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Cited by 916Probiotics and Fermented FoodsBacterial Genetics and BiotechnologyMicrobial Inactivation Methods

The DOI matches its Crossref record; 647 of the 647 references it cites were found in a registry or an index.

Stress Physiology of Lactic Acid Bacteria.

Open access
Papadimitriou, Konstantinos, Alegría, Ángel, Bron, Peter A., de Angelis, Maria, Gobbetti, Marco, Kleerebezem, Michiel, Lemos, José A., Linares, Daniel M., Ross, Paul, Stanton, Catherine, Turroni, Francesca, van Sinderen, Douwe, Varmanen, Pekka, Ventura, Marco, Zúñiga, Manuel, Tsakalidou, Effie, Kok, Jan·2016·Microbiology and Molecular Biology Reviews
DOI 10.1128/mmbr.00076-15PMC PMC4981675
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Abstract

Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms. The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by the technological implications of LAB robustness in the food industry. Survival of probiotic LAB in the host and the potential relatedness of LAB virulence to their stress resilience have intensified interest in the field. Thus, a wealth of information concerning stress responses exists today for strains as diverse as starter (e.g., Lactococcus lactis), probiotic (e.g., several Lactobacillus spp.), and pathogenic (e.g., Enterococcus and Streptococcus spp.) LAB. Here we present the state of the art for LAB stress behavior. We describe the multitude of stresses that LAB are confronted with, and we present the experimental context used to study the stress responses of LAB, focusing on adaptation, habituation, and cross-protection as well as on self-induced multistress resistance in stationary phase, biofilms, and dormancy. We also consider stress responses at the population and single-cell levels. Subsequently, we concentrate on the stress defense mechanisms that have been reported to date, grouping them according to their direct participation in preserving cell energy, defending macromolecules, and protecting the cell envelope. Stress-induced responses of probiotic LAB and commensal/pathogenic LAB are highlighted separately due to the complexity of the peculiar multistress conditions to which these bacteria are subjected in their hosts. Induction of prophages under environmental stresses is then discussed. Finally, we present systems-based strategies to characterize the "stressome" of LAB and to engineer new food-related and probiotic LAB with improved stress tolerance.

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Research works printed but not linked: 3

  1. Henick-Kling T, Cox DJ, Olsen EB. 1991. Production de l'energie durant la fermentation malolactique. Rev Fr Oenol 132:63–66.
  2. Aprea G, Mullan WMA, Mullan A, Murru N, Tozzi M, Cortesi ML. 2005. Isolation of polyphosphate-accumulating lactic acid bacteria from natural whey starters. Milchwissenschaft 60:256–258.
  3. Lim B, Gross CA. 2011. Cellular response to heat shock and cold shock, p 93–114. In Storz G, Hengge R (ed), Bacterial stress responses, 2nd ed. ASM Press, Washington, DC.

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Metadata

Authors
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., Turroni, F., van Sinderen, D., Varmanen, P., Ventura, M., Zúñiga, M., Tsakalidou, E., & Kok, J.
Affiliations
  • Agricultural University of Athens (GR)
  • University of Groningen (NL)
  • TiFN (NL)
  • Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy
  • University of Bari Aldo Moro (IT)
  • Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA
  • Teagasc - The Irish Agriculture and Food Development Authority (IE)
  • APC, Microbiome Institute, University College Cork, Cork, Ireland
  • University of Parma (IT)
  • University of Helsinki (FI)
  • Consejo Superior de Investigaciones Científicas (ES)
ORCID
Venue
Microbiology and Molecular Biology Reviews
Publisher
American Society for Microbiology
Published
2016-09
Volume
80
Issue
3
Pages
837-890
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
DOI
10.1128/mmbr.00076-15
PMC
PMC4981675
OpenAlex
W2499564842
Cited by
914
References
646
Citations by year
2026: 173 · 2025: 163 · 2024: 97 · 2023: 92 · 2022: 86 · 2021: 92 · 2020: 83 · 2019: 56 · 2018: 48 · 2017: 20 · 2016: 3
FWCI
4.84
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Microbiology and Molecular Biology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • Open Research (University of Surrey) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • European Commission (2007–2013, FP7 2007-2013, FP7/2007, 623448)
  • Science Foundation Ireland (13/IA/1953, 12/RC/2273, 12/RC/)
  • APC Microbiome Institute
  • National Institute of Dental and Craniofacial Research (DE019783, DE022559, R01DE019783, R01DE022559)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
Keywords
lactic acid bacteria, stress physiology, stress response, probiotics, Lactobacillus, Lactococcus lactis, Enterococcus, Streptococcus, stress tolerance, biofilm, dormancy, prophage induction, stress tolerance engineering, food industry
MeSH terms
Energy Metabolism, Fermentation, Food Microbiology, Lactobacillus, Osmotic Pressure, Streptococcus, Stress, Physiological, Signal Transduction, Enterococcus, Biofilms, Lactic Acid, Probiotics

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