Strong resetting of the mammalian clock by constant light followed by constant darkness
Open accessAbstract
The mammalian molecular circadian clock in the suprachiasmatic nuclei (SCN) regulates locomotor activity rhythms as well as clocks in peripheral tissues (Reppert and Weaver, 2002; Ko and Takahashi, 2006). Constant light (LL) can induce behavioral and physiological arrhythmicity by desynchronizing clock cells in the SCN (Ohta et al., 2005). We examined how the disordered clock cells resynchronize by probing the molecular clock and measuring behavior in mice transferred from LL to constant darkness (DD). The circadian locomotor activity rhythms disrupted in LL become robustly rhythmic again from the beginning of DD, and the starting phase of the rhythm in DD is specific, not random, suggesting that the desynchronized clock cells are quickly reset in an unconventional manner by the L/D transition. By measuring mPERIOD protein rhythms, we showed that the SCN and peripheral tissue clocks quickly become rhythmic again in phase with the behavioral rhythms. We propose that this resetting mechanism may be different from conventional phase shifting, which involves light induction of Period genes (Albrecht et al., 1997; Shearman et al., 1997; Shigeyoshi et al., 1997). Using our functional insights, we could shift the circadian phase of locomotor activity rhythms by 12 h using a 15 h LL treatment: essentially producing phase reversal by a single light pulse, a feat that has not been reported previously in wild-type mice and that has potential clinical utility.
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Both the endogenous circadian timing system and exposure to ambient light influence cognition and affective state.
“Both the endogenous circadian timing system and exposure to ambient light are known to influence cognition and affective state (Chaudhury and Colwell, 2002; Chen et al., 2008; Gonzalez and Aston-Jones, 2008; Hampp et al., 2008; Ruby et al., 2008).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Chen et al., 2008
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Vo, K. (2023) · doi:10.12794/metadc2179328
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J., O’Neil, D. S., Aagaard, K. M., Gibson, C. L., Heery, D. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-92938-1
Jandot, A., Calligaro, H., Dianak-Shoori, A., Tartour, K., Sandu, C., Haddjeri, N., Ribelayga, C., Ananthasubramaniam, B., Padmanabhan, K., Felder‐Schmittbuhl, M., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06298-8
- Authors
- Chen, R., Seo, D.-O., Bell, E., von Gall, C., & Lee, C.
- Affiliations
- Florida State University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-12
- Volume
- 28
- Issue
- 46
- Pages
- 11839-11847
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2626189
- OpenAlex
- W2071360237
- Cited by
- 53
- References
- 46
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-053616, R01NS053616)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, constant light, constant darkness, suprachiasmatic nucleus, clock resetting, phase reversal, locomotor activity rhythm, phase shifting, light pulses, mice
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Darkness, Light, Male, Mice, Inbred C57BL, Motor Activity, Nuclear Proteins, Photic Stimulation, Suprachiasmatic Nucleus, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins
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