The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins
Abstract
OBJECTIVE: The authors previously reported that in monozygotic twins discordant for schizophrenia the affected twin almost invariably had a smaller anterior pes hippocampus, measured with magnetic resonance imaging (MRI), and invariably had less regional cerebral blood flow (rCBF) in the dorsolateral prefrontal cortex during performance of the Wisconsin Card Sorting Test. The present study was an investigation of the relationship between hippocampal pathology and prefrontal hypofunction in the same twin pairs. METHOD: Nine pairs of monozygotic twins discordant for schizophrenia underwent MRI scanning for determination of anterior hippocampal volume and xenon-inhalation rCBF testing for determination of prefrontal physiological activation associated with the Wisconsin Card Sorting Test. RESULTS: The differences within twin pairs on the MRI and rCBF measures were strongly and selectively correlated. Specifically, the more an affected twin differed from the unaffected twin in left hippocampal volume, the more they differed in prefrontal physiological activation during the Wisconsin Card Sorting Test. In the affected twins as a group, prefrontal activation was strongly related to both left and right hippocampal volume. These relationships were not found in the group of unaffected twins. CONCLUSIONS: This finding is consistent with the notion that schizophrenia involves pathology of and dysfunction within a widely distributed neocortical-limbic neural network that has been implicated in, among other activities, the performance of cognitive tasks requiring working memory.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Cited by
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Self-citationThe neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Corcoran, R., Mercer, G., & Frith, C. D. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)00024-g · Cited by 1,340
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
Stephan, K. E., Friston, K. J., & Frith, C. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn176 · Cited by 1,134
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909
Structural MRI of pediatric brain development: what have we learned and where are we going?
Giedd, J. N., & Rapoport, J. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.040 · Cited by 836
Synaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841
A review of diffusion tensor imaging studies in schizophrenia
Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668
Meyer-Lindenberg, A. S., Olsen, R. K., Kohn, P. D., Brown, T., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.379 · Cited by 574
Self-citationImpaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S., Goff, D., Savage, C., Schacter, D., Fischman, A., & Alpert, N. (1998) · Nature Neuroscience · doi:10.1038/1137 · Cited by 570
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530
Prefrontal cortex regulates inhibition and excitation in distributed neural networks
Knight, R. T., Richard Staines, W., Swick, D., & Chao, L. L. (1999) · Acta Psychologica · doi:10.1016/s0001-6918(99)00004-9 · Cited by 498
Electron microscopy of oligodendroglia in severe mental illness
Uranova, N., Orlovskaya, D., Vikhreva, O., Zimina, I., Kolomeets, N., Vostrikov, V., & Rachmanova, V. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00528-7 · Cited by 495
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494
Blair, C. (2006) · Behavioral and Brain Sciences · doi:10.1017/s0140525x06009034 · Cited by 434
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376
Social threat perception and the evolution of paranoia
Green, M. J., & Phillips, M. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.006 · Cited by 369
An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia
Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K., Wilkins, J., Gerner, R., & Mintz, J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00836-2 · Cited by 369
Blair, C., Granger, D., & Peters Razza, R. (2005) · Child Development · doi:10.1111/j.1467-8624.2005.00863.x · Cited by 367
The basal ganglia and cognitive pattern generators
Graybiel, A. M. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.459 · Cited by 351
Giedd, J. N., Raznahan, A., Alexander-Bloch, A., Schmitt, E., Gogtay, N., & Rapoport, J. L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.236 · Cited by 297
Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease
Sigurdsson, T., & Duvarci, S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00190 · Cited by 309
Heinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00628-4 · Cited by 270
Neuropsychological evidence for frontostriatal dysfunction in schizophrenia
Elliott, R., McKenna, P. J., Robbins, T. W., & Sahakian, B. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700033523 · Cited by 267
The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges
Lilienfeld, S. O. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.07.019 · Cited by 248
Event-Related fMRI of Frontotemporal Activity During Word Encoding and Recognition in Schizophrenia
Ragland, J. D., Gur, R. C., Valdez, J., Turetsky, B. I., Elliott, M., Kohler, C., Siegel, S., Kanes, S., & Gur, R. E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.6.1004 · Cited by 206
Highley, J. R. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.11.1218 · Cited by 207
Schneider, F., Gur, R. E., Mozley, L. H., Smith, R. J., Mozley, P. D., Censits, D. M., Alavi, A., & Gur, R. C. (1995) · Psychiatry Research: Neuroimaging · doi:10.1016/0925-4927(95)02678-q · Cited by 188
Kumar, A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00124-4 · Cited by 181
Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.029 · Cited by 176
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141
Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging
Rapoport, J. L., & Gogtay, N. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301553 · Cited by 132
Nakao (2005) · doi:10.1016/j.pscychresns.2005.04.003 · Cited by 132
Fallgatter, A. J., & Strik, W. K. (1998) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050045 · Cited by 130
Lataster, J., Myin‐Germeys, I., Lieb, R., Wittchen, H. ‐., & van Os, J. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01805.x · Cited by 117
Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia
Le Pen, G., Grottick, A. J., Higgins, G. A., & Moreau, J.-L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300208 · Cited by 82
Schaer, M., Eric Schmitt, J., Glaser, B., Lazeyras, F., Delavelle, J., & Eliez, S. (2006) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.10.002 · Cited by 76
Kikuchi, M., Hashimoto, T., Nagasawa, T., Hirosawa, T., Minabe, Y., Yoshimura, M., Strik, W., Dierks, T., & Koenig, T. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.003 · Cited by 74
Kawashima, T., Nakamura, M., Bouix, S., Kubicki, M., Salisbury, D. F., Westin, C.-F., McCarley, R. W., & Shenton, M. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.014 · Cited by 65
Lohse, C., Bassett, D. S., Lim, K. O., & Carlson, J. M. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003712 · Cited by 62
The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems
Fallon, J. H., Opole, I. O., & Potkin, S. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00022-7 · Cited by 53
Heritability of the limbic networks
Budisavljevic, S., Kawadler, J. M., Dell'Acqua, F., Rijsdijk, F. V., Kane, F., Picchioni, M., McGuire, P., Toulopoulou, T., Georgiades, A., Kalidindi, S., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv156 · Cited by 46
Model-based dynamical analysis of functional disconnection in schizophrenia
Bányai, M., Diwadkar, V. A., & Érdi, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.046 · Cited by 40
Kubicki, M., Niznikiewicz, M., Connor, E., Ungar, L., Nestor, P. G., Bouix, S., Dreusicke, M., Kikinis, R., McCarley, R. W., & Shenton, M. E. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-009-9061-8 · Cited by 38
The Reticular Formation and the Limbic System
Strominger, N. L., Demarest, R. J., & Laemle, L. B. (2012) · Noback's Human Nervous System, Seventh Edition · doi:10.1007/978-1-61779-779-8_22 · Cited by 9
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1992-07-01
- Volume
- 149
- Issue
- 7
- Pages
- 890-897
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W144271823
- Cited by
- 668
- References
- 3
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
