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Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women's Health
Abstract
The prefrontal cortex (PFC) is exquisitely sensitive to its neurochemical environment. Minor fluctuations in cortical dopamine (DA) can profoundly alter working memory, a PFC-dependent cognitive function that supports an array of essential human behaviors. Dopamine's action in the PFC follows an inverted U-shaped curve, where an optimal DA level results in maximal function and insufficient or excessive DA impairs PFC function. In animals, 17β-estradiol (the major estrogen in most mammals, referred to henceforth as estradiol) has been shown to enhance DA activity, yet no human study has adequately addressed whether estradiol's impact on cognition occurs by way of modulating specific neurochemical systems. Here we examined the effects of endogenous fluctuations in estradiol on working memory in healthy young women as a function of baseline PFC DA [indexed by catechol-O-methyltransferase (COMT) Val 158 Met genotype and, at a finer scale, COMT enzyme activity]. The results demonstrate that estradiol status impacts working memory function and, crucially, the direction of the effect depends on indices of baseline DA. Moreover, consistent with a DA cortical efficiency hypothesis, functional MRI revealed that inferred optimal DA was associated with reduced PFC activity sustained across task blocks and selectively enhanced PFC activity on trials with the greatest demand for cognitive control. The magnitude of PFC activity during high control trials was predictive of an individual's performance. These findings show that although estrogen, considered in isolation, may have unpredictable effects on cognitive performance, its influence is clarified when considered within a larger neuromodulatory framework. Given the clinical prevalence of dopaminergic drugs, understanding the relationship between estrogen and DA is essential for advancing women's health.
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“Estradiol affects working memory through modulation of PFC dopamine activity.”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Jacobs and D'Esposito, 2011
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“In women who metabolize dopamine more quickly, low estradiol levels result in improper PFC activation during working memory tasks (Jacobs and D'Esposito, 2011).”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Jacobs and D'Esposito, 2011
In the citing paper
“PFC function has been characterized as an inverted U-shaped curve such that optimal executive function (EF) depends on a balance of factors including baseline monoaminergic and glutamatergic function (Arnsten and Jin, 2014) as well as hormonal status (Jacobs and D'Esposito, 2011).”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Jacobs and D'Esposito, 2011
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies.
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005) · Human Brain Mapping · doi:10.1002/hbm.20131 · Cited by 3,560
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 2×
“socortical pathway were dopaminergic (TH-immunoreactive) (Swanson, 1982).”
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · cited 1×
“Dopamine (DA) signaling in prefrontal cortex (PFC) is critical for WM function (Brozoski et al., 1979; Sawaguchi and Goldman-Rakic, 1991; Williams and Goldman-Rakic, 1995).”
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Neural mechanisms of general fluid intelligence
Gray, J. R., Chabris, C. F., & Braver, T. S. (2003) · Nature Neuroscience · doi:10.1038/nn1014 · Cited by 1,080
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013
Top-down suppression deficit underlies working memory impairment in normal aging
Gazzaley, A., Cooney, J. W., Rissman, J., & D'Esposito, M. (2005) · Nature Neuroscience · doi:10.1038/nn1543 · Cited by 934
Self-citationMattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893
Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-j0004.2000 · Cited by 608 · cited 2×
“In humans DA agonists modulate WM performance and the efficiency of prefrontal cortical networks (Mehta et al., 2000).”
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566
Berman, K. F., Schmidt, P. J., Rubinow, D. R., Danaceau, M. A., Van Horn, J. D., Esposito, G., Ostrem, J. L., & Weinberger, D. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8836 · Cited by 318
Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Cools, R., Gibbs, S. E., Miyakawa, A., Jagust, W., & D'Esposito, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4475-07.2008 · Cited by 302
Self-citationEstrogen mediates sex differences in stress-induced prefrontal cortex dysfunction
Shansky, R. M., Glavis-Bloom, C., Lerman, D., McRae, P., Benson, C., Miller, K., Cosand, L., Horvath, T. L., & Arnsten, A. F. T. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001435 · Cited by 200 · cited 1×
“Accordingly, a study in rats showed that the administration of a DA drug had different effects on WM performance depending on the rats’ estrous stage at the time of testing (Shansky et al., 2004).”
