CoChat
Sign Up
Cited by 250

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

Hiona, Asimina, Sanz, Alberto, Kujoth, Gregory C., Pamplona, Reinald, Seo, Arnold Y., Hofer, Tim, Someya, Shinichi, Miyakawa, Takuya, Nakayama, Chie, Samhan-Arias, Alejandro K., Servais, Stephane, Barger, Jamie L., Portero-Otín, Manuel, Tanokura, Masaru, Prolla, Tomas A., Leeuwenburgh, Christiaan·2010·PLoS ONE
DOI 10.1371/journal.pone.0011468PMC PMC2898813
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0011468

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Cells from mice deficient in mitochondrial DNA polymerase γ show impaired mitochondrial function but this is not accompanied by increased ROS production.

    “Cells from these mice show impaired mitochondrial function but, unexpectedly, this is not accompanied by increased ROS production (Edgar et al., 2009; Hiona et al., 2010).”

    From The Hallmarks of Aging (2013) · cites this paper as Hiona et al., 2010

    The Results (‘Mitochondrial bioenergetics is impaired in D257A mice’; page unavailable) report reduced respiration in skeletal-muscle mitochondria. The Results (‘Skeletal muscle mitochondria from D257A mice produce significantly fewer ROS’; page unavailable) report decreased H2O2 production, supporting the absence of increased ROS. The paper’s measurements are of skeletal-muscle mitochondria, however, not cells from these mice generally. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In mice, genetic manipulations that impair mitochondrial function but do not increase ROS accelerate aging.

    “genetic manipulations that impair mitochondrial function but do not increase ROS accelerate aging”

    From The Hallmarks of Aging (2013) · cites this paper as Hiona et al., 2010

    The Introduction reports accelerated aging in genetically engineered D257A mice, and the Results report impaired mitochondrial bioenergetics. The Discussion reports decreased mitochondrial ROS production in D257A skeletal muscle, but cautions that ROS production may be tissue-specific. Thus the paper supports the claim for this mouse model, not for genetic manipulations generally or for ROS levels in every tissue. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Dysfunctional mitochondria can contribute to aging independently of ROS, as exemplified by studies with mice deficient in DNA polymerase γ.

    “Dysfunctional mitochondria can contribute to aging independently of ROS, as exemplified by studies with mice deficient in DNA polymerase γ”

    From The Hallmarks of Aging (2013) · cites this paper as Hiona et al., 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 76

