The DOI matches its Crossref record.
Role of oxidized low density lipoprotein in atherogenesis.
Open accessAbstract
Abbreviations used in this paper: CAD, coronary artery disease; EDRF, endothelial-dependent relaxing factor; MDA-LDL, malodial- dehyde-conjugated LDL; Ox-LDL, oxidized LDL. per (Fig. 1).In addition, LDL can be oxidized by incubation with crude soybean lipoxygenase (9).Several lines of evidence suggest that oxidation induced by endothelial cells (10) or by macrophages ( 11) depends on lipoperoxides generated intracel- lularly and then transferred to the LDL.Cellular lipoxygenases, especially 1 5-lipoxygenase, appear to be involved (10, 1 1).Al- ternatively, reactive oxygen species, such as superoxide anion, may be secreted into the medium, leading to initiation of lipid peroxidation in the LDL.This mechanism may predominate in smooth muscle cells (7).Once the LDL is "seeded" with Role ofOxidized Low Density Lipoprotein in Atherogenesis 1785
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304
Swirski, F. K., Libby, P., Aikawa, E., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,148
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080
Napoli, C., D'Armiento, F. P., Mancini, F. P., Postiglione, A., Witztum, J. L., Palumbo, G., & Palinski, W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119813 · Cited by 1,014
Self-citationObesity, inflammation, and atherosclerosis
Rocha, V. Z., & Libby, P. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.55 · Cited by 994
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822
Boekholdt, S. M., Arsenault, B. J., Mora, S., Pedersen, T. R., LaRosa, J. C., Nestel, P. J., Simes, R. J., Durrington, P., Hitman, G. A., Welch, K. M. A., et al. (2012) · JAMA · doi:10.1001/jama.2012.366 · Cited by 795
A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism
Febbraio, M., Abumrad, N. A., Hajjar, D. P., Sharma, K., Cheng, W., Pearce, S. F. A., & Silverstein, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19055 · Cited by 769
Watson, A. D., Leitinger, N., Navab, M., Faull, K. F., Hörkkö, S., Witztum, J. L., Palinski, W., Schwenke, D., Salomon, R. G., Sha, W., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13597 · Cited by 753
Self-citationLack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice
Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., & Seishima, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000064374.15232.c3 · Cited by 748
Miettinen, T. A., Puska, P., Gylling, H., Vanhanen, H., & Vartiainen, E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332002 · Cited by 739
The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease
Erdmann, K., Cheung, B. W. Y., & Schröder, H. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.11.010 · Cited by 717
Parhami, F., Morrow, A. D., Balucan, J., Leitinger, N., Watson, A. D., Tintut, Y., Berliner, J. A., & Demer, L. L. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.4.680 · Cited by 619
Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease
Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A. (1996) · Circulation · doi:10.1161/01.cir.93.6.1107 · Cited by 582
O’Brien, K. D., Reichenbach, D. D., Marcovina, S. M., Kuusisto, J., Alpers, C. E., & Otto, C. M. (1996) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.16.4.523 · Cited by 560
Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease
Patrono, C., & FitzGerald, G. A. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.11.2309 · Cited by 453
Polyunsaturated Fatty Acids, Antioxidants, and Cognitive Function in Very Old Men
Kalmijn, S., Feskens, E. J. M., Launer, L. J., & Kromhout, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009029 · Cited by 453
Meisinger, C., Baumert, J., Khuseyinova, N., Loewel, H., & Koenig, W. (2005) · Circulation · doi:10.1161/circulationaha.104.529297 · Cited by 434
Presence of Oxidized Low Density Lipoprotein in Nonrheumatic Stenotic Aortic Valves
Olsson, M., Thyberg, J., & Nilsson, J. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.5.1218 · Cited by 417
Mitochondrial dysfunction in cardiovascular disease
Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405
Napoli, C., Martin-Padura, I., de Nigris, F., Giorgio, M., Mansueto, G., Somma, P., Condorelli, M., Sica, G., De Rosa, G., & Pelicci, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336359100 · Cited by 380
Chalasani, N., Deeg, M. A., & Crabb, D. W. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30159.x · Cited by 343
Devaraj, S., Li, D., & Jialal, I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118848 · Cited by 333
REQUENA, J. R., FU, M. X., AHMED, M. U., JENKINS, A. J., LYONS, T. J., BAYNES, J. W., & THORPE, S. R. (1997) · Biochemical Journal · doi:10.1042/bj3220317 · Cited by 293
Itabe, H., Takeshima, E., Iwasaki, H., Kimura, J., Yoshida, Y., Imanaka, T., & Takano, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36602-4 · Cited by 282
Characterization of antioxidants present in hawthorn fruits
Zhang, Z., Chang, Q., Zhu, M., Huang, Y., Ho, W. K. K., & Chen, Z.-Y. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00137-6 · Cited by 272
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271
Ulfig, A., & Leichert, L. I. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03591-y · Cited by 239
Gender-specific care of the patient with diabetes: review and recommendations
Legato, M. J., Gelzer, A., Goland, R., Ebner, S. A., Rajan, S., Villagra, V., & Kosowski, M. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80202-0 · Cited by 225
Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.
