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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β
Abstract
Control of stability of β-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both β-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced β-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized β-catenin. Fragments of APC that contained a conductin-binding domain also blocked β-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs β-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.
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Metadata
- Authors
- Behrens, J., Jerchow, B.-A., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kühl, M., Wedlich, D., & Birchmeier, W.
- Venue
- Science
- Published
- 1998-04-24
- Volume
- 280
- Issue
- 5363
- Pages
- 596-599
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1544046482
- Cited by
- 1,260
- References
- 2
- FWCI
- 30.95
- Type
- journal article
- Language
- en
- Open access
- closed
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