Cited by 150Seaweed-derived Bioactive CompoundsCell death mechanisms and regulationEchinoderm biology and ecology

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Apoptosis Inducing Activity of Fucoidan in HCT-15 Colon Carcinoma Cells

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Hyun, Jae-Hee, Kim, Sang-Cheol, Kang, Jung-Il, Kim, Min-Kyoung, Boo, Hye-Jin, Kwon, Jung-Mi, Koh, Young-Sang, Hyun, Jin-Won, Park, Deok-Bae, Yoo, Eun-Sook, Kang, Hee-Kyoung·2009·Biological & Pharmaceutical Bulletin

DOI 10.1248/bpb.32.1760

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Abstract

The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several apoptotic events such as DNA fragmentation, chromatin condensation and increase of the population of sub-G1 hypodiploid cells were observed. In the mechanism of fucoidan-induced apoptosis, we examined changes in Bcl-2 and Bax protein expression levels and activation of caspases. Fucoidan decreased Bcl-2 expression, whereas the expression of Bax was increased in a time-dependent manner compared to the control. In addition, the active forms of caspase-9 and caspase-3 were increased, and the cleavage of poly(ADP-ribose) polymerase (PARP), a vital substrate of effector caspase, was observed. Furthermore, the induction of apoptosis was also accompanied by a strong activation of extracellular signal-regulated kinase (ERK) and p38 kinase and an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a time-dependent manner. These findings provide evidence demonstrating that the pro-apoptotic effect of fucoidan is mediated through the activation of ERK, p38 and the blocking of the PI3K/Akt signal pathway in HCT-15 cells. These data support the hypothesis that fucoidan may have potential in colon cancer treatment.

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Authors: Hyun, J.-H., Kim, S.-C., Kang, J.-I., Kim, M.-K., Boo, H.-J., Kwon, J.-M., Koh, Y.-S., Hyun, J.-W., Park, D.-B., Yoo, E.-S., & Kang, H.-K.
Affiliations: Jeju National University (KR)
School of Medicine, Institute of Medical Sciences, Jeju National University
ORCID: Kim, Sang-Cheol
Boo, Hye-Jin
Kwon, Jung-Mi
Hyun, Jin-Won
Yoo, Eun-Sook
Kang, Hee-Kyoung
Venue: Biological & Pharmaceutical Bulletin
Publisher: Pharmaceutical Society of Japan
Published: 2009
Volume: 32
Issue: 10
Pages: 1760-1764
ISSN: 0918-6158 (ISSN-L)
1347-5215
DOI: 10.1248/bpb.32.1760
OpenAlex: W2084350967
Cited by: 150
References: 35
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 13 · 2020: 8 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 5
FWCI: 11.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological and Pharmaceutical Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: Jeju National University
Jeju National University Hospital
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords: fucoidan, Fucus vesiculosus, apoptosis, colon cancer, HCT-15 cells, Bcl-2, Bax, caspase-9, caspase-3, PARP cleavage, ERK, p38 MAPK, PI3K/Akt signaling, anticancer activity
MeSH terms: Adenocarcinoma, Antineoplastic Agents, Phytogenic, Colonic Neoplasms, Humans, Phytotherapy, Plant Extracts, Poly(ADP-ribose) Polymerases, Polysaccharides, Signal Transduction, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Phosphatidylinositol 3-Kinases, Fucus, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases, bcl-2-Associated X Protein, Proto-Oncogene Proteins c-akt, Caspase 3, Caspase 9

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Apoptosis Inducing Activity of Fucoidan in HCT-15 Colon Carcinoma Cells

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