The DOI matches its Crossref record; 174 of the 181 references it cites were found in a registry or an index.
Health benefits of physical activity: the evidence
Open accessAbstract
The primary purpose of this narrative review was to evaluate the current literature and to provide further insight into the role physical inactivity plays in the development of chronic disease and premature death. We confirm that there is irrefutable evidence of the effectiveness of regular physical activity in the primary and secondary prevention of several chronic diseases (e.g., cardiovascular disease, diabetes, cancer, hypertension, obesity, depression and osteoporosis) and premature death. We also reveal that the current Health Canada physical activity guidelines are sufficient to elicit health benefits, especially in previously sedentary people. There appears to be a linear relation between physical activity and health status, such that a further increase in physical activity and fitness will lead to additional improvements in health status.
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“It is well documented that physical activity has considerable beneficial ef fects on overall health, protecting against individual physical morbid ities and improving psychological well-being by reducing stress, anxiety, and depression (Warburton et al., 2006).”
From Psychosocial risk and protective factors associated with burnout in police officers: A systematic review (2023) · cites this paper as Warburton et al., 2006
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“Thus, it is unsurprising that physical fitness, which ultimately is related to total PA levels, is generally regarded as the single best predictor of all-cause mortality, independent of disease state.12”
From Reduced physical activity in young and older adults: Metabolic and musculoskeletal implications (2019) · cites this paper as [12]
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“Regular physical activity and/or exercise that is tailored to improve cardiorespiratory fitness, such as walking, dancing, or cycling, has significant health benefits such as reducing the risk of cardiovascular disease, diabetes, and obesity (28).”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [28]
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“Aerobic exercise is a low-cost, widely accessible activity known to provide multiple health benefits, including cardiovascular health and musculoskeletal health, as well as reduced rates of co-morbidity and mortality”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [28]
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Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Healthy People 2000: National Health Promotion and Disease Prevention Objectives.
Heidel, R. E. (1991) · Population and Development Review · doi:10.2307/1971966 · Cited by 3,162
Physical Activity, All-Cause Mortality, and Longevity of College Alumni
Paffenbarger, R. S., Hyde, R., Wing, A. L., & Hsieh, C.-C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603063141003 · Cited by 2,742
Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Blair, S. N. (1989) · JAMA · doi:10.1001/jama.1989.03430170057028 · Cited by 2,658
Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., Skidmore, B., Stone, J. A., Thompson, D. R., & Oldridge, N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.009 · Cited by 2,239
Tinetti, M. E., Baker, D. I., McAvay, G., Claus, E. B., Garrett, P., Gottschalk, M., Koch, M. L., Trainor, K. M., & Horwitz, R. I. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409293311301 · Cited by 2,160
Paffenbarger, R. S., Hyde, R. T., Wing, A. L., Lee, I.-M., Jung, D. L., & Kampert, J. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280804 · Cited by 1,972
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889
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7 of the 181 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [72]72. Courneya KS, Jones LW, Fairey AS, et al. Physical activity in cancer survivors: impli- cations for recurrence and mortality. Cancer Therapy 2004;2:1-12.
- [112]112. Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and man- agement of osteoporosis in Canada [published errata in CMAJ 2003;168(4):400, 2003;168(6):676 and 2003;168(5):544]. CMAJ 2002;167(10 Suppl):S1-34.
- [137]137. Warburton DER, Gledhill N, Jamnik V, et al. Induced hypervolemia, cardiac func- tion, VO 2max and performance of elite cyclists. Med Sci Sports Exerc 1999;31:800-8.
- [145]145. Ferreira I, Twisk JW, Stehouwer CD, et al. Longitudinal changes in VO 2max : associa- tions with carotid IMT and arterial stiffness. Med Sci Sports Exerc 2003;35:1670-8.
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Sorted by citations
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Physical Activity and Academic Performance: The Mediating Effect of Self-Esteem and Depression
Kayani, S., Kiyani, T., Wang, J., Zagalaz Sánchez, M. L., Kayani, S., & Qurban, H. (2018) · Sustainability · doi:10.3390/su10103633 · Cited by 60
Santos, A., Braaten, K., MacPherson, M., Vasconcellos, D., Vis-Dunbar, M., Lonsdale, C., Lubans, D., & Jung, M. E. (2023) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-023-01535-w · Cited by 59
“In contrast, increasing physical activity can lead to an abundance of benefits, some of which include primary and secondary prevention of chronic disease [4], improved cardiorespiratory fitness [5], improved psychological well-being [6], and a reduction in all-cause mortality [7].”
BackgroundLynch, C., Bird, S., Lythgo, N., & Selva-Raj, I. (2020) · American Journal of Health Promotion · doi:10.1177/0890117119895204 · Cited by 58
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Gorzelitz, J., Peppard, P. E., Malecki, K., Gennuso, K., Nieto, F. J., & Cadmus-Bertram, L. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.03.016 · Cited by 57
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UNICK, J. L., GAUSSOIN, S. A., HILL, J. O., JAKICIC, J. M., BOND, D. S., HELLGREN, M., JOHNSON, K. C., PETERS, A. L., CODAY, M., KITZMAN, D. W., et al. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001054 · Cited by 52
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Thorsteinsen, K., Vittersø, J., & Svendsen, G. B. (2014) · International Journal of Telemedicine and Applications · doi:10.1155/2014/746232 · Cited by 50
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Williams, K., Beeken, R. J., & Wardle, J. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.38 · Cited by 48
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VanBuskirk, K., Roesch, S., Afari, N., & Wetherell, J. L. (2014) · Behaviour Change · doi:10.1017/bec.2014.6 · Cited by 11
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Metadata
- Authors
- Warburton, D. E. R.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Warburton, D. E.R.
- ORCID
- Warburton, D. E.R.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2006-03-14
- Volume
- 174
- Issue
- 6
- Pages
- 801-809
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- PMC
- PMC1402378
- OpenAlex
- W2128621051
- Cited by
- 8,007
- References
- 181
- Citations by year
- 2026: 275 · 2025: 437 · 2024: 486 · 2023: 479 · 2022: 482 · 2021: 623 · 2020: 539 · 2019: 566 · 2018: 575 · 2017: 487 · 2016: 510 · 2015: 473 · 2014: 414 · 2013: 411 · 2012: 319
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Medical Association Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Michael Smith Health Research BC
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Social Sciences › Life-span and Life-course Studies › Recreational Sport and Physical Activity
- Keywords
- physical activity, physical inactivity, chronic disease prevention, premature mortality, cardiovascular disease, diabetes mellitus, cancer, hypertension, obesity, depression, osteoporosis, physical activity guidelines, sedentary individuals, dose-response relationship, health benefits
- MeSH terms
- Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Health Status, Humans, Life Expectancy, Neoplasms, Physical Fitness, Health Behavior, Exercise
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