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Potential of fecal microbiota for early-stage detection of colorectal cancer
Open accessAbstract
Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC-associated changes of fecal microbiota and their potential for cancer screening remain to be explored. Here, we used metagenomic sequencing of fecal samples to identify taxonomic markers that distinguished CRC patients from tumor-free controls in a study population of 156 participants. Accuracy of metagenomic CRC detection was similar to the standard fecal occult blood test (FOBT) and when both approaches were combined, sensitivity improved > 45% relative to the FOBT, while maintaining its specificity. Accuracy of metagenomic CRC detection did not differ significantly between early- and late-stage cancer and could be validated in independent patient and control populations (N = 335) from different countries. CRC-associated changes in the fecal microbiome at least partially reflected microbial community composition at the tumor itself, indicating that observed gene pool differences may reveal tumor-related host-microbe interactions. Indeed, we deduced a metabolic shift from fiber degradation in controls to utilization of host carbohydrates and amino acids in CRC patients, accompanied by an increase of lipopolysaccharide metabolism.
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“studies of fecal microbiomes that used either 16s rRNA or shotgun metagenomic sequencing found that F nucleatum to be increased in fecal samples from patients with CRC or adenoma compared with controls (Table 1).15, 18, 35–39”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [36]
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“The protein AvrA, produced by Salmonella, promotes inflammation and colon tumor development by activating beta-catenin signaling to STAT3.36, 180”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [36]
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Metadata
- Authors
- Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., Hercog, R., Koch, M., Luciani, A., Mende, D. R., Schneider, M. A., Schrotz‐King, P., Tournigand, C., Tran Van Nhieu, J., Yamada, T., Zimmermann, J., Benes, V., Kloor, M., Ulrich, C. M., von Knebel Doeberitz, M., Sobhani, I., & Bork, P.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Université Paris-Est Créteil (FR)
- German Cancer Research Center (DE)
- University Hospital Heidelberg (DE)
- Tokyo Institute of Technology (JP)
- Corresponding author
- Sobhani, Iradj
- ORCID
- Venue
- Molecular Systems Biology
- Published
- 2014-11-01
- Volume
- 10
- Issue
- 11
- Pages
- 766-766
- ISSN
- 1744-4292 (ISSN-L)
- PMC
- PMC4299606
- OpenAlex
- W2130725058
- Cited by
- 1,375
- References
- 98
- Citations by year
- 2026: 131 · 2025: 168 · 2024: 162 · 2023: 134 · 2022: 160 · 2021: 140 · 2020: 134 · 2019: 97 · 2018: 82 · 2017: 85 · 2016: 59 · 2015: 20 · 2014: 1
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Systems Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- European Research Council (268985)
- METACARDIS (FP7‐HEALTH‐2012‐INNOVATION‐I‐305312)
- International Human Microbiome Standards (HEALTH‐F4‐2010‐261376)
- French LNCC 2004 grant
- ACD grants
- PHRC 2009 Vatnimad grant
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, fecal microbiota, early cancer detection, cancer screening, metagenomics, fecal occult blood test, microbial biomarkers, host-microbe interactions, fiber degradation
- MeSH terms
- Feces, Humans, Occult Blood, Sensitivity and Specificity, Colorectal Neoplasms, Case-Control Studies, Early Detection of Cancer, Metagenomics, Molecular Typing, Microbiota
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