  1. R Roubenoff, 2000, Sarcopenia and its implications for the elderly., Eur J Clin Nutr, 54, S40, 10.1038/sj.ejcn.1601024 · DOI
  2. I Janssen, 2004, Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women., Am J Epidemiol, 159, 413, 10.1093/aje/kwh058 · DOI · Paper page
  3. MF Alexeyev, 2004, Mitochondrial DNA and aging., Clin Sci (Lond), 107, 355, 10.1042/CS20040148 · DOI
  4. A Hiona, 2008, The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging., Exp Gerontol, 43, 24, 10.1016/j.exger.2007.10.001 · DOI · Paper page
  5. G Barja, 2000, Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals., Faseb J, 14, 312, 10.1096/fasebj.14.2.312 · DOI
  6. A Herrero, 1999, 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging., Aging (Milano), 11, 294
  7. VA Bohr, 1999, Oxidative DNA damage processing in nuclear and mitochondrial DNA., Biochimie, 81, 155, 10.1016/S0300-9084(99)80048-0 · DOI
  8. NB Larsen, 2005, Nuclear and mitochondrial DNA repair: similar pathways?, Mitochondrion, 5, 89, 10.1016/j.mito.2005.02.002 · DOI
  9. DM Wilson 3rd, 2007, The mechanics of base excision repair, and its relationship to aging and disease., DNA Repair (Amst), 6, 544, 10.1016/j.dnarep.2006.10.017 · DOI
  10. D Harman, 1972, Free radical theory of aging: dietary implications., Am J Clin Nutr, 25, 839, 10.1093/ajcn/25.8.839 · DOI
  11. D Harman, 1972, The biologic clock: the mitochondria?, J Am Geriatr Soc, 20, 145, 10.1111/j.1532-5415.1972.tb00787.x · DOI
  12. JE Fleming, 1982, Is cell aging caused by respiration-dependent injury to the mitochondrial genome?, Gerontology, 28, 44, 10.1159/000212510 · DOI
  13. J Wanagat, 2001, Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia., Faseb J, 15, 322, 10.1096/fj.00-0320com · DOI · Paper page
  14. M Khaidakov, 2003, Accumulation of point mutations in mitochondrial DNA of aging mice., Mutat Res, 526, 1, 10.1016/S0027-5107(03)00010-1 · DOI
  15. M Corral-Debrinski, 1992, Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease., Mutat Res, 275, 169, 10.1016/0921-8734(92)90021-G · DOI
  16. CM Lee, 1993, Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys., J Gerontol, 48, B201, 10.1093/geronj/48.6.B201 · DOI
  17. Y Wang, 2001, Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication., Proc Natl Acad Sci U S A, 98, 4022, 10.1073/pnas.061013598 · DOI
  18. GC Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging., Science, 309, 481, 10.1126/science.1112125 · DOI · Paper page
  19. DL Troyer, 1990, A rapid and reliable sequential staining method for bovine muscle., Anat Histol Embryol, 19, 154, 10.1111/j.1439-0264.1990.tb00899.x · DOI
  20. SY Kim, 2005, PAGE: parametric analysis of gene set enrichment., BMC Bioinformatics, 6, 144, 10.1186/1471-2105-6-144 · DOI
  21. MC Wei, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death., Science, 292, 727, 10.1126/science.1059108 · DOI · Paper page
  22. MG Edwards, 2007, Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program., BMC Genomics, 8, 80, 10.1186/1471-2164-8-80 · DOI · Paper page
  23. D Edgar, 2009, Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice., Cell Metab, 10, 131, 10.1016/j.cmet.2009.06.010 · DOI · Paper page
  24. GA Cortopassi, 1990, Detection of a specific mitochondrial DNA deletion in tissues of older humans., Nucleic Acids Res, 18, 6927, 10.1093/nar/18.23.6927 · DOI
  25. AW Linnane, 1990, Mitochondrial gene mutation: the ageing process and degenerative diseases., Biochem Int, 22, 1067
  26. S Melov, 1994, Detection of deletions in the mitochondrial genome of Caenorhabditis elegans., Nucleic Acids Res, 22, 1075, 10.1093/nar/22.6.1075 · DOI
  27. SS Chung, 1994, Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice., Aging (Milano), 6, 193
  28. E Bua, 2006, Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers., Am J Hum Genet, 79, 469, 10.1086/507132 · DOI · Paper page
  29. Z Cao, 2001, Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection., Nucleic Acids Res, 29, 4502, 10.1093/nar/29.21.4502 · DOI · Paper page
  30. G Fayet, 2002, Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function., Neuromuscul Disord, 12, 484, 10.1016/S0960-8966(01)00332-7 · DOI · Paper page
  31. SH McKiernan, 2004, Early-onset calorie restriction conserves fiber number in aging rat skeletal muscle., Faseb J, 18, 580, 10.1096/fj.03-0667fje · DOI
  32. KR Short, 2005, Decline in skeletal muscle mitochondrial function with aging in humans., Proc Natl Acad Sci U S A, 102, 5618, 10.1073/pnas.0501559102 · DOI · Paper page
  33. P Dubessay, 2007, Aging impact on biochemical activities and gene expression of Drosophila melanogaster mitochondria., 10.1016/j.biochi.2007.03.018 · DOI
  34. M Ferguson, 2005, Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster., Biochem J, 390, 501, 10.1042/BJ20042130 · DOI
  35. DJ Marcinek, 2005, Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle., J Physiol, 569, 467, 10.1113/jphysiol.2005.097782 · DOI
  36. B Drew, 2003, Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart., Am J Physiol Regul Integr Comp Physiol, 284, R474, 10.1152/ajpregu.00455.2002 · DOI
  37. A Trifunovic, 2005, Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production., Proc Natl Acad Sci U S A, 102, 17993, 10.1073/pnas.0508886102 · DOI · Paper page
  38. TM Hagen, 2002, Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress., Proc Natl Acad Sci U S A, 99, 1870, 10.1073/pnas.261708898 · DOI
  39. TM Hagen, 1997, Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase., Proc Natl Acad Sci U S A, 94, 3064, 10.1073/pnas.94.7.3064 · DOI
  40. C Pieri, 1993, Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation., Mech Ageing Dev, 70, 201, 10.1016/0047-6374(93)90048-V · DOI
