A randomized controlled trial of Internet-delivered CBT and attention bias modification for early intervention of depression
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The conceptualization and empirical knowledge base related to major depression has increased dramatically in recent years. We now have well-developed and validated models of depression from a range of theoretical perspectives. These models have significantly enhanced the development of effective treatments and preventative interventions. Although various prevention programs are available, Web-based protocols can enhance accessibility to evidence-based prevention programs. The current study involved a randomized controlled trial focused on the prevention and treatment of depression in high-risk first- and second-year undergraduate students. Three Internet-delivered preventative programs were compared: cognitive behavioral therapy (CBT; MoodGym), attentional bias modification, and an active attentional control condition. Participants ( n = 350) completed symptom measurement pre- and post-intervention (6 weeks) and again at a 4-month follow-up, when they were also administered a structured diagnostic interview. Participants in the CBT condition showed more dramatic and continuous depressive symptom improvement between baseline and follow-up than did participants in the other two conditions. In addition, significantly fewer individuals in CBT condition met diagnostic criteria for major depression at follow-up than in the other conditions. These findings have important implications for future early intervention research and practice.
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Web-based interventions have been shown to effectively reduce the severity of symptoms of depression.
“web-based interventions have been shown to effectively reduce the severity of symptoms of depression [10], anxiety [11], and social anxiety [12]”
From Web-Based Interventions to Help Australian Adults Address Depression, Anxiety, Suicidal Ideation, and General Mental Well-being: Scoping Review (2022) · cites this paper as [10]
The quality of evidence for web-based interventions is high, with randomized controlled trials and systematic reviews illustrating their value.
“The quality of this evidence is high, with a number of randomized controlled trials (RCTs; eg, the studies by McDermott et al [10], Powell et al [12], and Kiropoulos et al [13]) and systematic reviews (eg, the studies by Renton et al [15] and Ashford et al [16]) illustrating their value.”
From Web-Based Interventions to Help Australian Adults Address Depression, Anxiety, Suicidal Ideation, and General Mental Well-being: Scoping Review (2022) · cites this paper as [10]
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Gaete, J., Núñez, D., Romo, V., Meza, D., Robinson, J., & Araya, R. (2025) · Pilot and Feasibility Studies · doi:10.1186/s40814-025-01738-x
- Authors
- McDermott, R., & Dozois, D. J. A.
- Affiliations
- Western University (CA)
- Corresponding author
- Dozois, David J. A.
- ORCID
- Dozois, David J. A.
- Venue
- Journal of Experimental Psychopathology
- Publisher
- SAGE Publications
- Published
- 2019-04-01
- Volume
- 10
- Issue
- 2
- ISSN
- 2043-8087 (ISSN-L)
- OpenAlex
- W2949015066
- Cited by
- 18
- References
- 81
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2019: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Experimental Psychopathology (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Scholarship@Western (Western University) (submittedVersion, cc-by-nc)
- Funders
- University of Western Ontario, Academic Development Fund (Major Grants Competition), New Research and Scholarly Initiative Awards
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
- Keywords
- depression prevention, early intervention, internet-based cognitive behavioral therapy, attentional bias modification, attentional control, MoodGYM, university students, vulnerable populations, depressive symptoms
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