Li, B.-M., & Mei, Z.-T. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80034-2 · Cited by 186
The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.022 · Cited by 147
Oestrogen Receptor α Localisation in the Prefrontal Cortex of Three Mammalian Species
Montague, D., Weickert, C. S., Tomaskovic‐Crook, E., Rothmond, D. A., Kleinman, J. E., & Rubinow, D. R. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01743.x · Cited by 95
Research works printed but not linked: 63
- 10.1523/JNEUROSCI.2097-04.2005 · DOI
- 10.1038/sj.npp.1301227 · DOI · Paper page
- 10.1093/cercor/bhq083 · DOI
- 10.1037/0033-2909.130.4.553 · DOI · Paper page
- 10.1016/0304-3940(90)90618-J · DOI
- Becker JB (2000) in Neuronal and cognitive effects of oestrogens, Oestrogen effects on dopaminergic function in striatum, eds Chadwick DJ Goode JA (Wiley, West Sussex, England), pp 134–145. · DOI
- 10.1016/j.yfrne.2007.07.003 · DOI · Paper page
- 10.1016/0028-3932(68)90038-9 · DOI
- 10.1016/0960-0760(95)00179-4 · DOI
- 10.1006/nimg.1996.0247 · DOI · Paper page
- Cai, 1997, Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys, J Pharmacol Exp Ther, 283, 183, 10.1016/S0022-3565(24)36983-6 · DOI · Paper page
- 10.1016/j.tips.2004.03.011 · DOI
- 10.1086/425589 · DOI · Paper page
- 10.1523/JNEUROSCI.0601-07.2007 · DOI
- 10.1016/j.biopsych.2007.03.001 · DOI · Paper page
- 10.1002/cne.10207 · DOI
- 10.1016/j.biopsych.2006.03.004 · DOI
- 10.1016/S0022-5371(80)90312-6 · DOI · Paper page
- 10.1006/hbeh.2000.1625 · DOI
- 10.1016/S0893-6080(02)00049-7 · DOI
- 10.1073/pnas.111134598 · DOI
- 10.1001/archpsyc.59.9.851 · DOI
- 10.1007/s00213-001-0944-7 · DOI
- 10.1016/j.psyneuen.2008.04.007 · DOI
- 10.3758/CABN.5.2.212 · DOI · Paper page
- Gibbs, 2005, A functional MRI study of the effects of bromocriptine, a dopamine receptor agonist, on component processes of working memory, Psychopharmacology, 180, 644, 10.1007/s00213-005-0077-5 · DOI · Paper page
- 10.1016/S0165-1781(02)00028-8 · DOI
- Granon, 2000, Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex, J Neurosci, 20, 1208, 10.1523/JNEUROSCI.20-03-01208.2000 · DOI · Paper page
- 10.1523/JNEUROSCI.3440-05.2006 · DOI
- 10.1046/j.0953-816x.2001.01856.x · DOI
- 10.1007/s002130051033 · DOI · Paper page
- 10.1016/S0091-3057(00)00218-5 · DOI
- 10.1097/00001756-199711100-00032 · DOI · Paper page
- 10.1523/JNEUROSCI.2637-08.2008 · DOI
- 10.1002/(SICI)1096-9861(19980525)395:1<1::AID-CNE1>3.0.CO;2-4 · DOI
- Laruelle, 2000, Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review, J Cereb Blood Flow Metab, 20, 423, 10.1097/00004647-200003000-00001 · DOI · Paper page
- 10.1016/S0893-133X(99)00070-6 · DOI · Paper page
- 10.1007/BF02246017 · DOI
- 10.1007/s00213-002-1183-2 · DOI
- Männistö, 1999, Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology and clinical efficacy of the new selective COMT inhibitors, Pharmacol Rev, 51, 593, 10.1016/S0031-6997(24)01423-6 · DOI · Paper page
- 10.1016/S0166-2236(02)02182-3 · DOI
- 10.1046/j.1471-4159.1995.65041651.x · DOI
- 10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1 · DOI · Paper page
- 10.1176/appi.ajp.158.7.1105 · DOI
- 10.1017/S1355617704105110 · DOI
- 10.1016/j.neuroscience.2005.03.055 · DOI
- 10.1523/JNEUROSCI.4653-03.2004 · DOI
- Rapp, 2003, Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys, J Neurosci, 23, 5708, 10.1523/JNEUROSCI.23-13-05708.2003 · DOI
- 10.1016/S0306-4530(01)00083-X · DOI · Paper page
- 10.1037/0012-1649.27.5.763 · DOI · Paper page
- 10.1037/a0014685 · DOI
- 10.1016/j.yhbeh.2004.12.002 · DOI
- 10.1046/j.1471-4159.1994.62051750.x · DOI · Paper page
- 10.1523/JNEUROSCI.1124-04.2004 · DOI
- 10.1016/j.biopsych.2005.10.024 · DOI
- 10.3758/BF03192720 · DOI · Paper page
- 10.1523/JNEUROSCI.3192-10.2010 · DOI
- Watanabe, 1997, Increase of extracellular dopamine in primate prefrontal cortex during a working memory task, J Neurophysiol, 78, 2795, 10.1152/jn.1997.78.5.2795 · DOI
- 10.1523/JNEUROSCI.0774-07.2007 · DOI
- 10.1016/j.tins.2004.08.002 · DOI
- 10.1006/nimg.1995.1023 · DOI
- 10.1016/0304-3940(94)90510-X · DOI
- Zahrt, 1997, Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance, J Neurosci, 17, 8528, 10.1523/JNEUROSCI.17-21-08528.1997 · DOI · Paper page
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Crone, E. A., & Dahl, R. E. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3313 · Cited by 2,507
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673
Self-citationSpontaneous eye blink rate as predictor of dopamine-related cognitive function—A review
Jongkees, B. J., & Colzato, L. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.020 · Cited by 300
Sundström Poromaa, I., & Gingnell, M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00380 · Cited by 291
Op de Macks, Z. A., Moor, B. G., Overgaauw, S., Güroğlu, B., Dahl, R. E., & Crone, E. A. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.06.003 · Cited by 203
Metadata
- Authors
- Jacobs, E., & D'Esposito, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-04-06
- Volume
- 31
- Issue
- 14
- Pages
- 5286-5293
- ISSN
- 0270-6474
- 1529-2401
- PMC
- PMC3089976
- Cited by
- 342
- References
- 21
- Language
- en
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