Engineering exosomes for targeted drug delivery

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099

The biology , function , and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,863

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760

Reassessment of exosome composition

Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832

Identification and proteomic profiling of exosomes in human urine

Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Controlled Drug Delivery Systems: Current Status and Future Directions

Adepu, S., & Ramakrishna, S. (2021) · Molecules · doi:10.3390/molecules26195905 · Cited by 1,691

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang, Y., Guo, X., Wu, Y., Chen, X., Feng, L., Xie, N., & Shen, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01745-z · Cited by 537

Role of tumor microenvironment in cancer progression and therapeutic strategy

Wang, Q., Shao, X., Zhang, Y., Zhu, M., Wang, F. X. C., Mu, J., Li, J., Yao, H., & Chen, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5698 · Cited by 499

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Mondal, J., Pillarisetti, S., Junnuthula, V., Saha, M., Hwang, S. R., Park, I.-K., & Lee, Y.-K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.027 · Cited by 416

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Weng, Z., Zhang, B., Wu, C., Yu, F., Han, B. R., Li, B., & Li, L. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01141-y · Cited by 420

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing

Duan, L., Ouyang, K., Xu, X., Xu, L., Wen, C., Zhou, X., Qin, Z., Xu, Z., Sun, W., & Liang, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.673286 · Cited by 377

A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication

Liu, Y., & Wang, C. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01103-6 · Cited by 425

Exosome engineering in cell therapy and drug delivery

Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351

Exosomes, a New Star for Targeted Delivery

Chen, H., Wang, L., Zeng, X., Schwarz, H., Nanda, H. S., Peng, X., & Zhou, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751079 · Cited by 349

Artificial exosomes for translational nanomedicine

Li, Y.-J., Wu, J.-Y., Liu, J., Xu, W., Qiu, X., Huang, S., Hu, X.-B., & Xiang, D.-X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 303

Nano-based drug delivery systems: Conventional drug delivery routes, recent developments and future prospects

Sultana, A., Zare, M., Thomas, V., Kumar, T. S. S., & Ramakrishna, S. (2022) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2022.100134 · Cited by 348

Role of prostaglandin E2 in tissue repair and regeneration

Cheng, H., Huang, H., Guo, Z., Chang, Y., & Li, Z. (2021) · Theranostics · doi:10.7150/thno.63396 · Cited by 337

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Desai, N., Rana, D., Patel, M., Bajwa, N., Prasad, R., & Vora, L. K. (2025) · Small · doi:10.1002/smll.202502315 · Cited by 341

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297

Emerging role of exosomes in cancer therapy: progress and challenges

Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297

Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes

Choi, H., Choi, Y., Yim, H. Y., Mirzaaghasi, A., Yoo, J., & Choi, C. (2021) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-021-00361-0 · Cited by 295

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Xu, M., Ji, J., Jin, D., Wu, Y. H., Wu, T., Lin, R., Zhu, S., Jiang, F., Ji, Y., Bao, B., et al. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.03.021 · Cited by 304

Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies

Xu, G., Jin, J., Fu, Z., Wang, G., Lei, X., Xu, J., & Wang, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02312-w · Cited by 320

Recent applications of immunomodulatory biomaterials for disease immunotherapy

Dai, H., Fan, Q., & Wang, C. (2022) · Exploration · doi:10.1002/exp.20210157 · Cited by 271

Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis

Yan, C., Chen, J., Wang, C., Yuan, M., Kang, Y., Wu, Z., Li, W., Zhang, G., Machens, H., Rinkevich, Y., et al. (2022) · Drug Delivery · doi:10.1080/10717544.2021.2023699 · Cited by 251

Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications

Tian, J., Han, Z., Song, D., Peng, Y., Xiong, M., Chen, Z., Duan, S., & Zhang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444582 · Cited by 246

Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo

Xu, X., Yuan, T., Dad, H. A., Shi, M.-Y., Huang, Y.-Y., Jiang, Z., & Peng, L. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c02530 · Cited by 234

Exosomes based strategies for brain drug delivery

Rehman, F. U., Liu, Y., Zheng, M., & Shi, B. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121949 · Cited by 240

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Claridge, B., Lozano, J., Poh, Q. H., & Greening, D. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734720 · Cited by 243

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Liang, Y., Xu, X., Xu, L., Iqbal, Z., Ouyang, K., Zhang, H., Wen, C., Duan, L., & Xia, J. (2022) · Theranostics · doi:10.7150/thno.69368 · Cited by 217

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Liu, Q., Li, D., Pan, X., & Liang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02081-0 · Cited by 201

Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

Trzyna, A., & Banaś-Ząbczyk, A. (2021) · Biomolecules · doi:10.3390/biom11060878 · Cited by 201

Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion

Zhu, M., Xu, H., Liang, Y.-J., Xu, J., Yue, N.-N., Zhang, Y., Tian, C., Yao, J., Wang, L., Nie, Y., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02065-0 · Cited by 208

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

Ding, J., Chen, M., Wu, L., Shu, G., Fang, S., Li, Z., Chu, X., Li, X., Wang, Z.-G., & Ji, J. (2023) · Military Medical Research · doi:10.1186/s40779-023-00472-w · Cited by 211

Nucleic acid drugs: recent progress and future perspectives

Sun, X., Setrerrahmane, S., Li, C., Hu, J., & Xu, H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02035-4 · Cited by 225

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Zhang, L., Liu, Y., Huang, H., Xie, H., Zhang, B., Xia, W., & Guo, B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114536 · Cited by 180

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

Mosquera-Heredia, M. I., Morales, L. C., Vidal, O. M., Barceló, E., Silvera-Redondo, C. A., Velez, J. I., & Garavito, P. (2021) · Biomedicines · doi:10.3390/biomedicines9081061 · Cited by 173

Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry

Yi, W., Xiao, P., Liu, X., Zhao, Z., Sun, X., Wang, J., Zhou, L., Wang, G., Cao, H., Wang, D., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01250-1 · Cited by 178

Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics

Yin, B., Ni, J., Witherel, C. E., Yang, M., Burdick, J. A., Wen, C., & Wong, S. H. D. (2021) · Theranostics · doi:10.7150/thno.62708 · Cited by 168

Exosome nanovesicles: A potential carrier for therapeutic delivery

Chavda, V. P., Pandya, A., Kumar, L., Raval, N., Vora, L. K., Pulakkat, S., Patravale, V. B., Salwa, Duo, Y., & Tang, B. Z. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101771 · Cited by 165

Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines

Liu, M., Wang, Y., Zhang, Y.-B., Hu, D., Tang, L., Zhou, B., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02112-8 · Cited by 189

Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162

Principles and Problems of Exosome Isolation from Biological Fluids

Yakubovich, E. I., Polischouk, A. G., & Евтушенко, В. И. (2022) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747822030096 · Cited by 158

Exosome as drug delivery system: Current advancements

Sharma, V., & Mukhopadhyay, C. D. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100032 · Cited by 156

Cell-free exosome-laden scaffolds for tissue repair

Huang, J., Xiong, J., Yang, L., Zhang, J., Sun, S., & Liang, Y. (2021) · Nanoscale · doi:10.1039/d1nr01314a · Cited by 152

Exosome for mRNA delivery: Strategies and therapeutic applications

Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Therapy

Chen, S., Sun, F., Qian, H., Xu, W., & Jiang, J. (2022) · Stem Cells International · doi:10.1155/2022/1779346 · Cited by 153

Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications

Jung, I., Shin, S., Baek, M., & Yea, K. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01132-8 · Cited by 139

Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Wen, C., Xu, L., Xu, X. G., Wang, D., Liang, Y., & Duan, L. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02662-0 · Cited by 130

Extracellular‐Vesicle‐Based Drug Delivery Systems for Enhanced Antitumor Therapies through Modulating the Cancer‐Immunity Cycle

Yong, T., Wei, Z., Gan, L., & Yang, X. (2022) · Advanced Materials · doi:10.1002/adma.202201054 · Cited by 129

CRISPR/Cas9 systems: Delivery technologies and biomedical applications

Du, Y., Liu, Y., Hu, J., Peng, X., & Liu, Z. (2023) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2023.100854 · Cited by 140

The role and application of small extracellular vesicles in gastric cancer

Wu, H., Fu, M., Liu, J., Chong, W., Fang, Z., Du, F., Liu, Y., Shang, L., & Li, L. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01365-z · Cited by 125

Clinical delivery of circular RNA: Lessons learned from RNA drug development

Young, T. L., Wang, K. C., Varley, A., & Li, B. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114826 · Cited by 130

Advances in materials-based therapeutic strategies against osteoporosis

Chen, L., Song, J., Li, S., Zhu, Y., Liu, M., Wan, M., 高木, 昭., Tay, F. R., & Niu, L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122066 · Cited by 127

Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies

Mehdizadeh, S., Mamaghani, M., Hassanikia, S., Pilehvar‐Soltanahmadi, Y., & Ertaş, Y. N. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03352-8 · Cited by 138

Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing

Li, Y., Zhu, Z., Li, S., Xie, X., Qin, L., Zhang, Q., Yang, Y., Wang, T., & Zhang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02684-1 · Cited by 133

Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Li, M., Fang, F., Sun, M., Zhang, Y., Hu, M., & Zhang, J. (2022) · Theranostics · doi:10.7150/thno.72812 · Cited by 121

