Mechanisms and Regulation of Cellular Senescence

Cites (375)

Items 201–371 of 371

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2. Molecular dissection of formation of senescence-associated heterochromatin foci
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3. BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
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4. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
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5. Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
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6. The power and the promise of oncogene-induced senescence markers
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7. Many roads lead to oncogene-induced senescence
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8. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
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9. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
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10. Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
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11. Recurrent turnover of senescent cells during regeneration of a complex structure
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12. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
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14. The genetics of human ageing
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15. Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
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16. Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
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17. In situ analyses of genome instability in breast cancer
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18. Transcriptome signature of cellular senescence
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19. Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
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20. Senescent cells harbour features of the cancer epigenome
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21. Histone demethylase JMJD3 contributes to epigenetic control of <i>INK4a/ARF</i> by oncogenic RAS
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22. The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53
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23. Virus-induced senescence is a driver and therapeutic target in COVID-19
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24. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
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25. NKG2D ligands mediate immunosurveillance of senescent cells
    Sagiv, Adi, Burton, Dominick G. A., Moshayev, Zhana, Vadai, Ezra, Wensveen, Felix, Ben-Dor, Shifra, Golani, Ofra, Polic, Bojan, Krizhanovsky, Valery · 2016 · Aging
26. Polycomb CBX7 has a unifying role in cellular lifespan.
    Gil, Jesús, Bernard, David, Martínez, Dolores, Beach, David · 2004 · Nature Cell Biology
27. Erosion of the telomeric single-strand overhang at replicative senescence
    Stewart, Sheila A., Ben-Porath, Ittai, Carey, Vincent J., O'Connor, Benjamin F., Hahn, William C., Weinberg, Robert A. · 2003 · Nature Genetics
28. Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence
    Tai, Haoran, Wang, Zhe, Gong, Hui, Han, Xiaojuan, Zhou, Jiao, Wang, Xiaobo, Wei, Xiawei, Ding, Yi, Huang, Ning, Qin, Jianqiong et al. · 2017 · Autophagy
29. Free radicals and senescence
    Lu, Teng, Finkel, Toren · 2008 · Experimental Cell Research
30. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.
    Sadaie, Mahito, Salama, Rafik, Carroll, Thomas, Tomimatsu, Kosuke, Chandra, Tamir, Young, Andrew R.J., Narita, Masako, Pérez-Mancera, Pedro A., Bennett, Dorothy C., Chong, Heung et al. · 2013 · Genes &amp; Development
31. Senolytics reduce coronavirus-related mortality in old mice
    Camell, Christina D., Yousefzadeh, Matthew J., Zhu, Yi, Prata, Larissa G. P. Langhi, Huggins, Matthew A., Pierson, Mark, Zhang, Lei, O’Kelly, Ryan D., Pirtskhalava, Tamar, Xun, Pengcheng et al. · 2021 · Science
32. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.
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33. Regulation of Murine Telomere Length by Rtel
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34. Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation
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35. Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis
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36. Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
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37. Senescence from G2 arrest, revisited
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38. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
    Yosef, Reut, Pilpel, Noam, Papismadov, Nurit, Gal, Hilah, Ovadya, Yossi, Vadai, Ezra, Miller, Stav, Porat, Ziv, Ben‐Dor, Shifra, Krizhanovsky, Valery · 2017 · The EMBO Journal
39. Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression
    Saleh, Reem, Elkord, Eyad · 2020 · Seminars in Cancer Biology
40. Oncogenic <i>ras</i> and p53 Cooperate To Induce Cellular Senescence
    Ferbeyre, Gerardo, de Stanchina, Elisa, Lin, Athena W., Querido, Emmanuelle, McCurrach, Mila E., Hannon, Gregory J., Lowe, Scott W. · 2002 · Molecular and Cellular Biology
41. Lysosomes and oxidative stress in aging and apoptosis
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42. Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence
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43. ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
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44. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
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45. Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle
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46. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16^ink4a
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47. Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
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48. Apoptosis or Senescence-like Growth Arrest: Influence of Cell-Cycle Position, P53, P21 and Bax in H2O2 Response of Normal Human FIbroblasts
    CHEN, Qin M., LIU, Juping, MERRETT, Jessica B. · 2000 · Biochemical Journal
49. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
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50. The Role of p53 in Metabolic Regulation
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51. IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’
    Hubackova, Sona, Krejcikova, Katerina, Bartek, Jiri, Hodny, Zdenek · 2012 · Aging
52. Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).
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53. Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
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54. Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions
    Cesare, Anthony J, Kaul, Zeenia, Cohen, Scott B, Napier, Christine E, Pickett, Hilda A, Neumann, Axel A, Reddel, Roger R · 2009 · Nature Structural &amp; Molecular Biology
55. Robust, universal biomarker assay to detect senescent cells in biological specimens
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56. Nuclear initiated NF-κB signaling: nemo and ATM take center stage
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57. DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
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58. Chromosome breakage after G2 checkpoint release
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59. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence
    Swanson, Eric C., Manning, Benjamin, Zhang, Hong, Lawrence, Jeanne B. · 2013 · Journal of Cell Biology
60. Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
    Hoenicke, L., Zender, L. · 2012 · Carcinogenesis
61. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
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62. Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype.
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63. The bystander effect contributes to the accumulation of senescent cells in vivo
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64. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
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65. Reactive Oxygen Species as Mediators of Cellular Senescence
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66. Granule exocytosis mediates immune surveillance of senescent cells
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67. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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68. Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
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69. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence
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70. Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease
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71. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
    Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam · 2008 · Proceedings of the National Academy of Sciences
72. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
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73. Five dysfunctional telomeres predict onset of senescence in human cells
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74. INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence
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75. Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts
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76. SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence
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77. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
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78. MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype
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79. DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
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80. MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
    Saretzki, Gabriele, Murphy, Michael P., Von Zglinicki, Thomas · 2003 · Aging Cell
81. p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress
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82. DNA damage checkpoint kinase Chk2 triggers replicative senescence
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83. Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence
    Krenning, Lenno, Feringa, Femke M., Shaltiel, Indra A., van den Berg, Jeroen, Medema, René H. · 2014 · Molecular Cell
84. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus
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85. Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction
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86. Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53
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87. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: Evidence for a telomere crisis
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88. HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci
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89. Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
    van Vliet, Thijmen, Varela-Eirin, Marta, Wang, Boshi, Borghesan, Michela, Brandenburg, Simone M., Franzin, Rossana, Evangelou, Konstantinos, Seelen, Marc, Gorgoulis, Vassilis, Demaria, Marco · 2021 · Molecular Cell
90. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
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91. The emerging role of alternative splicing in senescence and aging
    Mathieu Deschênes, Benoı̂t Chabot · 2017 · Aging Cell
92. Nucleotide metabolism, oncogene-induced senescence and cancer
    Aird, Katherine M., Zhang, Rugang · 2015 · Cancer Letters
93. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.
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94. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
    Tang, Y, Horikawa, I, Ajiro, M, Robles, A I, Fujita, K, Mondal, A M, Stauffer, J K, Zheng, Z-M, Harris, C C · 2013 · Oncogene
95. Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
    Gire, Veronique, Wynford-Thomas, David · 1998 · Molecular and Cellular Biology
96. Senescent fibroblasts resist apoptosis by downregulating caspase-3.
    Marcotte, Richard, Lacelle, Chantale, Wang, Eugenia · 2004 · Mechanisms of Ageing and Development
97. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
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98. The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response
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99. Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest
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100. Mitochondria and PGC-1α in Aging and Age-Associated Diseases
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101. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
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102. Biomarkers to identify and isolate senescent cells
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103. Induction of <i>ARF</i> tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
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104. Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts
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105. Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress
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106. FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
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107. Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women
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108. Telomere Loop Dynamics in Chromosome End Protection
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109. The Fountain of Youth by Targeting Senescent Cells?
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