An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Sheahan, Timothy P.; Sims, Amy C.; Zhou, Shuntai; Graham, Rachel L.; Pruijssers, Andrea J.; Agostini, Maria L.; Leist, Sarah R.; Schäfer, Alexandra; Dinnon, Kenneth H.; Stevens, Laura J.; Chappell, James D.; Lu, Xiaotao; Hughes, Tia M.; George, Amelia S.; Hill, Collin S.; Montgomery, Stephanie A.; Brown, Ariane J.; Bluemling, Gregory R.; Natchus, Michael G.; Saindane, Manohar; Kolykhalov, Alexander A.; Painter, George; Harcourt, Jennifer; Tamin, Azaibi; Thornburg, Natalie J.; Swanstrom, Ronald; Denison, Mark R.; Baric, Ralph S.

doi:10.1126/scitranslmed.abb5883

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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

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Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.abb5883

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A ribonucleoside analog inhibits SARS-CoV-2 in human airway epithelial cell cultures and SARS-CoV and MERS-CoV in mice.

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Authors: Sheahan, T. P., Sims, A. C., Zhou, S., Graham, R. L., Pruijssers, A. J., Agostini, M. L., Leist, S. R., Schäfer, A., Dinnon, K. H., Stevens, L. J., Chappell, J. D., Lu, X., Hughes, T. M., George, A. S., Hill, C. S., Montgomery, S. A., Brown, A. J., Bluemling, G. R., Natchus, M. G., Saindane, M., Kolykhalov, A. A., Painter, G., Harcourt, J., Tamin, A., Thornburg, N. J., Swanstrom, R., Denison, M. R., & Baric, R. S.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-04-29
Volume: 12
Issue: 541
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.abb5883
OpenAlex: W3014708904
Cited by: 1,071
References: 5
FWCI: 26.80
Type: journal article
Language: en
Open access: hybrid
Funders: National Institute of Allergy and Infectious Diseases (5U19AI109680, 5R01AI132178, AI108197, HHSN272201500008C, 1U19AI142759, F31AI133952, T32AI112541)

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This page: CoChat. (2026). Citation check: An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. https://app.cochat.ai/papers/10.1126/scitranslmed.abb5883
The paper: Sheahan, T. P., Sims, A. C., Zhou, S., Graham, R. L., Pruijssers, A. J., Agostini, M. L., Leist, S. R., Schäfer, A., Dinnon, K. H., Stevens, L. J., Chappell, J. D., Lu, X., Hughes, T. M., George, A. S., Hill, C. S., Montgomery, S. A., Brown, A. J., Bluemling, G. R., Natchus, M. G., . . . Baric, R. S. (2020). An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.abb5883

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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

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