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Cited by 851

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue

Ouchi, Noriyuki, Kihara, Shinji, Funahashi, Tohru, Nakamura, Tadashi, Nishida, Makoto, Kumada, Masahiro, Okamoto, Yoshihisa, Ohashi, Koji, Nagaretani, Hiroyuki, Kishida, Ken, Nishizawa, Hitoshi, Maeda, Norikazu, Kobayashi, Hideki, Hiraoka, Hisatoyo, Matsuzawa, Yuji·2003·Circulation
DOI 10.1161/01.cir.0000055188.83694.b3
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Abstract

Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma protein which was secreted specifically from adipocytes. The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue. Methods and Results— We studied a total of 101 male patients, 71 of whom had angiographically documented coronary atherosclerosis. As a control group, 30 patients with normal coronary angiogram were included. The plasma hs-CRP levels were negatively correlated with the plasma adiponectin levels ( r =−0.29, P <0.01). The plasma adiponectin concentrations were significantly lower and the hs-CRP levels were significantly higher in the CAD patients compared with control subjects. The mRNA levels of CRP and adiponectin were analyzed by quantitative real-time polymerase chain reaction method. We found that the CRP mRNA was expressed in human adipose tissue. A significant inverse correlation was observed between the CRP and adiponectin mRNA levels in human adipose tissue ( r =−0.89, P <0.01). In addition, the CRP mRNA level of white adipose tissue in adiponectin deficient mice was higher than that of wild-type mice. Conclusions— The reciprocal association of adiponectin and CRP levels in both human plasma and adipose tissue might participate in the development of atherosclerosis.

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Metadata

Authors
Ouchi, N., Kihara, S., Funahashi, T., Nakamura, T., Nishida, M., Kumada, M., Okamoto, Y., Ohashi, K., Nagaretani, H., Kishida, K., Nishizawa, H., Maeda, N., Kobayashi, H., Hiraoka, H., & Matsuzawa, Y.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-02-11
Volume
107
Issue
5
Pages
671-674
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000055188.83694.b3
OpenAlex
W2104340251
Cited by
851
References
5
FWCI
46.41
Type
journal article
Language
en
Open access
closed

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