an increase in oligodendrocytes after 8 days (25).”
InfluentialSelf-citationA new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794
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“It is now known that task learning can alter dMRI attributes (Hofstetter et al., 2013; McKenzie et al., 2014; Sampaio-Baptista et al., 2013; Xiao et al., 2016), suggesting a more dynamic role for white matter.”
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Stadelmann, C., Timmler, S., Barrantes‐Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 799
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Nasrabady, S. E., Rizvi, B., Goldman, J. E., & Brickman, A. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0515-3 · Cited by 723
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Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647
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Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
Oligodendrocyte Development and PlasticityPreprint
Bergles, D. E., & Richardson, W. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 604
Self-citationCancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex
Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J., & Bergles, D. E. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0121-5 · Cited by 540
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Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507
Self-citationMicroglia regulate central nervous system myelin growth and integrity
McNamara, N. B., Munro, D. A. D., Bestard-Cuche, N., Uyeda, A., Bogie, J. F. J., Hoffmann, A., Holloway, R. K., Molina-Gonzalez, I., Askew, K. E., Mitchell, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05534-y · Cited by 507
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Jäkel, S., & Dimou, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00024 · Cited by 571
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Safaiyan, S., Besson-Girard, S., Kaya, T., Cantuti-Castelvetri, L., Liu, L., Ji, H., Schifferer, M., Gouna, G., Usifo, F., Kannaiyan, N., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.027 · Cited by 477
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Hines, J. H., Ravanelli, A. M., Schwindt, R. K., Scott, E. K., & Appel, B. (2015) · Nature Neuroscience · doi:10.1038/nn.3992 · Cited by 460
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Filley, C. M., & Fields, R. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00221.2016 · Cited by 479
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Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 460
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Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R. A., Geraghty, A. C., Steenland, H. W., Monje, M., Josselyn, S. A., & Frankland, P. W. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.013 · Cited by 426
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Sampaio‐Baptista, C., & Johansen‐Berg, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.026 · Cited by 432
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Monje, M., & Iwasaki, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.006 · Cited by 415
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Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3991 · Cited by 398
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Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376
Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., et al. (2019) · Cell · doi:10.1016/j.cell.2018.10.049 · Cited by 372
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Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R., & Kheirbek, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0582-1 · Cited by 371
Mancusi, R. A., & Monje, M. (2023) · Nature · doi:10.1038/s41586-023-05968-y · Cited by 388
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Wang, F., Ren, S.-Y., Chen, J.-F., Liu, K., Li, R.-X., Li, Z.-F., Hu, B., Niu, J.-Q., Xiao, L., Chan, J. R., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0588-8 · Cited by 348
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Philips, T., & Rothstein, J. D. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90610 · Cited by 379
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Liu, G., Chang, C., Qiao, Z., Wu, K., Zhu, Z. H., Cui, G., Peng, W., Tang, Y., Li, J., & Fan, C. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201807862 · Cited by 317
Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308
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Arancibia‐Cárcamo, I. L., Ford, M. C., Cossell, L., Ishida, K., Tohyama, K., & Attwell, D. (2017) · eLife · doi:10.7554/elife.23329 · Cited by 325
Self-citationGlia in mammalian development and disease
Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304
van Tilborg, E., de Theije, C. G. M., van Hal, M., Wagenaar, N., de Vries, L. S., Benders, M. J. N. L., Rowitch, D. H., & Nijboer, C. H. A. (2017) · Glia · doi:10.1002/glia.23256 · Cited by 321
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Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 302