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

Lin, W., Chen, L., Zhang, H., Qiu, X., Huang, Q., Wan, F., Le, Z., Geng, S., Zhang, A., Qiu, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35710-7 · Cited by 119

Roles of exosomes in immunotherapy for solid cancers

Lyu, C., Sun, H., Sun, Z., Liu, Y., & Wang, Q. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06494-z · Cited by 126

Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

Zhong, L., Wang, J., Wang, P., Liu, X., Liu, P., Cheng, X., Cao, L., Wu, H., Chen, J., & Zhou, L. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03409-1 · Cited by 110

Engineering and Targeting Neutrophils for Cancer Therapy

Zhang, J., Gu, J., Wang, X., Ji, C., Yu, D., Wang, M., Pan, J., Santos, H. A., Zhang, H., & Zhang, X. (2024) · Advanced Materials · doi:10.1002/adma.202310318 · Cited by 116

Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

Rong, Y., Wang, Z., Tang, P., Wang, J., Ji, C., Chang, J., Zhu, Y., Wu, Y., Bai, J., Liu, W., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.011 · Cited by 117

Current challenges surrounding exosome treatments

Tzng, E., Bayardo, N., & Yang, P. C.-M. (2023) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100023 · Cited by 121

Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis

Qiu, F.-S., Wang, J., Guo, M.-Y., Li, X.-J., Shi, C.-Y., Wu, F., Zhang, H., Ying, H., & Yu, C.-H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115007 · Cited by 110

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110

Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases

Zou, Z., Han, L., Xu, G., Hu, Y., Zhang, W., & Tian, K. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s417422 · Cited by 115

Extracellular signals regulate the biogenesis of extracellular vesicles

Jin, Y., Ma, L., Zhang, W., Yang, W., Feng, Q., & Wang, H. (2022) · Biological Research · doi:10.1186/s40659-022-00405-2 · Cited by 121

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Huang, L., Wu, E., Liao, J., Wei, Z., Wang, J., & Chen, Z. (2023) · ACS Omega · doi:10.1021/acsomega.3c04479 · Cited by 113

Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma

Yang, H., Sun, B., Fan, L., Ma, W., Xu, K., Hall, S. R. R., Wang, Z., Schmid, R. A., Peng, R., Marti, T. M., et al. (2022) · Theranostics · doi:10.7150/thno.69590 · Cited by 107

Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy

Johnson, V., Vasu, S., Sukumar, U. K., & Kumar, M. (2023) · Cancers · doi:10.3390/cancers15102838 · Cited by 106

Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis

Liu, H., Song, P., Zhang, H., Zhou, F., Ji, N., Wang, M., Zhou, G., Han, R., Liu, X., Weng, W., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12429 · Cited by 106

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

Wang, Y., Deng, T., Liu, X., Fang, X., Mo, Y., Xie, N., Nie, G., Zhang, B., & Fan, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s459710 · Cited by 112

Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Peng, X., Fang, J., Lou, C., Yang, L., Shan, S., Wang, Z., Chen, Y., Li, H., & Li, X. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.010 · Cited by 111

Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

Liu, H., Zhang, H., Han, Y., Hu, Y., Geng, Z., & Su, J. (2022) · Theranostics · doi:10.7150/thno.78034 · Cited by 102

Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

Yang, G., Waheed, S., Wang, C., Shekh, M. I., Li, Z., & Wu, J. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80430 · Cited by 106

Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Moghassemi, S., Dadashzadeh, A., Sousa, M. J., Vlieghe, H., Yang, J., León-Félix, C. M., & Amorim, C. A. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.021 · Cited by 113

Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

Chen, Y., Douanne, N., Wu, T.-C., Kaur, I., Tsering, T., Erzingatzian, A., Nadeau, A., Juncker, D., Nerguizian, V., & Burnier, J. V. (2025) · Science Advances · doi:10.1126/sciadv.ads5249 · Cited by 107

“Double-sided protector” Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects

Xu, L., Zhang, J., Luo, J., Cui, Y., Chen, J., Zeng, B., Deng, Z., & Shao, L. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03438-3 · Cited by 106

Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

Xu, X., Xu, L., Wen, C., Xia, J., Zhang, Y., & Liang, Y. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100760 · Cited by 101

3D Bioprinting of Hydrogels for Cartilage Tissue Engineering

Huang, J., Xiong, J., Wang, D., Zhang, J., Yang, L., Sun, S., & Liang, Y. (2021) · Gels · doi:10.3390/gels7030144 · Cited by 98

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: Challenges and opportunities

Qin, Q., Yu, R., Eriksson, J., Tsai, H., & Zhu, H. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216859 · Cited by 102

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

Ghasempour, E., Hesami, S., Movahed, E., Keshel, S. H., & Doroudian, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03212-4 · Cited by 97

Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy

Ahmadi, S. E., Soleymani, M., Shahriyary, F., Amirzargar, M. R., Mahya, O., Fattahi, D., & Safa, M. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00597-z · Cited by 97

Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway

Chen, T., Song, P., He, M. Y., Rui, S., Duan, X., Ma, Y., Armstrong, D. G., & Deng, W. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad003 · Cited by 95

Ginger: a representative material of herb-derived exosome-like nanoparticles

Zhu, H., & He, W. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1223349 · Cited by 103

Engineered mammalian and bacterial extracellular vesicles as promising nanocarriers for targeted therapy

Liu, H., Geng, Z., & Su, J. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2022.04 · Cited by 95

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

Jeske, R., Liu, C., Duke, L. C., Castro, M. L. C., Muok, L., Arthur, P., Singh, M. S., Jung, S., Sun, L. J., & Li, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.004 · Cited by 95

Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx

Zheng, W., He, R., Liang, X., Roudi, S., Bost, J., Coly, P., van Niel, G., & Andaloussi, S. E. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12290 · Cited by 94

Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy

Chen, J., Pan, J., Liu, S., Zhang, Y., Sha, S., Guo, H., Wang, X., Hao, X., Zhou, H., Tao, S., et al. (2023) · Advanced Materials · doi:10.1002/adma.202304187 · Cited by 90

Engineered Exosomes for Tumor-Targeted Drug Delivery: A Focus on Genetic and Chemical Functionalization

Akbari, A., Nazari‐Khanamiri, F., Ahmadi, M., Shoaran, M., & Rezaie, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010066 · Cited by 98

Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration.

Zhang, H., Yan, W.-J., Wang, J., Xie, S.-Q., Tao, W., Lee, C.-W., Zhang, X., Zhang, G.-Y., Liu, Y.-F., Wei, D., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.009 · Cited by 88

Bone‐Targeted Exosomes: Strategies and Applications

Wang, J., Li, X., Wang, S., Cui, J., Ren, X., & Su, J. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203361 · Cited by 92

Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

Xu, X. G., Xu, L., Xia, J., Wen, C., Liang, Y., & Zhang, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.024 · Cited by 92

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Huang, M., Zhai, B., Fan, Y. B., Sun, J., Shi, Y., Zhang, X., Zou, J., Wang, J., & Guo, D. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s410688 · Cited by 90

Engineered exosomes and composite biomaterials for tissue regeneration

Hu, W., Wang, W., Chen, Z., Chen, Y., & Wang, Z. (2024) · Theranostics · doi:10.7150/thno.93088 · Cited by 89

Exosome-based drug delivery systems and their therapeutic applications

Lee, J., Lee, J.-H., Chakraborty, K., Hwang, J., & Lee, Y.-K. (2022) · RSC Advances · doi:10.1039/d2ra02351b · Cited by 85

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Zheng, W., Rädler, J., Sork, H., Niu, Z., Roudi, S., Bost, J., Görgens, A., Zhao, Y. H., Mamand, D. R., Liang, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40453-0 · Cited by 88

Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry

Menichetti, A., Mordini, D., & Montalti, M. (2024) · Journal of Xenobiotics · doi:10.3390/jox15010006 · Cited by 92

Precise nanoscale fabrication technologies, the “last mile” of medicinal development

Bi, Y., Xie, S., Li, Z., Dong, S., & Teng, L. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.03.040 · Cited by 90

Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention

Li, L., Wang, F., Zhu, D., Hu, S., Cheng, K., & Li, Z. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.03.025 · Cited by 87

Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

Duan, L., Ouyang, K., Wang, J., Xu, L., Xu, X., Wen, C., Xie, Y., Liang, Y., & Xia, J. (2021) · ChemBioChem · doi:10.1002/cbic.202100359 · Cited by 82

Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole

Wang, Y., Liu, L., Zhu, Y., Wang, L., Yu, D., & Liu, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112561 · Cited by 82

Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

Zhang, X. Y., Jiang, Y., Huang, Q., Wu, Z., Pu, H., Xu, Z., Li, B., Lu, X., Yang, X., Qin, J., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02475-7 · Cited by 80

Diagnostic and Therapeutic Potential of Extracellular Vesicles

Kodam, S. P., & Ullah, M. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211041203 · Cited by 85

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56

Bioengineering and modification of exosome nanovesicles for targeted drug delivery

Desai, N., Salave, S., & Vora, L. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00008-8 · Cited by 1

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 149

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 163

Biology and Therapeutic Potential of Exosomes, Targeted Drug Delivery

Mateos-Ramírez, F. A. G., Hernández‐Ortega, L. D., Gurrola‐Díaz, C. M., Gasca-Lozano, L. E., Sánchez-Orozco, L. V., & Salazar-Montes, A. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188145