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Cited by 1,223

The DOI matches its Crossref record.

Association of the APC Gene Product with β-Catenin

Rubinfeld, Bonnee, Souza, Brian, Albert, Iris, Müller, Oliver, Chamberlain, Scott H., Masiarz, Frank R., Munemitsu, Susan, Polakis, Paul·1993·Science
DOI 10.1126/science.8259518
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Abstract

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was purified and identified by sequencing as β-catenin, a protein that binds to the cell adhesion molecule E-cadherin. An antibody specific to β-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion.

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Metadata

Authors
Rubinfeld, B., Souza, B., Albert, I., Müller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S., & Polakis, P.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-12-10
Volume
262
Issue
5140
Pages
1731-1734
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8259518
OpenAlex
W2081758458
Cited by
1,223
References
0
FWCI
26.48
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.