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Micheva, K. D., Wolman, D. N., Mensh, B. D., Pax, E., Buchanan, J., Smith, S. J., & Bock, D. D. (2016) · eLife · doi:10.7554/elife.15784 · Cited by 291
Liu, J., Dupree, J. L., Gacias, M., Frawley, R., Sikder, T., Naik, P. K., & Casaccia, P. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3608-15.2016 · Cited by 275
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Bei, F., Lee, H. H. C., Liu, X., Gunner, G., Jin, H., Ma, L., Wang, C., Hou, L., Hensch, T. K., Frank, E., et al. (2016) · Cell · doi:10.1016/j.cell.2015.11.036 · Cited by 269
White matter involvement after TBI: clues to axon and myelin repair capacity
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Marton, R. M., & Pașca, S. P. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.11.004 · Cited by 253
Fard, M. K., van der Meer, F., Sánchez, P., Cantuti-Castelvetri, L., Mandad, S., Jäkel, S., Fornasiero, E. F., Schmitt, S., Ehrlich, M., Starost, L., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7816 · Cited by 249
Marisca, R., Hoche, T., Agirre, E., Hoodless, L. J., Barkey, W., Auer, F., Castelo‐Branco, G., & Czopka, T. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0581-2 · Cited by 243
Oligodendrocyte lineage cells and depression
Zhou, B., Zhu, Z., Ransom, B. R., & Tong, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00930-0 · Cited by 245
Olmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239
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Carr, M., Toma, J. S., Johnston, A. P. W., Steadman, P. E., Yuzwa, S. A., Mahmud, N., Frankland, P. W., Kaplan, D. R., & Miller, F. D. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.024 · Cited by 222
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Almeida, R. G., & Lyons, D. A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3185-16.2017 · Cited by 221
Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 225
Spaas, J., van Veggel, L., Schepers, M., Tiane, A., van Horssen, J., Wilson, D. M., Moya, P. R., Piccart, E., Hellings, N., Eijnde, B. O., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03802-0 · Cited by 224
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Etxeberria, A., Hokanson, K. C., Dao, D. Q., Mayoral, S. R., Mei, F., Redmond, S., Ullian, E. M., & Chan, J. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0908-16.2016 · Cited by 206
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de Faria, O., Pivoňková, H., Varga, B. V., Timmler, S., Evans, K. A., & Káradóttir, R. T. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00917-2 · Cited by 205
Cholesterol in myelin biogenesis and hypomyelinating disorders
Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.010 · Cited by 192
The role of myelin damage in Alzheimer’s disease pathology
Papuć, E., & Rejdak, K. (2020) · Archives of Medical Science · doi:10.5114/aoms.2018.76863 · Cited by 188
Neuromodulation in the restoration of function after spinal cord injury
James, N. D., McMahon, S. B., Field-Fote, E. C., & Bradbury, E. J. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30287-4 · Cited by 192
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination
He, D., Marie, C., Zhao, C., Kim, B., Wang, J., Deng, Y., Clavairoly, A., Frah, M., Wang, H., He, X., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4258 · Cited by 191
Myelin Dynamics Throughout Life: An Ever-Changing Landscape?
Williamson, J., & Lyons, D. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00424 · Cited by 194
Microglia regulation of central nervous system myelin health and regeneration
Kent, S. A., & Miron, V. E. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00907-4 · Cited by 183
Myelin: A gatekeeper of activity-dependent circuit plasticity?
Bonetto, G., Belin, D., & Káradóttir, R. T. (2021) · Science · doi:10.1126/science.aba6905 · Cited by 195
Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia
Maas, D. A., Vallès, A., & Martens, G. J. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.138 · Cited by 183
Remarkable Stability of Myelinating Oligodendrocytes in Mice
Tripathi, R. B., Jackiewicz, M., McKenzie, I. A., Kougioumtzidou, E., Grist, M., & Richardson, W. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.050 · Cited by 176
Self-citationHuang, B., Wei, W., Wang, G., Gaertig, M. A., Feng, Y., Wang, W., Li, X., & Li, S. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.026 · Cited by 179
χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain
Shin, H., Lee, J., Yun, Y. H., Yoo, S. H., Jang, J., Oh, S., Nam, Y., Jung, S., Kim, S., Fukunaga, M., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118371 · Cited by 201
Lazari, A., & Lipp, I. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117744 · Cited by 176
Remodeling myelination: implications for mechanisms of neural plasticity
Chang, K.-J., Redmond, S., & Chan, J. R. (2016) · Nature Neuroscience · doi:10.1038/nn.4200 · Cited by 171
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
Nguyen, L. D., & Ehrlich, B. E. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012075 · Cited by 181
Koudelka, S., Voas, M. G., Almeida, R., Baraban, M., Soetaert, J., Meyer, M. P., Talbot, W. S., & Lyons, D. A. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.070 · Cited by 170
