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Cited by 136Pharmacology and Obesity TreatmentAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 307 of the 311 references it cites were found in a registry or an index.

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

Open access
Shaik Mohamed Sayed, Ummul Fathima, Moshawih, Said, Goh, Hui Poh, Kifli, Nurolaini, Gupta, Gaurav, Singh, Sachin Kumar, Chellappan, Dinesh Kumar, Dua, Kamal, Hermansyah, Andi, Ser, Hooi Leng, Ming, Long Chiau, Goh, Bey Hing·2023·Frontiers in Pharmacology
DOI 10.3389/fphar.2023.1182937PMC PMC10318930
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Abstract

Obesity affects more than 10% of the adult population globally. Despite the introduction of diverse medications aimed at combating fat accumulation and obesity, a significant number of these pharmaceutical interventions are linked to substantial occurrences of severe adverse events, occasionally leading to their withdrawal from the market. Natural products serve as attractive sources for anti-obesity agents as many of them can alter the host metabolic processes and maintain glucose homeostasis via metabolic and thermogenic stimulation, appetite regulation, pancreatic lipase and amylase inhibition, insulin sensitivity enhancing, adipogenesis inhibition and adipocyte apoptosis induction. In this review, we shed light on the biological processes that control energy balance and thermogenesis as well as metabolic pathways in white adipose tissue browning, we also highlight the anti-obesity potential of natural products with their mechanism of action. Based on previous findings, the crucial proteins and molecular pathways involved in adipose tissue browning and lipolysis induction are uncoupling protein-1, PR domain containing 16, and peroxisome proliferator-activated receptor-γ in addition to Sirtuin-1 and AMP-activated protein kinase pathway. Given that some phytochemicals can also lower proinflammatory substances like TNF-α, IL-6, and IL-1 secreted from adipose tissue and change the production of adipokines like leptin and adiponectin, which are important regulators of body weight, natural products represent a treasure trove for anti-obesity agents. In conclusion, conducting comprehensive research on natural products holds the potential to accelerate the development of an improved obesity management strategy characterized by heightened efficacy and reduced incidence of side effects.

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Crossref · 10.3389/fphar.2023.1182937

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Figures

FIGURE 1 Pathways involved in the browning of white adipose tissue and producing brite adipocytes. (A) stimulation of thermogenesis and adipose tissue browning through PPARs and mitochondrial biogenesis. (B) SIRT1-AMPK pathway for lipolysis and fatty acid oxidation. (C) PRDM16-CtBP1/2 and -PGC-1α and β pathways for suppressing WAT genes and activating BAT genes. ATGL: adipose triglyceride lipase.
FIGURE 1 Pathways involved in the browning of white adipose tissue and producing brite adipocytes. (A) stimulation of thermogenesis and adipose tissue browning through PPARs and mitochondrial biogenesis. (B) SIRT1-AMPK pathway for lipolysis and fatty acid oxidation. (C) PRDM16-CtBP1/2 and -PGC-1α and β pathways for suppressing WAT genes and activating BAT genes. ATGL: adipose triglyceride lipase.CC BY · PubMed Central
FIGURE 2 The effects of several NPs on diverse physiological pathways as metabolic and thermogenic stimulants. AC: Adenylyl cyclase; AR: Adenosine receptor; DA: Dopamine; DR: Dopamine receptors; MAO: Monoamine oxidase; PDE: Phosphodiesterase; TAPV1: Transient receptor potential vanilloid-1; NE: Norepinephrine; EN: Epinephrine; COMT: Catechol-O-methyltransferase.
FIGURE 2 The effects of several NPs on diverse physiological pathways as metabolic and thermogenic stimulants. AC: Adenylyl cyclase; AR: Adenosine receptor; DA: Dopamine; DR: Dopamine receptors; MAO: Monoamine oxidase; PDE: Phosphodiesterase; TAPV1: Transient receptor potential vanilloid-1; NE: Norepinephrine; EN: Epinephrine; COMT: Catechol-O-methyltransferase.CC BY · PubMed Central
FIGURE 3 Mechanism of action(s) involved in reducing appetite and/or inducing the feeling of satiety exerted by selected plants and their main chemical constituents. ARC; The arcuate nucleus of the hypothalamus; GLP-1: Glucagon-like peptide-1; CCK: Cholecystokinin.
FIGURE 3 Mechanism of action(s) involved in reducing appetite and/or inducing the feeling of satiety exerted by selected plants and their main chemical constituents. ARC; The arcuate nucleus of the hypothalamus; GLP-1: Glucagon-like peptide-1; CCK: Cholecystokinin.CC BY · PubMed Central
FIGURE 4 Examples of few plant species with the main phytochemicals and/or groups that inhibit lipases and amylases. MG: monoglycerols, FFA: free fatty acids.
FIGURE 4 Examples of few plant species with the main phytochemicals and/or groups that inhibit lipases and amylases. MG: monoglycerols, FFA: free fatty acids.CC BY · PubMed Central
FIGURE 5 Natural products/plant species that enhance insulin resistance and reduce obesity. IR: insulin receptor; IRS-1: insulin receptor subunit-1; Glut4: Glucose transporter type 4; DGAT: Diglyceride acyltransferase; CCAATa/b: CCAAT/enhancer-binding protein a and b; FAS: Fatty acid synthase; Thick green arrow: increase; Thick red inhibition arrow (ꓕ): inhibition.
FIGURE 5 Natural products/plant species that enhance insulin resistance and reduce obesity. IR: insulin receptor; IRS-1: insulin receptor subunit-1; Glut4: Glucose transporter type 4; DGAT: Diglyceride acyltransferase; CCAATa/b: CCAAT/enhancer-binding protein a and b; FAS: Fatty acid synthase; Thick green arrow: increase; Thick red inhibition arrow (ꓕ): inhibition.CC BY · PubMed Central
FIGURE 6 The major molecular pathways in adipocytes’ apoptosis and adipogenesis.
FIGURE 6 The major molecular pathways in adipocytes’ apoptosis and adipogenesis.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 11

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Metadata

Authors
Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., Ming, L. C., & Goh, B. H.
Affiliations
  • Universiti Brunei Darussalam (BN)
  • Saveetha University (IN)
  • Lovely Professional University (IN)
  • IMU University (MY)
  • University of Technology Sydney (AU)
  • Universitas Airlangga (ID)
  • Sunway University (MY)
  • Monash University Malaysia (MY)
Corresponding author
  • Moshawih, Said
  • Hermansyah, Andi
  • Goh, Bey Hing
ORCID
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2023-06-20
Volume
14
Pages
1182937-1182937
ISSN
1663-9812 (ISSN-L)
DOI
10.3389/fphar.2023.1182937
PMC
PMC10318930
OpenAlex
W4381429870
Cited by
136
References
311
Citations by year
2026: 34 · 2025: 57 · 2024: 38 · 2023: 7
FWCI
4.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Monash University Research Portal (Monash University) (submittedVersion, cc-by)
  • Sunway Institutional Repository (Sunway University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
natural products, anti-obesity drugs, obesity, thermogenesis, adipose tissue browning, lipolysis, UCP1, PPARγ, SIRT1, AMPK signaling, appetite regulation, pancreatic lipase inhibition, insulin sensitivity, adipogenesis, adipocyte apoptosis, adipokines, leptin, adiponectin, inflammation, energy balance, phytochemicals

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