Gimbrone, M. A. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)80016-l · Cited by 225
Hazen, S. L., Hsu, F. F., Duffin, K., & Heinecke, J. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23080 · Cited by 221
Riss, J., Décordé, K., Sutra, T., Delage, M., Baccou, J.-C., Jouy, N., Brune, J.-P., Oréal, H., Cristol, J.-P., & Rouanet, J.-M. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070529g · Cited by 208
Chen, K., Febbraio, M., Li, W., & Silverstein, R. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.172064 · Cited by 202
Thukkani, A. K., McHowat, J., Hsu, F.-F., Brennan, M.-L., Hazen, S. L., & Ford, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000104564.01539.6a · Cited by 194
Tea and cardiovascular disease
Deka, A., & Vita, J. A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.03.009 · Cited by 184
Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis
Ursini, F., Zamburlini, A., Cazzolato, G., Maiorino, M., Bon, G. B., & Sevanian, A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00044-6 · Cited by 172
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158
Spickett, C. M., Jerlich, A., Panasenko, O. M., Arnhold, J., Pitt, A. R., Stelmaszyńska, T., & Schaur, R. J. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_3944 · Cited by 154
Pathophysiology and clinical significance of atherosclerotic plaque rupture
Gutstein, D. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00322-8 · Cited by 151
Oxidized Phosphatidylcholines That Modify Proteins
Itabe, H., Yamamoto, H., Suzuki, M., Kawai, Y., Nakagawa, Y., Suzuki, A., Imanaka, T., & Takano, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33208 · Cited by 128
Okura, Y., Brink, M., Itabe, H., Scheidegger, K. J., Kalangos, A., & Delafontaine, P. (2000) · Circulation · doi:10.1161/01.cir.102.22.2680 · Cited by 126
Yi, X., & Maeda, N. (2006) · Diabetes · doi:10.2337/db06-0251 · Cited by 117
Napoli, C., Witztum, J. L., de Nigris, F., Palumbo, G., D’Armiento, F. P., & Palinski, W. (1999) · Circulation · doi:10.1161/01.cir.99.15.2003 · Cited by 110
Self-citationCharlton-Menys, V., Betteridge, D. J., Colhoun, H., Fuller, J., France, M., Hitman, G. A., Livingstone, S. J., Neil, H. A. W., Newman, C. B., Szarek, M., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.111401 · Cited by 94
Rodríguez‐Villar, C., Pérez‐Heras, A., Mercadé, I., Casals, E., & Ros, E. (2004) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01086.x · Cited by 84
Blum, S., Aviram, M., Ben-Amotz, A., & Levy, Y. (2006) · Annals of Nutrition and Metabolism · doi:10.1159/000089560 · Cited by 73
Hofmann, A., Brunssen, C., & Morawietz, H. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2017.10.002 · Cited by 68
Chen, C.-Y., Yi, L., Jin, X., Zhang, T., Fu, Y.-J., Zhu, J.-D., Mi, M.-T., Zhang, Q.-Y., Ling, W.-H., & Yu, B. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9216-2 · Cited by 61
Yuan, X. M. (1999) · Free Radical Research · doi:10.1080/10715769900300241 · Cited by 59
Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., & Huff, M. W. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.9.1707 · Cited by 59
Dietary and Pharmacological Fatty Acids and Cardiovascular Health
Wu, H., Xu, L., & Ballantyne, C. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz174 · Cited by 59
Pardo-Andreu, G. L., Paim, B. A., Castilho, R. F., Velho, J. A., Delgado, R., Vercesi, A. E., & Oliveira, H. C. F. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.03.005 · Cited by 58
Plasma myeloperoxidase is related to the severity of coronary artery disease
Düzgünçinar, Ö., Yavuz, B., Hazirolan, T., Deniz, A., Tokgözoglu, S. L., Akata, D., & Demirpençe, E. (2008) · Acta Cardiologica · doi:10.2143/ac.63.2.2029520 · Cited by 54
Martin-Padura, I., de Nigris, F., Migliaccio, E., Mansueto, G., Minardi, S., Rienzo, M., Lerman, L. O., Stendardo, M., Giorgio, M., De Rosa, G., et al. (2008) · Endothelium · doi:10.1080/10623320802487791 · Cited by 52
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation
Gaut, J. P., Belaaouaj, A., Byun, J., Roberts, L. J., Maeda, N., Frei, B., & Heinecke, J. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.013 · Cited by 48
Nishimura, H., Higuchi, O., Tateshita, K., Tomobe, K., Okuma, Y., & Nomura, Y. (2006) · BioFactors · doi:10.1002/biof.5520260204 · Cited by 47
Fish oil and the management of hypertriglyceridemia
Mattar, M., & Obeid, O. (2009) · Nutrition and Health · doi:10.1177/026010600902000105 · Cited by 43
Holven, K. B., Scholz, H., Halvorsen, B., Aukrust, P., Ose, L., & Nenseter, M. S. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.11.3588 · Cited by 42
The effects of green tea ingestion over four weeks on atherosclerotic markers
Sung, H., Min, W.-K., Lee, W., Chun, S., Park, H., Lee, Y.-W., Jang, S., & Lee, D.-H. (2005) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/0004563054255597 · Cited by 35
Are dietary fish oil supplements appropriate for dyslipidemia management? A review of the evidence
Sherratt, S. C. R., Lero, M., & Mason, R. P. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000665 · Cited by 33
Álvarez, R., Carvalho, C. P., Sierra, J., Lara, O., Cardona, D., & Londoño-Londoño, J. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203353h · Cited by 32
Ito, T., Fujita, H., Tani, T., & Ohte, N. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.026 · Cited by 30
Metadata
- Authors
- Witztum, J. L., & Steinberg, D.
- Venue
- Journal of Clinical Investigation
- Published
- 1991-12-01
- Volume
- 88
- Issue
- 6
- Pages
- 1785-1792
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W3022864527
- Cited by
- 2,675
- References
- 0
- FWCI
- 32.94
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.