  41. N Miyoshi, 2006, Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis., Proc Natl Acad Sci U S A, 103, 1727, 10.1073/pnas.0510346103 · DOI
  42. ME Harper, 1998, Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes., Am J Physiol, 275, E197
  43. E Gottlieb, 2003, Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis., Cell Death Differ, 10, 709, 10.1038/sj.cdd.4401231 · DOI
  44. A Dirks, 2002, Apoptosis in skeletal muscle with aging., Am J Physiol Regul Integr Comp Physiol, 282, R519, 10.1152/ajpregu.00458.2001 · DOI · Paper page
  45. M Ott, 2007, Mitochondria, oxidative stress and cell death., Apoptosis, 12, 913, 10.1007/s10495-007-0756-2 · DOI
  46. S Orrenius, 2007, Mitochondrial oxidative stress: implications for cell death., Annu Rev Pharmacol Toxicol, 47, 143, 10.1146/annurev.pharmtox.47.120505.105122 · DOI
  47. DS Izyumov, 2004, “Wages of fear”: transient threefold decrease in intracellular ATP level imposes apoptosis., Biochim Biophys Acta, 1658, 141, 10.1016/j.bbabio.2004.05.007 · DOI
  48. D McKenzie, 2002, Mitochondrial DNA deletion mutations: a causal role in sarcopenia., Eur J Biochem, 269, 2010, 10.1046/j.1432-1033.2002.02867.x · DOI
  49. B Chabi, 2005, Random mtDNA deletions and functional consequence in aged human skeletal muscle., Biochem Biophys Res Commun, 332, 542, 10.1016/j.bbrc.2005.04.153 · DOI
  50. VG Desai, 1996, Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice., Arch Biochem Biophys, 333, 145, 10.1006/abbi.1996.0375 · DOI
  51. RE Beyer, 1984, Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat., Mech Ageing Dev, 24, 309, 10.1016/0047-6374(84)90116-7 · DOI
  52. J Kerner, 2001, Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content., Am J Physiol Endocrinol Metab, 281, E1054, 10.1152/ajpendo.2001.281.5.E1054 · DOI
  53. B Chabi, 2008, Mitochondrial function and apoptotic susceptibility in aging skeletal muscle., Aging Cell, 7, 2, 10.1111/j.1474-9726.2007.00347.x · DOI · Paper page
  54. D Harman, 1956, Aging: a theory based on free radical and radiation chemistry., J Gerontol, 11, 298, 10.1093/geronj/11.3.298 · DOI · Paper page
  55. V Geromel, 2001, Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA., Hum Mol Genet, 10, 1221, 10.1093/hmg/10.11.1221 · DOI
  56. JL Mott, 2001, Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations., Mutat Res, 474, 35, 10.1016/S0027-5107(00)00159-7 · DOI
  57. A Boveris, 1973, The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen., Biochem J, 134, 707, 10.1042/bj1340707 · DOI · Paper page
  58. SS Korshunov, 1997, High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria., FEBS Lett, 416, 15, 10.1016/S0014-5793(97)01159-9 · DOI · Paper page
  59. M Vermulst, 2007, Mitochondrial point mutations do not limit the natural lifespan of mice., Nat Genet, 39, 540, 10.1038/ng1988 · DOI · Paper page
  60. M Vermulst, 2008, DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice., Nat Genet, 40, 392, 10.1038/ng.95 · DOI · Paper page
  61. B Bandy, 1990, Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?, Free Radic Biol Med, 8, 523, 10.1016/0891-5849(90)90152-9 · DOI · Paper page
  62. M Katayama, 1991, Deleted mitochondrial DNA in the skeletal muscle of aged individuals., Biochem Int, 25, 47
  63. J Muller-Hocker, 1993, Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly., Virchows Arch A Pathol Anat Histopathol, 422, 7, 10.1007/BF01605127 · DOI · Paper page
  64. EJ Brierley, 1998, Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle., Ann Neurol, 43, 217, 10.1002/ana.410430212 · DOI
  65. A Sanz, 2007, Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice., Exp Gerontol, 42, 173, 10.1016/j.exger.2006.10.003 · DOI
  66. G Barja, 2002, The quantitative measurement of H2O2 generation in isolated mitochondria., J Bioenerg Biomembr, 34, 227, 10.1023/A:1016039604958 · DOI
  67. B Drew, 2003, Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction., Am J Physiol Regul Integr Comp Physiol, 285, R1259, 10.1152/ajpregu.00264.2003 · DOI
  68. RC Scaduto Jr, 1999, Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives., Biophys J, 76, 469, 10.1016/S0006-3495(99)77214-0 · DOI
  69. CK Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction., Science, 285, 1390, 10.1126/science.285.5432.1390 · DOI · Paper page
  70. C Cheadle, 2003, Application of z-score transformation to Affymetrix data., Appl Bioinformatics, 2, 209
  71. S Someya, 2007, Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice., Brain Res, 1182, 26, 10.1016/j.brainres.2007.08.090 · DOI
  72. A Sanz, 2005, Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals., Biogerontology, 6, 15, 10.1007/s10522-004-7380-0 · DOI
  73. A Latorre, 1986, Evolution of mitochondrial DNA in Drosophila subobscura., Proc Natl Acad Sci U S A, 83, 8649, 10.1073/pnas.83.22.8649 · DOI
  74. JG de la Asuncion, 1996, Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA., FASEB J, 10, 333, 10.1096/fasebj.10.2.8641567 · DOI
  75. H Schagger, 1991, Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form., Anal Biochem, 199, 223, 10.1016/0003-2697(91)90094-A · DOI
  76. MM Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding., Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Hiona, A., Sanz, A., Kujoth, G. C., Pamplona, R., Seo, A. Y., Hofer, T., Someya, S., Miyakawa, T., Nakayama, C., Samhan-Arias, A. K., Servais, S., Barger, J. L., Portero-Otín, M., Tanokura, M., Prolla, T. A., & Leeuwenburgh, C.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2010-07-07
Volume
5
Issue
7
Pages
e11468
ISSN
1932-6203
DOI
10.1371/journal.pone.0011468
PMC
PMC2898813
Cited by
250
References
11
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review