Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men ,

Koopman, René; Walrand, Stéphane; Beelen, Milou; Gijsen, Annemie P.; Kies, Arie K.; Boirie, Yves; Saris, Wim H.M.; van Loon, Luc J.C.

doi:10.3945/jn.109.109173

Cited by 167Muscle metabolism and nutritionNutrition and Health in AgingClinical Nutrition and Gastroenterology

Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men ,

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Koopman, René, Walrand, Stéphane, Beelen, Milou, Gijsen, Annemie P., Kies, Arie K., Boirie, Yves, Saris, Wim H.M., van Loon, Luc J.C.·2009·The Journal of Nutrition

DOI 10.3945/jn.109.109173

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Abstract

Impaired digestion and/or absorption of dietary protein lowers postprandial plasma amino acid availability and, as such, could reduce the postprandial muscle protein synthetic response in the elderly. We aimed to compare in vivo dietary protein digestion and absorption and the subsequent postprandial muscle protein synthetic response between young and elderly men. Ten elderly (64 +/- 1 y) and 10 young (23 +/- 1 y) healthy males consumed a single bolus of 35 g specifically produced, intrinsically l-[1-(13)C]phenylalanine-labeled micellar casein (CAS) protein. Furthermore, primed continuous infusions with l-[ring-(2)H(5)]phenylalanine, l-[1-(13)C]leucine, and l-[ring-(2)H(2)]tyrosine were applied and blood and muscle tissue samples were collected to assess the appearance rate of dietary protein-derived phenylalanine in the circulation and the subsequent muscle protein fractional synthetic rate over a 6-h postprandial period. Protein ingestion resulted in a rapid increase in exogenous phenylalanine appearance in both the young and elderly men. Total exogenous phenylalanine appearance rates (expressed as area under the curve) were 39 +/- 3 mumol.6 h.kg(-1) in the young men and 38 +/- 2 mumol.6 h.kg(-1) in the elderly men (P = 0.73). In accordance, splanchnic amino acid extraction did not differ between young (72 +/- 2%) and elderly (73 +/- 1%) volunteers (P = 0.74). Muscle protein synthesis rates, calculated from the oral tracer, were 0.063 +/- 0.006 and 0.054 +/- 0.004%/h in the young and elderly men, respectively, and did not differ between groups (P = 0.27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men.

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Although some age-related anatomical and physiological changes have been described in the gastrointestinal tract, these changes are relatively small and do not substantially impair amino acid availability from food.
“Although some age-related anatomical and physiological changes have been described in the gastrointestinal tract, 192 these changes are relatively small and do not substantially impair amino acid availability from food.194”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [194]

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Authors: Koopman, R., Walrand, S., Beelen, M., Gijsen, A. P., Kies, A. K., Boirie, Y., Saris, W. H. M., & van Loon, L. J. C.
Affiliations: Maastricht University (NL)
Université Clermont Auvergne (FR)
DSM (Netherlands) (NL)
ORCID: Koopman, René
Walrand, Stéphane
Beelen, Milou
Kies, Arie K.
Saris, Wim H.M.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2009-09
Volume: 139
Issue: 9
Pages: 1707-1713
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.109.109173
OpenAlex: W2109595244
Cited by: 167
References: 36
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 12
FWCI: 4.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4908 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords: dietary protein digestion, protein absorption, aging, older men, micellar casein, amino acid availability
MeSH terms: Aged, Aging, Amino Acids, Caseins, Dietary Proteins, Digestion, Humans, Insulin, Intestinal Absorption, Male, Middle Aged, Muscle Proteins, Postprandial Period, Area Under Curve, Young Adult

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Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men ,

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