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Bilirubin Is an Antioxidant of Possible Physiological Importance

Stocker, Roland, Yamamoto, Yorihiro, McDonagh, Antony F., Glazer, Alexander N., Ames, Bruce N.·1987·Science
DOI 10.1126/science.3029864
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Abstract

Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is shown here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated chemically in either homogeneous solution or multilamellar liposomes. The antioxidant activity of bilirubin increases as the experimental concentration of oxygen is decreased from 20% (that of normal air) to 2% (physiologically relevant concentration). Furthermore, under 2% oxygen, in liposomes, bilirubin suppresses the oxidation more than α-tocopherol, which is regarded as the best antioxidant of lipid peroxidation. The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.

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Metadata

Authors
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N.
Affiliations
  • Department of Biochemistry, University of California, Berkeley, CA 94720.
  • Department of Medicine and The Liver Center, university of California, San Francisco, CA 94143.
  • Department of Microbiology and Immunology, University of California, Berkeley, CA 94720.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1987-02-27
Volume
235
Issue
4792
Pages
1043-1046
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.3029864
Cited by
2,948
References
1
Language
en

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