Figlia, G., Gerber, D., & Suter, U. (2018) · Glia · doi:10.1002/glia.23273 · Cited by 165
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Micu, I., Plemel, J. R., Caprariello, A. V., Nave, K., & Stys, P. K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.128 · Cited by 166
Exercise training improves motor skill learning via selective activation of mTOR
Chen, K., Zheng, Y., Wei, J., Ouyang, H., Huang, X., Zhang, F., Lai, C. S. W., Ren, C., So, K., & Zhang, L. (2019) · Science Advances · doi:10.1126/sciadv.aaw1888 · Cited by 168
Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit
Cohen, C. C. H., Popovic, M. A., Klooster, J., Weil, M., Möbius, W., Nave, K., & Kole, M. H. P. (2019) · Cell · doi:10.1016/j.cell.2019.11.039 · Cited by 165
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
Wakhloo, D., Scharkowski, F., Curto, Y., Butt, U. J., Bansal, V., Steixner-Kumar, A. A., Wüstefeld, L., Rajput, A., Arinrad, S., Zillmann, M. R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15041-1 · Cited by 162
Salzer, J. L., & Zalc, B. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.074 · Cited by 161
Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160
Floriddia, E. M., Lourenço, T., Zhang, S., van Bruggen, D., Hilscher, M. M., Kukanja, P., dos Santos, J. P. G., Altınkök, M., Yokota, C., Llorens-Bobadilla, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19453-x · Cited by 163
Rapid and widespread white matter plasticity during an intensive reading intervention
Huber, E., Donnelly, P. M., Rokem, A., & Yeatman, J. D. (2018) · Nature Communications · doi:10.1038/s41467-018-04627-5 · Cited by 164
Glia as sculptors of synaptic plasticity
Sancho, L., Contreras, M., & Allen, N. J. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.11.005 · Cited by 160
Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10883 · Cited by 154
Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin
Franklin, R. J. M., Frisén, J., & Lyons, D. A. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.09.009 · Cited by 154
Demyelination as a rational therapeutic target for ischemic or traumatic brain injury
Shi, H., Hu, X., Leak, R. K., Shi, Y., An, C., Suenaga, J., Chen, J., & Gao, Y. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.017 · Cited by 159
Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain
Bechler, M. E., Swire, M., & ffrench‐Constant, C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22518 · Cited by 157
Kougioumtzidou, E., Shimizu, T., Hamilton, N. B., Tohyama, K., Sprengel, R., Monyer, H., Attwell, D., & Richardson, W. D. (2017) · eLife · doi:10.7554/elife.28080 · Cited by 154
Self-citationBurzynska, A. Z., Jiao, Y., Knecht, A. M., Fanning, J., Awick, E. A., Chen, T., Gothe, N., Voss, M. W., McAuley, E., & Kramer, A. F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00059 · Cited by 150
Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control
Djogo, T., Robins, S. C., Schneider, S. E., Kryzskaya, D., Liu, X., Mingay, A., Gillon, C. J., Kim, J. H., Storch, K.-F., Boehm, U., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.013 · Cited by 157
Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review
Buianova, I., & Arsalidou, M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.662031 · Cited by 158
Zhao, C., Dong, C., Frah, M., Deng, Y., Marie, C., Zhang, F., Xu, L., Ma, Z., Dong, X., Lin, Y., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.022 · Cited by 146
Li, Z., He, Y., Fan, S., & Sun, B. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1555-3 · Cited by 147
The molecular physiology of the axo-myelinic synapse
Micu, I., Plemel, J. R., Lachance, C., Proft, J., Jansen, A. J., Cummins, K., van Minnen, J., & Stys, P. K. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2015.10.006 · Cited by 140
Metadata
- Authors
- McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D.
- Affiliations
- University College London (GB)
- The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
- The University of Melbourne (AU)
- Iwate Medical University (JP)
- Corresponding author
- McKenzie, Ian A.
- Ohayon, David
- Richardson, William D.
- Venue
- Science
- Published
- 2014-10-17
- Volume
- 346
- Issue
- 6207
- Pages
- 318-322
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6324726
- OpenAlex
- W2085529478
- Cited by
- 1,177
- References
- 36
- Citations by year
- 2026: 68 · 2025: 90 · 2024: 103 · 2023: 107 · 2022: 101 · 2021: 146 · 2020: 108 · 2019: 122 · 2018: 83 · 2017: 101 · 2016: 88 · 2015: 53 · 2014: 3
- FWCI
- 28.41
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (100269, 100269/Z/12/Z, 066745)
- Biotechnology and Biological Sciences Research Council (BB/L003236/1)
- Japan Society for the Promotion of Science (24650181)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- motor skill learning, oligodendrocyte myelination, adult neurogenesis, white matter plasticity, oligodendrocyte precursor cells, juggling
- MeSH terms
- Animals, Brain, Humans, Learning, Male, Mice, Transgenic, Motor Skills, Myelin Sheath, Synaptic Transmission, Oligodendroglia, Mental Recall, Transcription Factors, Gene Deletion, Cell Proliferation, Mice
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